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  • heme
  • It was found that the heme iron in ferric cytochrome c does not react directly with peroxynitrite. (edu.pl)
  • Modifications of the heme center of cytochrome c by radiolytically produced radicals, ·OH, ·NO2 or CO3-·, were also studied. (edu.pl)
  • NO2 produced radiolytically did not interact with the heme center of cytochrome c. (edu.pl)
  • This means that modification of protein structure: oxidation of amino acids and/or tyrosine nitration, facilitates reaction of H2O2 with the heme iron of cytochrome c, followed by reaction with the second substrate. (edu.pl)
  • To perform this function efficiently, microorganisms have adapted multiheme c-type cytochromes to arrange heme cofactors into wires that cooperatively span the cellular envelope, transmitting electrons along distances greater than 100 Å. (pnas.org)
  • To shed light on this critical topic, we carried out extensive quantum mechanics/molecular mechanics simulations to calculate stepwise heme-to-heme electron transfer rates in the recently crystallized outer membrane deca-heme cytochrome MtrF. (pnas.org)
  • Cytochromes P450 are heme-containing enzymes responsible for the oxidative metabolism of a wide variety of small molecule substrates. (aspetjournals.org)
  • The interaction of covalently bound heme with the cytochrome c maturation protein CcmE. (ox.ac.uk)
  • The heme chaperone CcmE is a novel protein that binds heme covalently via a histidine residue as part of its essential function in the process of cytochrome c biogenesis in many bacteria as well as plant mitochondria. (ox.ac.uk)
  • In the continued absence of a structure of the holoform of CcmE, identification of the heme ligands is an important step in understanding the molecular function of this protein and the role of covalent heme binding to CcmE during the maturation of c-type cytochromes. (ox.ac.uk)
  • region of cytochrome
  • The rates of the absorbance changes in the Soret region of cytochrome c spectrum caused by peroxynitrite or peroxynitrite/bicarbonate were the same as the rate of spontaneous isomerization of peroxynitrite or as the rate of the reaction of peroxynitrite with bicarbonate, respectively. (edu.pl)
  • microsomal
  • in liver slices, at a low ethanol concentration, the enhanced rate of drug oxidation is the result of an increased NADH concentration, whereas the inhibitory effect observed with the microsomal fraction at high ethanol concentration is due to the interference by ethanol with the binding of drug substrates to cytochrome P -450. (biochemj.org)
  • However, it is likely to cause several perplexing features of microsomal P450s, such as biphasic kinetics of their reduction by NADPH and dithionite (Karyakin and Davydov, 1985), multiphasic kinetics of interactions with carbon monoxide (Davydov et al. (springer.com)
  • Davydov D.R., Kariakin A.A., Petushkova N.A., and Peterson J.A., 2000, Association of cytochromes P450 with their reductases: opposite sign of the electrostatic interactions in P450BM-3 as compared with the microsomal 2B4 system. (springer.com)
  • metabolic
  • Almost one half of prospective drugs, including new chemical entities are not suitable for clinical use because of their metabolic unstability and for danger of drug interactions. (imtm.cz)
  • peroxidase
  • Cytochrome c exhibited an increased peroxidase-like activity after reaction with peroxynitrite as well as with radiolytically produced ·OH, ·NO2 or CO3-· radicals. (edu.pl)
  • 2002) Protein oxidation of cytochrome c by reactive halogen species enhances its peroxidase activity. (edu.pl)
  • 2002) Peroxidase activity as a tool for studying the folding of c-type cytochromes. (edu.pl)
  • respiratory depression
  • Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death [see WARNINGS AND PRECAUTIONS , DRUG INTERACTIONS ]. (rxlist.com)
  • reaction
  • Kinetics of the reaction of peroxynitrite with ferric cytochrome c in the absence and presence of bicarbonate was studied. (edu.pl)
  • Ritonavir
  • 3.Liddy AM, McLaughlin G, Schmitz S, D'Arcy DM, Barry MG. The Pharmacokinetic Interaction between Ivacaftor and Ritonavir in Healthy Volunteers. (webmd.com)
  • species
  • This means that intermediate products of peroxynitrite decomposition, ·OH/·NO2 or, in the presence of bicarbonate, CO3-·/·NO2, are the species responsible for the absorbance changes in the Soret band of cytochrome c. (edu.pl)
  • Association of Cytochromes P450 1A2 and 2B4: are the Interactions between Different p450 Species Involved in the Control of the Monooxygenase Activity and Coupling? (springer.com)
  • Chemical
  • NMR spectra recorded for 13 C, 15 N-enriched samples in the presence increasing amounts of AQDS showed perturbations in the chemical shift signals of the cytochromes. (osti.gov)
  • interfere
  • Danthron was identified as an effective small molecule able to interfere with the interaction between HO-1 and CPR but not HO-2 and CPR. (biomedcentral.com)
  • In contrast, anthrarufin, a structural analog with no ability to interfere HO-1/CPR interaction, exhibited no significant effect on HO-1-overexpressing HeLa cells. (biomedcentral.com)
  • system
  • More than 90% of the cross-linked cytochrome c in the purified derivative was rapidly reduced upon addition of an NADPH-generating system, whereas approximately 80% of the cross-linked cytochrome b5 was rapidly reduced. (biomedsearch.com)