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  • pathways
  • These adhesive interactions of integrins with their ECM ligands are important not only in physically modulating HNSCC migration and invasion, but also in regulating the pathways required for survival and continued tumor expansion. (springer.com)
  • The complex signaling pathways transduced by integrin and cadherin receptors are poorly understood but are known to coordinately regulate such diverse cellular processes as apoptosis, proliferation, and the invasive phenotype. (springer.com)
  • apoptosis
  • The upregulated integrin β4 expression was identified to promote gefitinib resistance and proliferation, and inhibit apoptosis, while downregulation of integrin β4 was to inhibit gefitinib resistance and proliferation, and induce apoptosis. (springermedizin.de)
  • mice
  • I was however surprised to read that, based on their observations with these α6 mutant mice, the authors concluded that the α6β4 integrin can be classified as a tumour suppressor in the colon. (bmj.com)
  • expression
  • We also observed that expression of beta 4 integrin and E-cadherin is lost during the epithelial-to-mesenchymal transition (EMT) of mammary gland cells induced by transforming growth factor beta (TGFbeta), which is coincident with de novo DNA methylation, a decrease in active histone modifications (H3K9Ac and H3K4me3) and an increase in the repressive histone modification H3K27me3. (umassmed.edu)
  • Furthermore, TGFbeta withdrawal promotes a mesenchymal-to-epithelial transition (MET) and triggers the re-expression of beta 4 integrin and E-cadherin. (umassmed.edu)
  • It was found that the integrin β4 expression was increased in gefitinib-resistant gastric cell line. (springermedizin.de)
  • Schematic view of the colonic epithelium showing the differential expression of integrin α6β4 forms in the normal mucosa and in tumours. (bmj.com)
  • cell
  • Integrins also transmit chemical signals that regulate cell growth and the activity of certain genes. (nih.gov)