Integrin expression adhesion laminin. Medical search. Frequent questions

Indeed, granule cells from the rostral region of perinatal Gpr56 −/− cerebella show loss of adhesion to extracellular matrix molecules of the pial basement membrane. (jneurosci.org)
Consistent with this hypothesis, developing granule cells from the rostral region of Gpr56 −/− cerebella at birth exhibit a specific defect in cell adhesion to extracellular matrix (ECM) molecules of the pial basement membrane (BM) but no defects in migration, proliferation, or process outgrowth. (jneurosci.org)
Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. (embl.de)
The alphaM subunit of integrin Mac-1 contains several distinct regions in its extracellular segment. (embl.de)
KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
We here show that shifting the GFAP isoform ratio in favor of GFAPδ in astrocytoma cells, by selectively silencing the canonical isoform GFAPα with short hairpin RNAs, induced a change in integrins, a decrease in plectin, and an increase in expression of the extracellular matrix component laminin. (herseninstituut.nl)
In summary, isoform-specific silencing of GFAP revealed distinct roles of a specialized GFAP network in regulating the interaction of astrocytoma cells with the extracellular matrix through laminin. (herseninstituut.nl)
We observed alteration in biological functions related to extracellular matrix function and organization, cellular adhesion, muscle growth, lipid metabolism and proteolysis. (biomedcentral.com)
Using mass spectrometry, quantitative proteomic analysis and Gene Ontology terms filters, we observed that EVs released by EGFRvIII-transformed cells were enriched for extracellular exosome and focal adhesion related proteins. (cancer-genetics.org)
In the current study, we investigated the role of different extracellular matrix proteins in stellate cell proliferation, activation (alpha smooth muscle actin expression and retinoic acid uptake) and cytoglobin expression. (biomedcentral.com)
Our results demonstrate that cytoglobin expression is correlated with a more quiescent phenotype of stellate cells in culture and that cytoglobin is regulated by the extracellular matrix through integrin signalling dependent on activation of focal adhesion kinase. (biomedcentral.com)
HSCs express numerous cell surface receptors including both discoidin domain receptors (DDRs)-which are receptors for collagen I and many of the integrin subunits, which are a major family of cell surface receptors for extracellular molecules and play a critical role in many biological functions [ 7 , 10 ]. (biomedcentral.com)
Integrin mRNA expression is elevated in TGF B taken care of cells To get a metastases linked mRNA signature distinct to TGF B handled H157 NSCLC cells, we utilized the SABiosciences RT2 Profiler PCR Array that measures the expression of 94 genes relevant to adhesion molecules, proteases and extracellular matrix elements. (interleukin-receptor.com)
Moreover, significant adjustments in the expression of genes encoding extracellular matrix proteins had been observed, including collagens kind I, VII and XIV, fibronectin and laminin. (interleukin-receptor.com)
Analysis by RNA sequencing revealed altered expression of genes associated with extracellular matrix remodeling, endo-lysosomal processing, and mitochondrial energy metabolism under pathophysiological flow conditions. (biomedcentral.com)
MECs synthesize key extracellular matrix (ECM) proteins of the meninges such as various collagens, as well as fibronectin, laminin and tenascin, important for pia basal lamina integrity and thus for neuronal support and function [ 7 ]. (biomedcentral.com)
T here are adhesion molecules involved in the attachment of cells to the extracellular matrix and others in linking one cell to another. (uvigo.es)
I ntegrins are probably the most important proteins involved in the adhesion of cells to the extracellular matrix, and comprise a large family of transmembrane proteins present in all animals. (uvigo.es)
An intracellular domain that interacts with actin filaments of the cytoskeleton (sometimes with intermediate filaments), an extracellular domain that binds collagen, fibronectins and laminins, and an intramembrane domain containing hydrophobic amino acid sequences inserted among the lipid fatty acid chains. (uvigo.es)
The ability of integrins to mechanically connect extracellular matrix and cytoskeleton allows the structural continuity between the internal and external environments of the cell. (uvigo.es)
Furthermore, integrins may change the behavior of the cell according to the molecular composition of the extracellular matrix (they behave like receptors). (uvigo.es)
Cells, in turn, may regulate the strength of adhesion by increasing or decreasing the number of integrins, by synthesizing different integrin subunit subtypes, or by changing the adhesion affinity after modulation of the intracellular domain, which in turn will modify the adhesion ability of the extracellular domain. (uvigo.es)
The strength of the adhesion of a cell to the extracellular matrix depends on the number, the active state and type of integrins that are expressed in the plasma membrane. (uvigo.es)
These cell adhesion molecules (CAM) will mediate the contact between two cells or between cells and the extracellular matrix, an essential process to the success of the implant. (bvsalud.org)
The main reported mechanisms involve cell adhesion molecules (CAMs) and extracellular matrix components. (bvsalud.org)
Some of these molecules are glycoproteins expressed on the cell surface, socalled cell adhesion molecules (CAM), which mediate either the contact between two cells or the contact among cells and the extracellular matrix, being therefore of fundamental importance for adhesion 3 . (bvsalud.org)
To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)

This gene encodes the integrin beta 4 subunit, a receptor for the laminins. (wikipedia.org)
The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. (wikipedia.org)
Molecular cloning of the human alpha 6 integrin subunit. (wikipedia.org)
The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. (embl.de)
Integrin alpha 2 is one of twelve integrin family alpha subunits that share the beta 1 subunit (1‑3). (novusbio.com)
Cloned integrin α 2 subunit complementary DNA was expressed on human rhabdomyosarcoma (RD) cells to give a functional VLA-2 (α 2 β 1 ) adhesion receptor. (tmu.edu.tw)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)

Previous studies have implicated β1 integrins in cancer since they regulate cell adhesion and migration/invasion on tumor stroma proteins such as fibronectin laminin and collagen (33). (biotech-angels.com)
During liver fibrosis, the composition of the ECM changes from one dominated by collagen IV and laminin [ 4 ], to one of fibrillar collagen, predominantly collagen I and III, as well as fibronectin [ 5 ]. (biomedcentral.com)
Cell motility measurements by computer-assisted time-lapse videomicroscopy of the alpha 7-transfected cells revealed an 8-10-fold increase in motility on laminin-1 and its E8 fragment, but not on fibronectin. (uea.ac.uk)

These studies establish a novel role for GPR56 in the adhesion of developing neurons to basal lamina molecules and suggest that this adhesion is critical for maintenance of the pia and proper cerebellar morphogenesis. (jneurosci.org)
Moreover, integrins, laminins, NF-κB and other regulative molecules were found as crucial proteins. (nature.com)
Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin fundamental protein in growing sciatic nerve. (palazzopantininicchiarelli.it)
Moreover, it significantly increased MHC-II and co-stimulatory molecules expression on infected dendritic cells, suggesting an enhanced immune response. (bvsalud.org)
These factors include neurotrophins, such as Nerve Growth Factor (NGF), and adhesion molecules, such as laminin. (mun.ca)
One adhesion molecule does not make a strong bond, but cell adhesion is performed by many adhesion molecules that altogether make a strong linking, as if they were a molecular Velcro. (uvigo.es)
Some adhesion molecules may interact laterally between each other and form molecular complexes that increase the adhesion strength in some local points of the cell surface. (uvigo.es)
For example, cells can change the type and amount of adhesion molecules in the plasma membrane by synthesis, degradation, or hidden them temporarily in internal compartments by endocytosis and exocytosis. (uvigo.es)
Another mechanism to control the strength and specificity of adhesion is by activating or inactivating the adhesion molecules in the plasma membrane. (uvigo.es)
In general, the adhesion strength of integrins is weaker than that of other adhesion molecules. (uvigo.es)
In order to be effective and integrated to the receiving area, the bone graft is required to allow a strong cell adhesion, interacting with several molecules to induce migration, differentiation, and thus the mineralization of the new bone on the graft. (bvsalud.org)
This paper is a systematic review of the literature on the mechanisms of cell adhesion to bone grafts associated to nanotechnology, describing the importance and the role of those molecules in the adhesion and thus in tissue regeneration. (bvsalud.org)
Several molecules are involved in the process of cell adhesion to bone grafts, highlighting the role of integrins, the focal adhesion mechanism, the influence of the collagen matrix, and the activity of alkaline phosphatase in bone matrix formation. (bvsalud.org)
Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)

We suggest the potential roles certain integrins, the urokinase plasminogen activator (uPA), its receptor (uPAR), and plasmin may play in the pathogenesis of Alport kidney disease. (hindawi.com)
These results show that a specific adhesion receptor (VLA-2) can markedly enhance both experimental and spontaneous metastasis. (tmu.edu.tw)
These findings demonstrate crosstalk between a tyrosine kinase receptor and an integrin involved in carcinoma cell invasion and metastasis and may explain in part how inhibitors of EGFR impact malignant disease. (biotech-angels.com)
A specific inhibitor of PKCd, rottlerin, completely abrogated Go¨6976-dependent increase in PC12 cell adhesion to laminin as well as the activation of small GTPases, Rac1 and Cdc42, that are downstream of PKCd in adhesion receptor signaling. (mirnamimic.com)
In PC12 cells, we recently showed that the engagement of integrin a3b1 to a binding sequence within the human laminin a2 chain was sufficient to recruit PKCa and PKCd to the integrin receptor [6]. (mirnamimic.com)

In experiments probing for a role of PKCa in human laminin-2-integrin-mediated cell adhesion and spreading of PC12 cells, we observed unexpected enhancements of adhesion, spreading and stress fiber formation to 1 mM Go¨6976 with concomitant increase in membrane translocation of PKCd and autophosphorylation of focal adhesion kinase (FAK). (mirnamimic.com)
Pharmacologic blockade of PKC inhibits cell adhesion and spreading as well as focal adhesion formation and focal adhesion kinase (FAK) phosphorylation [13,14]. (mirnamimic.com)
Publicity to TGF B induced the phosphorylation of the focal adhesion kinase in H157 cells, a kinase that mediates integrin activation in response to TGF B remedy. (interleukin-receptor.com)

Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. (wikipedia.org)
These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
B3 integrin is required to mediate the TGF B driven increases in cell transmigration across LECs Based to the considerable induction of integrin expression observed in our experimental ailments, we investigated the part of integrins in NSCLC adhesion to LECs. (interleukin-receptor.com)
H-JEB is caused by loss-of-function mutations in LAMA3 , LAMB3 , or LAMC2 , leading to complete loss of laminin 332, the major component of anchoring filaments, which mediate epidermal-dermal adherence. (holostem.com)

The VLA-2-positive RDA2 cells not only showed increased adhesion to collagen and laminin in vitro, but also formed substantially more metastatic tumor colonies in nude mice after either intravenous or subcutaneous injection. (tmu.edu.tw)

Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells. (uchicago.edu)
Taken together, these results show that intestinal epithelial cells express a number of laminin binding integrins and that each is associated with a distinct cell function. (usherbrooke.ca)
These results demonstrate the loss of AND-34 dysregulates focal adhesion complex signaling in lens epithelial cells and suggest that AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens. (molvis.org)

Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. (wikipedia.org)
Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. (biotech-angels.com)
Biological activities of laminin are mediated through binding to a subset of integrin family of cell adhesion receptors, a3b1, a6b1, a6b4, and a7b1 [2]. (mirnamimic.com)
This could be considered to be part of a feedback loop as changes in ECM composition results in changes in HSC cell surface receptors, particularly integrins indicating that the ECM should not be regarded simply as an inert physical scaffold but a dynamic structure that is able to influence the phenotype of HSCs [ 2 , 8 , 9 ]. (biomedcentral.com)
One of the major laminin receptors of myoblasts is the alpha 7 beta 1 integrin, which was first described in human MeWo melanoma cells and Rugli glioblastoma cells. (uea.ac.uk)

This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. (cancer-genetics.org)
Cell adhesion relies on transmembrane proteins, known as adhesion proteins , found in the plasma membrane. (uvigo.es)
In fact, adhesion proteins are very similar when comparing the different animal groups, including marine sponges. (uvigo.es)
Previously we have shown that the locomotion of murine skeletal myoblasts is specifically and significantly enhanced on laminin but not on other matrix proteins. (uea.ac.uk)
These properties will act mediating the action of cell adhesion proteins, regulating cell behavior and causing tissue regeneration. (bvsalud.org)

Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. (wikipedia.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Beta 4 (ITGb4) in tissue homogenates, cell lysates and other biological fluids. (hudsen.org)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Integrin Beta 4 (ITGb4) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (hudsen.org)
Description: Quantitativesandwich ELISA kit for measuring Rat Integrin beta-4 (ITGB4) in samples from serum, plasma, tissue homogenates, cell lysates. (hudsen.org)

Importantly knockdown of β5 did not influence β1 integrin expression (Supplemental Fig. S1C) or primary tumor growth (Fig. 1C) indicating that EGF and αvβ5 coordinately and specifically regulate the spontaneous metastasis of FG cells in this model. (biotech-angels.com)
It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. (cancer-genetics.org)
Cells can also regulate the intensity of adhesion and to what molecule they adhere to by way of different mechanisms. (uvigo.es)

Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor dependence. (molvis.org)
These findings prove that alpha 7 integrin expression confers a gain of function-motile phenotype to immobile cells and may be responsible for transduction of the laminin-induced cell motility. (uea.ac.uk)

Synthetic peptides or recombinant fragments containing bio- logically active motifs have been shown to partially mimic the effects of native laminin in various cellular functions, such as cell adhesion, spreading, migration, neurite outgrowth, and tumor metastasis [6-10], suggesting that laminin-derived-short peptide- modified biomaterials may have therapeutic potential in tissue regeneration applications. (mirnamimic.com)
Adult Dorsal Root Ganglion (DRG) neurons plated on surfaces coated with a thin film of laminin exhibited increased neurite outgrowth, this growth was correlated with increased expression of laminin binding integrin subunits. (mun.ca)

α2β1γ1) stimulates oligodendrocytes to extend elaborate membrane sheets in vitro (cell spreading), mediated by integrin α6β1. (rupress.org)
Importantly, the gentamicin-induced laminin β3 led to the restoration of laminin 332 assembly, secretion, and deposition within the dermal/epidermal junction, as well as proper polarization of α6β4 integrin in basal keratinocytes, as assessed by immunoblot analysis, immunofluorescent microscopy, and an in vitro 3D skin equivalent model. (holostem.com)

in vivo yet does not influence primary tumor growth or activation of other integrins on these cells. (biotech-angels.com)
While EGF stimulation had no effect on primary tumor growth it increased pulmonary metastasis 3-fold HIF-C2 which was abolished by shRNA-mediated knockdown of integrin β5 (Fig. 1C). (biotech-angels.com)
Curiously, PF 573228 did not reduce tumor adhesion to LEC monolayers in control cells. (interleukin-receptor.com)

In this study, we evaluated the ability of gentamicin to induce PTC readthrough in H-JEB laminin β3-null keratinocytes transfected with expression vectors encoding eight different LAMB3 nonsense mutations. (holostem.com)

Knockdown of Rap1b expression in FG cells selectively blocked EGF-induced migration on vitronectin (Fig. 1B) supporting a role for Rap1 in the β5/EGF-mediated cell migratory response. (biotech-angels.com)
Since αvβ5 requires activation to promote cell migration we considered whether EGF and integrin αvβ5 could coordinately influence the spontaneous metastasis of FG HIF-C2 cells in vivo. (biotech-angels.com)
PKC activation by phorbol myristate acetate has been shown to induce the adhesion, spreading, and migration of cells [12]. (mirnamimic.com)
These studies have served to highlight the role of AND-34/BCAR3 and p130Cas in cell adhesion and migration signaling pathways. (molvis.org)
To find out whether or not TGF B enhances NSCLC cell migration via lymphatic vessels, we studied H157 cell adhesion and transmigration across monolayers of principal human LECs. (interleukin-receptor.com)
In order to investigate and directly test the role of the alpha 7 integrin in cell migration on laminin, we expressed the murine alpha 7B splice variant in human 293 kidney cells and 530 melanoma cells which cannot migrate on laminin and are devoid of endogenous alpha 7. (uea.ac.uk)

CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)

In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)

not only can gene expression be manipulated and lineages traced at single-cell and whole-tissue levels, but complete population counts of all cell types are possible. (stanford.edu)
By uncovering four different hair placode cell populations organized in three spatially distinct areas, with fine gene expression gradients between them, we posit early biases in cell fate establishment. (bvsalud.org)
The GFAP gene is alternatively spliced, and expression of GFAP is highly regulated during development, on brain damage, and in neurodegenerative diseases. (herseninstituut.nl)
Piglets (14 from each genetic type) were slaughtered at weaning (28 days) and longissimus dorsi was sampled for composition and gene expression studies. (biomedcentral.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancer-genetics.org)
As neurons in the adult rat DRG can be classified into at least three separate subpopulations based on morphologic and phenotypic differences, a cell selection approach was utilized to show that laminin-induced neurite growth occurs in the absence of added trophic factors only in heavy chain neurofilament positive and calcitonin gene related peptide positive DRG neurons (NGF-responsive population). (mun.ca)
There are numerous downstream signalling targets of FAK with many of the effects ultimately mediated by changes in gene expression [ 11 - 13 ]. (biomedcentral.com)
This is possible because the adhesion state of integrins is transmitted to their intracellular domain by conformational change, triggering molecular interaction cascades in the cytosol, that eventually change gene expression. (uvigo.es)

The expression of biomarkers can be detected intracellularly or on the cell membrane of melanoma cells or noncancer cells in association with the melanoma. (hindawi.com)

At the age of defect onset, GPR56 expression is restricted specifically to developing granule cells in the rostral cerebellum, suggesting that GPR56 regulates properties of these cells. (jneurosci.org)
cancer cell growth and spreading, it has also been proposed that GPR56 regulates cell adhesion, but this has remained untested in the nervous system. (jneurosci.org)

Interaction with ECM is a major driver of HSC morphology [ 11 ], and signal transduction from integrin activation occurs at least partly through aggregation and subsequent activation of focal adhesion kinases (FAKs) by autophosphorylation of tyrosine 397 (Y397). (biomedcentral.com)

By combination, they are able to form up to 24 different integrins, which are differentially expressed depending on the tissue and the physiological state of the cell. (uvigo.es)

This pattern of expression was reproduced in Caco-2/15 cells where [alpha]7B protein levels peaked between confluence and five days post-confluence coinciding almost perfectly with laminin-1 deposition, which was shown to be critical for triggering terminal differentiation in these cells. (usherbrooke.ca)

Interference RNA-mediated knockdown of GPR56 recapitulates the loss of adhesion seen in knock-outs, and reexpression of GPR56 rescues the adhesion defect in knock-out granule cells. (jneurosci.org)
Importantly, enhanced cellular behavior and membrane translocation of PKCd induced by Go¨6976 was retained in siRNA-transfected PC12 cells to knockdown PKCa expression. (mirnamimic.com)
siRNA knockdown of Rac1 and Cdc42 expression inhibited cell spreading and lamellipodia formation in PC12 cells. (mirnamimic.com)

These results support a novel hypothesis that the cerebellar defects in Gpr56 knock-outs, and potentially in human patients with GPR56 mutations, arise from the disrupted adhesion of developing granule cells to the pial BM. (jneurosci.org)
Scope includes mutations and abnormal protein expression. (cancer-genetics.org)
LAMB3 (laminin β3) mutations account for 80% of patients with H-JEB, and ∼95% of H-JEB-associated LAMB3 mutations are nonsense mutations leading to premature termination codons (PTCs). (holostem.com)

Integrin alpha 2 beta 1 is the non-covalent heterodimer of 160 kDa alpha 2 (CD49b) and 130 kDa beta 1 (CD29) type I transmembrane glycoprotein subunits and is one of six very late antigens on activated T cells, designated VLA2 (3). (novusbio.com)

Integrators of epidermal growth and differentiation: distinct functions for beta 1 and beta 4 integrins. (embl.de)
It was however, associated with highly proliferative cells, such as those found in the developing crypts in fetal intestine, as well as in HIEC and Caco-215 cells where, in the latter, [alpha]9[bêta]1 expression was down-regulated as the cells stopped proliferating and undertook their differentiation. (usherbrooke.ca)

First, we hypothesized that plerixafor treatment might induce negative feedback mechanisms like alterations in the CXCR4 surface expression on HSCs. (academic-accelerator.com)

It is a defect in the expression of ligands for selectins due to lack of enzymes required for expression of selectin ligands. (medscape.com)
CAMs have been classified into: cadherins, the immunoglobulin superfamily, integrins and selectins. (bvsalud.org)

Integrin, molecular conformation (Modified from Luo et al. (uvigo.es)

Description: A sandwich ELISA kit for detection of Integrin Beta 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (hudsen.org)
Accurate identification of these mechanisms of cell adhesion is essential for further advancement in tissue engineering, such as the production of biological bone substitutes that achieve a better clinical outcome. (bvsalud.org)

Integrin alpha (beta-propellor repeats). (embl.de)
Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. (embl.de)
Our data provide new insights into how different domains in the integrin alpha and beta subunits may interact. (embl.de)
Detects human Integrin alpha 2/CD49b. (novusbio.com)
The I domain-containing beta 1 integrins ( alpha 1 beta 1, alpha 2 beta 1, alpha 10 beta 1 and alpha 11 beta 1) all bind collagens, with alpha 2 beta 1 preferring collagens I‑III (4, 5). (novusbio.com)
In mammals, integrins family consists of 18 alpha units and 3 beta units. (uvigo.es)
Mock-transfected cells did not migrate significantly of alpha 7-transfected 293 cells through laminin-coated filters in a Boyden chamber assay was significantly enhanced in comparison to mock transfected cells. (uea.ac.uk)

Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
Laminin-induced neurite growth was integrin-dependent as it was attenuated by treatment with either a cyclic Arg-Gly-Asp (RGD) peptide or a β1 integrin-blocking antibody (β1i). (mun.ca)

We observed that EGFRvIII expression alters the expression of EV-regulating genes (vesiculome) and EV properties, including their protein composition. (cancer-genetics.org)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. (molvis.org)

Laminins are multifunctional basement membrane glycoproteins composed of a, b, and g polypeptide chains. (mirnamimic.com)

PKC family of serine-threonine kinases plays key roles in many of the signaling pathways that control cellular function, including those mediated through integrin signaling. (mirnamimic.com)
These experiments allowed us to associate each individual integrin to a particular cellular function. (usherbrooke.ca)
Finally, newly restored laminin 332 corrected the abnormal cellular phenotype of H-JEB cells by reversing abnormal cell morphology, poor growth potential, poor cell-substratum adhesion, and hypermotility. (holostem.com)

This integrin was also found to be reexpressed in an onco-fetal like pattern of expression in a subset of colon cancers. (usherbrooke.ca)

Correlation among the expression of these RF and DE genes show relevant differences between genetic types. (biomedcentral.com)
We also observed enhanced expression of MMPs, ADAMTS, TIMP and CTGF, amongst other genes. (interleukin-receptor.com)
Accordingly, the differential expression of 18 chosen genes was confirmed by Serious MEK162 MEK inhibitor Time PCR, including the many integrins detected. (interleukin-receptor.com)

The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)

In preliminary experiments examining the role of PKCa in cell adhesion and spreading, we found that Go¨6976, a widely used, nonglycosidic indolocarbazole inhibitor of PKCa/b, had effects that could not be explained by inhibition of PKCa/b alone. (mirnamimic.com)
In performing these experiments it was observed that not all DRG neurons were responding to laminin and NGF with increased neurite growth. (mun.ca)
To verify the participation on the integrin signaling pathway in cell adhesion to LEC monolayers, we performed adhesion experiments with H157 cells pretreated with PF 573228, a chemical inhibitor of FAK. (interleukin-receptor.com)

Adhesion to anti-β1 led to Rac1 and Rap1 activity impartial of EGF stimulation whereas cells attached to anti-αvβ5 showed strong EGF-dependent activation of Rac1 or Rap1 (Fig. 1A). (biotech-angels.com)
Prior data link AND-34 expression to the activation of Akt signaling. (molvis.org)
CYTOKINES, and expression of cell activation markers and is a critical regulator of SEPTIC SHOCK. (bvsalud.org)

Go¨6976 also induced laminin-dependent cell adhesion in NIH/3T3 and CV-1 fibroblasts, suggesting of a mechanism that may be common to multiple cell-types. (mirnamimic.com)

In contrast, laminin alone is not sufficient to stimulate significant neurite growth from lectin Griffonia simplicifolia 1B4 positive neurons (IB4+ve), although it is still required to elicit a growth response from these cells in the presence of Glial Cell Line Derived Neurotrophic Factor (GDNF) (e.g., neurite growth occurred only when cells were plated on laminin in the presence of GDNF). (mun.ca)
Further analysis indicated that Src was potentially a key point of collaboration between NGF and laminin induced neurite growth in NGF-responsive adult DRG neurons. (mun.ca)

100-fold difference in the adhesion of astrocytoma cells to laminin. (herseninstituut.nl)
All mast cells in the muscularis propria were colocalised with patches of laminin. (bmj.com)
The addition of NGF to cells plated on laminin resulted in a significant and synergistic increase in the integrin-dependent outgrowth. (mun.ca)
Indeed, though only 30% of untreated cells moved about the endothelial surface, from the presence of TGF B the amount of motile cells multiply 3 fold and moved by emitting filopodia, indicative of integrin mediated displacement. (interleukin-receptor.com)
Adhesion is not just for anchoring and placing cells to form tridimensional structures, but also for communication between each other. (uvigo.es)
In other words, the type of adhesion and to what a cell is adhered to is a very useful information for the cells. (uvigo.es)
In this case, cells travel together by cell-cell adhesion. (uvigo.es)

The expression and distribution of each of these integrins was characterized in the developing and mature, human small and large intestine. (usherbrooke.ca)

Another reported type of leukocyte adhesion deficiency involves dysfunction in platelet aggregation in addition to a defect in leukocyte adhesion. (medscape.com)

Anatomy39

Organisms9

Diseases10

Chemicals and Drugs121

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes49

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Technology, Industry, Agriculture1

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Extracellular27

Subunit7

Fibronectin3

Molecules14

Receptor5

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Receptors5

Proteins5

ITGB44

Regulate3

Motility2

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Vitro2

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Antigen1

Basal lamina1

Gene8

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Regulates2

Signal Transduction1

Differentially expressed1

Deposition1

Knockdown3

Mutations3

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Molecular1

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