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Transcription FactorsTranscription, GeneticPromoter Regions, GeneticDNA-Binding ProteinsSp1 Transcription FactorTranscription Factors, TFIIIGene Expression RegulationMolecular Sequence DataBase SequenceTranscriptional ActivationBinding SitesTrans-ActivatorsBasic Helix-Loop-Helix Transcription FactorsRNA, MessengerProtein BindingNuclear ProteinsTranscription Factor AP-1Repressor ProteinsCell LineForkhead Transcription FactorsHomeodomain ProteinsGene Expression Regulation, DevelopmentalSignal TransductionAmino Acid SequenceDNABasic-Leucine Zipper Transcription FactorsTranscription Factor AP-2MutationCell NucleusCell DifferentiationTransfectionKruppel-Like Transcription FactorsTranscription Factors, TFIIChromatin ImmunoprecipitationGenes, ReporterYY1 Transcription FactorHeLa CellsSTAT3 Transcription FactorGATA4 Transcription FactorTranscription Factor TFIIDCells, CulturedActivating Transcription Factor 3NFATC Transcription FactorsSp3 Transcription FactorTranscription Initiation SiteNF-kappa BReverse Transcriptase Polymerase Chain ReactionZinc FingersPaired Box Transcription FactorsElectrophoretic Mobility Shift AssayActivating Transcription Factor 2Transcription Factor TFIIBEnhancer Elements, GeneticRegulatory Sequences, Nucleic AcidE2F1 Transcription FactorRNA Polymerase IIGene Expression ProfilingCloning, MolecularBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMEF2 Transcription FactorsRecombinant Fusion ProteinsPlasmidsGATA3 Transcription FactorGATA1 Transcription FactorGATA2 Transcription FactorGene ExpressionGene Expression Regulation, FungalTCF Transcription FactorsGATA Transcription FactorsMicrophthalmia-Associated Transcription FactorLuciferasesSTAT1 Transcription FactorProtein Structure, TertiaryActivating Transcription FactorsTranscription Factor RelAE2F Transcription FactorsCell Line, TumorPhosphorylationHelix-Loop-Helix MotifsChromatinSaccharomyces cerevisiaeOligonucleotide Array Sequence AnalysisSaccharomyces cerevisiae ProteinsGene Expression Regulation, PlantGATA6 Transcription FactorActivating Transcription Factor 4Models, BiologicalTranscription Factor 7-Like 1 ProteinActivating Transcription Factor 1Cyclic AMP Response Element-Binding ProteinSequence Homology, Amino AcidTranscription Factor TFIIIAProto-Oncogene ProteinsBlotting, WesternMice, KnockoutTATA BoxNFI Transcription FactorsModels, GeneticTumor Cells, CulturedDown-Regulation
P300HistoneGenePromoterProteinCellsGrowth factorsExpressionHumanSignaling pathwayActivationGrowth
P3003
  • In this study, we provide evidence of a novel CAF transcriptional axis regulating the expression of SDF1, a major driver of cancer cell migration, involving the transcription factor GLI1 and histone acetyltransferase p300. (bvsalud.org)
  • Mapping experiments highlight the requirement of GLI1 N-terminal for the interaction with p300. (bvsalud.org)
  • GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration. (mayo.edu)
Histone1
  • Histone deacetylases can be regulated by endogenous factors, dietary components, synthetic inhibitors and bacteria-derived signals. (wikipedia.org)
Gene1
  • Here, we show that p97/VCP, an AAA+ ATPase known to contribute to ER stress-induced gene expression, regulates the transcription factor GLI1, a primary effector of Hedgehog (Hh) signaling. (bvsalud.org)
Promoter1
  • Further analysis showed that GLI1 cooperates with ATF6f to induce promoter activity and expression of XBP1, a key transcription factor driving UPR. (bvsalud.org)
Protein1
  • Furthermore, the deleterious aftereffect of missense mutations can occur not merely from immediate disruption of CAPN3 function(s), but additionally from disruption from the protein's structural integrity, that could affect its intra or intermolecular protein lead and interactions to decreased stability or altered localization. (exposed-skin-care.net)
Cells3
  • These interactions are responsible of calibrating epithelial cells responses necessary to establish a normal relationship between the host and the commensal as well as to maintain intestinal homeostasis. (wikipedia.org)
  • Aberrant activation of the Hedgehog (Hh) signaling pathway, through which the GLI family of transcription factors (TF) is stimulated, is commonly observed in cancer cells. (bvsalud.org)
  • Further analysis using as a model GLI1, a major TF activator of the GLI family in PDAC cells, shows the interaction of SUFU and GLI1 in the nucleus through previously characterized domains. (bvsalud.org)
Growth factors1
  • Secretion of cytokines and growth factors underlies the pro-tumoral effect of CAFs. (bvsalud.org)
Expression1
  • Although this paracrine function has been extensively documented, the molecular mechanisms controlling the expression of these factors remain elusive. (bvsalud.org)
Human1
  • We developed a new single-molecule method to probe non-specific DNA interactions for two HMGB homologs: the human HMGB2 box A domain and yeast Nhp6Ap, along with chimeric mutants replacin. (shengsci.com)
Signaling pathway1
  • Aberrant activation of the Hedgehog (Hh) signaling pathway, through which the GLI family of transcription factors (TF) is stimulated, is commonly observed in cancer cells. (bvsalud.org)
Activation2
  • For instance, TFII-I is required for growth factor-induced transcriptional activation of the c-fos gene, which is essential for cell cycle entry. (nih.gov)
  • of NETs Ansatrienin A is usually partially due to impaired NET clearance by extracellular DNases as DNase substitution improved NET dissolution and reduced FXII activation for articles that Pcdhb5 included the following search terms: Inflammation and thrombosis in COVID-19, NETs and COVID-19, and Factor XII and COVID-19. (exposed-skin-care.net)
Growth2
  • TFII-I is a unique, signal-induced multifunctional transcription factor that is activated upon a variety of signaling pathways and appears to participate in distinct phases of cell growth. (nih.gov)
  • Secretion of cytokines and growth factors underlies the pro-tumoral effect of CAFs. (bvsalud.org)