• ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). (genecards.org)
  • Here, we address the mechanism by which PN-integrin interaction mediates SMC migration in vitro. (nih.gov)
  • These results reveal a mechanism whereby PN mediates vascular SMC migration through an interaction with alphaV-integrins (mainly alphanubeta3) and subsequent activation of FAK pathway. (nih.gov)
  • Cathepsin Z has an exposed integrin-bindign Arg-Gly-Asp motif within the propeptide of the enzyme, through which cathepsin Z has been shown to interact with several integrins during normal homeostasis, immune processes and cancer. (wikipedia.org)
  • The results presented in this paper set the stage for the advancement of integrin α v β 3 -targeted NSs as therapeutic nanoconstructs for effective cancer therapy. (dovepress.com)
  • In both types of SMCs, adenovirus-mediated overexpression of HA-tagged PN to a similar extent, which induced a robust cell migration concomitantly with an increase in beta3-integrin expression and phosphorylation of FAK (Tyr397). (nih.gov)
  • Hantavirus entry into cells is dependent upon the cell-surface expression of integrins bearing the β 3 subunit ( 10 , 11 ). (asm.org)
  • The entry of pathogenic hantaviruses into susceptible human cells is dependent upon expression of the α v β 3 integrin, and transfection of human β 3 integrin is sufficient to confer infectibility onto CHO (Chinese hamster ovary) cells. (asm.org)
  • Integrin αVβ3 is potential drug target because abnormal expression of v3 is linked to the development and progression of various diseases. (wikipedia.org)
  • Perhaps paradoxically for these rodent-borne viruses, human integrins such as α v β 3 confer susceptibility to infection to CHO (Chinese hamster ovary) cells, whereas their murine ( Mus musculus ) counterparts do not. (asm.org)
  • Although integrin alphavbeta3 in K-RAS wild type colorectal cancer HT-29 cells was far less than that in K-RAS mutant HCT116 cells, HT-29 was more sensitive to both tetrac and NDAT. (pri-albany.org)
  • Active targeting of NSs to integrin α v β 3 offers the potential to increase accumulation preferentially in tumors and thereby enhance therapy efficacy. (dovepress.com)
  • In all, we have identified novel peptides that inhibit entry by SNV and HTNV via β 3 integrins and that can be used as lead compounds for further structural optimization and consequent enhancement of activity. (asm.org)