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Integrin beta ChainsIntegrin beta3LamininIntegrinsAntigens, CD29Integrin beta4TalinCell AdhesionMolecular Sequence DataAmino Acid SequenceReceptors, LamininIntegrin alphaVbeta3Integrin alpha5beta1Macromolecular SubstancesIntegrin alpha6beta4Integrin alpha6Protein SubunitsIntegrin alpha ChainsIntegrin alpha5Integrin alpha3beta1Integrin alpha6beta1Integrin alphaVFibronectinsIntegrin alpha2Base SequenceIntegrin alpha2beta1Integrin alpha3Protein BindingIntegrin alpha4Integrin alpha1Integrin alpha1beta1Cell LineBinding SitesReceptors, VitronectinCells, CulturedSignal TransductionCell MovementRecombinant ProteinsCloning, MolecularMutationProtein Structure, TertiaryExtracellular MatrixChorionic Gonadotropin, beta Subunit, HumanProton-Translocating ATPasesProtein ConformationKineticsPhosphorylationSequence Homology, Amino AcidRNA, MessengerBasement MembraneAntigens, CD18HemidesmosomesTransfectionPeptide FragmentsElectrophoresis, Polyacrylamide GelInterleukin-1betaRecombinant Fusion ProteinsEscherichia coliReceptors, FibronectinMolecular WeightCytoplasmCell Adhesion MoleculesMutagenesis, Site-DirectedOligopeptidesModels, MolecularAntigens, CDPlatelet Glycoprotein GPIIb-IIIa ComplexCollagenBlotting, WesternVitronectinCricetinaeAntibodies, MonoclonalCHO CellsPrecipitin TestsFollicle Stimulating Hormone, beta SubunitCell MembranePlatelet Membrane GlycoproteinsDNA, ComplementaryTumor Cells, CulturedLigandsFluorescent Antibody TechniqueSequence AlignmentDNA PrimersGene ExpressionFocal Adhesion Protein-Tyrosine KinasesStructure-Activity Relationshipbeta 2-MicroglobulinDNAGene Expression RegulationEnzyme ActivationMembrane ProteinsReceptors, CollagenGlycoprotein Hormones, alpha SubunitCattleCell Line, TumorFocal Adhesion Kinase 1ImmunohistochemistryAntibodiesMice, KnockoutExtracellular Matrix Proteins
ReceptorsITGB4ExtracellularReceptorAntigenHeterodimersTransmembrane glycoproteinCollagenGlycoproteinCD29Beta3FibronectinPolypeptidesAlpha3Junctional epidermCD18Monoclonal AntibodyAlphaAntibodyAdhesion moleculesGeneChainsAntibodiesActinHumanMolecularSequenceInteractComplexBasalAmino acidPhysiologicalInteractsInsulinRegulateGenesCell
Receptors5
  • Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. (wikipedia.org)
  • The laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and other receptors. (embl.de)
  • The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS. (lookformedical.com)
  • Furthermore, integrins may change the behavior of the cell according to the molecular composition of the extracellular matrix (they behave like receptors). (uvigo.es)
  • Laminin receptors in the retina: sequence analysis of the chick integrin alpha 6 subunit. (silverchair.com)
ITGB45
  • Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. (wikipedia.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Beta 4 (ITGb4) in tissue homogenates, cell lysates and other biological fluids. (hudsen.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Integrin Beta 4 (ITGb4) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (hudsen.org)
  • Description: Quantitativesandwich ELISA kit for measuring Rat Integrin beta-4 (ITGB4) in samples from serum, plasma, tissue homogenates, cell lysates. (hudsen.org)
  • Subsequent screening for structural variants in candidate genes located in the same regions identified a homozygous deletion that includes exons 17 to 23 of the integrin beta 4 ( ITGB4 ), a gene that was previously associated with the same defect in humans. (biomedcentral.com)
Extracellular11
  • Each laminin is a heterotrimer assembled from alpha, beta and gamma chain subunits, secreted and incorporated into cell-associated extracellular matrices. (embl.de)
  • Functional analyses indicated that some of the genes induced by dragonfly larvae caused an increase in laminins necessary for cell adhesion in the extracellular matrix. (biomedcentral.com)
  • An intracellular domain that interacts with actin filaments of the cytoskeleton (sometimes with intermediate filaments), an extracellular domain that binds collagen, fibronectins and laminins, and an intramembrane domain containing hydrophobic amino acid sequences inserted among the lipid fatty acid chains. (uvigo.es)
  • The ability of integrins to mechanically connect extracellular matrix and cytoskeleton allows the structural continuity between the internal and external environments of the cell. (uvigo.es)
  • Cells, in turn, may regulate the strength of adhesion by increasing or decreasing the number of integrins, by synthesizing different integrin subunit subtypes, or by changing the adhesion affinity after modulation of the intracellular domain, which in turn will modify the adhesion ability of the extracellular domain. (uvigo.es)
  • The strength of the adhesion of a cell to the extracellular matrix depends on the number, the active state and type of integrins that are expressed in the plasma membrane. (uvigo.es)
  • β1 integrin is the major β integrin subunit in pancreatic beta-cells and forms heterodimers with 12 α integrin subunits, which interact with components of the extracellular matrix (ECM) to control intracellular signaling via the focal adhesion kinase (FAK) and extracellular signal related kinase 1 and 2 (ERK1/2) pathways [ 4 ]. (oncotarget.com)
  • Among the extracellular matrix compounds used in this study, two (collagen I and fibronectin) allowed only a weak attachment of cortical neurons to the substratum, while the others (collagen IV, laminin, and basal lamina from Engelbreth-Holm-Swarm sarcoma) allowed both firm attachment and moderate to extensive neurite outgrowth from neuronal cell bodies. (curehunter.com)
  • An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)
  • Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. (embl.de)
  • The alphaM subunit of integrin Mac-1 contains several distinct regions in its extracellular segment. (embl.de)
Receptor6
  • This gene encodes the integrin beta 4 subunit, a receptor for the laminins. (wikipedia.org)
  • Integrin alpha 6 beta 1 is a receptor for laminin. (rndsystems.com)
  • Integrin alpha 6 beta 4 is also a receptor for laminin and is a structural component of hemidesmosomes in stratified epithelia. (rndsystems.com)
  • Furthermore, these results suggest that the sequences comprising peptides GD-3 and GD-4 use an integrin as a receptor, of which the beta 1 integrin subunit is a component for these various cell types. (rupress.org)
  • The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. (assaygenie.com)
  • providing a ligand for the α6β1 integrin receptor expressed by OLs. (jneurosci.org)
Antigen3
  • The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. (wikipedia.org)
  • VLA-3 (Very Late Antigen 3) is a member of the integrin family, beta1 subfamily, of cell membrane adhesion molecules (1-3). (bio-techne.com)
  • These observations establish laminin-332 as a novel basement membrane antigen in dogs with autoimmune blistering diseases with variable clinical phenotypes. (morulaivf.com)
Heterodimers2
  • An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. (lookformedical.com)
  • Integrins are nondisulfide-linked transmembrane (TM) heterodimers that contain an alpha- and beta-subunit (1). (bio-techne.com)
Transmembrane glycoprotein2
  • Integrin alpha 2 beta 1 is the non-covalent heterodimer of 160 kDa alpha 2 (CD49b) and 130 kDa beta 1 (CD29) type I transmembrane glycoprotein subunits and is one of six very late antigens on activated T cells, designated VLA2 (3). (novusbio.com)
  • The human beta1/CD29 subunit is a 130-140 kDa type I transmembrane glycoprotein (8). (bio-techne.com)
Collagen1
  • Immunological investigations consisted of direct immunofluorescence (IF), indirect IF with intact and salt-split canine gingival, and salt-split normal or laminin-332-deficient human skin, immunoblotting with purified human laminin-332 and immunoblotting with recombinant NC1 domain of human collagen VII. (morulaivf.com)
Glycoprotein2
  • Laminin is a large molecular weight glycoprotein present only in basement membranes in almost every animal tissue. (embl.de)
  • The alpha3/CD49c subunit is a 130-150 kDa type I TM glycoprotein. (bio-techne.com)
CD291
  • The Integrin alpha 6 subunit, also known as CD49f and VLA-6 alpha subunit, forms a heterodimer with Integrin beta 1 (CD29) or beta 4 (CD104) subunits. (rndsystems.com)
Beta32
  • Laminin IV domain is also found in the perlecan protein, an integral component of basement membranes, which serves also as an attachment substrate for cells, but it is not found in short laminin chains (alpha4 or beta3). (embl.de)
  • Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C. (lookformedical.com)
Fibronectin2
  • Polyclonal and monoclonal antibodies raised against chicken gizzard 5′-nucleotidase were tested in adhesion assays of embryonic chicken fibroblasts (CEF) for their ability to interfere with the adhesion process of these cells on either laminin or fibronectin substrata. (morulaivf.com)
  • The initial attachment process of CEF on fibronectin and laminin substrata was not influenced by preincubating these cells with antibodies against chicken gizzard 5′-nucleotidase. (morulaivf.com)
Polypeptides2
  • Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. (wikipedia.org)
  • Laminin-332 polypeptides are targeted by auto-antibodies in human patients with mucous membrane (cicatricial) pemphigoid or, more rarely, subepidermal vesicular diseases that resemble epidermolysis bullosa acquisita (EBA) or bullous pemphigoid (BP). (morulaivf.com)
Alpha31
Junctional epiderm1
  • The names 'acquired junctional epidermolysis bullosa', 'anti-laminin-332 mucous membrane pemphigoid (MMP)' and 'mixed auto-immune subepidermal blistering dermatosis' are proposed for dogs with clinical signs reminiscent of EBA, MMP or BP respectively. (morulaivf.com)
CD181
  • Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
Monoclonal Antibody1
  • In vitro assays demonstrated a competition of laminin and this monoclonal antibody for the binding site on purified 5′-nucleotidase. (morulaivf.com)
Alpha23
  • This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. (wikipedia.org)
  • Molecular cloning of the human alpha 6 integrin subunit. (wikipedia.org)
  • Detects human Integrin alpha 6/CD49f. (rndsystems.com)
  • Be the first to review Human Integrin alpha 6/CD49f Alexa Fluor® 405-conjugated Antibody and earn rewards! (rndsystems.com)
  • Detects human Integrin alpha 2/CD49b. (novusbio.com)
  • Integrin alpha 2 is one of twelve integrin family alpha subunits that share the beta 1 subunit (1‑3). (novusbio.com)
  • The I domain-containing beta 1 integrins ( alpha 1 beta 1, alpha 2 beta 1, alpha 10 beta 1 and alpha 11 beta 1) all bind collagens, with alpha 2 beta 1 preferring collagens I‑III (4, 5). (novusbio.com)
  • Unlike the alpha-subunit, it does not undergo proteolytic cleavage. (bio-techne.com)
  • They are composed of two subunits (alpha and beta) (Figure 1). (uvigo.es)
  • In mammals, integrins family consists of 18 alpha units and 3 beta units. (uvigo.es)
  • Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses. (lookformedical.com)
  • One of the subunits of alpha-crystallins. (lookformedical.com)
  • The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits. (lookformedical.com)
  • The product of this gene belongs to the integrin alpha chain family. (assaygenie.com)
  • Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. (assaygenie.com)
  • The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. (assaygenie.com)
  • Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. (assaygenie.com)
  • Integrin alpha (beta-propellor repeats). (embl.de)
  • They contain both alpha and beta subunits. (embl.de)
  • Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. (embl.de)
  • The four mAbs were mapped to three subregions in three different beta-sheets, making it unlikely that each recognized an interface between the alpha and beta subunits. (embl.de)
  • Our data provide new insights into how different domains in the integrin alpha and beta subunits may interact. (embl.de)
  • Laminin-332 (laminin-5) is a basement membrane heterotrimeric protein composed of alpha-3, beta-3 and gamma-2 laminin chains. (morulaivf.com)
Antibody1
  • Combination Therapy with a Bispecific Antibody Targeting the hERG1/β1 Integrin Complex and Gemcitabine in Pancreatic Ductal Adenocarcinoma. (unifi.it)
Adhesion molecules1
  • In general, the adhesion strength of integrins is weaker than that of other adhesion molecules. (uvigo.es)
Gene2
  • Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. (wikipedia.org)
  • This is possible because the adhesion state of integrins is transmitted to their intracellular domain by conformational change, triggering molecular interaction cascades in the cytosol, that eventually change gene expression. (uvigo.es)
Chains2
  • The different laminin chains share a 600-residue domain I/II which oligomerises into a rod-like coiled-coil structure forming the long arm of laminins. (embl.de)
  • Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. (lookformedical.com)
Antibodies5
Actin2
  • In hemidesmosomes, the cytosolic domains of integrins are connected to intermediate filaments, instead of actin filaments. (uvigo.es)
  • Spreading-arrested and rounded CEF do not develop prominent intracellular stress-fibers like control cells, instead they seem to concentrate their available actin in areas of presumptive initial contact with the laminin substratum. (morulaivf.com)
Human2
  • Description: A sandwich ELISA kit for detection of Integrin Beta 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (hudsen.org)
  • In five dogs, IgG variably recognized the basement membrane of laminin-332-deficient human skin (three dogs negative, two dogs positive). (morulaivf.com)
Molecular1
  • Integrin, molecular conformation (Modified from Luo et al. (uvigo.es)
Sequence2
  • This study was conducted to define the potential sequence(s) originating from the G domain of laminin with any of these functional activities. (rupress.org)
  • Each subunit then has a transmembrane sequence and a short cytoplasmic tail. (novusbio.com)
Interact1
  • Synthetic peptides from the carboxy-terminal globular domain of the A chain of laminin: their ability to promote cell adhesion and neurite outgrowth, and interact with heparin and the beta 1 integrin subunit. (rupress.org)
Complex2
  • A subset of four mAbs that reacted with the alphaM/beta2 complex but not with the unassociated alphaM subunit were mapped to one subregion, residues 718-759, and five other mAbs that recognized both the unassociated and the complexed alphaM subunit were localized to three other subregions, residues 599-679, 820-882, and 943-1047. (embl.de)
  • Integrin-linked kinase (ILK) is a major structural adaptor protein governing signaling complex formation and cytoskeletal dynamics. (jneurosci.org)
Basal1
Amino acid1
  • The N-terminal region has been predicted to fold into a beta-propeller domain composed of seven beta-sheets each about 60 amino acid residues long, with the I-domain inserted between beta-sheets 2 and 3. (embl.de)
Physiological2
  • 1 in cardiomyocytes, indicating a powerful interaction between these two calcium-channel subunits under physiological conditions. (plasignaling.com)
  • By combination, they are able to form up to 24 different integrins, which are differentially expressed depending on the tissue and the physiological state of the cell. (uvigo.es)
Interacts1
  • A straightforward hypothesis to explain this big difference is that the 6 subunit interacts directly with 3. (plasignaling.com)
Insulin1
  • We utilized a mouse insulin 1 promoter driven tamoxifen-inducible Cre-recombinase β1 integrin knockout mouse model (MIPβ1KO) to investigate β1 integrin function in adult pancreatic beta-cells. (oncotarget.com)
Regulate1
  • This integrin may regulate angiogenesis and cancer progression. (assaygenie.com)
Genes1
  • ELAV - like1 , methyltransferase like 7A , dolichyl-phosphate mannosyltransferase , laminin subunit beta-1 , gremlin 1 , BCL6 corepressor-like 1 , and three genes of unknown identity. (biomedcentral.com)
Cell9
  • residues 2,110-3,060) of the A chain of murine-derived laminin has been shown to promote heparin binding, cell adhesion, and neurite outgrowth. (rupress.org)
  • Therefore, laminin appears to have multiple, independent sequences in the G domain that serve a similar cell adhesion promoting function for different cell types. (rupress.org)
  • β1 integrin is essential for pancreatic beta-cell development and maintenance in rodents and humans. (oncotarget.com)
  • However, the effects of a temporal beta-cell specific β1 integrin knockout on adult islet function are unknown. (oncotarget.com)
  • Morphological analyses demonstrated that beta-cell mass, islet density, and the number of large-sized islets was significantly reduced in male MIPβ1KO mice. (oncotarget.com)
  • Female MIPβ1KO mice did not develop glucose intolerance or reduced beta-cell mass until 16 weeks post-tamoxifen. (oncotarget.com)
  • This data demonstrates that β1 integrin is required for the maintenance of glucose homeostasis through postnatal beta-cell function and expansion. (oncotarget.com)
  • The role of β1 integrin in maintaining optimal islet function has previously been identified in vitro using cell lines and isolated islets. (oncotarget.com)
  • By contrast, four mAbs to the beta-propeller domain did not react with the unassociated alphaM precursor nor with the uncomplexed alphaM subunit expressed on COS cell surface. (embl.de)