• Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. (mblwhoilibrary.org)
  • Despite increased efficiency of uptake, interaction between iC3b-opsonized apoptotic cells and iDCs down-regulated the expression of major histocompatibility complex class II, CD86, CC chemokine receptor (CCR)2, CCR5, and beta2-integrins (P (nih.gov)
  • Gang J, Choi J, Lee JH, Nham SU: Identification of critical residues for plasminogen binding by the alphaXI-domain of the beta2 integrin, alphaXbeta2. (exbio.cz)
  • Myou S, Zhu X, Boetticher E, Qin Y, Myo S, Meliton A, Lambertino A, Munoz NM, Hamann KJ, Leff AR: Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2. (exbio.cz)
  • Affinity of integrin lymphocyte function-associated antigen 1 (LFA-1) is enhanced by conformational changes from the low-affinity closed form to the high-affinity (HA) open form of the ligand-binding inserted (I) domain as shown by work with purified I domains. (timothyspringer.org)
  • The location of activating mutations traces out an allosteric interface in the interior of the inserted domain that connects the ligand binding site to the alpha7-helix, which communicates allostery to neighboring domains in intact integrins. (timothyspringer.org)
  • Integrins on cell surfaces often need to be activated before they will bind their ligand. (anaesthetist.com)
  • In medicine , glycoprotein IIb/IIIa ( GPIIb/IIIa , also known as integrin α IIb β 3 ) is an integrin complex found on platelets . (wikidoc.org)