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  • ITGA6
  • Integrin alpha-6 (ITGA6) is a particular isoform of the integrin family, which is expressed across stem cell populations and has been shown to play an integral role in embryonic pluripotent stem cell self-renewal (Villa-Diaz 2016). (oakland.edu)
  • peptide
  • The crystal structure of a complex between the I domain of integrin alpha2beta1 and a triple helical collagen peptide containing a critical GFOGER motif has been determined. (sdbonline.org)
  • human
  • In particular, integrins are expressed in varying stem cell populations as well as other cell populations throughout the human body. (oakland.edu)
  • Isolated cells were immunoreactive for cytokeratin-7 (CK-7), placental growth factor, placental alkaline phosphatase, human leukocyte antigen G1 (HLA-G1), and α1 and α5 integrins, similarly to the EVT markers from first trimester placental villi. (biomedcentral.com)
  • domain
  • Nine integrin alpha subunits contain an additional domain (termed A or I) that is inserted into the head region, where it plays a central role in ligand binding: thus, recombinant I domains recapitulate many of the ligand-binding properties of the intact integrin. (sdbonline.org)
  • An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. (embl-heidelberg.de)
  • general
  • The structural features observed here may represent a general mechanism for integrin-ligand recognition (Emsley, 2000). (sdbonline.org)