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  • ligand
  • We analyzed the ability of integrin-transfected K562 cells to adhere to MAdCAM-1, an α4β7 ligand, and ICAM-1, an αLβ2 ligand, under static (no flow) conditions (Fig. 3). (nih.gov)
  • CD18
  • Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic, and motor function. (pubfacts.com)
  • heterodimer
  • In the present study we explored in detail quantitative, phenotypic and functional aspects of erythropoiesis at homeostasis in a large number of animals for each of 3 murine models with specific β1 heterodimer integrin deficiencies. (haematologica.org)
  • blockade
  • First, rats were treated intravenously with BIO5192 (10 mg/kg) or with vehicle (controls) to assess effects of integrin blockade for 24 h or 72 h after thoracic clip-compression SCI. (pubfacts.com)
  • antigen
  • The B cell antigen receptor controls integrin activity through Btk and PLCgamma2. (nih.gov)
  • Integrin-mediated adhesion and B cell antigen receptor (BCR) signaling play a critical role in B cell development and function, including antigen-specific B cell differentiation. (nih.gov)
  • conjugated to a near i
  • We further demonstrate that LLP2A can be used to image alpha4beta1-expressing lymphomas with high sensitivity and specificity when conjugated to a near infrared fluorescent dye in a mouse xenograft model. (nih.gov)
  • therapeutic
  • Thus, LLP2A provides an important tool for noninvasive monitoring of alpha4beta1 expression and activity during tumor progression, and it shows great potential as an imaging and therapeutic agent for alpha4beta1-positive tumors. (nih.gov)
  • Timing and duration of anti-alpha4beta1 integrin treatment after spinal cord injury: effect on therapeutic efficacy. (pubfacts.com)
  • cells
  • These cells are found to colonize sites of future PP and LN development and in addition to LTα1β2, they express CD45, the integrin α4β7, and the CXCL13 (BLC) receptor, CXCR5 ( 2 , 6 ). (rupress.org)
  • The fact that integrins participate in mitigating stress in erythroid cells through redox activation of distinct signaling pathways by specific integrin heterodimers is a link that has not been appreciated until now. (haematologica.org)
  • Furthermore, Btk is also involved in the control of integrin-mediated adhesion of preB cells. (nih.gov)
  • E) Namalwa cells were preincubated for 1 h at 4°C with medium alone (none), 10 μg/ml of an IgG1 isotype control (IgG1), or antibody TS1/22 blocking LFA-1 (TS1/22), Act-1 blocking α4β7 (Act-1), HP2/1 blocking α4β1 (HP2/1), or antibody TS2/16 activating integrin α4β1 (TS2/16). (nih.gov)
  • impairment
  • Mice lacking all α4 and β1 integrins (double knockouts) had, at homeostasis, the most severe phenotype with selective impairment of erythroid responses. (haematologica.org)
  • responses
  • At 2-4 weeks after SCI, anti-alpha4beta1 treatment decreased blood pressure responses during autonomic dysreflexia by as much as 43% and, at 2-8 weeks, decreased mechanical allodynia elicited from the trunk and hind paw by up to 54% and 40%, respectively. (pubfacts.com)
  • cell surface
  • This study provides evidence that in a scintillation proximity assay levocabastine (IC(50) 406 microM), but not the first-generation antihistamine chlorpheniramine, displaced (125)I-FN binding to human integrin alpha(4)beta(1) and, in flow cytometry analysis, levocabastine antagonized the binding of a primary antibody to integrin alpha(4) expressed on the Jurkat cell surface. (unict.it)
  • alpha
  • In a model of AC levocabastine eye drops reduced the clinical aspects of the late-phase reaction and the conjunctival expression of alpha(4)beta(1) integrin by reducing infiltrated eosinophils. (unict.it)
  • Previous studies have shown that integrin alpha chain tails make strong positive contributions to integrin-mediated cell adhesion. (nih.gov)
  • These results suggest that integrin alpha 4 beta 1 could play a role in controlling melanoma cell metastasis at the invasive stage. (edu.au)
  • propose
  • We propose that CO-regulated integrin deactivation provides a basis for modulation of immune cell adhesion as well as rapid cell mobilization, for example as shown for splenic monocytes in response to surgically induced ischemia of the myocardium. (nih.gov)