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  • beta4-integrin
  • The following cancer signaling pathways are hosted by Netpath: Epidermal growth factor receptor Pathway Transforming growth factor beta receptor pathway Tumor necrosis factor alpha pathway Alpha6 Beta4 Integrin pathway Inhibitor of DNA binding pathway Hedgehog pathway Notch pathway Wnt pathway Androgen receptor pathway Kit receptor pathway The community participation programme is aimed at training the students in various universities from India on curation of pathway reactions. (wikipedia.org)
  • Collagen
  • The membrane proximal part of the ectodomain, within amino acids 506-519, is responsible for binding to alpha 6 integrin, this binding seems to be important for the collagen XVII integration into hemidesmosomes (citation needed). (wikipedia.org)
  • mediate
  • Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. (wikipedia.org)
  • Electron
  • Low-resolution images of detergent extracts of intact integrin GPIIbIIIa, obtained using electron microscopy, and even data from indirect techniques that investigate the solution properties of integrins using ultracentrifugation and light scattering, were combined with fragmentary high-resolution crystallographic or NMR data from single or paired domains of single integrin chains, and molecular models postulated for the rest of the chains. (wikipedia.org)
  • proteins
  • An acidic amino acid features in the integrin-interaction site of many ECM proteins, for example as part of the amino acid sequence Arginine-Glycine-Aspartic acid ("RGD" in the one-letter amino acid code). (wikipedia.org)
  • interaction
  • The presence of integrins allows rapid and flexible responses to events at the cell surface (e.g. signal platelets to initiate an interaction with coagulation factors). (wikipedia.org)