• ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). (rcsb.org)
  • We also provide evidence that when combined with a guinea pig polyclonal serum, or serotype-specific monoclonal antibodies, the integrin can be used to detect viruses representative of all FMDV serotypes. (pirbright.ac.uk)
  • Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence. (turku.fi)
  • Vessels in embryoid bodies derived from normal and β1- ES cells express similar amounts of β3 (Fig. 12, B and D) and αv integrin (Fig. 12, F and H). These data indicate that the absence of β1 integrin is not associated with an altered expression of other endothelial cell integrins. (nih.gov)
  • Double immunostaining of normal (+/+) and β1- (−/−) embryoid bodies for β3 integrin and PECAM (A-D), and αv integrin and PECAM (E-H). Normal and mutant ES cells were differentiated for 20 d, fixed and stained for PECAM (A and C, red) and β3 (B and D, green), or PECAM (E and G, red) and αv (F and H, green), respectively. (nih.gov)
  • Proliferating endothelial cells express large amounts of αvβ3 and αvβ5 integrins. (nih.gov)
  • To determine whether the expression of β3 or αv integrin is altered on β1- endothelial cells, normal and β1- embryoid bodies were double-immunostained for either PECAM and β3 integrin (Fig. 12, A-D), or PECAM and αv integrin (Fig. 12, E-H), respectively. (nih.gov)
  • High resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin αvβ6. (turku.fi)
  • In normal embryoid bodies large vessels stain for PECAM (A and C) and β3 (B), or αv integrin (D). In β1- embryoid bodies the vessel diameters are smaller but the staining for PECAM (E and G), β3 (D), and αv (H) is similar, like in normal bodies. (nih.gov)