• Integrin alpha 2 is one of twelve integrin family alpha subunits that share the beta 1 subunit (1‑3). (novusbio.com)
  • The N-terminus of Nischarin interacts with a short segment of the cytoplasmic domain of the alpha5 integrin subunit. (nih.gov)
  • The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. (embl.de)
  • The alphaM subunit of integrin Mac-1 contains several distinct regions in its extracellular segment. (embl.de)
  • Here we demonstrate that Egr-1 expression is mainly regulated by integrin-mediated adhesion. (unito.it)
  • Integrin-dependent adhesion plays a dual role in Egr-1 regulation, either being sufficient 'per se' to induce Egr-1, or required for EGF-dependent expression of Egr-1, which occurs only in adherent cells and not in cells in suspension. (unito.it)
  • Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. (embl.de)
  • Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. (wikipedia.org)
  • The extracellular domain of integrin avB3 contains a receptor for thyroid hormone and hormone analogs. (tmu.edu.tw)
  • Met interaction with integrins is shown to modulate the downstream signaling to Akt and ERK (extracellular-regulated kinase). (ebi.ac.uk)
  • Thus integrins modulate the efficiency of the Erk (extracellular-signal-regulated kinase)/MAP kinase (mitogen-activated protein kinase) pathway, acting at several distinct levels. (nih.gov)
  • Integrins lack enzymatic activity and depend on adapters to signal proteins. (wikipedia.org)
  • Integrin trafficking may also guide mRNA to ribosomes associated with the protrusive regions of metastatic cells, and thus localise the synthesis of pro-migratory proteins. (gla.ac.uk)
  • A major aim of our research is to characterise the mechanisms by which integrin-associated proteins command mRNA transport and translation during the invasive migration of cancer cells. (gla.ac.uk)
  • Integrin-linked kinases (ILKs) are a subfamily of Raf-like kinases (RAF). (wikipedia.org)
  • We have shown that both cAMP-dependent protein kinase and PAKs (p21-activated kinases) play a role in integrin regulation of the Erk pathway, acting primarily at the level of Raf-1. (nih.gov)
  • To dissect the molecular basis of integrin-dependent Egr-1 regulation, we show by FLIM-based FRET that in living cells beta1-integrin associates with the EGF receptor (EGFR) and that EGF further increases the extent complex formation. (unito.it)
  • Here we report that the modeled dynamics of the response to AXT050 revealed that receptor trafficking is sufficient to explain the effect of Met-integrin interactions on HGF signaling. (ebi.ac.uk)
  • Overall, the model provides a valuable framework for studying the efficacy of drugs targeting receptor tyrosine kinase interaction with integrins, and identification of synergistic drug combinations for the patients. (ebi.ac.uk)
  • Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. (wikipedia.org)
  • Here we demonstrate that v5 integrin/FAK-mediated phagocytosis by TM cells is regulated by the GTPases Rac1 ONX-0914 IC50 and RhoG. (bioshockinfinitereleasedate.com)
  • Rab GTPases that control integrin trafficking are linked to cancer. (gla.ac.uk)
  • Thus we have discovered a novel protein that links the alpha5beta1 integrin to migration controlled by Rho-family GTPases. (nih.gov)
  • These studies emphasize the intricate connection between integrins and Rho-family GTPases and their effectors in controlling both mitogenesis and migration. (nih.gov)
  • Integrin alpha 2 beta 1 is the non-covalent heterodimer of 160 kDa alpha 2 (CD49b) and 130 kDa beta 1 (CD29) type I transmembrane glycoprotein subunits and is one of six very late antigens on activated T cells, designated VLA2 (3). (novusbio.com)
  • Our data provide new insights into how different domains in the integrin alpha and beta subunits may interact. (embl.de)
  • Integrin-linked kinase has been shown to interact with: ACP6, AKT1, ILKAP, and LIMS1, ILKs function by interacting with the many transmembrane receptors to regulate different signaling cascades. (wikipedia.org)
  • Interestingly, Egr-1 induction depends on integrin-dependent PI3K/Akt activation, as indicated by the decrease in Egr-1 levels in presence of the pharmacological inhibitor LY294002, the kinase-defective Akt mutant and Akt1/2 shRNAs. (unito.it)
  • Taxol-induced TRPV4-mediated hyperalgesia and the enhanced osmotransduction in cultured nociceptors were dependent on integrin/Src tyrosine kinase signaling. (jneurosci.org)
  • We also demonstrate that Taxol-induced TRPV4-mediated hyperalgesia is essentially dependent on integrin/Src tyrosine kinase signaling. (jneurosci.org)
  • In the current study, we investigated the signaling components involved in phagocytosis by TM cells downstream of v5 integrin/FAK signaling. (bioshockinfinitereleasedate.com)
  • These data suggest a novel link between Tiam1 and RhoG/ILK/ELMO2 pathway as upstream effectors of the Rac1-mediated phagocytic process in TM cells. (bioshockinfinitereleasedate.com)
  • 2010). Tiam1 (T-Cell Lymphoma Invasion And Metastasis 1), which is the best characterized GEF known to activate Rac1 has, to date, not been shown to play a major role in integrin-mediated phagocytosis. (bioshockinfinitereleasedate.com)
  • Finally, these research recommend there may become a differential make use of of GEFs by integrins in the TM to control phagocytosis. (bioshockinfinitereleasedate.com)
  • Understanding how integrin-mediated systems control phagocytosis in TM cells should offer understanding into book techniques and therapies to manage signaling paths regulating regular TM function. (bioshockinfinitereleasedate.com)
  • Opsonins are often antibodies or components of the complement pathway that bind to the surface of target organisms to facilitate this phagocytosis. (medscape.com)
  • These actions of Nanotetrac include disruption of transcription of cell survival pathway genes, promotion of apoptosis by multiple mechanisms, and interruption of repair of double-strand deoxyribonucleic acid breaks caused by irradiation of cells. (tmu.edu.tw)
  • The neutrophil maturation and differentiation pathway termed myelopoiesis takes approximately 12 days. (medscape.com)
  • Integrators of epidermal growth and differentiation: distinct functions for beta 1 and beta 4 integrins. (embl.de)
  • These data demonstrate that integrin/EGFR cross-talk is required for expression of Egr-1 through a novel regulatory cascade involving the activation of the PI3K/Akt/Forkhead pathway. (unito.it)
  • Activation of this pathway utilizes ELMO2, ILK, and Tiam1. (bioshockinfinitereleasedate.com)
  • Covalently bound to a 200 nm nanoparticle that limits its activity to the cell exterior, tetrac reformulated as Nanotetrac has additional effects mediated by avB3 beyond the inhibition of binding of T4 and T3 to the integrin. (tmu.edu.tw)
  • Our work aims for a full description of the molecular machinery that coordinates integrin traffic during cell migration as these may represent novel targets for anti-metastatic drugs. (gla.ac.uk)
  • Integrins clearly play a key role in regulating both mitogenic signalling and cell migration. (nih.gov)
  • Integrins and PAKs also play a role in the control of cell migration. (nih.gov)
  • Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)
  • It is a 59kDa protein originally identified in a yeast-two hybrid screen with integrin β1 as the bait protein. (wikipedia.org)
  • In this study, we developed a mechanistically detailed systems biology model of HGF/Met signaling pathway that incorporated specific interactions with integrins to investigate the efficacy of integrin-binding peptide, AXT050, as monotherapy and in combination with other therapeutics targeting this pathway. (ebi.ac.uk)
  • Combination Therapy with a Bispecific Antibody Targeting the hERG1/β1 Integrin Complex and Gemcitabine in Pancreatic Ductal Adenocarcinoma. (unifi.it)
  • The I domain-containing beta 1 integrins ( alpha 1 beta 1, alpha 2 beta 1, alpha 10 beta 1 and alpha 11 beta 1) all bind collagens, with alpha 2 beta 1 preferring collagens I‑III (4, 5). (novusbio.com)
  • Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. (embl.de)
  • ILK is linked to beta-1 and beta-3 integrin cytoplasmic domains and is one of the best described integrins. (wikipedia.org)
  • Detects human Integrin alpha 2/CD49b. (novusbio.com)
  • Integrin alpha (beta-propellor repeats). (embl.de)
  • The integrin is amply expressed by tumor cells and dividing blood vessel cells. (tmu.edu.tw)
  • We previously demonstrated that an v5 integrin/FAK- mediated pathway regulated the phagocytic properties of human being trabecular meshwork (HTM) cells. (bioshockinfinitereleasedate.com)
  • We show here that emperipolesis is a dynamic process mediated actively by both lineages, in part through the β2-integrin/ICAM-1/ezrin pathway. (elifesciences.org)