• This gene encodes the integrin beta 4 subunit, a receptor for the laminins. (nih.gov)
  • The integrin α6 subunit associates with the integrin β1 chain (CD29) to form VLA-6 and with the integrin β4 chain (CD104) to form the integrin α6β4 complex, also known as the laminin and kalinin receptor. (bdbiosciences.com)
  • Integrins are heterodimeric, transmembrane receptors, composed of an and a subunit that mediate adhesion simply by presenting extracellular matrix necessary protein and the actin cytoskeleton13 at the same time. (cancerhugs.com)
  • Integrin cytoplasmic domains are normally less than 50 amino acids in length, with the beta-subunit sequences exhibiting greater homology to each other than the alpha-subunit sequences. (embl-heidelberg.de)
  • 2006). The role of the laminin beta subunit in laminin heterotrimer assembly and basement membrane function and development in C. elegans. (jhu.edu)
  • The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. (embl.de)
  • The alphaM subunit of integrin Mac-1 contains several distinct regions in its extracellular segment. (embl.de)
  • The integrin α1 subunit is predominantly present in stromal and smooth muscle cells and fibroblasts and is generally absent from normal epithelia although it has been reported to be expressed in developing organs such as the kidney and skin [ 11 ]. (biomedcentral.com)
  • In this study, as a first step to test this hypothesis, we investigated α1 integrin subunit expression in a set of colorectal adenocarcinoma specimens. (biomedcentral.com)
  • In the digestive system, α1 integrin subunit expression in epithelia has only been reported in the small intestine and found to be confined to the lower crypts which contain the progenitor cells [ 12 , 13 ]. (biomedcentral.com)
  • CD104 is a 202 kDa subunit that associates with integrin alpha 6 (CD49f), thereby forming the laminin receptor. (thermofisher.com)
  • Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). (childrensmercy.org)
  • There are 5 alpha (alpha1/LAMA1- alpha5/LAMA5), 3 beta (beta1/LAMB1- beta 3/ LAMB3), and 3 gamma (gamma1/LAMC1 - gamma3/LAMC3) chains, and at least 16 laminin isoforms can be formed by various combinations of each subunit. (grantome.com)
  • From NCBI Gene: Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. (nih.gov)
  • CD49a is a 200 kD type I transmembrane glycoprotein also known as α 1 integrin, VLA-1 α chain, or Integrin α 1 . (biolegend.com)
  • Osteopontin is a secreted matricellular glycoprotein that signals partially through integrin receptors and its downregulation is associated with increased strength, reduced fibrosis, and milder muscle pathology 10 , 11 . (nature.com)
  • Integrin alpha 7 is a 1148 amino acid ~130 kDa type 1 single pass transmembrane glycoprotein. (bio-rad-antibodies.com)
  • This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. (cancerindex.org)
  • Cells interact with their root ECM through transmembrane cell-surface receptors known as integrins, heterodimeric elements composed of transmembrane leader and beta subunits, which are connected to cytoskeletal protein such as talin intracellularly, vinculin, and/or paxillin.1 Integrins bind to ECM elements through particular and multiple synergistic sequences on ECM protein often. (bio2009.org)
  • Of the 5 PS integrin subunits encoded by the genome12 antibodies can be found for PS1, PS2, and PS3. (cancerhugs.com)
  • There are two integrin subunits in embryos ECM indicators are discovered around the external edge of the gonad at stage 16. (cancerhugs.com)
  • An integrin receptor is a heterodimer composed of alpha and beta subunits. (embl-heidelberg.de)
  • 2003). Laminin alpha subunits and their role in C. elegans development. (jhu.edu)
  • Our data provide new insights into how different domains in the integrin alpha and beta subunits may interact. (embl.de)
  • Integrins are heterodimeric single-pass transmembrane receptors consisting of α and β subunits found in all animals from sponges to humans ( Hughes, 2001 ). (silverchair.com)
  • We screened for genetic interactions between sog and genes encoding a variety of extracellular components and uncovered interactions between sog and myospheroid ( mys ), multiple edematous wing ( mew ) and scab ( scb ), which encode βPS,αPS1 and αPS3 integrin subunits, respectively. (biologists.com)
  • The billed power of ECM elements in assisting cell connection and dispersing, as well as leading cell phenotype, is certainly one of the many factors that ECM elements, such as collagen, laminin, and fibronectin (Fn), are employed for tissues system goals routinely. (bio2009.org)
  • Considering the current knowledge on the function of mammalian LOX isoforms in ECM remodeling, we propose that LOXL2/L3/L4 members might have preferentially been involved in making cross-linked collagen IV-based basement membrane, whereas the diversification of LOX/L1/L5 forms contributed to chordate/vertebrate-specific ECM innovations, such as elastin and fibronectin. (nature.com)
  • MAbs and antibody toxin conjugates can be targeted to specific receptors or proteins found on cancer cells. (medscape.com)
  • The GoH3 monoclonal antibody specifically binds to CD49f which is also known as integrin α6 chain. (bdbiosciences.com)
  • It is normally tough to guideline this out totally, but we analyzed the various other known ECM receptor present in (CNN) particular antibody, and dividing cells had been branded with Phospho-Histone L3. (cancerhugs.com)
  • We screened and identified a specific antibody BCMab1 against bladder cancer. (bvsalud.org)
  • The following product was used in this experiment: CD104 (Integrin beta 4) Monoclonal Antibody (439-9B), eBioscience™ from Thermo Fisher Scientific, catalog # 14-1049-82, RRID AB_1210460. (thermofisher.com)
  • Description: The monoclonal antibody 439-9B recognizes human CD104, also known as integrin beta 4. (thermofisher.com)
  • The following product was used in this experiment: CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), PE-Cyanine7, eBioscience™ from Thermo Fisher Scientific, catalog # 25-0495-82, RRID AB_10804881. (thermofisher.com)
  • Description: The eBioGoH3 monoclonal antibody reacts with mouse and human CD49f, also known as integrin alpha 6, very late activation antigen 6 (VLA-6 alpha chain), and platelet gpIc. (thermofisher.com)
  • The eBioGoH3 antibody is cross-reactive to integrin alpha 6 on human, mouse and bovine cells. (thermofisher.com)
  • This antibody has also been reported to have functional activity in blocking the binding of integrin alpha 6 to laminin. (thermofisher.com)
  • 14. Treatment with the anti-IL-6 receptor antibody attenuates muscular dystrophy via promoting skeletal muscle regeneration in dystrophin-/utrophin-deficient mice. (nih.gov)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) in tissue homogenates, cell lysates and other biological fluids. (clinical-trial-logistics.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (clinical-trial-logistics.com)
  • Furthermore, ECM protein frequently contain many distinctive presenting sites for multiple integrins and some VX-222 specific integrin presenting sequences within the ECM can join multiple integrins. (bio2009.org)
  • Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
  • Antisense molecules are a small, complementary, single-stranded type of DNA that binds targeted messenger RNA (mRNA) within the cell and prevents specific protein translation. (medscape.com)
  • Integrin alpha chain family, Type I membrane protein, alpha chain of heterodimeric integrin receptor, 200 kD. (biolegend.com)
  • The distribution of these necessary protein suggests that ECM is normally set up at a period when integrin-mediated adhesion is normally essential for gonad morphogenesis. (cancerhugs.com)
  • Tumor cells home in to bone via the same protein interactions that hematopoietic stem cells use, relying on integrins, chemokines, bone morphogenetic proteins, and osteopontin, among others, to settle in bone. (basicmedicalkey.com)
  • Human IGSF8 is synthesized as a 613 aa protein that includes a 27 aa signal peptide, a 552 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 13 aa cytoplasmic tail. (bio-techne.com)
  • IGSF8 is an inducible receptor for Heat Shock Protein A8 (HSPA8) on activated dendritic cells (5). (bio-techne.com)
  • their deduced products are a basement membrane protein and a trans-membrane receptor, respectively. (jhu.edu)
  • 2001). mua-3, a gene required for mechanical tissue integrity in Caenorhabditis elegans, encodes a novel transmembrane protein of epithelial attachment complexes. (jhu.edu)
  • Interestingly, this apparent correlation between α1β1 expression and the proliferative status of the cells appears to be consistent with a pro-proliferative role for α1β1 signaling involving the transmembrane caveolin-1, adaptor protein Shc and activation of the downstream RAS/ERK proliferative pathway [ 11 , 14 ]. (biomedcentral.com)
  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. (cancerindex.org)
  • CD49f is a 120 kD transmembrane protein. (thermofisher.com)
  • CDf (Integrin alpha-6, ITGA6) is the integrin alpha chain alpha 6 protein. (thermofisher.com)
  • This amino terminus extension does not interfere with cleavage or function in mechanosensory neurons, but it does permit specific targeting of the EYS protein to the apical photoreceptor membrane. (sdbonline.org)
  • Our RNA interference screen for genes that prevent integrin-dependent cell spreading identifies Z band alternatively spliced PDZ-motif protein ( zasp ), encoding the only known Drosophila melanogaster Alp/Enigma PDZ-LIM domain protein. (silverchair.com)
  • Ten-4 is a transmembrane protein that is highly expressed in neurons and oligodendrocytes, but its function is unknown. (grantome.com)
  • Sclera protein samples were also analyzed with immunoblotting with specific antibodies to selected proteins. (molvis.org)
  • GTP, gap and article), 3) organization of the catabolism upon Following of the such back-to-back acid, and components production, germ and dissociation, with partial X to the severe XIAP, 4) physiological resulting and cycle protein microRNA, and 5) GTP haem and allowing of the tissue-specific new metalloproteinase. (evakoch.com)
  • The NEXT3 synthesis of NOTCH3 is further well-insulated at the S3 matrix by the provirus protein membrane, leading the different integrin migration into the Werge( Groot et al. (evakoch.com)
  • Transient receptor potential cation channel subfamily V member 5 (Trpv5) is a calcium channel protein that is encoded by the TRPV5 gene in human. (bicellscientific.com)
  • Trpv5 protein consists in six transmembrane domains, six ANK repeats and an N-linked glycosylation site in the extracellular loop. (bicellscientific.com)
  • The integrin family of heterodimeric transmembrane receptors mediates cell-matrix adhesion. (silverchair.com)
  • Antisense molecules can be targeted toward specific proteins that are crucial in tumorigenesis. (medscape.com)
  • LamininA (LanA) and Nidogen (Ndg), a laminin-associated Rabbit polyclonal to CXCL10 proteins, had been generously portrayed in the gonadal ECM at this period (Fig. 3a,c). (cancerhugs.com)
  • Nano-flow cytometry revealed that the EV output from individual glioma cell lines was highly heterogeneous, such that only a fraction of vesicles contained specific proteins (including EGFRvIII). (cancerindex.org)
  • Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. (thermofisher.com)
  • conducted a series of experiments to identify specific proteins in the melanoma cellsthat were responsible for making the cancer more invasive after it interacted with the lymph vessel cells. (elifesciences.org)
  • These experiments identified proteins called MMP14, Notch3, and β1-integrin as critical to the invasive spread of melanoma cells. (elifesciences.org)
  • It strongly associates with tetraspanins CD9 and CD81 which may act as physical linkers to form a complex with alpha3 beta1 integrin that may regulate cell aggregation and motility on laminin-5 (4). (bio-techne.com)
  • A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans. (jhu.edu)
  • We also found that laminin-1-mediated clustering of GM1 caused translocation and enrichment of the beta1 integrin in the lipid rafts. (grantome.com)
  • It associates with CD29 (β 1 integrin) to form VLA-1 complex, a collagen IV and alminin-1 receptor. (biolegend.com)
  • Integrin-mediated adhesion between the ECM and the cytoskeleton is crucial for tissue interactions during development. (silverchair.com)
  • Proteomic analysis showed increases in molecules involved in integrin-linked kinase signaling and actin cytoskeleton signaling pathways at 1 and 6 weeks after experimental glaucoma. (molvis.org)
  • Scleral fibroblasts in experimental mouse glaucoma show increases in actin cytoskeleton and integrin-related signaling, increases in cell division, and features compatible with myofibroblast transition. (molvis.org)
  • Proteomics and structural analysis revealed that excessive collagen deposition alone is not pathological, and can be compensatory, as revealed by overexpression of sarcospan and its associated ECM receptors in dystrophic muscle. (nature.com)
  • Basement membranes consist of laminin, collagen IV, perlecan, nidogen/entactin, and other molecules, which interact with one another to form the supramolecular structure. (grantome.com)
  • Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. (nih.gov)
  • Morphogenesis of most tissue in metazoans needs cell-to-matrix adhesion mediated by the integrin course of adhesion receptors11, 12. (cancerhugs.com)
  • Integrins are a family of heterodimeric glycoproteins involved in bidirectional cell signaling and participate in the regulation of cell shape, adhesion, migration, differentiation, gene transcription, survival and proliferation. (biomedcentral.com)
  • It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. (cancerindex.org)
  • Integrins are known to participate in cell adhesion as well as cell-surface mediated signaling. (thermofisher.com)
  • The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. (childrensmercy.org)
  • Zasp localizes to integrin adhesion sites and its depletion disrupts integrin adhesion sites. (silverchair.com)
  • Our observations point to an important function for Zasp in the assembly of integrin adhesion sites both in cell culture and in tissues. (silverchair.com)
  • Disruption of the ECM, integrins, or their cytoskeletal adaptors affects integrin-mediated adhesion. (silverchair.com)
  • Neurite outgrowth is a key event in the differentiation of neuronal cells, and is regulated by extracellular environment factors such as nerve growth factor (NGF) and cell adhesion molecules such as laminins. (grantome.com)
  • We propose that integrins act by binding and possibly regulating the activity/availability of different forms of Sog during pupal development through an adhesion independent mechanism. (biologists.com)
  • In addition, the activity of intervein genes, which are required for intersurface adhesion, such as those coding for the integrins, must be excluded from veins to permit the non-adherent strips of cells in the veins to form open channels between the two wing surfaces( Brown, 2000 ). (biologists.com)
  • It interacts with a specific transmembrane receptor, CD44. (wikipedia.org)
  • Finally, Zasp interacts genetically with integrins, showing that it regulates integrin function. (silverchair.com)
  • Perl interacts with many extracellular molecules and cell surface receptors, and is implicated in many biological functions in tissue homeostasis and diseases. (grantome.com)
  • We find that Sog can diffuse from its intervein site of production into adjacent provein domains, but only on the dorsal surface of the wing, where Sog interacts functionally with integrins. (biologists.com)
  • CD49f also associates with CD104, the integrin beta 4 chain, to form the alpha 6 beta 4 complex. (thermofisher.com)
  • Although ß2 integrins have been shown to mediate neutrophil transendothelial migration during systemic and local inflammation, relatively little information is available regarding neutrophil migration in sepsis beyond the endothelial cell layer. (bvsalud.org)
  • This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
  • Glioblastoma multiforme (GBM) is a highly aggressive and heterogeneous form of primary brain tumors, driven by a complex repertoire of oncogenic alterations, including the constitutively active epidermal growth factor receptor (EGFRvIII). (cancerindex.org)
  • Immunofluorescence analysis of CD104 (Integrin beta 4) was performed using A-431 and HEK 293 cells. (thermofisher.com)
  • As a total result, cells can display different phenotypic replies to the same ECM molecule depending on the integrins that join,2,3 which is certainly in convert described not really just by mobile reflection of particular integrins but also by the conformation of the ECM ligand, the availability of particular ligand sequences, and the avidity of particular integrins to contending sites of engagement. (bio2009.org)
  • To understand directed migration, we must identify the cues provided by substratum cells and establish their spatial distribution, identify complementary receptors on migrating cells and elucidate navigational programs that activate these receptors in proper sequence, and determine how receptor/ligand binding actually steers the leading edge of a cell or growth cone. (jhu.edu)
  • Finally, it seems that some interactions in TEM can be not only cancer-specific, but also patient-specific, and their recognition would help to predict patient response to therapy. (encyclopedia.pub)
  • The interactions of laminins with cells are essential for laminin-mediated biological activities in tissue development and adult tissue functions. (grantome.com)
  • These results suggest that the binding of laminin-1 to GM1 facilitates the formation of a focal microdomain in the lipid rafts, and enhances signal transduction for neurite outgrowth by linking and cooperating with NGF-TrkA and laminin-integrin signaling pathways. (grantome.com)
  • Portion of beta integrins that lies N-terminal to their EGF-like repeats. (embl-heidelberg.de)
  • Some members of this family have EGF repeats at the C terminus and also have a vWA domain inserted within the integrin domain at the N terminus. (embl-heidelberg.de)
  • Integrin alpha (beta-propellor repeats). (embl.de)
  • Some mig genes affect specific navigational steps while others are strikingly pleiotropic. (jhu.edu)
  • Finally, α9ß1 cross-suppressed many α3ß1-dependent genes, including the gene that encodes MMP-9, which we implicated as a regulator of integrin-dependent cross talk to endothelial cells. (bvsalud.org)
  • Of the genes affected by all three arsenicals, only one, that coding for interleukin-1 receptor, type II, showed enhanced expression, a finding confirmed by the reduced increase in NF-κB (nuclear factor kappa B) activity seen in response to interleukin-1β in iAs III -exposed cells. (nih.gov)
  • While these findings have led to the development of mouse models of these diseases, little is known at the systems level about how these disease genes impact the function of a specific neural circuit. (nih.gov)
  • Western Blot analysis of integrin Alpha 7 expression in Jurkat cell lysate using Mouse anti Human integrin Alpha 7 ( MCA5238Z ). (bio-rad-antibodies.com)
  • Western blot-specific recognition antibodies are made against the same epitope sequence with novel denaturing and stabilizing technique to prevent the natural folding of epitope in order to lock its conformation in unfolded state. (bicellscientific.com)
  • Consistent with proangiogenic roles for α3ß1, α3-null keratinocytes showed reduced paracrine stimulation of endothelial cell migration and survival, and wounds of epidermis-specific α3 knockout mice displayed impaired angiogenesis. (bvsalud.org)
  • Integrin-mediated migration of neutrophils to infected tissue sites is vital for pathogen clearance and therefore host survival. (bvsalud.org)
  • Fn has the capacity to interact with integrins that promote re-epithelization as well as those that have been shown to induce EMT. (bio2009.org)
  • Indeed, FGL2-specific polyclonal antibodies showed antitumor activity against GBM tumor cells in syngeneic mouse models 23 . (researchsquare.com)
  • FFPE-specific recognition antibodies are made against the same epitope sequence with novel cross-linking and stabilizing technique to lock the conformational state of epitope in a folded state similar to aldehyde induced fixation. (bicellscientific.com)
  • Accumulation of elastic fibres was confirmed by assay of desmosine, an elastin-specific crosslink compound. (researchgate.net)
  • In this study, we generated mice with epidermis-specific deletion of α3ß1, α9ß1, or both integrins as well as keratinocyte lines expressing these integrin combinations. (bvsalud.org)
  • Genome combinations, or specific clades, can be displayed as if individual trees had been produced. (cam.ac.uk)
  • The autoimmune attack occurs when autoantibodies form against the nicotinic acetylcholine postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)
  • [ 1 , 2 ] Although the chief target of the autoimmune attack in most cases is the skeletal muscle nicotinic acetylcholine receptor (nAChR), other antigenic targets that are components of the neuromuscular junction (NMJ) have also been implicated. (medscape.com)
  • Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)
  • C , Cross section of a frog neuromuscular junction reveals three juxtaposed cellular elements: the perisynaptic Schwann cell, nerve terminal (N), and muscle fiber (M). The perisynaptic Schwann cell body (S indicates nucleus) and its processes cap the nerve terminal, but the processes do not wrap around the nerve terminal region facing acetylcholine receptors on muscle. (jneurosci.org)
  • Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. (embl.de)
  • For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. (thermofisher.com)
  • 7. Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice. (nih.gov)
  • Integrins, alpha-dystroglycan (alphaDG), and proteoglycans (PGs) such as syndecans have been identified as major cellular receptors for laminins. (grantome.com)
  • Clonal analysis reveals that integrin mutations affect the trajectory of veins inside the provein domain and/or their width and that misexpression of sog can alter the behavior of cells in such clones. (biologists.com)
  • The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
  • and (5) form deposits capable of surviving in the new environment 10 ( Fig. 19-1, A ). The basic biology, molecular mechanisms, and genetic and epigenetic changes that drive these steps are extremely complex and probably differ depending on the source of the metastasis and specific type of tumor. (basicmedicalkey.com)
  • 1. Skeletal muscle-specific overexpression of miR-486 limits mammary tumor-induced skeletal muscle functional limitations. (nih.gov)
  • Tissue-resident memory T cells (T RM ) specific to previously encountered pathogens have been characterized, but tumor-specific T RM cells in brain have not been reported in the literature. (researchsquare.com)
  • We discovered that T cells armed with FGL2-blocking single-chain variable fragments (T-αFGL2) are able to induce tumor-specific CD8 + T RM cells, which prevent glioblastoma recurrence, a major obstacle in achieving long term survivors. (researchsquare.com)
  • These tumor-specific CD8 + T RM displayed a unique highly expanded T cell receptor repertoire distinct from that found in peripheral tissues. (researchsquare.com)
  • These findings are the first to show tumor-specific brain resident CD8 + T RM generation via adoptive cellular treatment and may have promising implications for cancer immunotherapy. (researchsquare.com)
  • T cells armed with FGL2-blocking single-chain variable fragments (T-αFGL2) were able to induce tumor-specific CD8 + T RM cells. (researchsquare.com)
  • These tumor-specific CD8 + T RM cells are tumor reactive and transplantable. (researchsquare.com)
  • The induced tumor-specific CD69 + CD62L - CD8 + T RM cells, displayed a highly expanded T cell receptor repertoire. (researchsquare.com)
  • Our studies found that mice with conditional integrin β 4 (ITGB4) knockout presented lung dysplasia and increased stiffness of lung tissues. (frontiersin.org)
  • Integrins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • Laminin isoforms show tissue- and developmental stage-specific expression and play important roles in the structures and functions of basement membranes. (grantome.com)
  • Hence, integrins are particularly needed for centre cells to localize at the anterior post of male embryonic gonads. (cancerhugs.com)
  • Integrins often localize in highly organized structures, such as focal adhesions in tissue culture and myotendinous junctions in muscles. (silverchair.com)
  • Integrins typically localize in highly organized structures at sites of transmembrane linkage. (silverchair.com)
  • These research show the importance of synergy in controlling epithelial cell phenotype relevant to tissues system as well as the tool of constructed integrin-specific ECM pieces in helping cell phenotype. (bio2009.org)
  • How can cells, while differentiating and implementing their specific epigenetic programs, form tissues and organs and organisms? (uncommondescent.com)
  • In tissues, Zasp colocalizes with βPS integrin in myotendinous junctions and with α-actinin in muscle Z lines. (silverchair.com)
  • CD103 binds to epithelial E-cadherin, while CD69 blocks cellular egress via inhibition of the function of Sphingosine-1-phosphate receptor-1 (S1PR1) 9 , both help T RM cells retain in peripheral tissues. (researchsquare.com)
  • Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed). (embl-heidelberg.de)
  • This domain corresponds to the integrin beta VWA domain. (embl-heidelberg.de)
  • Integrators of epidermal growth and differentiation: distinct functions for beta 1 and beta 4 integrins. (embl-heidelberg.de)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) in samples from tissue homogenates, cell lysates or other biological fluids. (clinical-trial-logistics.com)
  • Laminin-1 (LAM-111), which is composed of alpha1, beta1 and gamma 1 chains, is crucial for early basement membrane assembly, and embryonic implantation and development. (grantome.com)
  • Data suggest that epithelial cells employ RGD just with sixth is v integrins and screen a significant change toward a mesenchymal phenotype credited, in component, to improved modifying development aspect- account activation and/or signaling likened with cells on the synergy formulated with FnIII910. (bio2009.org)
  • 8. Hormonally Regulated Myogenic miR-486 Influences Sex-specific Differences in Cancer-induced Skeletal Muscle Defects. (nih.gov)
  • 10. Secondary reduction of alpha7B integrin in laminin alpha2 deficient congenital muscular dystrophy supports an additional transmembrane link in skeletal muscle. (nih.gov)