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Adenovirus E1A ProteinsAdenoviruses, HumanAdenovirus E4 ProteinsAdenovirus E1B ProteinsAdenovirus Early ProteinsAdenovirus E3 ProteinsAdenoviridaeAdenovirus Infections, HumanAdenovirus E2 ProteinsAdenoviridae InfectionsAdenovirus E1 ProteinsOncogene Proteins, ViralS100 Calcium Binding Protein beta SubunitHeLa CellsGenetic VectorsMolecular Sequence DataCell LineBase SequenceTranscription, GeneticMastadenovirusAdenoviruses, CanineDNA-Binding ProteinsTranscription FactorsGenes, ViralDNA, ViralPromoter Regions, GeneticCell Transformation, ViralAmino Acid SequenceViral ProteinsTransfectionE1A-Associated p300 ProteinGene Expression Regulation, ViralHMGA1b ProteinVirus ReplicationS100 ProteinsNuclear ProteinsRetinoblastoma ProteinAntigens, Viral, TumorMutationTranscription Factor DP1Adenoviruses, PorcineAviadenovirusRetinoblastoma-Binding Protein 1Protein BindingGenetic TherapyTranscriptional ActivationE2F Transcription FactorsFowl adenovirus ARecombinant Fusion ProteinsPlasmidsGene Expression RegulationGene Transfer TechniquesRNA, MessengerBinding SitesCell NucleusTumor Cells, CulturedCapsid ProteinsTrans-ActivatorsTumor Suppressor Protein p53CucumovirusCell Line, TransformedRNA, ViralCells, CulturedSimian virus 40Receptors, VirusGene ExpressionCell Transformation, NeoplasticOncolytic VirotherapyActivating Transcription FactorsCloning, MolecularAntigens, Polyomavirus TransformingOncolytic VirusesApoptosisRecombinant ProteinsDNA ReplicationKeratoconjunctivitisTransduction, GeneticCarrier ProteinsRepressor ProteinsRetinoblastoma-Like Protein p107CREB-Binding ProteinCell Cycle ProteinsChloramphenicol O-AcetyltransferaseOpen Reading FramesPapillomavirus E7 ProteinsViral Nonstructural ProteinsE2F1 Transcription FactorOncogenesKB CellsPrecipitin TestsDNAConjunctivitis, ViralSequence Homology, Amino AcidEnhancer Elements, GeneticCell CycleBlotting, WesternNerve Growth FactorsPhosphoproteinsProto-Oncogene ProteinsCell Line, Tumor
BCL219kDaBNIP3VectorsApoptosisHOMEODOMAIN PROTEINSGenomeEarly transcribed regionsInfectionReplicationGENESMitochondrialStrainsRecombinantMitochondriaEukaryoticInteractionCellularHomeoboxMediatesModulateGenetic transcriptionBindApoptoticMembraneSpeciesNucleusVirusesStemSynthesisVitroCellsGlucoseHuman proteinIsoformsSequenceFamilyFacilitateFunctionRegionsExpressionProtection
BCL26
  • BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene. (wikipedia.org)
  • This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. (wikipedia.org)
  • The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2. (thermofisher.com)
  • BCL2 and adenovirus E1B 19-kDa interacting protein 3 (BNIP3), a well-known atrogene, was identified as a potential mediator of muscle fiber atrophy in LOPD muscle biopsies. (nih.gov)
  • Bax Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. (affbiotech.cn)
  • Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), MCL1 and A1. (affbiotech.cn)
19kDa1
  • these include the E1B-19KDa protein, which is a homologue of the Bcl-2 protein, the E3-14.7KDa protein (called E3-14.7K) and the E3-14.5KDa/10.4KDa heterodimer. (yu.edu)
BNIP34
  • The key regulator of this process, hypoxia inducible factor 1 (HIF-1), can initiate apoptosis by inducing high concentrations of proapoptotic proteins, such as BNIP3, and can cause stabilisation of p53. (bmj.com)
  • The current data suggested that BNIP3 expression is regulated by inhibition of the AKT-mammalian target of rapamycin pathway, leading to phosphorylation of Unc-51 like autophagy activating kinase 1 (ULK1) at Ser317 by AMP-activated protein kinase. (nih.gov)
  • BNIP3 and NIX are related multi-functional outer mitochondrial membrane proteins. (1library.net)
  • Here, after a general discussion of mitophagy, we will review and discuss two related outer mitochondrial membrane (OMM) proteins, BNIP3 and BNIP3L (NIX). (1library.net)
Vectors6
  • The adenoviral vectors provided by Genemedi are based on human adenovirus type 5 (Ad5), which is replication-incompetent (-E1/-E3) and can't be integrated into host genome, guaranteeing the security for subsequent operations. (9lb.cc)
  • Transduction results of various Adenovirus vectors. (9lb.cc)
  • Several different viral vectors have been developed for gene therapy, including ret-rovirus, adenovirus, adeno-associated virus (AAV), and herpes simplex virus (HSV). (pharmacy180.com)
  • Adenoviral vectors are based on natural adenoviruses of serotypes 2 and 5. (pharmacy180.com)
  • In these first generation adenoviral-vectors, additional partial dele-tions of E1B and E3 genes can be made to create more space for transgene insertion. (pharmacy180.com)
  • Schematic of the adenovirus genome and adenovirus-based vectors. (genemedi.com)
Apoptosis2
  • Apoptosis regulatory proteins are delicately balanced. (bmj.com)
  • These paclitaxel resistant ovarian cells demonstrate: (1) Increased IC 50 for paclitaxel and docetaxel (10 to 75-fold) and cross-resistance to anthracyclines (2) Reduced cell apoptosis in the presence of paclitaxel (3) Gene depletion involving mitotic regulators BUB1 mitotic checkpoint serine/threonine kinase, cyclin BI (CCNB1), centromere protein E (CENPE), and centromere protein F (CENPF), and (4) Functional data validating gene depletion among mitotic regulators. (biomedcentral.com)
HOMEODOMAIN PROTEINS2
Genome5
  • Adenoviruses and AAVs do not integrate their genes into the host cell genome. (pharmacy180.com)
  • They carry an inherent risk of mutagenesis by inserting their genome (called insertion mutagenesis) within a functional gene, which can compromise the functionality of a critical normal human protein. (pharmacy180.com)
  • For producing transgene-containing therapeutic adenoviruses, their genome is modified by deletion of the viral replication specific gene known as early gene 1 ( E1A ). (pharmacy180.com)
  • Top panel: a simplified map of the adenovirus serotype 5 genome showing the early genes (E1-E4) and the region from which the major late transcript is produced. (genemedi.com)
  • Without integration into host genome, adenovirus genome remains in an episomal state, which guarantees the low risk of mutation (Fig. 8). (genemedi.com)
Early transcribed regions1
  • Simply, the E1 gene products are early proteins that are transcribed in the early transcribed regions and required for proceeding subsequent steps in viral replication. (9lb.cc)
Infection7
  • A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection. (leibniz-liv.de)
  • Protein-Protein Interactions Facilitate E4orf6-Dependent Regulation of E1B-55K SUMOylation in HAdV-C5 Infection. (leibniz-liv.de)
  • E1B-55K is a phosphorylation-dependent transcriptional and post-transcriptional regulator of viral gene expression in HAdV-C5 infection. (leibniz-liv.de)
  • Human Adenovirus Type 5 Infection Leads to Nuclear Envelope Destabilization and Membrane Permeability Independently of Adenovirus Death Protein. (leibniz-liv.de)
  • Recombinant protein expression of interest is detectable from 24 hours post infection. (9lb.cc)
  • For most serotypes, adenovirus infection is mediated by the high-affinity binding of the fiber-knob region to a receptor of target cell, named as the coxsackie-Ad receptor (CAR), which mainly determines the viral tropism [44]. (genemedi.com)
  • Infection process of adenovirus. (genemedi.com)
Replication10
  • Adipocyte commitment of 3T3-L1 cells is required to support human adenovirus 36 productive replication concurrent with altered lipid and glucose metabolism. (leibniz-liv.de)
  • Evidence that the Adenovirus Single-Stranded DNA Binding Protein Mediates the Assembly of Biomolecular Condensates to Form Viral Replication Compartments. (leibniz-liv.de)
  • Viral DNA Binding Protein SUMOylation Promotes PML Nuclear Body Localization Next to Viral Replication Centers. (leibniz-liv.de)
  • Bronchial epithelial cells (BEAS-2B cells and primary bronchial epithelial cells) were exposed to heat-inactivated Haemophilus influenzae , Pseudomonas aeruginosa or Streptococcus pneumoniae and subsequently infected with respiratory syncytial virus (RSV), type 2 human adenovirus or influenza B. Levels of pro-inflammatory cytokines, viral replication and expression of pattern recognition receptors were determined in culture supernatants and/or cell lysates. (biomedcentral.com)
  • Recombinant adenovirus (Adenovirus), a replication-defective adenoviral vector system, is widely used for gene delivery in most cell types. (9lb.cc)
  • The E1 gene contains E1A and E1B, involved in the replication of adenovirus. (9lb.cc)
  • E1A is critical to start viral replication by promoting transcription from rep gene promoters, P5 and P19, and facilitate viral replication by activating the early adenovirus promoters. (9lb.cc)
  • Adenovirus transcription is a two-phase event, early and late, occurring before and after viral DNA replication, respectively (Figure. (genemedi.com)
  • Life cycle of adenovirus is separated by DNA replication process into two distinct phases: the early and late, occurring before and after viral DNA replication, respectively. (genemedi.com)
  • To prevent infected cell lysis, recombinant replication deficiency virus has been developed as a gene delivery tool to replace wild-type adenovirus (recombinant AdV in "application" part). (genemedi.com)
GENES4
  • Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
  • The adenovirus without E1/E3 can express all of the other genes in the viral backbone and hence induces immunogenic responses, while rAAV does not have any of the AAV genes, thus no immunogenicity from viral protein. (9lb.cc)
  • Gene therapy is a method for the treatment or prevention of disease that uses genes to provide the patient's somatic cells with the genetic information necessary to produce specific therapeutic proteins needed to correct or to modulate a disease. (pharmacy180.com)
  • Reprime la TRANSCRIPCIÓN GENÉTICA de los GENES diana y desempeña una función fundamental en la ODONTOGÉNESIS. (bvsalud.org)
Mitochondrial2
  • In the PARK2-dependent pathway, PINK1 activates PARK2 to target many mitochondrial proteins, including NDP52, OPTN and p62, and it combines with LC3 to deliver damaged mitochondria to autophagosomes [ 15 ]. (ijbs.com)
  • Furthermore, we uncovered that autophagy promotes proline biosynthesis through mitophagy-mediated regulation of NADK2 (NAD kinase 2, mitochondrial), an enzyme responsible for production of mitochondrial NADP(H). Using an orthotopic mouse model of PDAC, we found that inhibiting mitophagy by targeting PRKN (parkin RBR E3 ubiquitin protein ligase) in the stroma reduced tumor weight. (bvsalud.org)
Strains1
  • Genomic and phylogenetic analysis of two guinea pig adenovirus strains recovered from archival lung tissue. (leibniz-liv.de)
Recombinant1
  • Adenovirus packaging by Genemedi shows almost 100% gene delivery in most cell types in the recombinant protein expression system both in vivo and in vitro. (9lb.cc)
Mitochondria2
  • Through our study of these proteins, we hope to gain a better apprecia-tion of the relaapprecia-tionship between mitochondria and cells. (1library.net)
  • The mitochondria have their own chaperones and proteolytic enzymes that remove damaged or unfolded proteins [ 18 - 20 ]. (hindawi.com)
Eukaryotic1
Interaction2
  • Mutagenesis analysis has shown that the GTP-binding domain of FIP-1 is indispensable for its interaction with E3-14.7K. FIP-1 is very similar to two proteins: (1) an S. cerevisiae GTP-binding protein that presumably has a role in phosphate transport and (2) a C. elegans protein of unknown function. (yu.edu)
  • CAR receptor-fiber-knob adenovirus interaction and internalization process [46]. (genemedi.com)
Cellular4
  • Differential Regulation of Cellular FAM111B by Human Adenovirus C Type 5 E1 Oncogenes. (leibniz-liv.de)
  • The goal of our current studies is to identify and characterize the cellular targets which interact with E3-14.7K and to further our understanding of the TNF-{dollar}\alpha{dollar} signaling pathways. (yu.edu)
  • TNF-{dollar}\alpha{dollar} induced rapid but transient phosphorylation and association of FIP-1 with other cellular proteins. (yu.edu)
  • Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
Homeobox1
  • Antennapedia homeodomain protein is a homeobox protein involved in limb patterning in ARTHROPODS. (lookformedical.com)
Mediates1
  • Hexon and penton structures form the capsid of AdV, and fiber protein mediates the binding of the virion to the cell surface and is a major determinant of viral tropism. (genemedi.com)
Modulate1
Genetic transcription1
  • Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)
Bind4
Apoptotic2
  • Though the specific function is unknown, it interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL-2, also an apoptotic protector. (wikipedia.org)
  • The Bcl-2 homology 3 (BH3) domain is crucial for the death-inducing and dimerization properties of pro-apoptotic members of the Bcl-2 protein family, including Bak, Bax, and Bad. (lookformedical.com)
Membrane1
  • Whether the cargo is a membrane-bound organelle, precipitated protein aggregate, or an intracellular pathogen, the solution is the same: erect a barrier, direct destructive agents into the newly-formed com-partment, and recycle or remove the debris. (1library.net)
Species3
  • Conserved E1B-55K SUMOylation in different human adenovirus species is a potent regulator of intracellular localization. (leibniz-liv.de)
  • Proteins that originate from insect species belonging to the genus DROSOPHILA. (lookformedical.com)
  • The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development. (lookformedical.com)
Nucleus3
Viruses1
  • Adenoviruses are nonenveloped DNA viruses carrying linear double-stranded DNA of about 35 kb length. (pharmacy180.com)
Stem1
  • Adenovirus has the ability to infect dividing, quiescent cells, stem cells, and primary cells, allowing genetic materials to be delivered to a highly diverse range of cell types and tissues. (9lb.cc)
Synthesis1
  • The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
Vitro1
  • We showed that FIPs interact in vitro and colocalize in vivo with E3-14.7K. Each of the four FIPs was able to cause cytolysis when overexpressed in human cells. (yu.edu)
Cells3
  • Cancer-associated fibroblasts (CAFs) are considered one of the most critical stromal cells that interact with pancreatic ductal adenocarcinoma (PDAC) and promote tumor growth, metastasis, and treatment resistance. (bvsalud.org)
  • Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
  • Selected results of Adenovirus transduction in the adult rat cardiac cells (A), eyes (B), neuron cells (C). (9lb.cc)
Glucose1
  • Specifically, we uncovered a role for nucleosides, which are secreted by CAFs through autophagy in a nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)-dependent manner, increased glucose utilization and promoted growth of PDAC. (bvsalud.org)
Human protein1
  • Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). 8 isoforms of the human protein are produced by alternative splicing. (affbiotech.cn)
Isoforms1
  • Lee, S. Hee, K. Caviness, E. R. Albright, J-H. Lee, C. B. Gelbmann, M. Rak, F. Goodrum, and R. F. Kalejta, 'Long and Short Isoforms of the Human Cytomegalovirus UL138 Protein Silence IE Transcription and Promote Latency. (arizona.edu)
Sequence4
  • Immunoglobulin J Recombination Signal Sequence-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
  • This graph shows the total number of publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Harvard Catalyst Profiles by year, and whether "Immunoglobulin J Recombination Signal Sequence-Binding Protein" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Profiles. (harvard.edu)
Family1
  • Adenovirus (AdV) is a member of the family Adenoviridae, whose name derives from their initial isolation from human adenoids in 1953 [42]. (genemedi.com)
Facilitate1
  • The PCM is an ordered lattice that anchors a large number of microtubule (MT)-associated proteins, many of which bear putative coiled-coil domains, a tertiary structure known to facilitate protein-protein interactions [ 4 ]. (biomedcentral.com)
Function1
  • Several other genetic backgrounds result in enlargement of the haltere significantly beyond the normal range of haploinsufficient phenotypes, suggesting genetic variation in cofactors that mediate homeotic protein function. (lookformedical.com)
Regions1
  • FIP-1 has regions of homology with other Ras-related small GTP binding proteins but has a unique carboxyl terminus. (yu.edu)
Expression2
  • Protein level and Gene expression were tested by Western blotting analysis and by the Applied Biosystems® Tagman® Array Plates, respectively. (longdom.org)
  • Thus, the duration of gene expression is much longer with retroviruses (weeks to months) as compared to adenoviruses and AAVs (days to weeks). (pharmacy180.com)
Protection1
  • KIR3DS1 directs NK cell-mediated protection against human adenovirus infections. (leibniz-liv.de)