Integrin subunit. Medical search. Frequent questions

Integrin alpha 2 beta 1 is the non-covalent heterodimer of 160 kDa alpha 2 (CD49b) and 130 kDa beta 1 (CD29) type I transmembrane glycoprotein subunits and is one of six very late antigens on activated T cells, designated VLA2 (3). (novusbio.com)
CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin α X and CR4. (biolegend.com)

Integrin subunit beta like 1 is a protein that in humans is encoded by the ITGBL1 gene. (wikipedia.org)
This gene encodes a beta integrin-related protein that is a member of the EGF-like protein family. (wikipedia.org)
The ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cells called platelets. (medlineplus.gov)
The beta3 subunit attaches (binds) to the alphaIIb subunit, which is produced from the ITGA2B gene, to form integrin αIIbβ3. (medlineplus.gov)
The mutations that cause this disorder occur in both copies of the gene in each cell and impair the production or activity of the beta3 subunit, which disrupts the formation of functional integrin αIIbβ3. (medlineplus.gov)
Unlike Glanzmann thrombasthenia, this disorder results from a mutation in only one copy of the ITGB3 gene in each cell, and the mutations result in the formation of some integrin αIIbβ3 that is abnormally turned on (active), even when no clot is being formed. (medlineplus.gov)
Because the mutation that causes this disorder affects only one copy of the ITGB3 gene, some normal integrin is formed and normal platelets produced, which accounts for the mild signs and symptoms in affected individuals. (medlineplus.gov)
The integrin β6 (ITGB6) gene which encodes the limiting subunit of the integrin αvβ6 heterodimer plays CGS 21680 HCl a significant role in wound healing and carcinogenesis. (researchatlanta.org)
We report on the generation and phenotype of mutant alleles of multiple edematous wings (mew), the gene encoding the α(PS1) subunit of the PS1 integrin of Drosophila. (elsevierpure.com)
Integrin alpha-2 or CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene . (wikidoc.org)

Echovirus serotypes 1 and 8 bind a subunit of the very late antigen (VLA) integrin molecule. (medscape.com)

We identify previously unreported components of integrin adhesion complexes and observe receptor-specific enrichment of molecules with previously reported links to cell migration and cell signaling processes. (nih.gov)
These datasets provide a resource for future studies of integrin receptor-specific signaling events. (nih.gov)
Integrin/cytokine receptor interaction provides permissive signals leading to neoangiogenesis, and integrins are crucial for differentiation of endothelial progenitor cells (EPCs). (unito.it)
Integrin alpha 5 beta 1 is a receptor for fibronectin and neural adhesion molecule L1. (rndsystems.com)
Integrin α-l/β-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. (lu.se)
Integrin α-m/β-2 is also a receptor for Factor X. Integrin α-d/β 2 is a receptor for ICAM3 and VCAM1. (lu.se)

αvβ6 expression depends on integrin β6 (ITGB6) expression as ITGB6 only partners with αv forming a single heterodimer. (researchatlanta.org)
Integrin beta 7 forms a nondisulfide linked heterodimer with alpha 4 and alpha E integrins. (rndsystems.com)
The alpha 5 subunit, also known as CD49e and VLA-5 alpha subunit, forms a heterodimer with the Integrin beta 1 subunit (CD29). (rndsystems.com)
CD29 is expressed on the cell surface as a heterodimer with one of the distinct integrin α chains. (bdbiosciences.com)
We have used monoclonal antibodies (mAbs) as probes to study the dependence of the structure of different regions of the alphaM subunit on association with the beta2 subunit in the alphaM/beta2 heterodimer. (embl.de)
Heterodimer of an α and a β subunit. (lu.se)

Multiple inherited mutations in the integrin β2 protein (CD18) that reduce expression or function have been identified as the causative factor in patients with LAD1. (guidetopharmacology.org)
1998) Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. (guidetopharmacology.org)
CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. (biolegend.com)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)

In Western blots, approximately 50% cross-reactivity with recombinant mouse (rm) Integrin alpha 5 is observed and less than 2% cross-reactivity with recombinant human Integrin alpha M, rmIntegrin alpha 2, rmIntegrin alpha 4, and rmIntegrin alpha E is observed. (rndsystems.com)

2019) Beta2-Integrins and Interacting Proteins in Leukocyte Trafficking, Immune Suppression, and Immunodeficiency Disease. (guidetopharmacology.org)
The ability of the fusion proteins to interfere with IL-3Rβc/β1 integrin interaction was assessed on endothelial cells (ECs), EPCs and murine-derived ECs. (unito.it)
Pull-down experiments showed that Fc1.4 and Fc4 fusion proteins specifically interacted with β1 integrin. (unito.it)
Integrin αIIbβ3 can also bind other proteins on platelets and in the blood as well as proteins within the intricate lattice that forms in the space between cells (extracellular matrix) to ensure proper clot formation and promote wound healing. (medlineplus.gov)
A shortage (deficiency) of functional integrin αIIbβ3 prevents sufficient binding of fibrinogen or other proteins, impairing the formation of blood clots. (medlineplus.gov)
The overactive integrin αIIbβ3 binds inappropriately to clotting proteins within the cell during the formation of platelets, causing the platelets to become misshapen and large. (medlineplus.gov)
Introduction CGS 21680 HCl Integrins are heterodimeric trans-membrane proteins that are composed of non-covalently associated and subunits [1]. (researchatlanta.org)
Integrins are cell adhesion molecules that reside on the surface of cells as transmembrane proteins made of an alpha and beta subunit. (harvard.edu)
Podosomes are structurally divided into a core, which mainly contains proteins involved in actin polymerization (such as WASP, the Arp2/3 complex and cortactin ), and a surrounding ring populated by integrin receptors and adhesion proteins (for example, paxillin and focal adhesion kinase (FAK/Pyk2) ) [15] . (cellmigration.org)
A capsid composed of 60 subunits is formed from 4 proteins-VP1 to VP4. (medscape.com)

Integrin adhesion receptors mediate cell-cell and cell-extracellular matrix interactions, which control cell morphology and migration, differentiation, and tissue integrity. (nih.gov)
We have examined the expression of integrins on primary oligodendroglial cells during the differentiation of the proliferative oligodendrocyte precursor (O-2A progenitor) cell to the postmitotic oligodendrocyte. (uea.ac.uk)
They also suggest a simple model by which switching of integrin β subunits might regulate differentiation. (uea.ac.uk)
As chimeric β1 integrins with a β5 cytoplasmic domain support proliferation less well than normal β1 integrins the switch from αvβ1 to αvβ5 might play a key instructive role in the cessation of proliferation and subsequent differentiation. (uea.ac.uk)
Integrators of epidermal growth and differentiation: distinct functions for beta 1 and beta 4 integrins. (embl.de)
2010). Ataxin-3 plays a role in mouse myogenic differentiation through regulation of integrin subunit levels . (up.pt)
Cell attachment, proliferation and differentiation were studied using enzyme-linked immunosorbant assays, and immunofluorescence microscopy was used to detect integrin subunits and cytoskeletal arrangement 24 h after cellular attachment. (ucl.ac.uk)

CD51, an ~120 kDa surface molecule can also non-covalently associate with other beta subunits of the integrin family including beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. (thermofisher.com)
The Ha2/5 monoclonal antibody specifically binds to the 130 kDa integrin β1 chain (CD29). (bdbiosciences.com)

The following product was used in this experiment: CD51/CD61 (Integrin alpha v beta 3) Monoclonal Antibody (23C6), Biotin, eBioscience™ from Thermo Fisher Scientific, catalog # 13-0519-82, RRID AB_529536. (thermofisher.com)
Description: The 23C6 monoclonal antibody reacts with the human CD51/CD61 dimer, also known as the integrin alphav/beta3. (thermofisher.com)

During clot formation, integrin αIIbβ3 binds to a protein called fibrinogen. (medlineplus.gov)
Intercellular adhesion molecule 5, which binds to and activates integrins, may be a direct target of perisynaptic MMP proteolysis during LTP. (nature.com)

The different functions of specific integrin heterodimers, such as α4β1 and α5β1, have been attributed to distinct signal transduction mechanisms that are initiated by selective recruitment of adhesion complex components to integrin cytoplasmic tails. (nih.gov)
The NPXY sequence is highly conserved among integrin beta subunit cytoplasmic tails, suggesting that it plays a fundamental role in regulating integrin-mediated function. (silverchair.com)

Two integrin beta subunits are encoded in the Drosophila genome. (nih.gov)
These results demonstrate that the second beta subunit can partially compensate for loss of betaPS integrins, and that integrins are essential for migration of the primordial midgut cells. (nih.gov)
The two beta subunits mediate midgut migration by distinct mechanisms: one that requires talin and one that does not. (nih.gov)
ITGB2 is the beta component of the β2 integrins. (guidetopharmacology.org)
1987) Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency. (guidetopharmacology.org)
In the primary sequence of the integrin beta subunit, the N-terminal region (NTR) and mid-region are separated by the I-like domain. (amsterdamumc.org)
To determine the spatial relationship and functional properties of the integrin beta(2) NTR and mid-region, we constructed beta(2)/beta(7) chimeras in which the NTR, I-like domain, and the mid-region of the beta(2) subunit were replaced by those of beta(7). (amsterdamumc.org)
Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. (silverchair.com)
Evidence is provided that the NPXY structural motif within the beta 3 subunit, comprising residues 744-747, is essential for cell morphological and migratory responses mediated by integrin alpha v beta 3 in vitro and in vivo. (silverchair.com)
Transfection of CS-1 melanoma cells with a cDNA encoding the wild-type integrin beta 3 subunit, results in de novo alpha v beta 3 expression and cell attachment, spreading, and migration on vitronectin. (silverchair.com)
These findings demonstrate that the NPXY motif within the integrin beta 3 cytoplasmic tail is essential for alpha v beta 3-dependent post-ligand binding events involved in cell migration and the metastatic phenotype of melanoma cells. (silverchair.com)
Integrin alpha 2 is one of twelve integrin family alpha subunits that share the beta 1 subunit (1‑3). (novusbio.com)
The I domain-containing beta 1 integrins ( alpha 1 beta 1, alpha 2 beta 1, alpha 10 beta 1 and alpha 11 beta 1) all bind collagens, with alpha 2 beta 1 preferring collagens I‑III (4, 5). (novusbio.com)
Staining of M21 cells with 0.5 µg of Mouse IgG1 kappa Isotype Control Biotin (Product # 13-4714-85) (open histogram) or 0.5 µg of Anti-Human CD51/CD61 (Integrin alpha/beta 3) Biotin (filled histogram) followed by Streptavidin PE (Product # 12-4317-87). (thermofisher.com)
CD51 and CD61 molecules (alpha V and beta 3 integrins) form a complex. (thermofisher.com)
Detects human Integrin beta 7 in direct ELISAs and Western blots. (rndsystems.com)
Human Integrin beta 7 (also Integrin beta P and M290 IEL Ag) is a 120 kDa member of the Integrin beta chain family of molecules. (rndsystems.com)
Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. (wikidoc.org)
Integrin alpha (beta-propellor repeats). (embl.de)
They contain both alpha and beta subunits. (embl.de)
Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. (embl.de)
The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. (embl.de)
Dependence on beta subunit association and prediction of domains. (embl.de)
By contrast, four mAbs to the beta-propeller domain did not react with the unassociated alphaM precursor nor with the uncomplexed alphaM subunit expressed on COS cell surface. (embl.de)
The four mAbs were mapped to three subregions in three different beta-sheets, making it unlikely that each recognized an interface between the alpha and beta subunits. (embl.de)
These results suggest that folding of different beta-propeller subregions is coordinate and is dependent on association with the beta2 subunit. (embl.de)
This suggests that much of the region C-terminal to the beta-propeller domain folds independently of association with the beta2 subunit. (embl.de)
Our data provide new insights into how different domains in the integrin alpha and beta subunits may interact. (embl.de)

Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. (embl.de)

The betaPS subunit is widely expressed and heterodimers containing this subunit are required for many developmental processes. (nih.gov)
It forms αβ heterodimers with the CD11 alpha subunits ITGAL (αL aka CD11a forming integrin LFA-1), ITGAM (αM aka CD11b, forming integrin Mac-1) and ITGAX (αX aka CD11c, forming integrin p150/95). (guidetopharmacology.org)
To date 18 and 8 subunits have been identified and are capable of forming more than 24 heterodimers that account for the structural and functional diversity of the integrin family [2]. (researchatlanta.org)

All of the mAbs to the I-domain immunoprecipitated the unassociated alphaM precursor and reacted with the alphaM subunit expressed alone on the surface of COS cells. (embl.de)

Detects human Integrin alpha 2/CD49b. (novusbio.com)
Detects human Integrin alpha 5/CD49e in Western blots. (rndsystems.com)
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Have you used Human Integrin alpha 5/CD49e Biotinylated Antibody? (rndsystems.com)
The CD49b protein is an integrin alpha subunit. (wikidoc.org)

Integrins recruit multimolecular adhesion complexes to their cytoplasmic domains, which provide structural and mechanosensitive signaling connections between the extracellular and intracellular milieux. (nih.gov)
With α1 through α6 (CD49a through CD49f), it forms the VLA-1 through VLA-6 complexes, respectively, and with αV (CD51), it forms αVβ1 integrin. (bdbiosciences.com)

Attachment of integrin αIIbβ3 from adjacent platelets to the same fibrinogen protein helps platelets cluster together (platelet cohesion) to form a blood clot. (medlineplus.gov)
Integrins α-m/β-2 and α-x/β-2 are receptors for the IC3B fragment of the third complement component and for fibrinogen. (lu.se)
Integrin α-x/β 2 recognizes the sequence g-p-r in fibrinogen α-chain. (lu.se)
Integrin α-m/β-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. (lu.se)

There are 24 known integrin molecules classified into different families depending on the subunits (i.e. αv family of integrins) or by the ligands they bind to (i.e. (harvard.edu)

Having generated the tools to eliminate integrin function completely, we confirm that Drosophila integrins do not control proliferation as they do in mammals, and have identified alphaPS3 as a heterodimeric partner for betanu. (nih.gov)

Antibody inhibitors and siRNA were used to manipulate the expression profiles of LX-2 cells that were incubated under normal culture conditions or after treatment with TGF-Β, a known ligand for the αv integrins and a pro-fibrotic cytokine, to mimic a pro-fibrotic environment in vitro. (harvard.edu)
Cells were analyzed by qPCR and flow cytometry to assess the changes in the integrin expression profile. (harvard.edu)
Upon knockdown of β3 or β5 expression using small interfering RNA (si-RNA) treatment, a marked decrease in the cell surface expression of the αv subunit was observed without a change in the mRNA levels of the αv subunit. (harvard.edu)
Immunofluorescence studies detected no marked variation in the integrin subunit expression and organisation of the cytoskeletal network of the cells. (ucl.ac.uk)

Together, these results suggest that the two GSK2118436A novel inhibtior phenylalanine residues of the GFFKR motif provide a site for interaction of the alpha6A subunit with beta1, whereas the cytoplasmic GSK2118436A novel inhibtior domain C-terminal of this motif is involved in the regulation of bidirectional signalling via alpha6Abeta1. (healthyconnectionsinc.com)

Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. (wikidoc.org)

The objectives of this study were to characterize how the αv integrins regulate each other in both a normal and pro-fibrotic environment in order or decipher any mutual regulation between the αv integrins and to assess if there is a good in vitro model to look at potential compensation mechanisms specifically in an inflammatory environment. (harvard.edu)

However, this mutant was targeted to focal contacts formed by GSK2118436A novel inhibtior other integrins, even when they had not bound ligand. (healthyconnectionsinc.com)

The alphaM subunit of integrin Mac-1 contains several distinct regions in its extracellular segment. (embl.de)

We show that the two AAA+ modules of the subunits form a unique complex of 3 dimers related by a three-fold axis. (lu.se)

RDG binding family of integrins). (harvard.edu)

A subset of four mAbs that reacted with the alphaM/beta2 complex but not with the unassociated alphaM subunit were mapped to one subregion, residues 718-759, and five other mAbs that recognized both the unassociated and the complexed alphaM subunit were localized to three other subregions, residues 599-679, 820-882, and 943-1047. (embl.de)

Such proteolytically active MMPs then signal through β1-containing integrins to promote dendritic spine enlargement and synaptic potentiation concurrently. (nature.com)

Other examples of developmental cell migration, such as that of the primordial germ cells, occurred normally in the absence of integrins. (nih.gov)

Anatomy32

Organisms14

Diseases3

Chemicals and Drugs123

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes55

Disciplines and Occupations1

Information Science3

Type I transmembrane glycoprotein2

Gene10

Antigen1

Receptor6

Heterodimer6

CD184

Cross-reactivity with recombinant human1

Proteins10

Differentiation7

CD292

Monoclonal Antibody2

Binds2

Cytoplasmic tails2

Beta28

Mediate1

Heterodimers3

Precursor1

Alpha5

Complexes2

Fibrinogen4

Molecules1

Drosophila1

Expression4

Beta11

Adhesion1

Regulate1

Ligand1

Distinct1

Dimers1

Family1

Residues1

Dendritic1

Developmental1