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  • type IV colla
  • This happens firstly because the DEJ, formed by basal and reticular lamina, is in direct contact with the ECM and secondly, because of the rich content in type IV collagen, proteoglycans and laminin glycoproteins that the basal lamina of the DEJ has, which provide structural support and bioadhesive properties. (happi.com)
  • proteins
  • Both papers focus on the activation of integrins, proteins that allow cells to attach to their external environment and respond to signals coming from other cells. (phys.org)
  • Integrins are transmembrane proteins: part lies on the cell surface and part lies inside the cell. (phys.org)
  • Timothy Springer of Harvard University, who co-discovered the integrin family of proteins in the 1980s and has largely defined their mechanism of activation, and Satyajit Mayor of The National Centre for Biological Sciences, Bangalore, were principal collaborators with Waterman on the project. (phys.org)
  • tumor
  • However, in prostate cancer the AR-expressing tumor cells exclusively express integrin α6β1 and adhere to a remodeled matrix containing the α6β1-specific substrate laminin 10 ( 10, 11 ). (aacrjournals.org)
  • novel
  • The selectively affected LM composition and the novel expression of alpha11 integrin chain in scarred keratoconus corneas as well as the pathologic healing in ko mice, indicate that alpha11 integrin and LM chains also play an important role in the process of corneal healing, remodeling and scarring and might participate in the pathogenesis of corneal disease. (diva-portal.org)
  • Thus, AR-mediated control of integrin α6 and the engagement of α6β1 in AR-expressing cells could provide a novel mechanism for prostate cancer cell survival. (aacrjournals.org)
  • stroma
  • At 10-17 wg alpha11 integrin chain was present in the human corneal stroma, especially in the anterior portion, but it was scarce at 20 wg, in normal adult corneas and in Fuchs' endothelial dystrophy. (diva-portal.org)
  • survival
  • This study aimed to assess the importance of the cytoskeleton in the alpha6beta1 integrin-mediated actions of laminin on survival, proliferation and steroidogenesis of ovine GC. (biomedcentral.com)
  • It could enhance proliferation and survival of GC through its alpha6beta1 integrin-mediated actions on cytoskeleton. (biomedcentral.com)
  • axonal
  • We show that in the absenceβ 1 integrins, the thickness of myelin sheets was reduced in axonal tracts in the spinal cord, optic nerves and cerebellum. (biologists.org)
  • Mutation in CRASH syndrome leads to dysfunction of the grip & slip mechanism and disrupts laminin-induced axonal haptotaxis. (medicalxpress.com)
  • family
  • The two integrins we worked on were about as structurally different as you can get in the integrin family," says Springer, yet both types, when activated, oriented in a direction dictated by intracellular actin flow. (phys.org)
  • human
  • Our objective was to investigate whether copy number variation (CNV) of a five gene signature (ITGB4, ITGA3, LAMB3, PLEC and SYNE3) comprised of essential genes for laminin adhesion would correlate with the reported clinical outcome in human epithelial tumors. (aacrjournals.org)
  • The aims were to thoroughly characterize the ECM in the developing and adult human eye, with particular focus on the cornea, LM and alpha11 integrin chains, and to examine alpha11 integrin chain in an animal model of corneal wound healing and remodeling. (diva-portal.org)
  • Here we use a human BCC model system and mouse mutants to re-evaluate the role of laminin-511 in epithelial invagination in the skin. (biomedcentral.com)
  • tissue
  • It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. (genetex.com)
  • axons
  • The study shows that L1-CAM grips and slips on laminin to steer axons to their final destination. (medicalxpress.com)
  • The new study by the Inagaki lab showed that neurons will produce four times more traction force when placed on adhesive substrates coated with laminin than those without laminin, assuring the axons reach their final destination. (medicalxpress.com)
  • results
  • These results are incorporated into an integrated model of pronephric duct guidance consistent with all present evidence, proposing roles for the previously implicated glial cell-line derived neurotrophic factor and its receptor as well as for laminin 1 and α6β1 integrin. (biologists.org)
  • role
  • Our data provides support for a primary role of laminin-511 promoting hair follicle epithelial downgrowth without affecting dermal primary cilia and Shh target gene induction. (biomedcentral.com)
  • Our data suggest that β1 integrins play an instructive role in CNS myelination by promoting myelin wrapping in a process that depends on AKT. (biologists.org)