The alpha 5 subunit, also known as CD49e and VLA-5 alpha subunit, forms a heterodimer with the Integrin beta 1 subunit (CD29). (rndsystems.com)
Short interfering RNA-mediated knockdown of the αV integrin subunit also delays SC extension along axons in vitro, suggesting that αV -containing integrins participate in axo-glial interactions. (bvsalud.org)
However, mice lacking the αV subunit in SCs, alone or in combination with the potentially compensating α5 subunit, or the αV partners ß3 or ß8 , myelinate normally during development and remyelinate normally after nerve crush, indicating that overlapping or compensatory mechanisms may hide the in vivo role of RGD-binding integrins. (bvsalud.org)
Fibronectin3
The 5H10-27 (MFR5) monoclonal antibody specifically binds to the α5 chain of the integrin α5β1 fibronectin receptor (CD49e/CD29, VLA-5) on thymocytes, activated T lymphocytes, precursor and activated B cells, mast cells, platelets, epithelial and endothelial cells, fibroblasts and a variety of mouse cell lines. (bdbiosciences.com)
Schultz JF, Armant DR. Beta 1- and beta 3-class integrins mediate fibronectin binding activity at the surface of developing mouse peri-implantation blastocysts. (bdbiosciences.com)
Integrin alpha 5 beta 1 is a receptor for fibronectin and neural adhesion molecule L1. (rndsystems.com)
CD49e4
CD49e+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) ITGA5 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine Overview of all the structural information available in the PDB for UniProt: P08648 (Human Integrin alpha-5) at the PDBe-KB. (wikipedia.org)
Detects human Integrin alpha 5/CD49e in Western blots. (rndsystems.com)
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Receptor1
Enhancement of VLA integrin receptor function on thymocytes by cAMP is dependent on the maturation stage of the thymocytes. (bdbiosciences.com)
Gene3
Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene. (wikipedia.org)
The product of this gene belongs to the integrin alpha chain family. (wikipedia.org)
This gene encodes the integrin alpha 5 chain. (wikipedia.org)
Receptors1
Gomez M, Cano A. Expression of beta 1 integrin receptors in transformed mouse epidermal keratinocytes: upregulation of alpha 5 beta 1 in spindle carcinoma cells. (bdbiosciences.com)
Reactivity1
In Western blots, approximately 50% cross-reactivity with recombinant mouse (rm) Integrin alpha 5 is observed and less than 2% cross-reactivity with recombinant human Integrin alpha M, rmIntegrin alpha 2, rmIntegrin alpha 4, and rmIntegrin alpha E is observed. (rndsystems.com)
PDZ interaction sites in integrin alpha subunits. (wikipedia.org)
Role of alpha 5 beta 1 integrin in TGF-beta 1-costimulated CD8+ T cell growth and apoptosis. (bdbiosciences.com)
Sites1
αV integrins in SC localize to sites of contact with axons and are expressed early in development during radial sorting and myelination. (bvsalud.org)
ITGB11
Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. (nih.gov)
Adhesion4
In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. (wikipedia.org)
1. [Integrin α5 promotes the proliferation, invasion and adhesion of gastric cancer by regulating the FAK/Src/Rac1 signaling pathway]. (nih.gov)
8. Steroid receptor coactivator-1 upregulates integrin α₅ expression to promote breast cancer cell adhesion and migration. (nih.gov)
Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. (nih.gov)
Tumor6
2. Upregulation of microRNA-31 targeting integrin α5 suppresses tumor cell invasion and metastasis by indirectly regulating PI3K/AKT pathway in human gastric cancer SGC7901 cells. (nih.gov)
4. ITGA5 Promotes Tumor Progression through the Activation of the FAK/AKT Signaling Pathway in Human Gastric Cancer. (nih.gov)
ITGA5 silencing also reduced tumor cell colonization of the bone marrow and formation of osteolytic lesions in vivo. (whiterose.ac.uk)
Pharmacological inhibition of ITGA5 with humanized monoclonal antibody M200 (volociximab) recapitulated inhibitory effects of ITGA5 silencing on tumor cell functions in vitro and tumor cell colonization of the bone marrow in vivo. (whiterose.ac.uk)
ITGA5 was not only expressed by tumor cells but also osteoclasts. (whiterose.ac.uk)
This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. (nih.gov)
Subunits3
PDZ interaction sites in integrin alpha subunits. (wikipedia.org)
Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. (nih.gov)
Highly expressed2
Integrin alpha-4 is highly expressed in the glomerular mesangial cells of the kidney. (bicellscientific.com)
Here, we found that integrin alpha5 (ITGA5) was highly expressed in bone metastases, compared to lung, liver, or brain metastases. (whiterose.ac.uk)
Inhibits1
3. FGA inhibits metastases and induces autophagic cell death in gastric cancer via inhibiting ITGA5 to regulate the FAK/ERK pathway. (nih.gov)
Antibody1
Anti-Integrin alpha-4 (ITGA4) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. (bicellscientific.com)
14. Integrin α5/ITGA5 Promotes The Proliferation, Migration, Invasion And Progression Of Oral Squamous Carcinoma By Epithelial-Mesenchymal Transition. (nih.gov)
19. Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation. (nih.gov)
Clinical1
ITGA5 was also predictive of poor bone metastasis-free survival in two separate clinical data sets (n = 855, HR = 1.36, p = 0.018 and n = 427, HR = 1.62, p = 0.024). (whiterose.ac.uk)
Metastasis4
5. AKR1B10 promotes breast cancer metastasis through integrin α5/δ-catenin mediated FAK/Src/Rac1 signaling pathway. (nih.gov)
15. Integrin α5 down-regulation by miR-205 suppresses triple negative breast cancer stemness and metastasis by inhibiting the Src/Vav2/Rac1 pathway. (nih.gov)
Conversely, ITGA5 overexpression promoted bone metastasis. (whiterose.ac.uk)
Overall, this study identifies ITGA5 as a mediator of breast-to-bone metastasis and raises the possibility that volociximab/M200 could be repurposed for the treatment of ITGA5-positive breast cancer patients with bone metastases. (whiterose.ac.uk)
Expression1
Furthermore, genes near the chromosome-12q13 breakpoint exhibited increased expression of GG-62 including ERBB3, NR4A1 (nuclear receptor subfamily 4, group A, member 1), cyclin-dependent kinase 2 (CDK2), and alpha 5 integrin (ITGA5). (elsevierpure.com)
Invasion2
17. Alcohol promotes breast cancer cell invasion by regulating the Nm23-ITGA5 pathway. (nih.gov)
18. TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways. (nih.gov)
Facilitate1
11. AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway. (nih.gov)
Breast cancer1
7. SNHG3 silencing suppresses the malignant development of triple-negative breast cancer cells by regulating miRNA-326/integrin α5 axis and inactivating Vav2/Rac1 signaling pathway. (nih.gov)