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  • protein
  • In an advance online publication in the Journal of Clinical Investigation, Ana Carneiro, Ph.D., and colleagues report that a well-known protein found in blood platelets, integrin beta3, physically associates with and regulates the serotonin transporter (SERT), a protein that controls serotonin availability. (bio-medicine.org)
  • Hence a proper understanding of the polypyrimidine tract binding protein-1 (PTBP1) dependent signaling pathway may reveal new insights in the functions and features of the integrin beta-3 protein as a cell-adhesive (and voltage-gated! (openwetware.org)
  • As previously, the first chain of the protein is "integrin alpha-V", but a trimmed-down version with only 116 segments instead of 193. (fold.it)
  • tumor
  • Integrin distributionin malignant melanoma: association of the beta 3 sub uni twith tumor progression. (springer.com)
  • Recently, integrins have emerged as a key target in anti-cancer therapy as integrins are involved in promoting tumor metastasis and cancer blood vessel formation. (fold.it)
  • therapeutic
  • Novel aspects of IGF1R/IR in cancer, such as biased agonism, integrin β3 signaling, AHR, and new therapeutic targeting strategies will be discussed. (frontiersin.org)
  • Allostery
  • Allostery in the beta3 I domain alters three metal binding sites, associated loops and alpha1- and alpha7-helices. (rcsb.org)
  • proteins
  • We dont think the platelet itself contributes to autism, said Blakely, but rather we believe that the brains serotonin transporter may be controlled by integrin proteins in a very similar manner. (bio-medicine.org)