• CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1. (wikipedia.org)
  • In association with CD18, the CD11a/CD18 complex forms LFA-1. (biolegend.com)
  • CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). (exbio.cz)
  • Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
  • CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
  • The M17/4 antibody reacts with the 180 kDa αL chain of LFA-1 (CD11a/CD18, αLβ2 integrin), a heterodimeric surface glycoprotein expressed on almost all leukocytes. (bdbiosciences.com)
  • CD18 is a 90-95 kD type I transmembrane protein also known as integrin ß2 subunit, LFA-1 ß subunit, and ß2 integrin. (angioproteomie.com)
  • CD18 non-covalently associates with CD11a, CD11b or CD11c. (angioproteomie.com)
  • Leukocyte function-associated antigen-1 ( LFA-1 ), also known as CD11a/CD18 and αLβ2, is a member of the β2-integrin family found on lymphocytes and other leukocytes. (immune-system-research.com)
  • It is a type I transmembrane glycoprotein with two Ig-like C2-type domains, and binds to the leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). (betalifesci.com)
  • The integrin LFA-1 (CD11a/CD18) plays a critical role in the interaction of T cells with antigen presenting cells (APCs) to promote lymphocyte differentiation and proliferation. (helmholtz-hzi.de)
  • In humans, lymphocyte adhesion to cells is mediated by the protein heterodimer CD11a/CD18 (Leu-CAMa, LFA-1) and its ligand CD54 (ICAM-1). (csb-bioenergetics.nl)
  • It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. (nih.gov)
  • Multiple inherited mutations in the integrin β2 protein (CD18) that reduce expression or function have been identified as the causative factor in patients with LAD1. (guidetopharmacology.org)
  • 1998) Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. (guidetopharmacology.org)
  • The beta-2 (B2) integrin (leukocyte integrin, CD11/CD18) subfamily comprising three members, each consisting of a shared beta subunit (CD18) non-covalently associated with unique alpha subunits (CD11a, CD11b, CD11c). (medicaljournals.se)
  • Background: CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). (icbinhibitor.com)
  • Description: The N418 monoclonal antibody reacts with mouse CD11c, the integrin alpha X. CD11c non-covalently associates with beta 2 integrin to form the CD11c/CD18 heterodimer. (thermofisher.com)
  • The dissociation rates were calculated under low force conditions for ICAM-1 interactions with both β 2 -integrins, LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18), together and separately by using functional blocking antibodies on PMNs. (psu.edu)
  • Li R, Nortamo P, Valmu L , Tolvanen M, Huuskonen J, Kantor C and Gahmberg C G (1993) A peptide from ICAM-2 binds to the Leu-kocyte Integrin CD11a/CD18 and inhibits endot-helial cell adhesion. (leenavalmu.fi)
  • Vermot-Desroches C, Wijdenes J, Valmu L , Roy C, Pigott R, Nortamo P and Gahmberg C G (1995) A CD44 monoclonal antibody differentially regulates CD11a/CD18 binding to intercellular adhesion molecules CD54, CD102 and CD50. (leenavalmu.fi)
  • Valmu L and Gahmberg C G (1995) Treatment with okadaic acid reveals strong threonine phosphorylation of CD18 after activation of CD11/CD18 leukocyte integrins with phorbol esters or CD3 antibodies. (leenavalmu.fi)
  • Valmu L , Hilden T J, van Willigen G and Gahmberg C G (1999) Characterization of b2 (CD18) integrin phosphorylation in phorbol ester activated T lymphocytes. (leenavalmu.fi)
  • Valmu L , Fagerholm S, Suila H and Gahmberg C G (1999) The cytoskeletal association of CD11/CD18 leukocyte integrins in phorbol ester activated cells correlates with CD18 phosphorylation. (leenavalmu.fi)
  • It forms αβ heterodimers with the CD11 alpha subunits ITGAL (αL aka CD11a forming integrin LFA-1), ITGAM (αM aka CD11b, forming integrin Mac-1) and ITGAX (αX aka CD11c, forming integrin p150/95). (guidetopharmacology.org)
  • In particular, CD11 is composed of CD11a, CD11b and CD11c. (thermofisher.com)
  • The amino-terminal region of the CD11a (αL) subunit of LFA-1 contains an inserted domain (termed the I-domain). (immune-system-research.com)
  • An integrin alpha subunit that is unique in that it does not contain an I-domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane, as in other integrin alpha subunits. (musc.edu)
  • The CD49b protein is an integrin alpha subunit. (wikidoc.org)
  • The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods. (embl.de)
  • In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. (icbinhibitor.com)
  • This integrin can be present either in a closed or in an open active conformation and its activation upon T-cell receptor (TCR) stimulation is a critical step to allow interaction with APCs. (helmholtz-hzi.de)
  • The Langerhans' cells (LC) were identified with a monoclonal antibody to OKT6 antigen, by employing an immunofluorescence technique. (medicaljournals.se)
  • Intercellular adhesion molecule 2 (ICAM-2, CD12), belongs to the ICAM family consisting of three members identified as ligands for integrin receptors. (betalifesci.com)
  • Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocytewith other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc. (betalifesci.com)
  • Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
  • Frozen sections of mouse spleen were reacted with the anti-CD11a antibody. (bdbiosciences.com)
  • The M17/4 antibody specific for mouse CD11a is recommended to test for immunohistochemical staining of acetone-fixed frozen sections. (bdbiosciences.com)
  • CD11a plays an important role in intercellular adhesion and costimulation by binding its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50). (biolegend.com)
  • The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation. (exbio.cz)
  • As a second ligand of leukocyte function-associated antigen-1, ICAM-2 functions as a costimulatory molecule for effector cells. (betalifesci.com)
  • ICAM-1 is an integral membrane protein, a member of the immunoglobulin superfamily, and a ligand for LFA-1, a beta 2 leukocyte integrin. (csb-bioenergetics.nl)
  • CD11a is a 180 kD glycoprotein, also known as a L integrin, LFA-1 a, Ly-15, or Ly-21. (biolegend.com)
  • Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion . (wikidoc.org)
  • ANA production can precede symptoms and indications of disease by 5 or more years, with more complete serological evaluation demonstrating increasing creation of antibodies to nuclear antigens such as for example DNA, Sm, RNP, Ro, and La.4 This stage of disease could be known as preautoimmunity because symptomatology isn't manifest. (columbiagypsy.net)
  • Hallikas O K, Aaltonen J M, von Koskull H, Lindberg L A, Valmu L , Kalkkinen N, Wahlström T, Kataoka H, Andersson L, Lindholm D and Schröder J (2006) Identification of antibodies against HAI-1 and integrin α6β4 as immunohistochemical markers of human villous cytotrophoblast. (leenavalmu.fi)
  • Integrins are cell surface molecules of importance in a wide variety of cellular functions, including morphogenesis, cell migration and cell matrix interactions. (medicaljournals.se)
  • The interactions between melanoma cells and PMNs are mediated by the β 2 -integrins expressed by PMNs and intercellular adhesion molecules (ICAM-1) expressed on melanoma cells. (psu.edu)
  • It was concluded that the small number of constitutively expressed active β 2 -integrins on PMNs are sufficient to bind to ICAM-1 expressed on melanoma cells and that the intrinsic dissociation rate for these adhesion molecules appear to be more dependent on what method is used to determine them than on what cells express them. (psu.edu)
  • Integrin alpha-2 or CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene . (wikidoc.org)
  • Osteopontin mediates macrophage chemotaxis via a4 and a9 integrins and survival via the a4 integrin. (musc.edu)
  • Beta2-integrins are essential for leukocyte extravasation to sites of infection ( i.e. leukocyte trafficking), and other immunological processes including neutrophil phagocytosis and ROS production, and T cell activation. (guidetopharmacology.org)
  • 2019) Beta2-Integrins and Interacting Proteins in Leukocyte Trafficking, Immune Suppression, and Immunodeficiency Disease. (guidetopharmacology.org)
  • beta2 integrin). (icbinhibitor.com)
  • Hilden T J, Valmu L , Kärkkäinen S and Gahmberg C G (2003) Threonine phosphorylation sites in the beta2 and beta7 leukocyte integrin polypeptides. (leenavalmu.fi)
  • Using an adenoviral (Ad) vector platform, we generated Ad5-S.Mod, a recombinant COVID-19 vaccine that encodes modified-spike (S) antigen and the genetic adjuvant human CXCL9. (bvsalud.org)
  • Ndr2 itself becomes activated upon TCR stimulation and phosphorylates the intracellular integrin binding partner Filamin A (FLNa) at serine 2152. (helmholtz-hzi.de)
  • Functional studies revealed increased expression of ICAM-1 on induced patient-derived endothelial cells (iECs) and of β2-integrins on patient neutrophils that increase neutrophil adhesion and vascular transendothelial migration (TEM). (nature.com)
  • Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. (wikidoc.org)
  • Immunohistochemical staining of CD11a positive cells. (bdbiosciences.com)
  • cDC1 cells were required for the generation of antigen-specific CD8+ T-cell responses and CD8+ tissue-resident memory T-cell development in intranasal Ad5-S.Mod vaccinated mice. (bvsalud.org)
  • p38MAPK induces cell surface alpha4 integrin downregulation to facilitate erbB-2-mediated invasion. (musc.edu)
  • Overall primary concerns are: extrapolating human clinical studies, seeding durable effective T cell resident memory (Trm), population human leucocyte antigen (HLA) coverage, and the potential for T cell-mediated immune escape. (mdpi.com)
  • This kind of pDC activation was dependent on direct integrin-mediated cell‒cell contacts and involved stimulation of the TLR7 and STING signaling pathways. (nature.com)
  • C57BL/6 mouse splenocytes were stained with CD11a (clone I21/7) Alexa Fluor® 488 (filled histogram) or rat IgG2a, κ isotype control Alexa Fluor® 488 (open histogram). (biolegend.com)
  • Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. (wikidoc.org)