The CD49b protein is an integrin alpha subunit. (wikidoc.org)
Different epithelial membrane zone components have been recognized by antibodies in patients with mucous membrane pemphigoid, including BP antigens 1 and 2 (BP230 and BP180), laminin-332, laminin-311, type VII collagen, b4 integrin subunit, and antigens with unknown identities (a 45-kd protein, uncein, a 168-kd epithelial protein, and a 120-kd epithelial protein). (medscape.com)
Laminin-332 contains disulfide-linked alpha, beta, and gamma chains, of which the alpha subunit is the major site of mucous membrane pemphigoid reactivity. (medscape.com)
Synthetic peptides from the carboxy-terminal globular domain of the A chain of laminin: their ability to promote cell adhesion and neurite outgrowth, and interact with heparin and the beta 1 integrin subunit. (rupress.org)
Antibodies against the beta 1 integrin subunit inhibited HT-1080 cell adhesion and neurite outgrowth on surfaces adsorbed with peptides GD-3 and GD-4. (rupress.org)
Furthermore, these results suggest that the sequences comprising peptides GD-3 and GD-4 use an integrin as a receptor, of which the beta 1 integrin subunit is a component for these various cell types. (rupress.org)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
Receptors3
Our results suggest that beta1 integrin is a common receptor for AfaD invasins and that additional AfaD-type-specific receptors exist. (pasteur.fr)
CD51, an ~120 kDa surface molecule can also non-covalently associate with other beta subunits of the integrin family including beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. (thermofisher.com)
Delayed recovery from COVID19 was associated with changes in metabolic and signalling proteins, complement, chemokine and leukotriene receptors, integrins and inhibitory receptors. (cdc.gov)
Antigen3
VLA-4 (Integrin α4β1 or very late antigen-4) is normally expressed on leukocyte membranes, and it directs the leukocytes to damaged sites in the vascular system. (igem.org)
Studies have shown that the ITGA-4 chain of VLA-4 antigen can sufficient bind to VCAM-1. (igem.org)
Sampaio AL, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF, Perretti M: Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis. (exbio.cz)
Proteins5
The product of this gene belongs to the integrin alpha chain family of proteins. (wikipedia.org)
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. (wikipedia.org)
Despite their differences, the recombinant rAfaD-III and rAfaD-VIII proteins both bound to beta1 integrins. (pasteur.fr)
Moreover, integrins, laminins, NF-κB and other regulative molecules were found as crucial proteins. (nature.com)
Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. (nih.gov)
CD185
Description: The N418 monoclonal antibody reacts with mouse CD11c, the integrin alpha X. CD11c non-covalently associates with beta 2 integrin to form the CD11c/CD18 heterodimer. (thermofisher.com)
Leukocyte adhesion deficiency type I is caused by a mutation in the common chain of the β2 integrin family CD18. (lu.se)
There are three β2 integrins with different α chains but a common β chain, called CD18. (lu.se)
Defects in CD18 determine the loss of β2 integrin and the clinical symptoms. (lu.se)
The CD11/CD18 complex is part of the beta-2 integrin family and is important in adhesion and phagocytosis (see Table 1). (medscape.com)
Protein10
The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. (nature.com)
Integrin alpha-2 or CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene . (wikidoc.org)
HA is synthesized in the absence of a protein core at the inner face of the plasma membrane and consequently found in the form of free chains whereas other GAG types are covalently bound into protein cores to form proteoglycans (PGs). (hindawi.com)
PGs, molecules which consist of a protein core that is covalently modified with GAG chains, are distributed both to the ECM "proper" associated with the cell membrane as well as located to intracellular compartment. (hindawi.com)
also Del-1 and integrin-binding DEL1) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. (rndsystems.com)
Glycosylation is classified by the way the carbohydrate chain is linked to the protein. (iucr.org)
From NCBI Gene: The ITGB3 protein product is the integrin beta chain beta 3. (nih.gov)
RON is a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity. (spandidos-publications.com)
Maturation occurs in the cell membrane resulting in a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity ( 5 , 6 ). (spandidos-publications.com)
The rat monoclonal antibody 5H10-27 (MFR5) recognizes an extracellular epitope of murine CD49e, a 135 kDa protein serving as VLA-5 alpha chain, expressed on thymocytes, activated T cells, splenic B cells, and mast cells. (exbio.cz)
Extracellular5
The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)
Within the extracellular domain, human Integrin alpha 2b shares 80% and 78% amino acid sequence identity with mouse and rat Integrin alpha 2b, respectively. (rndsystems.com)
Free GAGs chains are secreted to the extracellular space and distributed both in the pericellular matrix and extracellular matrix proper. (hindawi.com)
Here we report the crystal structure of the extracellular segment of integrin alphaVbeta3 in complex with a cyclic peptide presenting the Arg-Gly-Asp sequence. (rcsb.org)
The extracellular sequences of RON contain several domains including an N-terminal semaphorin (sema) domain, followed by the plexin, semaphorin, integrin (PSI) domain, and four immunoglobulin, plexin, transcription factor (IPT) domains. (spandidos-publications.com)
Fibrinogen1
Integrin alpha 2b associates with Integrin beta 3 to form complexes that interact with Fibrinogen, von Willebrand factor, Fibronectin, and Vitronectin. (rndsystems.com)
Subunits2
Studies in marmosets and humans indicate that thalidomide, and a teratogenic analogue, decrease the expression of beta integrin subunits, most notably beta 3 and the beta 2 produced by leukocytes. (nih.gov)
The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods. (embl.de)
Membrane2
Upon prolonged high intracellular rises in Ca 2+ , platelets develop a procoagulant phenotype that is characterized by the surface membrane exposure of phosphatidylserine and by the inactivation of integrin α IIb β 3 (procoagulant platelet population) ( 5 ). (frontiersin.org)
α2β1γ1) stimulates oligodendrocytes to extend elaborate membrane sheets in vitro (cell spreading), mediated by integrin α6β1. (rupress.org)
Monoclonal4
The following product was used in this experiment: CD51/CD61 (Integrin alpha v beta 3) Monoclonal Antibody (23C6), Biotin, eBioscience™ from Thermo Fisher Scientific, catalog # 13-0519-82, RRID AB_529536. (thermofisher.com)
Description: The 23C6 monoclonal antibody reacts with the human CD51/CD61 dimer, also known as the integrin alphav/beta3. (thermofisher.com)
Human peripheral blood platelets were stained with FITC-conjugated Anti-Human Integrin a2b/CD41 Antibody (Clone P2) and either (A) Mouse Anti-Human Integrin a2b/CD41 APC-conjugated Monoclonal Antibody (Catalog # FAB7616A) or (B) Mouse IgG 1 Allophycocyanin Isotype Control (Catalog # IC002A ). (rndsystems.com)
Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. (xenbase.org)
Integrin alpha 2b (ITGA2b), also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. (rndsystems.com)
Integrin beta 3 is found along with the alpha IIb chain in platelets. (nih.gov)
Vitro1
Similarly, depletion of either Rasip1 or Arhgap29 in cultured ECs blocks in vitro lumen formation, fundamentally alters the cytoskeleton, and reduces integrin-dependent adhesion to ECM . (xenbase.org)
Alpha 4 chain associates with either beta 1 chain or beta 7 chain. (wikipedia.org)
Staining of M21 cells with 0.5 µg of Mouse IgG1 kappa Isotype Control Biotin (Product # 13-4714-85) (open histogram) or 0.5 µg of Anti-Human CD51/CD61 (Integrin alpha/beta 3) Biotin (filled histogram) followed by Streptavidin PE (Product # 12-4317-87). (thermofisher.com)
Detects human Integrin alpha 2b/CD41 in direct ELISAs. (rndsystems.com)
In direct ELISAs, no cross-reactivity with recombinant human Integrin alpha 5, alpha 8, alpha V, beta 3, beta 5, beta 6, recombinant mouse Integrin beta 2b or beta 3 is observed. (rndsystems.com)
Integrin alpha 2b is required for platelet aggregation, and defects lead to disorders of coagulation. (rndsystems.com)
Be the first to review Human Integrin alpha 2b/CD41 APC-conjugated Antibody and earn rewards! (rndsystems.com)
The RGD motif of EDIL3 binds alpha v beta 5 integrin, which, in turn, leads to increased angiogenic transcription factor HoxD3 expression. (rndsystems.com)
CD49e, the alpha 5 integrin, noncovalently associates with the beta 1integrin (CD29) to form VLA-5 integrin complex. (exbio.cz)
Beta11
Consistent with the previous observation that an antibody blockade involving anti-alpha5beta1 integrin abolishes bacterial internalization, we show here that the entry of rAfaD-coated beads was dependent on the production and accessibility of beta1 integrins on the cells. (pasteur.fr)
Complement1
We show that selective stimulation of Mac-1 integrin (complement receptor 3) by specific ligands initiates the generation of EVs which are able to impair bacterial growth and to induce the secretion of the pro-inflammatory cytokine IL-8 (aEV). (stanford.edu)
Laminin2
Compared to ECs, pancreatic pericytes produce significantly higher levels of α2 and α4 laminin chains, which constitute the peri-islet and vascular BM. (nature.com)
residues 2,110-3,060) of the A chain of murine-derived laminin has been shown to promote heparin binding, cell adhesion, and neurite outgrowth. (rupress.org)
It is cleaved into two disulfide-linked chains (114 kDa and 22 kDa) during transit through the Golgi. (rndsystems.com)
CD49e itself is composed of two disulfide-linked chains of 135 kDa and 25 kDa. (exbio.cz)
Complex1
Combination Therapy with a Bispecific Antibody Targeting the hERG1/β1 Integrin Complex and Gemcitabine in Pancreatic Ductal Adenocarcinoma. (unifi.it)
Structural1
The structural basis for the divalent cation-dependent binding of heterodimeric alphabeta integrins to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown. (rcsb.org)
Immunoglobulin1
The immunoglobulin M (IgM) and immunoglobulin G (IgG) heavy chains are also not fucosylated. (medscape.com)
Polypeptide1
BCAM produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 755 amino acids (32-547a.a.) and having a molecular mass of 83.2kDa. (neuromics.com)
Interactions1
Since integrins are crucial for cell-matrix interactions, and the beta 2 integrins of leukocytes mediate adhesion to endothelium, it is reasonable to postulate that thalidomide inhibits cell migration in susceptible species, and that this accounts for its anti-inflammatory, anti-angiogenic, and teratogenic activity. (nih.gov)
Cell4
Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. (wikidoc.org)
EDIL3 has also been shown to be an endogenous inhibitor of inflammatory cell recruitment by interfering with the integrin LFA-1-dependent leukocyte-endothelial adhesion. (rndsystems.com)
Binding of B-chain containing PDGF molecules can stimulate cell proliferation. (biolegend.com)
Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. (nih.gov)
Cells1
Furthermore, BCAM interacts with integrin in sickle red cells, and participates in vasoocclusive episodes. (neuromics.com)
Amino2
Human EDIL3 is synthesized as a precursor with a 16 amino acid (aa) signal sequence and a 464 aa mature chain (SwissProt # O43854). (rndsystems.com)
The RON cDNA encodes 1,400 amino acids, which are synthesized first as a single-chain precursor (pro-RON) ( 1 ). (spandidos-publications.com)
Sequence1
Sequence data from infections among household members can define the expected genomic diversity of a virus along a defined transmission chain. (cdc.gov)
Glycosylation1
The best understood subclass is N -glycosylation, in which the glycans are linked to the N δ 2 atom of an Asn side chain. (iucr.org)
Inflammatory1
Previously we have shown that Mac-1 integrin is a key factor that switches anti-inflammatory EV generation into pro-inflammatory and antibacterial EV production. (stanford.edu)