By exploiting four monoclonal antibodies recognizing distinct conformational epitopes, we show that in endothelial cells (ECs), the extracellular βI domain, but not the hybrid or I-EGF2 domain of active β1 integrins, promotes their FAK-regulated clustering into tensin 1-containing fibrillar adhesions and impairs their endocytosis. (life-science-alliance.org)
Moreover, PVRL4 triggers a form of signaling between the cells called integrin β4 signaling that allows them to survive without being anchored to the extracellular matrix. (elifesciences.org)
Integrin-mediated interactions with the extracellular matrix (ECM) are required for the attachment, cytoskeletal organization, mechanosensing, migration, proliferation, differentiation and survival of cells in the context of a multitude of biological processes including fertilization, implantation and embryonic development, immune response, bone resorption and platelet aggregation. (thno.org)
Extracellular factors that influence integrin activation are ligand binding, divalent cation concentration, chemokine signaling and mechanical stress. (thno.org)
The tTG-FN complex can maintain cell viability of tTG-null mouse dermal fibroblasts when apoptosis is induced by inhibition of RGD-dependent adhesion (anoikis), suggesting an extracellular survival role for tTG. (ntu.ac.uk)
We hypothesize there is a relation between these two processes whereby the cells that die do so because of anoikis: loss of contact with the necessary extracellular matrix produced by radial glia. (udel.edu)
In the absence of integrin ligation, these processes are abrogated therefore pharmacological inhibition of integrin ligation is of great interest for the therapy of numerous diseases resulting from abberant integrin mediated signaling. (thno.org)
tTG-FN supports RGD-independent cell adhesion of different cell types and the formation of distinctive RhoA-dependent focal adhesions following inhibition of integrin function by competitive RGD peptides and function blocking antiintegrin antibodies α5β1. (ntu.ac.uk)
Metastasis4
ANGPTL4 disrupts endothelial cell junctions by directly interacting with integrin, VE-cadherin and claudin-5 in a sequential manner to facilitate metastasis. (wikipedia.org)
Integrins also function in pathological processes such as inflammation, wound healing, angiogenesis, and tumor metastasis. (thno.org)
Retraction: ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling. (nih.gov)
CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation. (sinica.edu.tw)
Apoptosis1
CEA AND ANOIKIS Another important function that has been attributed to CEA manifestation is definitely inhibition of apoptosis in particular the apoptosis caused by absence of attachment of cells to a substratum (anoikis)[23,40]. (campaignfornonviolentschools.org)
Angiogenesis2
ANGPTL4 induces nitric oxide production through an integrin/JAK/STAT3-mediated upregulation of iNOS expression in wound epithelia, and enhances angiogenesis to accelerate wound healing in diabetic mice. (wikipedia.org)
Modulation of integrin function is required in many physiological and pathological settings, such as angiogenesis and cancer. (life-science-alliance.org)
Transmembrane2
Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. (cancer-genetics.org)
Upregulation1
The cocoon provides the tissue support for cell survival, promotes integrin upregulation for better engraftment of the cells onto the heart tissue, and protect the cells from the harsh post-MI environment. (europa.eu)
Survival1
We propose a novel RGD-independent cell adhesion mechanism that promotes cell survival when the anti-apoptotic role mediated by RGD-dependent integrin function is reduced as in tissue injury, which is consistent with the externalisation and binding of tTG to fibronectin following cell damage/stress. (ntu.ac.uk)
Kinase1
The integrin tails have no intrinsic kinase activity but rather serve as a site for the docking of various kinases and related adaptor proteins that comprise focal adhesions. (thno.org)
Fibronectin1
In this regard, the βI domain-dependent clustering of active β1 integrins is necessary to favor fibronectin-elicited directional EC motility, which cannot be effectively promoted by β1 integrin conformational activation alone. (life-science-alliance.org)
Regulate2
The biodirectional nature of integrin mediated signaling allows both extra- and intracellular cues to regulate activation [ 4 ] (Fig. 1 ). (thno.org)
It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. (cancer-genetics.org)
Tumor2
ANGPTL4 contributes to tumor growth and protects cells from anoikis, a form of programmed cell death induced when contact-dependent cells detach from the surrounding tissue matrix. (wikipedia.org)
This would play an important part in metastases formation to a distant organ as unattached tumor cells in the blood circulation would be more susceptible to anoikis. (campaignfornonviolentschools.org)
Endothelial1
Recently, however they showed that secreted (soluble) CEA can directly activate endothelial cells integrin 3 signaling[24,47]. (campaignfornonviolentschools.org)
Receptors2
Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
integrin receptors on the neuronal membrane, initiating an intracellular cascade which eventually increases expression of Bcl-2, an anti-apoptotic molecule. (udel.edu)
Promotes1
PVRL4 promotes anchorage-independence by driving cell-to-cell attachment and matrix-independent integrin β4/SHP-2/c-Src activation. (elifesciences.org)
Pathway1
Further analysis showed that higher expression of plakoglobin was able to promote activation of the PI3K/Akt/Bcl-2 pathway, which might protect the clusters from anoikis. (jcancer.org)
Tumors1
ANGPTL4 secreted from tumors can bind to integrins, activating downstream signaling and leading to the production of superoxide to promote tumorigenesis. (wikipedia.org)
Intracellular3
Intracellular signaling events that converge on the cytoplasmic domain of integrin tails are also capable of activating the high affinity state. (thno.org)
Intracellular signals that result in integrin activation are referred to as 'inside-out' signaling events. (thno.org)
Integrin ligation via cell-to-cell and cell-to-matrix contacts transduces intracellular signaling events in a process called 'outside-in' signaling (Fig. 2 ). (thno.org)
Cells5
In addition, integrin binding has been identified as a means of viral entry into cells [ 3 ]. (thno.org)
Despite numerous attempts at injecting stem cells into post-MI heart to affect regeneration, the consensus is that anoikis (cell death) induced by the lack of contact between the cells and the tissue scaffold during injection, the harsh environment at the injection site, and powerful myocardial contractions cause massive cell loss rendering the therapy ineffective. (europa.eu)
the great majority of these cells underwent anoikis when maintained in suspension. (unifesp.br)
However, if these tumour cells are deprived of the matrix, they die a form of programmed cell death called anoikis. (researchmatters.in)
The dynamic regulation of the physical interactions of integrins with the ECM is necessary for physiological function, and it is disrupted in pathological settings ( Seguin et al, 2015 ). (life-science-alliance.org)
Activation1
Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)
Migration1
No significant differences in cell surface expression of integrins were detected, but a clear electrophoretic migration shift, compatible with an altered glycosylation pattern, was observed for beta(1) chain in transformed cell lines. (unifesp.br)
Role2
Studies suggest that pY14Cav1-mediated control of raft internalization plays an important role in integrin-mediated control of cell proliferation that, when de-regulated, can lead to anchorage-independent growth and transformation and thereby the acquisition of tumorigenic potential. (diff.org)
This surprising observation made the team question the role of AMPK in resisting anoikis, while most of the studies until then had always credited Akt for this phenomenon. (researchmatters.in)
Great1
Therefore, pharmacological inhibition of integrins is of great interest for the treatment and prevention of disease. (thno.org)
Dynamic1
Integrin mediated cellular adhesion is dynamic process that is both indicative of and influenced by cell status. (thno.org)