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  • collagen
  • Endocytosis of CV-A9 has recently been shown to occur via a novel Arf6- and dynamin-dependent pathways, while, contrary to collagen binding, E-1 binds inactive β 1 integrin and enters via macropinocytosis. (hindawi.com)
  • Agonists such as thrombin or collagen trigger the integrin into its high affinity state, which causes increased fibrinogen binding, causing platelet aggregation. (wikipedia.org)
  • Signaling
  • Together, these findings indicate that seizures activate integrin signaling and induce a turnover in adhesive contacts and that both processes contribute to lasting changes in circuit and synaptic function underlying epileptogenesis. (springer.com)
  • In a process called "outside-in" signaling, the engagement of integrins results in the recruitment of cytoskeletal proteins to sites of cell-ECM contacts, thereby promoting integrin clustering and driving the formation of focal adhesions. (abcam.com)
  • however, studies of ADAP, the exchange factor Vav1, and WASP suggest that TCR and integrin clustering may be controlled by distinct signaling pathways. (sciencemag.org)
  • Subsequently, evidence that integrins also control crucial signaling cascades in cancer cells is discussed. (hindawi.com)
  • Lastly, the important role of integrin signaling in tumor cells as well as in stromal cells that support cancer growth, metastasis, and therapy resistance indicates that integrin signaling may be an attractive target for (combined) cancer therapy strategies. (hindawi.com)
  • Integrins act as bidirectional signaling molecules [ 2 ]. (hindawi.com)
  • The growth signaling pathways downstream of β 1 and β 3 integrins are well characterized. (hindawi.com)
  • β 1 and β 3 integrins activate differential survival signaling, yet both integrins initiate survival signaling downstream of ubiquitination and the kinase pathway including phosphoinositol-3-kinase (PI3K)/Akt. (hindawi.com)
  • Further characterization of these integrin-signaling mechanisms may lead to drug targets to prevent decompensation to heart failure. (hindawi.com)
  • platelets
  • The presence of integrins allows rapid and flexible responses to events at the cell surface (e.g. signal platelets to initiate an interaction with coagulation factors). (wikipedia.org)
  • They block activation of the integrin responsible for aggregation of platelets (αIIbβ3, also known as glycoprotein IIb/IIIa) in response to the blood glycoproteins fibrinogen and von Willebrand factor. (wikipedia.org)
  • motif
  • These include coxsackievirus A9 (CV-A9), echovirus 9, and human parechovirus 1 that are among the most common and epidemic human picornaviruses and bind to α V-integrins via RGD motif that resides on virus capsid. (hindawi.com)
  • bind
  • Immunoglobulin superfamily CAMs (IgSF CAMs) are either homophilic or heterophilic and bind integrins or different IgSF CAMs. (wikipedia.org)
  • 1990
  • integrin heterodimer is a component of hemidesmosomes," Proceedings of the National Academy of Sciences of the United States of America , vol. 87, no. 22, pp. 8970-8974, 1990. (hindawi.com)
  • 1990). "Purification and functional characterization of integrin alpha v beta 5. (wikipedia.org)
  • Molecular
  • This paper provides readers with an overview of the molecular and structural bases of integrin activation as well as rationale for using anti-alpha4 integrin therapy for multiple sclerosis and then chronicles the rise and fall of this treatment strategy using natalizumab, a humanized anti-alpha4 integrin. (hindawi.com)
  • Low-resolution images of detergent extracts of intact integrin GPIIbIIIa, obtained using electron microscopy, and even data from indirect techniques that investigate the solution properties of integrins using ultracentrifugation and light scattering, were combined with fragmentary high-resolution crystallographic or NMR data from single or paired domains of single integrin chains, and molecular models postulated for the rest of the chains. (wikipedia.org)
  • Understanding of the molecular basis of binding to integrins has enabled the development of several drugs for cardiovascular disease and cancer, including eptifibatide, tirofiban, cilengitide, and the PET radiotracer fluciclatide. (wikipedia.org)
  • peptide
  • Moreover, intraperitoneal injection of the α V integrin blocking peptide cRGDfV (Calbiochem, United Kingdom) increased the growth response and also greatly reduced the calculated remodeling index. (ahajournals.org)
  • Thus, to the extent that the α V integrin blocking peptide is having a specific effect, and future experiments need to determine this, the results point to an important role for this integrin in the remodeling process. (ahajournals.org)
  • Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. (wikipedia.org)
  • Fluciclatide, an (18)F-labeled small peptide that binds to integrin αVβ3 and integrin αVβ5, is being tested as a tool to monitor treatment response of tumors to anti-angiogenic therapies. (wikipedia.org)
  • binds
  • 1999) The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. (els.net)
  • amino acid seq
  • An acidic amino acid features in the integrin-interaction site of many ECM proteins, for example as part of the amino acid sequence Arginine-Glycine-Aspartic acid ("RGD" in the one-letter amino acid code). (wikipedia.org)
  • high affinity
  • Most exist at rest in a low affinity state, which can be altered to high affinity through an external agonist which causes a conformational change within the integrin, increasing their affinity. (wikipedia.org)
  • complement
  • The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. (wikipedia.org)