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Integrin beta ChainsIntegrin beta3IntegrinsIntegrin beta4Antigens, CD29Integrin alphaVbeta3Cell AdhesionIntegrin alpha5beta1Integrin alphaVIntegrin alpha5Integrin alpha6Integrin alpha3beta1Integrin alpha6beta4Integrin alpha ChainsIntegrin alpha4Receptors, VitronectinIntegrin alpha6beta1Integrin alpha2beta1Integrin alpha2Integrin alpha3TalinIntegrin alpha1beta1FibronectinsAntigens, CD18Molecular Sequence DataAmino Acid SequenceCell MovementIntegrin alpha1LamininSignal TransductionCell LineReceptors, FibronectinCells, CulturedVitronectinExtracellular MatrixAntigens, CDProtein BindingOligopeptidesBase SequenceMacromolecular SubstancesPolymerase Chain ReactionCell Adhesion MoleculesPlatelet Glycoprotein GPIIb-IIIa ComplexAntibodies, MonoclonalHemidesmosomesInterleukin-1betaFocal Adhesion Protein-Tyrosine KinasesPlatelet Membrane GlycoproteinsBinding SitesTransfectionFocal Adhesion Kinase 1CHO CellsCytoplasmFibrinogenLigandsReceptors, Antigen, T-Cell, alpha-betaReceptors, CollagenLymphocyte Function-Associated Antigen-1RNA, MessengerIntegrin alpha4beta1Flow CytometryPhosphorylationCricetinaeProtein Structure, TertiaryFocal AdhesionsCollagenRecombinant ProteinsPeptide Fragmentsbeta 2-MicroglobulinProtein ConformationTumor Cells, CulturedReceptors, LamininCell Line, TumorCytoskeletonMacrophage-1 AntigenPrecipitin TestsReverse Transcriptase Polymerase Chain ReactionFilaminsMutationHemoglobins, AbnormalIntegrin alphaXbeta2Fluorescent Antibody TechniquePaxillinT-LymphocytesExtracellular Matrix ProteinsRecombinant Fusion ProteinsReceptors, Antigen, T-CellKineticsAntibodiesMice, KnockoutProtein-Tyrosine KinasesCloning, MolecularMice, Inbred C57BLTransforming Growth Factor betaBlotting, WesternSequence Homology, Amino AcidGene Expression RegulationGene ExpressionCell DifferentiationCell Membrane
SubunitAntigenSubunitsHeterodimeric integralALPHA2-BETA1ProteinAdhesionGlycoproteinPlateletsFibrinogenGene encodesStructuralCD18ReceptorDuplexLIGANDProteinsIntegralDisulfide-linkedVitroCD61HumansDetectsExtracellularPolypeptideNeutrophilsDifferentiationFormCell-surfaceHeavy chainsInflammatoryMouseFoundFunctionPartners
Subunit5
  • CD49d is an integrin alpha subunit. (wikipedia.org)
  • The CD49b protein is an integrin alpha subunit. (wikidoc.org)
  • β1 integrin is the major β integrin subunit in pancreatic beta-cells and forms heterodimers with 12 α integrin subunits, which interact with components of the extracellular matrix (ECM) to control intracellular signaling via the focal adhesion kinase (FAK) and extracellular signal related kinase 1 and 2 (ERK1/2) pathways [ 4 ]. (oncotarget.com)
  • The basic subunit of beta-crystallins. (lookformedical.com)
  • Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
Antigen1
  • In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. (utsouthwestern.edu)
Subunits4
  • Studies in marmosets and humans indicate that thalidomide, and a teratogenic analogue, decrease the expression of beta integrin subunits, most notably beta 3 and the beta 2 produced by leukocytes. (nih.gov)
  • CD51, an ~120 kDa surface molecule can also non-covalently associate with other beta subunits of the integrin family including beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. (thermofisher.com)
  • Beta-crystallins exist as oligomers formed from acidic (BETA-CRYSTALLIN A CHAIN) and basic (BETA-CRYSTALLIN B CHAIN) subunits. (lookformedical.com)
  • The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits. (lookformedical.com)
Heterodimeric integral1
ALPHA2-BETA11
  • Integrin alpha II combines with Integrin beta 1 to form the alpha2/beta1 integrin duplex. (ximbio.com)
Protein3
  • Integrin alpha-2 or CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene . (wikidoc.org)
  • From NCBI Gene: The ITGB3 protein product is the integrin beta chain beta 3. (nih.gov)
  • Integrin E Rabbit Polyclonal Antibody detects endogenous levels of Integrin E protein. (ebiocell.com)
Adhesion6
  • Since integrins are crucial for cell-matrix interactions, and the beta 2 integrins of leukocytes mediate adhesion to endothelium, it is reasonable to postulate that thalidomide inhibits cell migration in susceptible species, and that this accounts for its anti-inflammatory, anti-angiogenic, and teratogenic activity. (nih.gov)
  • Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. (wikidoc.org)
  • Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. (nih.gov)
  • Similarly, depletion of either Rasip1 or Arhgap29 in cultured ECs blocks in vitro lumen formation, fundamentally alters the cytoskeleton, and reduces integrin-dependent adhesion to ECM . (xenbase.org)
  • Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes. (ximbio.com)
  • The CD11/CD18 complex is part of the beta-2 integrin family and is important in adhesion and phagocytosis (see Table 1). (medscape.com)
Glycoprotein1
  • Integrin alpha 2b, (ITGA2b) also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. (rndsystems.com)
Platelets1
  • Integrin beta 3 is found along with the alpha IIb chain in platelets. (nih.gov)
Fibrinogen4
  • ITGA2b associates with integrin beta 3 to form complexes that interact with fibrinogen, von Willebrand factor, fibronectin, and vitronectin. (rndsystems.com)
  • Integrins α-m/β-2 and α-x/β-2 are receptors for the IC3B fragment of the third complement component and for fibrinogen. (lu.se)
  • Integrin α-x/β 2 recognizes the sequence g-p-r in fibrinogen α-chain. (lu.se)
  • Integrin α-m/β-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. (lu.se)
Gene encodes3
  • This gene encodes an alpha 4 chain. (wikipedia.org)
  • This gene encodes the integrin alpha M chain. (dimabio.cn)
  • This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. (utsouthwestern.edu)
Structural1
  • The structural basis for the divalent cation-dependent binding of heterodimeric alphabeta integrins to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown. (rcsb.org)
CD181
  • Three CD11 alpha chains and a common CD18 beta chain form heterodimer transmembrane complexes (CD11a/CD18, CD11b/CD18, CD11c/CD18). (medscape.com)
Receptor2
  • Integrin α-l/β-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. (lu.se)
  • Integrin α-m/β-2 is also a receptor for Factor X. Integrin α-d/β 2 is a receptor for ICAM3 and VCAM1. (lu.se)
Duplex1
  • It makes up half of the α2β1 integrin duplex. (wikidoc.org)
LIGAND1
  • Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. (xenbase.org)
Proteins2
  • The product of this gene belongs to the integrin alpha chain family of proteins. (wikipedia.org)
  • Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. (nih.gov)
Integral1
Disulfide-linked2
  • Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. (wikipedia.org)
  • It is cleaved into two disulfide-linked chains (114 kDa and 22 kDa) during transit through the Golgi. (rndsystems.com)
Vitro1
  • The role of β1 integrin in maintaining optimal islet function has previously been identified in vitro using cell lines and isolated islets. (oncotarget.com)
CD614
  • The following product was used in this experiment: CD51/CD61 (Integrin alpha v beta 3) Monoclonal Antibody (23C6), Biotin, eBioscience™ from Thermo Fisher Scientific, catalog # 13-0519-82, RRID AB_529536. (thermofisher.com)
  • Staining of M21 cells with 0.5 µg of Mouse IgG1 kappa Isotype Control Biotin (Product # 13-4714-85) (open histogram) or 0.5 µg of Anti-Human CD51/CD61 (Integrin alpha/beta 3) Biotin (filled histogram) followed by Streptavidin PE (Product # 12-4317-87). (thermofisher.com)
  • Description: The 23C6 monoclonal antibody reacts with the human CD51/CD61 dimer, also known as the integrin alphav/beta3. (thermofisher.com)
  • CD51 and CD61 molecules (alpha V and beta 3 integrins) form a complex. (thermofisher.com)
Humans1
  • β1 integrin is essential for pancreatic beta-cell development and maintenance in rodents and humans. (oncotarget.com)
Detects1
  • Detects mouse Integrin alpha 2b/CD41 in direct ELISAs. (rndsystems.com)
Extracellular1
  • Here we report the crystal structure of the extracellular segment of integrin alphaVbeta3 in complex with a cyclic peptide presenting the Arg-Gly-Asp sequence. (rcsb.org)
Polypeptide1
Neutrophils1
  • The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. (dimabio.cn)
Differentiation2
  • Integrins are important regulators of cellular differentiation, migration, maturation, and survival [ 1 - 3 ]. (oncotarget.com)
  • Comparison of integrin expression and terminal differentiation capacity in cell lines derived from oral squamous cell carcinomas. (ximbio.com)
Form1
  • Gamma-crystallins are similar in structure to BETA-CRYSTALLINS in that they both form into a Greek key-like structure. (lookformedical.com)
Cell-surface1
Heavy chains1
  • The immunoglobulin M (IgM) and immunoglobulin G (IgG) heavy chains are also not fucosylated. (medscape.com)
Inflammatory1
  • TGFβ activating integrins β6 and β8 are dysregulated in inflammatory skin disease and cutaneous melanoma. (ucsf.edu)
Mouse3
  • E�H) E9.5 littermate mouse embryos showing defects in Rasip1 / embryos (F) and yolk sacs (H). (I�L) Whole-mount Flk1 -lacZ beta-galactosidase staining of Rasip1+/ (I and K) and Rasip1 / (J and L) yolk sacs (I and J) and embryonic heads (K and L), showing narrow Rasip1 / blood vessels that fail to remodel. (xenbase.org)
  • We utilized a mouse insulin 1 promoter driven tamoxifen-inducible Cre-recombinase β1 integrin knockout mouse model (MIPβ1KO) to investigate β1 integrin function in adult pancreatic beta-cells. (oncotarget.com)
  • Mouse monoclonal antibody to Integrin beta 3. (revoluciondelosgladiolos.org)
Found1
Function2
  • However, the effects of a temporal beta-cell specific β1 integrin knockout on adult islet function are unknown. (oncotarget.com)
  • This data demonstrates that β1 integrin is required for the maintenance of glucose homeostasis through postnatal beta-cell function and expansion. (oncotarget.com)
Partners1
  • A given chain may combine with multiple partners resulting in different integrins. (nih.gov)