• It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). (wikipedia.org)
  • Transcription factors bind to specific areas of DNA and help control whether particular genes are turned on or off. (medlineplus.gov)
  • Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. (yeastgenome.org)
  • An interaction is defined as an experimentally observed physical or genetic interaction between two genes. (yeastgenome.org)
  • This synthetic genetic interaction is seen at the level of single genes and acts downstream of promoter nucleosome reorganization. (sdbonline.org)
  • The common plant regulatory factors (CPRFs) from parsley are transcription factors with a basic-leucine-zipper motif that bind to cis-regulatory elements frequently found in promoters of light-regulated genes. (embl-heidelberg.de)
  • Proposed to function in concert with members of other transcription factor families, CPRFs regulate the transcriptional activity of many target genes. (embl-heidelberg.de)
  • Transcription factors attach to noncoding DNA, regulating the expression of protein-coding genes. (stanford.edu)
  • Like other transcription factors, the RUNX1 protein attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
  • This important work substantially advances our understanding of the interplay between genetic variation, chromatin, and genes within topologically associated domains and how this interplay regulates gene expression. (elifesciences.org)
  • Using M-P2 as a yeast one- hybrid bait, 23 different transcription factors or genes that interacted with MaPIP1;1 were screened. (bvsalud.org)
  • Genetic fine-mapping and CRISPRi screens identify functional variants and their target genes associated with Alzheimer's disease in microglia. (nature.com)
  • Reprime la TRANSCRIPCIÓN GENÉTICA de los GENES diana y desempeña una función fundamental en la ODONTOGÉNESIS. (bvsalud.org)
  • It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS. (bvsalud.org)
  • From genetic and expression studies, ULT functions redundantly with other genes like CLV1, CLV3 and PAN (PERIANTHIA) which plays a role in regulating meristem cell accumulation and floral organ pattern determination respectively, whereas ULT function independently of ERA1 (Fletcher et al. (grassius.org)
  • We develop a computational model for the hematopoietic erythroid-myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. (lu.se)
  • We used precisely engineered alleles to show that this genetic interac- tion arises from variation in the genes GAL2, GAL1/10/7, and PGM1 from the galactose metabolic pathway. (escholarship.org)
  • NRL interacts with homeodomain protein CRX and numerous other regulatory factors to control expression of most rod-expressed genes. (nih.gov)
  • The last 2 CDA types are caused by mutations in the erythroid transcription factor genes KLF1 (19p13.2) and GATA1 (Xp11.23). (orpha.net)
  • Nusslein-Volhard and Wieschaus discovered the transcription factor RUNX in a screen that was conducted to identify mutations that affect segment number and polarity in Drosophila. (wikipedia.org)
  • Our laboratory uses genetic, cell biological, and biochemical approaches to explore the pathogenesis of polyglutamine neurodegenerative diseases, the function of Math1 in neurodevelopment, and how MECP2 mutations cause postnatal neurodevelopmental disorders. (bcm.edu)
  • We also map differences in gene expression in live worms and discovered that mutations in the co-chaperone sti-1 upregulate the transcription of HSP-90. (escholarship.org)
  • Why do some mutations manifest later in life even though the genetic change was present at birth? (nih.gov)
  • Can we find common cellular pathways associated with photoreceptor cell death caused by distinct genetic mutations? (nih.gov)
  • Recent multi-omics studies have revealed the heterogeneity and complexity of tumor features such as their genetic mutations, transcriptome, proteins, and signaling pathways. (rsc.org)
  • CDA I is due to mutations in the CDAN1 gene (15q15.2), coding for a histone chaperone interacting protein, or in the C15ORF41 gene (15q14), coding for a predicted endonuclease putatively involved in DNA replication and/or chromatin assembly. (orpha.net)
  • Drugs, aging, genetic mutations, and disorders can increase (upregulate) or decrease (downregulate) the number and binding affinity of receptors. (msdmanuals.com)
  • Genetic testing for mutations in the VHL gene is performed at many laboratories throughout the United States and the world. (medscape.com)
  • RUNX1 is a transcription factor that regulates the differentiation of hematopoietic stem cells into mature blood cells. (wikipedia.org)
  • The variant histone H2A.Z regulates gene transcription, and deletion of the gene encoding H2A.Z strongly increases the requirement for SNF/SWI and SAGA. (sdbonline.org)
  • We recently reported that the MondoA:Mlx dimeric transcription factor directly regulates glycolysis. (duke.edu)
  • Smooth muscle cell (SMC) phenotypic transition, which leads to the formation of various cell types in atherosclerotic plaques, is regulated by a network of genetic and epigenetic mechanisms and governs the risk of disease. (stanford.edu)
  • To better understand the epigenetic and transcriptional mechanisms that mediate these cell state changes, and how they relate to risk for coronary artery disease (CAD), we have investigated the causality and function of transcription factors (TFs) at genome wide associated loci. (stanford.edu)
  • Here we undertake a genome-scale analysis of these interactions in a genetically diverse population to systematically identify global genetic-epigenetic interaction, and reveal constraints imposed by chromatin structure. (elifesciences.org)
  • With 176 samples profiled for genotype, gene expression, and open chromatin, we used regression modeling to infer genetic-epigenetic interactions on a genome-wide scale. (elifesciences.org)
  • These findings provide evidence that genetic and epigenetic factors operate within the context of three-dimensional chromatin structure. (elifesciences.org)
  • Yet the interacting effects that genetic and epigenetic factors produce on gene transcription are rarely studied at a genome-wide scale, leaving us without global information on a key step between the genetic code and the phenotype. (elifesciences.org)
  • Conversely, phenotypic variation in genetically diverse populations is a result of both genetic and epigenetic factors operating in tandem. (elifesciences.org)
  • Epigenetic regulation of transcription in intermediate heterochromatin. (omicsdi.org)
  • Regulators of Transcription with epigenetic changes in a (TaRGET) Program particular type of tissue. (medlineplus.gov)
  • The first phase of TaRGET and drugs, how an individual's genetic makeup interacts focused on how environmental exposures affect epigenetic with the environment, and how those affect their health. (medlineplus.gov)
  • The androgen receptor (AR) is a ligand-dependent transcription factor that has an essential role in the normal growth, development, and maintenance of the prostate gland. (nih.gov)
  • Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) is a protein that in humans is encoded by the RUNX1 gene. (wikipedia.org)
  • As a transcription factor (TF), its DNA binding ability is encoded by the runt domain (residues 50 - 177), which is homologous to the p53 family. (wikipedia.org)
  • Although the protein encoded by runt was demonstrated to exhibit nuclear translocation, it was not yet established that this protein is a transcription factor. (wikipedia.org)
  • 26 The suggested role in TP53 dependent apoptotic signalling 27 and interaction with the ankyrin repeats of proto-oncoprotein BCL3, thereby possibly modulating the activity of transcription factor NFKB, 28 represent BRCA1 independent functions of BARD1. (bmj.com)
  • Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. (nih.gov)
  • Using the model plant Arabidopsis thaliana, a research group led by Prof. Brigitte Poppenberger has been able to elucidate how a specific transcription factor - a special protein responsible for switching certain sections of the DNA on or off - is regulated by brassinosteroids. (sflorg.com)
  • This transcription factor, called BES1, can interact with heat shock factors thereby allowing genetic information to be targeted towards increased synthesis of heat shock proteins. (sflorg.com)
  • Sometimes, no transcription factor is attached to something that looks like a perfect motif. (stanford.edu)
  • In this study, we're showing that the STR sequence around the motif can have a really big effect on transcription factor binding, providing clues as to what these repeated sequences might be doing. (stanford.edu)
  • In the experiment we asked, 'How do these changes impact the strength of transcription factor binding? (stanford.edu)
  • The large number - over 6,000 - of experiments the team ran made it possible to develop a model of the rules governing transcription-factor binding. (stanford.edu)
  • Transcription factor codes play an essential role in neuronal specification and axonal guidance in both vertebrate and invertebrate organisms. (biologists.com)
  • One such code defined by the homeodomain transcription factor Even-skipped (Eve) and by the GATA 2/3 homologue Grain (Grn) is specifically required for motor axon projection towards dorsal muscles in Drosophila . (biologists.com)
  • Each transcription factor can independently induce unc-5 expression but unc-5 expression is more robust when both factors are expressed together. (biologists.com)
  • The RUNX1 gene provides instructions for making a protein called runt-related transcription factor 1 (RUNX1). (medlineplus.gov)
  • This protein interacts with another protein called core binding factor beta or CBFβ (produced from the CBFB gene), which helps RUNX1 bind to DNA and prevents it from being broken down. (medlineplus.gov)
  • Because this genetic change affects CBF, the condition is classified as core binding factor AML (CBF-AML). (medlineplus.gov)
  • Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. (medlineplus.gov)
  • WUSCHEL (WUS), a homeodomain transcription factor expressed in the rib meristem of the Arabidopsis SAM, is a key regulatory factor controlling SAM stem cell populations, and is thought to establish the shoot stem cell niche through a feedback circuit involving the CLAVATA3 (CLV3) peptide signalling pathway. (caltech.edu)
  • In an dual luciferase assay for complementarity verification, the transcription factor MADS3 positively regulated MaPIP1;1 transcription when combined with the banana promoter. (bvsalud.org)
  • In banana plants grown in 45% soil moisture to mimic drought stress, MaPIP1;1 expression was maximized, which further demonstrated that the MADS3 transcription factor can synergize with MaPIP1;1. (bvsalud.org)
  • We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
  • 2014). Arabidopsis gynoecium organ patterning along several axes is regulated by ULT1 and KAN1 (KANADI1) transcription factor. (grassius.org)
  • We previously discovered that that Maf-family bZIP transcription factor NRL is critical for rod photoreceptor fate and functional differentiation, and that loss of NRL leads to S-cones instead of rods. (nih.gov)
  • As a transcription factor whose expression is increased by DNA damage, p53 blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • Genomic location of these long noncoding RNA is disproportionately enriched near CAD-related TFs (transcription factors), genetic loci, and gene regulators of SMC identity, suggesting the importance of their function in disease. (stanford.edu)
  • A stable gene expression during plant and animal development is maintained by opposite functions of Polycomb group (PcG) chromatin remodeling factors that represses target gene expression through H3K27 trimethylation and trithorax group (trxG) chromatin remodeling factors that maintain transcription of target gene loci by H3K4-trimethylation (Schwartz and Pirrotta. (grassius.org)
  • We observed a large effect genetic interaction for growth in galactose among three loci in crosses involving the soil strain CBS2888. (escholarship.org)
  • Expression quantitative trait loci (eQTLs), genetic variants associated with gene expression levels, are identified in eQTL mapping studies. (escholarship.org)
  • During the past several decades genetic linkage studies have been effective in mapping genetic loci responsible for many Mendelian diseases that are caused by a single genetic variant [ 1 ]. (biomedcentral.com)
  • Here, we describe loci with intermediate properties of heterochromatin in which transcription downregulation is inherited in a manner similar to constitutive heterochromatin, although the loci are associated with opposing histone marks--H3K4me2 and H3K9me2. (omicsdi.org)
  • The immune system consists of a large number of molecules and processes, and immunodeficiencies can therefore be caused by genetic alterations at many loci. (lu.se)
  • Transcriptional co-regulators that interact with the AR may have a role in defining AR activity and may be involved in directing AR-specific responses. (nih.gov)
  • Isolation and characterization of four novel parsley proteins that interact with the transcriptional regulators CPRF1 and CPRF2. (embl-heidelberg.de)
  • Here we demonstrate that the Arabidopsis HAIRY MERISTEM (HAM) family of transcription regulators act as conserved interacting cofactors with WUS/WOX proteins. (caltech.edu)
  • Our strategy of modulating senescence response in vivo is to manipulate the expression of key senescence regulators identified in our genetic screen studies. (umassmed.edu)
  • Researchers are working to identify the proteins that interact with menin and determine its specific role as a tumor suppressor. (medlineplus.gov)
  • This model predicts that most proteins that interact with wild-type Ataxin-1 should interact with the mutant protein and that modifications of Ataxin-1 that might alter its conformation are critical to pathogenesis. (bcm.edu)
  • Purpose Next-generation sequencing has implicated some risk variants for human spina bifida (SB), but the genome-wide contribution of structural variation to this complex genetic disorder remains largely unknown. (researchgate.net)
  • Their discovery may help researchers understand complex genetic conditions, including autism, schizophrenia, cancer and Crohn's disease. (stanford.edu)
  • Surprisingly, we recently found that DELLA directly interacts with multiple classes of key regulatory proteins in other signaling pathways. (duke.edu)
  • This "in vivo biochemistry" approach has enabled us to demonstrate that there are in fact several independent, competing pathways of homologous recombination, each with its own genetic requirements. (brandeis.edu)
  • Using forward genetic screen as well as reverse genetics, we are interested in elucidating the genetic pathways that govern senescence. (umassmed.edu)
  • To identify large genetic differences in pathways within a single species, We performed a genome-wide scan for higher-order genetic interactions in segregants from 16 highly diverse S. cerevisiae crosses grown in 38 different conditions. (escholarship.org)
  • We are now focused on delineating the transcription factors and signaling pathways that are responsible for generating photoreceptors from retinal progenitor cells. (nih.gov)
  • Studies are generally limited to examination of individual regions or overlapping single-nucleotide polymorphisms (SNPs) and open chromatin peaks with limited investigation into how these regulatory elements combine to affect gene transcription 1 , 2 . (elifesciences.org)
  • Chlamydia trachomatis is an obligate intracellular human pathogen that exhibits stage-specific gene transcription throughout a biphasic developmental cycle. (plos.org)
  • Representative σ 66 -dependent gene transcription was repressed in the absence of rsbV1 or upon increased expression of RsbW, and increased upon elevated expression of RsbV1. (plos.org)
  • Plus3 domains occur in the Saccharomyces cerevisiae Rtf1p protein, which interacts with Spt6p, and in parsley CIP, which interacts with the bZIP protein CPRF1. (embl-heidelberg.de)
  • Three of these factors represent new parsley bZIP factors, designated CPRF5-CPRF7, whereas the fourth, named CPRF1-interacting protein (CIP), shows no homology to any other known protein. (embl-heidelberg.de)
  • Nucleosomes impose a block to transcription that can be overcome in vivo by remodeling complexes such as SNF/SWI and histone modification complexes such as SAGA. (sdbonline.org)
  • Arabidopsis, ULT1 interacts directly with AG and activates its locus by regulating its histone modification status. (grassius.org)
  • Gene expression is known to be affected by interactions between local genetic variation and DNA accessibility, with the latter organized into three-dimensional chromatin structures. (elifesciences.org)
  • Understanding the scope and landscape of these interactions on a genome-wide scale is a vital step towards deciphering the genetic regulation of gene expression and, in turn, the mechanisms of non-coding variation on phenotypic outcomes. (elifesciences.org)
  • Our results show that bal- ancing selection can preserve, functionally distinct states of a multi-locus genetic network, providing a general mechanism for maintenance of complex, interacting genetic variation at co-adapted alleles. (escholarship.org)
  • The commonest type of genetic variation is the single nucleotide polymorphism (SNP) that results when a single nucleotide is replaced by another in the genome sequence. (biomedcentral.com)
  • This research holds great potential for elucidating how genetic variation and regulatory elements lead to diverse visual phenotypes. (nih.gov)
  • Scholars@Duke publication: Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. (duke.edu)
  • We conducted cell-type-specific genetic fine mapping of AD variants and performed extensive functional characterization to unravel the causal variants that contribute to transcriptional regulation and AD-related phenotypes in microglia. (nature.com)
  • [ 8 ] Other classification systems categorize the ectodermal dysplasias based on defects in cell-cell communication and signaling, adhesion, transcription regulation, or development. (medscape.com)
  • These new models, which we term Multi-Functional Human Tissue Genetics, allow up to 10 alleles or more to be altered simultaneously, permitting genetic experiments with an unprecedented degree of rapidity and complexity. (stanford.edu)
  • This mouse population segregates millions of variants from eight inbred founders, enabling precision genetic mapping with extensive genotypic and phenotypic diversity. (elifesciences.org)
  • Our results demonstrate that statistical interactions between genetic variants and chromatin accessibility are common throughout the genome. (elifesciences.org)
  • Genetic studies have associated thousands of non-coding variants with Alzheimer's disease (AD), yet the functions of these variants remain elusive. (nature.com)
  • These results provide support for applying BCM to identify potential genetic variants such as SNPs from high dimensional GWAS datasets. (biomedcentral.com)
  • More recently, genetic studies have indicated that most common diseases are likely to be polygenic where multiple genetic variants acting singly and in combination underlie the expression of disease [ 2 ]. (biomedcentral.com)
  • This hypothesis posits that common diseases in most individuals are caused by relatively common genetic variants that have low penetrance and hence have small to moderate influence in causing disease. (biomedcentral.com)
  • This diagram displays physical (purple lines) and genetic (green lines) interactions between the given gene (yellow circle) and its interactors (gray circles) based on the number of experiments supporting each interaction (adjustable using the slider at the bottom). (yeastgenome.org)
  • Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. (embl-heidelberg.de)
  • DELLA proteins play a central role in these processes via direct protein-protein interactions with key transcription factors. (duke.edu)
  • Genetic analyses are a powerful approach that allow the study of these interactions. (elifesciences.org)
  • Identifying genetic interactions in data obtained from genome-wide association studies (GWASs) can help in understanding the genetic basis of complex diseases. (biomedcentral.com)
  • The large number of single nucleotide polymorphisms (SNPs) in GWASs however makes the identification of genetic interactions computationally challenging. (biomedcentral.com)
  • This paper addresses the challenge of identifying interacting SNPs that may have small effects and describes a Bayesian combinatorial method (BCM) for identifying such interactions that are associated with disease. (biomedcentral.com)
  • As background, we provide brief summaries about GWASs, genetic interactions, and Alzheimer's disease in the following sections. (biomedcentral.com)
  • CIC, homolog of the Capicua transcription repressor, has been reported to interact with ataxin-1 (ATXN1) and participate in the pathogenesis of spinocerebellar ataxia type 1. (cdc.gov)
  • We applied BCM to two late-onset Alzheimer's disease (LOAD) GWAS datasets to identify SNPs that interact with known Alzheimer associated SNPs. (biomedcentral.com)
  • Strong evidence indicates that transcription elongation by RNA polymerase II (pol II) is a highly regulated process. (embl-heidelberg.de)
  • To understand how these antivirals would interact with RdRp (RNA dependent RNA polymerase), the enzyme facilitating transcription, molecular docking simulations were performed. (uwo.ca)
  • Significance Genetic investigations of most structural birth defects, including spina bifida (SB), congenital heart disease, and craniofacial anomalies, have been underpowered for genome-wide association studies because of their rarity, genetic heterogeneity, incomplete penetrance, and environmental influences. (researchgate.net)
  • Source: All physical and genetic interaction annotations listed in SGD are curated by BioGRID . (yeastgenome.org)
  • Mutation results of ult1/2 and kan1/2 indicate dose dependent genetic defects in gynoecium (Pires et al. (grassius.org)
  • In fact, the RUNX family is often referred to as α-subunits, together with binding of a common β-subunit CBFβ, RUNX can behave as heterodimeric transcription factors collectively called the core binding factors (CBFs). (wikipedia.org)
  • However, how transcription codes regulate axon pathfinding remains poorly understood. (biologists.com)
  • The genetic etiology of human NTDs remains poorly understood despite intensive investigation. (cdc.gov)
  • These data demonstrate that RanBPM interacts with steroid receptors to selectively modify their activity. (nih.gov)
  • However, the nature of the genetic regime in stem cell niches that centre on WOX gene function has been elusive, and molecular links underlying conserved WUS/WOX function in stem cell niches remain unknown. (caltech.edu)
  • Hematopoietic stem cell lineage choices are decided by genetic networks that are turned ON/OFF in a switch-like manner. (lu.se)
  • The transcription of RUNX1 is regulated by 2 enhancers (regulatory element 1 and regulatory element 2), and these tissue specific enhancers enable the binding of lymphoid or erythroid regulatory proteins, therefore the gene activity of RUNX1 is highly active in the haematopoietic system. (wikipedia.org)
  • Physical distance along a linear genome is a common metric for determining whether a putative regulatory element will affect a given gene's transcription. (elifesciences.org)
  • This study provides evidence that a switch-protein kinase regulatory network controls availability of σ 66 , the main sigma subunit for transcription in Chlamydia . (plos.org)
  • In occurs through the inhibition of DNA binding of cognate cis- hematopoiesis there exist several lineage branch points with regulatory motif while in the other case DNA binding is unaffected identified key transcription factors and external signals [3-5]. (lu.se)
  • The mechanisms that control modulation in transcription and associated phenotypic changes are poorly understood. (plos.org)
  • Elucidating the genetic basis of common diseases will lead to an understanding of the biological mechanisms that underlie such diseases and can help in risk assessment, diagnosis, prognosis and development of new therapies. (biomedcentral.com)
  • The experiments compared how tightly transcription factors attached to thousands of DNA sequences - those with a preferred motif, those without one, and those surrounded by random sequences or by a wide variety of STRs. (stanford.edu)
  • We examined copy-number variant (CNV) participation in the genetic architecture underlying SB risk. (researchgate.net)
  • Activated receptors directly or indirectly regulate cellular biochemical processes (eg, ion conductance, protein phosphorylation, DNA transcription, enzymatic activity). (msdmanuals.com)
  • Genetic studies in mice and fruit flies have shed the most light on SCA1 pathogenesis. (bcm.edu)
  • An important development in cancer research over the past 2 decades has been the recognition that genetic changes drive the pathogenesis of tumors of both adulthood and childhood. (medscape.com)
  • We investigated the possible origin of this outbreak and its relations with CNFB-associated rabies in mainland China via genomic organization and characterization and analysis of genetic diversity and phylogeographic origin of RABV-TWFB. (cdc.gov)
  • Using different mutant combinations, we present genetic evidence that both Grn and Eve are in the same pathway as Unc-5 in dorsal motoneurons (dMNs). (biologists.com)
  • In vitro analysis revealed that a putative switch-protein kinase regulator, RsbW, is capable of interacting directly with σ 66 , as well as phosphorylating its own antagonist, RsbV1, rendering it inactive. (plos.org)
  • 6, 7 BRCA1 interacts with a variety of proteins and is involved in multiple cellular processes including DNA repair, transcription, and checkpoint control. (bmj.com)
  • With the recent identification of the causative genetic defect for a number of the ectodermal dysplasias, newer classification systems have been devised. (medscape.com)
  • During the last five years, enormous progress has been made in understanding the molecular basis of circadian systems, mainly by molecular genetic studies using the mouse and fly. (bioone.org)
  • Modern genetic techniques have helped us hugely in characterizing these disorders and providing a molecular diagnosis in the face of nonspecific clinical data. (medscape.com)
  • This led us to propose that wild-type Ataxin-1 might take on a conformation that resists clearance or interacts strongly with other proteins and that such conformation is favored by the expanded polyglutamine tract. (bcm.edu)
  • It has been subject of many evolutionary studies within the group, due to its considerable ability to successfully occupy a wide range of environments and also because of its great genetic variability expressed by different markers. (scielo.br)
  • Genetic studies of complex traits in animals have been hindered by the need to generate, maintain, and phenotype large panels of recombinant lines. (escholarship.org)
  • We have learned a lot more about the line-ups of both teams through recent genetic advances, although autosomal dominant (AD) Tubulointerstitial Nephritis may be the pre-match favorite due to its star performer uromodulin-associated kidney disease (UMOD) Nephropathy. (medscape.com)
  • The translocation, written as t(8;21), combines genetic information from chromosome 21 and chromosome 8, fusing the RUNX1 gene on chromosome 21 with a gene on chromosome 8 called RUNX1T1 (also known as ETO ). (medlineplus.gov)
  • The researchers concluded that the transcription factors directly interact with the repetitive genetic code, attaching to it and the motif with the DNA binding domain. (stanford.edu)
  • Key Laboratory of Genetic Improvement of Bananas, Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou, China. (bvsalud.org)
  • CPRF5, CPRF6 and CPRF7 are transcription factors that exhibit sequence-specific DNA-binding as well as transactivation abilities, whereas the function of CIP remains elusive. (embl-heidelberg.de)
  • PLOS Pathogens publishes Open Access research and commentary that significantly advance the understanding of pathogens and how they interact with host organisms. (plos.org)
  • APOBEC3B interacts with R-loops and helps mediate their resolution in a deamination-dependent way. (nature.com)
  • 2004). Polycomb response elements (PRE) are not only recognized by the PcG complex to mediate gene silencing but also targeted by trxG complex to initiate transcription activation. (grassius.org)