Integrin receptor. Medical search. Frequent questions

ide-cel) as the first B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T cell immunotherapy for the treatment of adult patients with relapsed or refractory multiple myeloma after four or more prior lines of therapy, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 monoclonal antibody. (drugs.com)

A plant protein with structural similarity to integrins contains the amino acid sequence Asn-Gly-Asp (NGD). (wikipedia.org)
This protein shares functional homology with mammalian integrins in that it connects the ECM to the intracellular matrix to both stabilize the cell structure and allow for signal exchange. (wikipedia.org)
Multiple inherited mutations in the integrin β2 protein (CD18) that reduce expression or function have been identified as the causative factor in patients with LAD1. (guidetopharmacology.org)
Outside-in signaling consists of partly ligand-dependent clustering of integrins that brings signaling domains of integrin-proximal protein close enough jointly to start intracellular indicators. (tam-receptor.com)
Integrin-linked kinase (ILK) is a major structural adaptor protein governing signaling complex formation and cytoskeletal dynamics. (jneurosci.org)
KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
This gene encodes a member of the low-density lipoprotein receptor related protein family. (nih.gov)
It tests negative for the three main targets of hormonal and protein receptor therapies: estrogen receptors, progesterone receptors and an upregulation of HER2 protein. (asbmb.org)
CD151 is a scaffolding protein that interacts with integrin receptors. (asbmb.org)
The integrin dependent COX-2 expression was shown to be mediated through the activation of CD47 and its associated G?i3 protein, which in turn lead to protein kinase C? (lu.se)

Inhibition of integrin receptors reduces extracellular matrix levels, ameliorating benign prostate hyperplasia. (physiciansweekly.com)
More importantly, integrin receptor inhibition in a mouse model of BPH significantly ameliorated prostate hyperplasia. (physiciansweekly.com)
Our results show that the amount of VLP binding and the expression level of alpha(6) integrin are correlated, which was confirmed by an inhibition experiment using antibodies and by immunocytochemistry. (nih.gov)
These inhibitory effects may be associated with its dual‑receptor inhibition on P2Y12 and TP receptors. (spandidos-publications.com)

Inhibitors of the CD11/CD18 or CD18 integrin receptors have been shown to reduce infarct size in experimental models. (johnshopkins.edu)
General integrin-based therapeutics show medically MLN8237 (Alisertib) significant benefits in lots of patients resulting in continued medical curiosity about the further advancement of book integrin inhibitors. (tam-receptor.com)
Prior reviews about them have centered on various other aspects including information on integrin framework and allosteric inhibitors 7 leukocyte integrins 8 feasible focuses on in airway hyper-responsiveness 9 and applicant substances in early-stage studies 10. (tam-receptor.com)
These findings demonstrate crosstalk between a tyrosine kinase receptor and an integrin involved in carcinoma cell invasion and metastasis and may explain in part how inhibitors of EGFR impact malignant disease. (biotech-angels.com)
Many substances including peptides comprising RGD theme [11] have already been lately created as inhibitors of V3 integrin, in tests regarding tumor angiogenesis, displaying a reduced amount of practical vessel density connected with retardation of tumor development and metastasis development [6,17]. (cancerhugs.com)

1998) Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. (guidetopharmacology.org)
Of the 8 plasma membrane receptors for complement, only deficiencies of CR3 and CR4 due to CD18 deficiency have been described, known as leukocyte adhesion deficiency (LAD) type 1 . (medscape.com)
The CD11/CD18 complex is part of the beta-2 integrin family and is important in adhesion and phagocytosis (see Table 1). (medscape.com)
OBJECTIVES: The purpose of this study was to determine whether Hu23F2G (LeukoArrest), an antibody to the CD11/CD18 integrin receptors, would reduce infarct size in patients undergoing primary angioplasty for an acute myocardial infarction. (johnshopkins.edu)
CONCLUSIONS: The results of this multicenter, double-blind, placebo-controlled, randomized clinical trial demonstrated that an antibody to CD11/CD18 leukocyte integrin receptor did not reduce infarct size in patients who underwent primary angioplasty. (johnshopkins.edu)
Description: The N418 monoclonal antibody reacts with mouse CD11c, the integrin alpha X. CD11c non-covalently associates with beta 2 integrin to form the CD11c/CD18 heterodimer. (thermofisher.com)

Beta2-integrins are essential for leukocyte extravasation to sites of infection ( i.e. leukocyte trafficking), and other immunological processes including neutrophil phagocytosis and ROS production, and T cell activation. (guidetopharmacology.org)
2019) Beta2-Integrins and Interacting Proteins in Leukocyte Trafficking, Immune Suppression, and Immunodeficiency Disease. (guidetopharmacology.org)
In contrast, citrullination had only a minor effect on the function of α1β1 and α2β1 integrins, which have been reported to play a critical role in regulating leukocyte function. (abo.fi)
Leukocyte and platelet integrins undergo conformational "activation" and adjustments. (tam-receptor.com)
Both platelet and leukocyte integrins are experts at integrin affinity regulation by inside-out signaling. (tam-receptor.com)

The complement system exerts many of its effects through complement receptors (CRs). (medscape.com)
Integrins α-m/β-2 and α-x/β-2 are receptors for the IC3B fragment of the third complement component and for fibrinogen. (lu.se)
Antibodies, the complement system, and the cellular receptors regulating signaling, such as Fc receptors and integrins, are natural components to study. (lu.se)
Delayed recovery from COVID19 was associated with changes in metabolic and signalling proteins, complement, chemokine and leukotriene receptors, integrins and inhibitory receptors. (cdc.gov)

The present study was performed to determine the specific receptor of type HPV-16 using recombinant human papillomavirus-like particle (HPV-16 L1-VLP). (nih.gov)
The binding of different collagen receptor integrins to citrullinated collagen was studied by CHO cell lines, each overexpressing 1 of the 4 human collagen receptors on the cell surface, and with solid-phase binding assays, using the recombinant human integrin α1I, α2I, α10I, and α11I domains. (abo.fi)
In Western blots, no cross-reactivity with recombinant human Integrin beta 1, recombinant mouse (rm) Integrin beta 2, rmIntegrin beta 3, rmIntegrin beta 4, or rmIntegrin beta 6 is observed. (rndsystems.com)

Based on the home-and-abroad progress in relevant clinical research, this expert consensus aims to establish principles for clinical application of RGD-based peptides for integrin imaging. (guidelines-registry.org)
The monocyte alpha(v)beta(3) integrin was involved in TNF synthesis since peptides containing RGD sequences and blocking antibodies against alpha(v)beta(3) integrin inhibited TNF transcripts induced by C. burnetii. (nih.gov)
A database search curated for known matrix protease substrates and predicted signaling motifs enabled identification of 73 MWCNT-responsive peptides, which were significantly associated with an abnormal cardiovascular phenotype, extracellular matrix organization, immune-inflammatory processes, cell receptor signaling, and a MWCNT-altered serum exosome population. (cdc.gov)
Other identified peptides point to integrin ligand functionality and more broadly to a diversity of receptor-mediated bioactivity induced by the peptidomic response to nanoparticle exposure. (cdc.gov)
Integrin α-m/β-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. (lu.se)

in-teraction is mediated by integrins, transmembrane nonco-valently linked heterodimeric receptors consisting of␣ and ␤ subunits (6). (123dok.org)

Integrin-like receptors (ILRs) are found in plants and carry unique functional properties similar to true integrin proteins. (wikipedia.org)
Mammalian integrins are heterodimer transmembrane proteins that play a large role in bidirectional signal transduction. (wikipedia.org)
As transmembrane proteins, integrins connect the extracellular matrix (ECM) to the plasma membrane of the animal cell. (wikipedia.org)
Integrin-like receptors and integrin-linked kinases together have been implicated in surface adhesion, immune response, and ion accumulation in plant cells in a manner akin to the family of integrin proteins. (wikipedia.org)
Most commonly, ILRs resembles the β1 subunit found in integrin proteins. (wikipedia.org)
These proteins are around 55 to 110 kDa and some studies have found them to react with animal anti-β1 antibodies suggesting the structural similarity between animal integrins and these plant integrin-like receptors. (wikipedia.org)
Some ILRs mimic the α-subunit of integrin proteins containing the ligand binding region known as the I-domain. (wikipedia.org)
Well-known intracellular occasions that are reliant on integrin outside-in signaling consist of activation from the spleen tyrosine kinase Syk 3 4 and Src family members proteins tyrosine kinases in platelets 5 and leukocytes 3 and activation of NADPH oxidase in leukocytes MLN8237 (Alisertib) 6. (tam-receptor.com)
Previous studies have implicated β1 integrins in cancer since they regulate cell adhesion and migration/invasion on tumor stroma proteins such as fibronectin laminin and collagen (33). (biotech-angels.com)
Actually if different integrins understand different proteins comprising the RGD triad, many reports have demonstrated the aminoacids flanking the RGD series of high-affinity ligands look like essential in modulating their specificity of connection with integrin complexes [15,16]. (cancerhugs.com)
Moreover, integrins, laminins, NF-κB and other regulative molecules were found as crucial proteins. (nature.com)
CD324 binds to the α E β 7 integrin to mediate cell adhesion and also interacts with a number of intracellular proteins including including erbin, ezrin, caspase-3, caspase 8, β-catenin, presenilin 1, casein kinase II , as well as other extracellular proteins including the EGF receptor. (biolegend.com)

As to the basis for their collaboration, integrins and growth factor receptors may form macromolecular complexes on the cell membrane (7, 8, 13, 16 -18). (123dok.org)
We reported previously which the tumorigenicity of HEp3 individual carcinoma cells would depend on the connections of urokinase plasminogen activator (uPA)/uPA receptor (uPAR) complexes with 51-integrin (Aguirre Ghiso (Beverly, MA). (oaxacalibre.net)

10). Two types of allosteric antagonists for these integrins have already been defined: α/β I-like allosteric antagonists and α I allosteric antagonists (10). (bioinf.org)
No allosteric antagonists possess yet been discovered for non-I area formulated with integrins (such as for example VLA-4). (bioinf.org)
Among the top features of competitive integrin antagonists is certainly to take up the ligand binding pocket and induce a conformational transformation that is like the conformational transformation induced by an all natural ligand. (bioinf.org)
Of be aware virtually all integrin antagonists used or in late-stage scientific trials LRRC46 antibody focus on the ligand binding site or the ligand itself. (tam-receptor.com)
The goal of this Opinion piece is certainly to supply a biological framework for integrins as medication targets to showcase integrin antagonists which have proven benefit in sufferers or guarantee in late-stage scientific trials also to critique ongoing efforts to build up new integrin-targeted medications. (tam-receptor.com)
All integrin antagonists available on the market or in late-stage scientific trials focus on the ligand binding sites of integrins portrayed in bloodstream cells: leukocytes or platelets. (tam-receptor.com)
Vedolizumab injection is in a class of medications called integrin receptor antagonists. (medlineplus.gov)

How is the insulin tyrosine kinase receptor unusual? (flashcardmachine.com)
How is a tyrosine kinase receptor activated? (flashcardmachine.com)

Evidence suggests that C1q binds a receptor present on phagocytic cells, termed C1qRP. (medscape.com)
The C3a receptor binds C3a and C4a. (medscape.com)
It binds free and membrane-bound TNF and thus prevents the cytokine from binding to its cell surface receptor and exerting biological activity. (medscape.com)
It specifically binds to TNF-alpha and blocks its interaction with p55 and p75 cell surface TNF receptors. (medscape.com)

The post-ischemic cerebral angiogenic response was inhibited by antibodies against TNFR1 but not TNFR2, and this correlated with reduced endothelial proliferation and decreased α5β1 and αVβ3 integrin expression after 4 and 7 days post-ischemia. (biomedcentral.com)
Consistent with these findings, in vitro studies showed that TNF-α induced endothelial proliferation and upregulation of α5β1 and αVβ3 integrins was abrogated by anti-TNFR1 but not anti-TNFR2 antibodies in cultured HBMECs. (biomedcentral.com)
In addition, blocking antibodies to α5β1 and αVβ3 integrins significantly inhibited TNF-α-induced HBMEC proliferation. (biomedcentral.com)
Nevertheless, the cross-linking of alpha(v)beta(3) integrin by specific antibodies was not sufficient to induce TNF synthesis. (nih.gov)
Anti-CD29 (1-integrin) and anti-CD55/DAF monoclonal antibodies had been from NeoMarkers (Union Town, CA). Regular mouse IgG, fluorochrome-labeled supplementary antibodies, anti-human FN polyclonal antibody (F3648), and anti-FLAG (M2) monoclonal antibody had been from Sigma. (oaxacalibre.net)
Rat anti-1 and 51-integrin preventing monoclonal antibodies AIIB2 and BIIG2 (Werb 0.001 Mann-Whitney test. (oaxacalibre.net)
We also demonstrated that treatment of cells in lifestyle with antibodies that disrupt the connections of 1-integrin with uPAR triggered a decrease in ERK activity that translated right into a condition of transient dormancy upon inoculation of the cells on CAMs. (oaxacalibre.net)
New antibodies and little substances concentrating on β7 integrins (α4β7 and αEβ7) and MAdCAM-1 are in scientific advancement for treatment of the inflammatory bowel illnesses. (tam-receptor.com)

Integrin engagement by ECM can modulate growth factor signaling pathways, increasing the activity of growth factor RTKs (7, 8) and their downstream intracellular mediators (9, 10). (123dok.org)
Upon prolonged high intracellular rises in Ca 2+ , platelets develop a procoagulant phenotype that is characterized by the surface membrane exposure of phosphatidylserine and by the inactivation of integrin α IIb β 3 (procoagulant platelet population) ( 5 ). (frontiersin.org)
2006) Combined integrin activation and intracellular cAMP cause Rho GTPase dependent growth cone collapse on laminin-1. (assumption.edu)

Integrin-mediated RON growth factor receptor phosphorylation requires tyrosine kinase activity of both the receptor and c-Src. (123dok.org)
Integrin-in-duced epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) RTK phosphorylation depends on the kinase activity of the receptor (7, 13). (123dok.org)
Interestingly, Egr-1 induction depends on integrin-dependent PI3K/Akt activation, as indicated by the decrease in Egr-1 levels in presence of the pharmacological inhibitor LY294002, the kinase-defective Akt mutant and Akt1/2 shRNAs. (unito.it)
Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. (biotech-angels.com)
Src activation downstream of EGFR is required for αvβ5-mediated carcinoma cell invasion and metastasis EGF receptor ligation and Src activation have been linked to the growth and malignant properties of many tumors (2 4 To assess whether HIF-C2 EGF-mediated migration was Src-dependent FG cells had been treated using a Src kinase inhibitor (SKI-606) ahead of EGF excitement. (biotech-angels.com)
What are physical characteristics found in all tyrosine kinase receptors? (flashcardmachine.com)
We observed that direct stimulation with LT D4, induced intestinal epithelial cell migration, through activation of the CysLT1 receptor, phosphotidylinositol-3 kinase, Vav2 and Rac localisation to membrane ruffles. (lu.se)

Human CD49d molecules are integrin a4 chains that are expressed as heterodimers with CD29 (b1 integrin) or (b7 integrin) and function as adhesion receptors. (biosave.com)
Launch Integrins are adhesion receptors hooking up cells to extracellular matrix ligands also to counter-receptors on various other cells. (tam-receptor.com)
The integrins are cell adhesion receptors that mediate cell-cell and cell-matrix connections and organize signaling allowing an in depth legislation of physiological phenomena including mobile migration, proliferation and differentiation. (cancerhugs.com)

An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. (frontiersin.org)
The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)
Although these platelet activation processes are relatively well-studied as a function of the platelet environment, only since recently it is becoming clear that a multitude of proteases present in plasma or produced by platelets themselves are important for the distinct properties of platelet populations, often by cleaving specific receptors. (frontiersin.org)
Here, we review current knowledge how proteases act on platelet receptors and the platelet membrane surface. (frontiersin.org)
Integrin αIIbΒ3 bound to fibrin helps contract the platelet actin-myosin cytoskeleton, pulling the clot in and extruding excess fluid. (medscape.com)

Oocyte-specific, beta1 integrin conditional knockout mice allowed us to obtain mature eggs lacking. (lu.se)
We found that the beta1 integrin null eggs were fully functional in fertilization both in vivo and in vitro. (lu.se)
Furthermore, neither anti-mouse beta3 integrin function-blocking monoclonal antibody (mAb) nor alphav integrin function-blocking mAb inhibited sperm binding to or fusion with beta1 integrin null eggs. (lu.se)
To dissect the molecular basis of integrin-dependent Egr-1 regulation, we show by FLIM-based FRET that in living cells beta1-integrin associates with the EGF receptor (EGFR) and that EGF further increases the extent complex formation. (unito.it)

TNF-α interacts with two types of cell surface receptors, TNF receptor 1 (TNFR1) and TNFR2 [ 12 ]. (biomedcentral.com)
A long clot retraction time is abnormal and suggests an abnormality somewhere in the coagulation cascade after integrin αIIbΒ3 interacts with fibrin. (medscape.com)

an enzyme involved in the production of various eicosanoids) expression, by activating integrin collagen receptors. (lu.se)

We performed immunohistochemistry for CAR and integrin α v expression in bladder cancer specimens in 50 paraffin-embedded tumor-normal pairs and confirmed the results by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of 11 separate bladder tumors and 4 separate normal bladder controls. (elsevierpure.com)
Jointly these results BCI hydrochloride suggest that uPAR and its own connections using the BCI hydrochloride integrin is highly recommended important goals for induction of tumor dormancy. (oaxacalibre.net)
in vivo yet does not influence primary tumor growth or activation of other integrins on these cells. (biotech-angels.com)
While EGF stimulation had no effect on primary tumor growth it increased pulmonary metastasis 3-fold HIF-C2 which was abolished by shRNA-mediated knockdown of integrin β5 (Fig. 1C). (biotech-angels.com)
Importantly knockdown of β5 did not influence β1 integrin expression (Supplemental Fig. S1C) or primary tumor growth (Fig. 1C) indicating that EGF and αvβ5 coordinately and specifically regulate the spontaneous metastasis of FG cells in this model. (biotech-angels.com)

It is widely expressed during development, but in the adult is the predominant laminin receptor ( RECEPTORS, LAMININ ) in mature SMOOTH MUSCLE CELLS , where it is important for maintenance of the differentiated phenotype of these cells . (online-medical-dictionary.org)

Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN . (online-medical-dictionary.org)

In vivo and in vitro experiments were used to confirm the role of integrin receptors. (physiciansweekly.com)
In parallel in vitro studies, flow cytometry was used to determine the influence of TNF-α on proliferation and integrin expression of human brain microvascular endothelial cells (HBMECs). (biomedcentral.com)
It's been also reported that V3 is definitely under the limited control of VEGF: this integrin isn't indicated in quiescent vessels [10], but VEGF induces V3 manifestation em in vitro /em and, oddly enough, the VEGF and V3 integrin manifestation are extremely correlated em in vivo /em [11,12]. (cancerhugs.com)
Results implicate receptor ligand functionality in driving systemic effects, exemplified by an identified 59-mer thrombospondin fragment, replete with CD36 modulatory motifs, that when synthesized produced an anti-angiogenic response in vitro matching that of the peptide fraction. (cdc.gov)

2014), as well as cytokine and integrin receptors (Rizk et al. (europa.eu)
Is cytokine receptor association with PTK reversible or irreversible? (flashcardmachine.com)
These agents prevent the endogenous cytokine from binding to cell surface receptor and exerting biological activity. (medscape.com)

What is the most common activity found intrinsic to transmembrane receptors? (flashcardmachine.com)

Despite the cited progress in this area of research, the molecular mechanisms underlying growth factor receptor activation by integrins remain to be defined. (123dok.org)

More recently, we described that in response to cerebral ischemia, vascular expression of fibronectin (Fn), and its two receptors, α5β1 and αVβ3 integrins, were all noticeably increased by day 4, peaked at day 7, then declined at day 14. (biomedcentral.com)

It forms αβ heterodimers with the CD11 alpha subunits ITGAL (αL aka CD11a forming integrin LFA-1), ITGAM (αM aka CD11b, forming integrin Mac-1) and ITGAX (αX aka CD11c, forming integrin p150/95). (guidetopharmacology.org)
Integrins are obligatory type I αβ heterodimers and molecular MLN8237 (Alisertib) devices that undergo huge conformational adjustments within their extracellular domains brought about by signaling substances inside cells. (tam-receptor.com)

This technique also known as inside-out signaling is set up by adaptor substances that affect the positioning from the integrin α and β cytoplasmic tails in accordance with each other also to the plasma membrane. (tam-receptor.com)
Are receptors always on the plasma membrane? (flashcardmachine.com)

La subunidad alfa es el ANTÍGENO CD11c, un antígeno de superficie que se expresa en algunas células mieloides. (bvsalud.org)

2019) Integrins Have Cell-Type-Specific Roles in Development of Motor Neuron Connectivity. (assumption.edu)

Interestingly, brain endothelial cell (BEC) proliferation followed the same time-course, suggesting a mechanistic relationship, with the Fn-α5β1/αVβ3 integrin axis driving BEC proliferation and angiogenesis. (biomedcentral.com)
This is consistent with our previous work in the chronic hypoxia model in which transgenic mice lacking endothelial expression of α5 integrin (α5-EC-KO mice) showed a delayed and reduced angiogenic response to mild hypoxia [ 6 ]. (biomedcentral.com)
TNFR1 is expressed on all cell types, and this is a major signaling receptor for TNF-α, whereas TNFR2 is expressed primarily by endothelial cells and hematopoietic and some neuronal populations and mediates limited biological responses [ 12 ]. (biomedcentral.com)
This integrin participates in the activation of vascular endothelial development element receptor-2 (VEGFR-2), offering a survival sign towards the proliferating vascular cells during fresh vessel development [7,8] and in addition appears to be important in the stage of vacuolation and lumen development [9]. (cancerhugs.com)
Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells , and may play a role in angiogenesis. (online-medical-dictionary.org)
The serum peptide fraction, having cell-surface receptor ligand properties, conveys peripheral bioactivity in promoting endothelial cell inflammation, vasodilatory dysfunction and inhibiting angiogenesis. (cdc.gov)

CD51, an ~120 kDa surface molecule can also non-covalently associate with other beta subunits of the integrin family including beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. (thermofisher.com)
Detects mouse Integrin beta 1/CD29 in direct ELISAs and Western blots. (rndsystems.com)
The Integrin beta 1 subunit, also known as CD29, associates with multiple distinct Integrin alpha subunits. (rndsystems.com)
Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29. (online-medical-dictionary.org)

however, the role of the two distinct TNF-α receptors, TNFR1 and TNFR2, in mediating angiogenic signaling after cerebral ischemic stroke is relatively unknown. (biomedcentral.com)
Our results suggest that TNFR1-mediated signaling plays a critical role in triggering angiogenic integrins and subsequent angiogenic responses following cerebral ischemia. (biomedcentral.com)
Integrins are activatable adhesion and signaling substances. (tam-receptor.com)
Once turned on integrins support ligand-dependent mobile signaling an activity known as outside-in signaling since it is initiated with the binding of extracellular ligands towards the integrins. (tam-receptor.com)
The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. (frontiersin.org)
In light of these findings, precisely how β1 integrin transduces ECM cues via signaling intermediates, and the mechanism by which this translates to cellular responses, need to be addressed. (jneurosci.org)
2008) Integrin signaling is integral to regeneration. (assumption.edu)
A normal value means that outside-in signaling through integrin αIIbΒ3 in the clotting process is normal. (medscape.com)
Outside-in signaling refers to a cascade of reactions started by integrin ligand binding. (medscape.com)

Integrin α v expression increases in various tumors suggest its importance in differentiation, proliferation, and migration. (elsevierpure.com)

For kinetic dissociation measurements without inside-out activation cell examples had been preincubated using the fluorescent probe (25 nm ～2 x (12 nm) for the relaxing condition of VLA-4 68 of receptor occupancy (22)) treated with surplus unlabeled LDV formulated with little molecule (1 μm) or substances appealing (10-30 μm) as well as the dissociation from the fluorescent molecule was implemented. (bioinf.org)
Altogether, our results identify a TSLP-periostin reciprocal activation loop that links the skin to the spinal cord via peripheral sensory neurons, and we characterize the non-canonical functional role of an integrin in itch. (fu-berlin.de)
In the present work, we investi-gated the pathway involved in integrin-mediated activation of RON. (123dok.org)
For most if not absolutely all integrins such conformational adjustments ("activation") must actuate their adhesive function. (tam-receptor.com)
The best-known positive regulators of integrin activation will be the adaptor substances talin-1 1 as well as the kindlins (kindlin-1 kindlin-2 and kindlin-3) 2. (tam-receptor.com)
These data demonstrate that integrin/EGFR cross-talk is required for expression of Egr-1 through a novel regulatory cascade involving the activation of the PI3K/Akt/Forkhead pathway. (unito.it)
Since αvβ5 requires activation to promote cell migration we considered whether EGF and integrin αvβ5 could coordinately influence the spontaneous metastasis of FG HIF-C2 cells in vivo. (biotech-angels.com)
It was also found that LGP exhibited marked inhibitory effects on the activation of αIIbβ3 integrin, the secretion of serotonin from granules, and the synthesis of thromboxane A2. (spandidos-publications.com)

yet, eggs null for the alpha6 integrin exhibit normal fertilization. (lu.se)

Various beta1 integrins and alphav integrins are present on mouse eggs. (lu.se)
Thus, function of beta3 or alphav integrins does not seem to be involved in compensating for the absence of beta1 integrins. (lu.se)
Description: The 23C6 monoclonal antibody reacts with the human CD51/CD61 dimer, also known as the integrin alphav/beta3. (thermofisher.com)

To evaluate the expression of the coxsackie and adenovirus receptor (CAR) and α v integrins in clinical specimens of bladder cancer to determine the susceptibility to adenoviral gene therapy. (elsevierpure.com)
Furthermore, we found a stage and grade-dependent increase in α v integrin expression (13.3%, 46.0%, and 56.3% of normal urothelium, superficial TCC, and invasive TCC and 25% and 52.6% of low and high-grade TCC, respectively). (elsevierpure.com)
The expression levels of alpha(6), beta(1), and beta(4) integrins were determined and compared with the amount of HPV-VLP binding in ten cell lines by flow cytometry. (nih.gov)
Both the expression level of alpha(6) integrin and the amount of HPV-VLP binding were high in cervical cancer cell lines, as the type HPV-16 is the main cause of cervical cancer. (nih.gov)
The degree of binding of HPV-VLP matched the alpha(6) integrin expression level in cell lines but was not correlated with beta(1) and beta(4) levels, which suggests that alpha(6) integrin is the main receptor of HPV type 16. (nih.gov)
Vascular remodeling and α5β1 and αVβ3 integrin expression were then examined in the brains of these mice after 4, 7, and 14 days post-ischemia. (biomedcentral.com)
Adult Dorsal Root Ganglion (DRG) neurons plated on surfaces coated with a thin film of laminin exhibited increased neurite outgrowth, this growth was correlated with increased expression of laminin binding integrin subunits. (mun.ca)
Here we describe a model system, SELective Expression and Controlled Transduction In Vivo (SELECTIV), that enables efficient and specific expression of transgenes by coupling adeno-associated virus (AAV) vectors with Cre-inducible overexpression of the multi-serotype AAV receptor, AAVR. (nature.com)
Our approach exploits the absolute dependence of AAV transduction on the expression of its receptor 22 , AAVR (also named KIAA0319L). (nature.com)
By directing AAV transduction through the regulated expression of its receptor, the approach provides precise control over which cells express the AAV-vectored transgene. (nature.com)
Here we demonstrate that Egr-1 expression is mainly regulated by integrin-mediated adhesion. (unito.it)
Integrin-dependent adhesion plays a dual role in Egr-1 regulation, either being sufficient 'per se' to induce Egr-1, or required for EGF-dependent expression of Egr-1, which occurs only in adherent cells and not in cells in suspension. (unito.it)
Hypoxia Selectively Enhances Integrin α 5 ß 1 Receptor Expression in Breast Cancer to Promote Metastasis. (bvsalud.org)
Indirect stimulation, by activating COX-2 expression in a ?2?1 integrin dependent manner was able to elicit a migratory response. (lu.se)

This sequence is commonly found in integrins and other molecules that attach to the extracellular matrix for cell adhesion. (wikipedia.org)
CD51 and CD61 molecules (alpha V and beta 3 integrins) form a complex. (thermofisher.com)

Current dogma retains the fact that ligand binding area in relaxing integrins isn't readily available to adhesive ligands. (tam-receptor.com)

True homologs of integrins exist in mammals, invertebrates, and some fungi but not in plant cells. (wikipedia.org)
Recent investigations have shown that the RON receptor is expressed in various cell types including epithelial cells (23) and that MSP-mediated effects on epithelial cells are integrin-dependent (23, 24). (123dok.org)
Coxiella burnetii, the agent of Q fever, enters human monocytes through alpha(v)beta(3) integrin and survives inside host cells. (nih.gov)
These receptors are present on phagocytic cells, mast cells, and lung epithelial and smooth muscle cells. (medscape.com)
The addition of NGF to cells plated on laminin resulted in a significant and synergistic increase in the integrin-dependent outgrowth. (mun.ca)
Staining of M21 cells with 0.5 µg of Mouse IgG1 kappa Isotype Control Biotin (Product # 13-4714-85) (open histogram) or 0.5 µg of Anti-Human CD51/CD61 (Integrin alpha/beta 3) Biotin (filled histogram) followed by Streptavidin PE (Product # 12-4317-87). (thermofisher.com)
We've lately designed and synthesized a book and selective peptide antagonist, known as RGDechiHCit, to imagine V3 receptor on tumour cells [20]. (cancerhugs.com)
The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. (frontiersin.org)

Laminin-induced neurite growth was integrin-dependent as it was attenuated by treatment with either a cyclic Arg-Gly-Asp (RGD) peptide or a β1 integrin-blocking antibody (β1i). (mun.ca)

In order for the aforementioned pathway to work normally, Integrin αIIbΒ3 and the factors in the final common coagulation cascade must function normally. (medscape.com)

Multiple substances of the type had been created for αIIbβ3 αvβ3 and α4β1 integrins. (bioinf.org)

We discovered that EBV an infection induces the appearance of integrin beta 7 (ITGB7), an integrin that affiliates with integrin alpha 4 to create the LPAM-1 dimer. (healthanddietblog.info)

Given that the integrins regulate cell metabolism, proliferation, and migration, we suggest that collagen citrullination modifies the pathogenesis of RA. (abo.fi)
Integrin-based effects on growth factor re-ceptors include enhancement of cell migration (11, 12), survival (13), and proliferation (14 -17). (123dok.org)

Recent data suggest that integrin association with RTKs might also protect the latter against the activity of phosphatases (17, 19) and/or ensure the correct subcellular juxtaposition of cytoplasmic tails of dimer-ized growth factor receptors (17). (123dok.org)

whether a distinct receptor for C4a is present is unclear (see Table 1). (medscape.com)

Anatomy39

Organisms9

Diseases8

Chemicals and Drugs125

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes51

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Antigen1

Protein10

Inhibition4

Inhibitors5

CD186

Leukocyte5

Complement4

Recombinant human3

Peptides5

Heterodimeric receptors1

Proteins12

Complexes2

Antagonists7

Tyrosine kinase receptor2

Binds4

Antibodies8

Intracellular3

Kinase7

Adhesion receptors3

Platelet5

Beta1 integrin4

Interacts2

Collagen receptors1

Tumor5

Laminin receptor1

Functions as a receptor1

Vitro4

Cytokine3

Transmembrane1

Growth factor r1

Fibronectin1

Heterodimers2

Plasma membrane2

CD11c1

20191

Endothelial6

CD294

Signaling9

Differentiation1

Activation8

Alpha61

Alphav3

Expression14

Molecules2

Ligands1

Cells8

Peptide1

Pathway1

Substances1

Induces1

Proliferation2

Cytoplasmic tails1

Distinct1