CollagenProteinsProteomicsSuperfamilyProteoglycanMacromoleculesDifferentiationBiomimeticHyaluronic acidFibronectinHeparanMicroenvironmentAngiogenesisBiomarkersTissueInflammationIntegrinsPolymericDegradationBiochemistryIntegrinCellsOrganoidBasementMetalloproteinaseBiologicalGeneComponentsProcessesRegulateNanoparticlesTissuesCompositionClinicalRolesContextMechanicalAreasStudiesAssemblyMajor
Collagen13
- In biology, the extracellular matrix (ECM), also called intercellular matrix, is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells. (wikipedia.org)
- In the extracellular matrix, especially basement membranes, the multi-domain proteins perlecan, agrin, and collagen XVIII are the main proteins to which heparan sulfate is attached. (wikipedia.org)
- In fact, collagen is the most abundant protein in the human body and accounts for 90% of bone matrix protein content. (wikipedia.org)
- Collagen is exocytosed in precursor form (procollagen), which is then cleaved by procollagen proteases to allow extracellular assembly. (wikipedia.org)
- The hydroscaffold is made of hyaluronic acid and composed of liver extracellular matrix components (galactosamine, collagen I/IV) with RGDS (Arg-Gly-Asp-Ser) sites for cell adhesion. (utc.fr)
- Irving, United States, 16th November 2022 / Sciad Newswire / Darling Ingredients' Health Brand, Rousselot, the global leader in collagen-based solutions, and Gelomics, the world-leading provider of fully integrated 3D cell, organoid and tissue culture technologies, have entered into a cobranding partnership. (bio-itworld.com)
- Dysregulation of the remodeling process resulting in the breakdown of collagen by matrix metalloproteinases is a hallmark of heart failure pathophysiology and produces functional changes encompassing all matrix proteins. (pitt.edu)
- Discussed in this paper is the role of inflammation, collagen cross-linking and of myofibroblasts in matrix dysfunction and the mechanisms with which these changes occur in heart failure. (pitt.edu)
- 2000. Section 22.3: Collagen: The Fibrous Proteins of the Matrix p. (pitt.edu)
- Ricard-Blum S, Ruggiero F. The collagen superfamily: from the extracellular matrix to the cell membrane. (pitt.edu)
- The extracellular matrices used for coating plates integrated collagen IV, fibronectin, laminin, and Matrigel. (kinasepathway.com)
- GO and KEGG analyses showed that the upregulated DEGs were mainly enriched in the extracellular matrix (ECM) organization of the biological process (BP), the collagen-containing ECM of cellular component (CC), and the ECM structural constituent of molecular function (MF). (hindawi.com)
- Several molecules are involved in the process of cell adhesion to bone grafts, highlighting the role of integrins, the focal adhesion mechanism, the influence of the collagen matrix, and the activity of alkaline phosphatase in bone matrix formation. (bvsalud.org)
Proteins5
- A subset of plant intracellular NLR immune receptors detect effector proteins, secreted by phytopathogens to promote infection, through unconventional integrated domains which resemble the effector's host targets. (elifesciences.org)
- We used an integrated mathematical and experimental approach to investigate whether melanoma cells recruit, activate and stimulate fibroblasts to deposit certain proteins known to be pro-survival for melanoma cells," Anderson said. (newswise.com)
- The Extracellular Matrix is a dynamic entity, showing constant degradation and deposition while providing the framework for the cardiomyocytes and interstitial proteins to lie on. (pitt.edu)
- More studies must be conducted to discover the specific matrix proteins and cytokines that modulate the pathological remodeling process. (pitt.edu)
- Our findings included a significant class of proteoglycans not previously associated with lymphomas as well as significant modulation of genes that code for extracellular matrix-associated proteins. (fortunepublish.com)
Proteomics4
- Lindsey ML, Hall ME, Harmancey R, Ma Y. Adapting extracellular matrix proteomics for clinical studies on cardiac remodeling post-myocardial infarction. (pitt.edu)
- Methods To investigate molecular characteristics associated with clinical instability of atherosclerosis, we performed a proteomics comparison of the vascular extracellular matrix and associated molecules in human carotid endarterectomy specimens from symptomatic versus asymptomatic patients. (ox.ac.uk)
- The proteomics data were integrated with gene expression profiling and an analysis of protein secretion by lipid-loaded human vascular smooth muscle cells. (ox.ac.uk)
- Results The molecular signature of plaques from symptomatic patients identified by proteomics and at least one of the other two approaches comprised matrix metalloproteinase-9, chitinase-3-like protein 1, S100 calcium binding protein A8, S100 calcium binding protein A9, cathepsin B, fibronectin and galectin-3-binding protein. (ox.ac.uk)
Superfamily2
- Her Extracellular matrix research integrates issues from SUPERFAMILY, ADAMTS, Thrombospondin and Interstitial cell. (research.com)
- We first demonstrate that the Ig superfamily molecule contactin is associated in oligodendrocytes with integrins, extracellular matrix receptors that regulate target-dependent survival by amplification of growth factor signaling. (uea.ac.uk)
Proteoglycan1
- Described below are the different types of proteoglycan found within the extracellular matrix. (wikipedia.org)
Macromolecules1
- Extracellular matrix (ECM) macromolecules, apart from structural role for the surrounding tissue, have also been defined as crucial mediators in several cell mechanisms. (iucc.ac.il)
Differentiation5
- Here, we report that adipocytes from tumor-invasive mammary fat undergo de-differentiation to fibroblast-like precursor cells during tumor progression and integrate into the tumor microenvironment. (usda.gov)
- Part of the cells were grown in extracellular matrix coated plates with serum containing culture medium containing 5% FBS plus the antibiotic cock tail to induce differentiation. (kinasepathway.com)
- Introduction: Ribosome biogenesis is integrated with many cellular processes including proliferation, differentiation and oncogenic events. (bvsalud.org)
- Chondrogenic proliferation and differentiation require a high cellular translational capacity to facilitate cartilaginous extracellular matrix production. (bvsalud.org)
- In order to be effective and integrated to the receiving area, the bone graft is required to allow a strong cell adhesion, interacting with several molecules to induce migration, differentiation, and thus the mineralization of the new bone on the graft. (bvsalud.org)
Biomimetic1
- The unique LunaGel™ photocrosslinking technology enables the rapid generation of highly biomimetic extracellular microenvironments with the largest range of mechanical tuneability on the market, enabling scientists to replicate the properties of various healthy and diseased tissues. (bio-itworld.com)
Hyaluronic acid1
- Hyaluronic acid in the extracellular space confers upon tissues the ability to resist compression by providing a counteracting turgor (swelling) force by absorbing significant amounts of water. (wikipedia.org)
Fibronectin1
- Her Procollagen peptidase research includes elements of Fibronectin, Extracellular matrix and Cleavage. (research.com)
Heparan1
- Jeremy E. Turnbull integrates Heparan sulfate and Glucuronic acid in his research. (research.com)
Microenvironment1
- Newswise - Using mathematical models, researchers in the Integrated Mathematical Oncology (IMO) program at Moffitt Cancer Center are focusing their research on the interaction between the tumor and its microenvironment and the "selective forces" in that microenvironment that play a role in the growth and evolution of cancer. (newswise.com)
Angiogenesis1
- Her Pathology research integrates issues from Extracellular matrix, Angiogenesis and Gene expression. (research.com)
Biomarkers1
- Serum biomarkers of extracellular degradation products, selective metalloproteinase inhibitors and a personalized treatment approach with a revisal of the current classification of heart failure are topics requiring further exploration. (pitt.edu)
Tissue8
- Rousselot Biomedical will supply Gelomics with its X-Pure GelMA (gelatin methacryloyl), a photo cross-linkable extracellular matrix, for use in Gelomics' LunaGel™ 3D Tissue Culture System. (bio-itworld.com)
- Founded in 2018 in Australia, Gelomics has rapidly become a world-leading provider of fully integrated 3D cell, organoid and tissue culture technologies. (bio-itworld.com)
- Gelomics is a world-leading provider of fully integrated 3D cell, organoid, and tissue culture technologies. (bio-itworld.com)
- It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. (cshlpress.com)
- Fibroblasts, the most common connective tissue functioning in the extra cellular matrix, were known to be activated by and drawn to cancer cells. (newswise.com)
- Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering. (pitt.edu)
- A laboratory- oriented course designed to integrate plant molecular biology, recombinant DNA technology, and plant cell and tissue culture. (charlotte.edu)
- These studies integrate both basic scientists and clinicians to more effectively translate these basic science findings into new, innovative human health care protocols of using tissue engineering to repair skeletal tissues as in this accompanying figure. (case.edu)
Inflammation2
- Functional analysis showed that the muscle contraction, immune system/inflammation, and extracellular matrix pathways were the most affected pathways. (cdc.gov)
- Single-cell sequencing reveals that these de-differentiated adipocytes lose their original identities and transform into multiple cell types, including myofibroblast- and macrophage-like cells, with their characteristic features involved in immune response, inflammation, and extracellular matrix remodeling. (usda.gov)
Integrins1
- Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. (embl.de)
Polymeric2
- Some single-celled organisms adopt multicellular biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances (EPS). (wikipedia.org)
- Currently, it is unknown whether and which domain(s) [i.e. leucine-rich repeat domain (LRR), immunoglobulin domains, peroxidase domain, von Willebrand factor type C domain] of PXDN interact with the polymeric networks of the extracellular matrix (ECM), and how these interactions integrate and regulate the enzyme's cross-linking activity, without imparting oxidative damage to the ECM. (ku.dk)
Degradation2
- Physiologically, CTSB is integrated into almost all lysosome-related processes, including protein turnover, degradation, and lysosome-mediated cell death. (jcancer.org)
- CTSB can lead to the development of various pathological processes through degradation and remodeling of the extracellular matrix. (jcancer.org)
Biochemistry2
- Jeremy E. Turnbull integrates Biochemistry and Polysaccharide in his research. (research.com)
- Betty Nusgens spends much of her time researching Cell biology, Pathology, Extracellular matrix, Biochemistry and Molecular biology. (research.com)
Integrin3
- The alphaM subunit of integrin Mac-1 contains several distinct regions in its extracellular segment. (embl.de)
- We further demonstrate that the signals from contactin and integrin are integrated by differential phosphorylation of the Src family kinase Fyn. (uea.ac.uk)
- We conclude, therefore, that a novel integrin/contactin complex coordinates signals from extracellular matrix and the axonal surface to regulate both oligodendrocyte survival and myelination by controlling Fyn activity. (uea.ac.uk)
Cells4
- Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). (wikipedia.org)
- Chinese researchers believe they've gotten a step closer to producing all-weather photovoltaics by integrating phosphors into solar cells. (materialstoday.com)
- Gelomics' first product series, LunaGel™ is a photocrosslinkable cell culture system that recreates the natural extracellular matrix (ECM) surrounding cells in the human body, allowing researchers to grow three-dimensional microscopic tissues, rather than just cells on plastic surfaces. (bio-itworld.com)
- These cell adhesion molecules (CAM) will mediate the contact between two cells or between cells and the extracellular matrix, an essential process to the success of the implant. (bvsalud.org)
Organoid1
- the right extracellular environment in organoid models. (hcs-pharma.com)
Basement1
- The animal extracellular matrix includes the interstitial matrix and the basement membrane. (wikipedia.org)
Metalloproteinase3
- The concepts of her Pathology study are interwoven with issues in Aneurysm, Abdominal aortic aneurysm and Matrix metalloproteinase. (research.com)
- Her research investigates the connection between Immunohistochemistry and topics such as Matrix metalloproteinase that intersect with issues in Aneurysm, MMP1, PET-CT and Collagenase. (research.com)
- A 4-biomarker signature (matrix metalloproteinase-9, S100A8/S100A9, cathepsin D, and galectin-3-binding protein) improved risk prediction in terms of risk discrimination and classification and was successfully replicated in a second independent population (SAPHIR Study). (ox.ac.uk)
Biological1
- Methods Biological composite scaffolds are composed of integrated 3DP interconnected macrofiber and random ESP microfiber networks. (desktopmetal.com)
Gene2
- Integrated analysis of transcriptomics data and DNA methylation data revealed concordant changes in gene expression. (cdc.gov)
- Gene Ontology (GO) analysis and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway analysis were performed using the Database for Annotation, Visualization, and Integrated Discovery (DAVID). (hindawi.com)
Components3
- This article details how the chip integrates the major components of bone marrow, modeling both its composition and blood flow characteristics. (genengnews.com)
- This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. (cshlpress.com)
- The main reported mechanisms involve cell adhesion molecules (CAMs) and extracellular matrix components. (bvsalud.org)
Processes1
- The combined integration process of directed assembly and nanoscale soldering can be used in conjunction with other microfabrication processes to integrate functional nanoelectronic elements with substrates to generate integrated nanoelectronic devices. (nanowerk.com)
Regulate1
- Here, we investigate how signals from adhesion molecules can be integrated to regulate these initial steps of myelination. (uea.ac.uk)
Nanoparticles3
- This overcomes the difficulty in making electrical contacts to nanoparticles, which so far has been a major limitation to fabricating integrated nanoelectronic devices containing large numbers of nanoparticles. (nanowerk.com)
- We therefore were able to demonstrate a strategy to integrate nanowires and other nanoparticles with substrates to form functional nanoelectronic circuits. (nanowerk.com)
- She helped to develop a dual-catalytic nanohybrid by integrating glucose-oxidase and dextran-coated nanoparticles with peroxidase-like activity. (upenn.edu)
Tissues1
- To improve our knowledge of the sheep prolificacy traits, we conducted mRNA-miRNA integrated profiling of ovarian tissues from two pure breeds with large (Finnsheep) vs. small (Texel) litter sizes and their F1 crosses, half of which were fed a flushing diet. (biomedcentral.com)
Composition1
- The microfluidic platelet bioreactor recapitulates features such as bone marrow stiffness, extracellular matrix composition, micro-channel size, and blood flow stability under high-resolution live-cell microscopy to make human platelets. (genengnews.com)
Clinical1
- Hirschsprung disease - integrating basic science and clinical medicine to improve outcomes. (medscape.com)
Roles1
- Understanding extracellular protein roles within this context would allow for specific drug targeting and thus prevention of heart failure in the early stages of the disease. (pitt.edu)
Context1
- This course integrates information into the context of regulation of cellular function. (charlotte.edu)
Mechanical2
- Contribution of extracellular matrix to the mechanical properties of the heart. (pitt.edu)
- The 3DP scaffold retains intact 3D architecture and mechanical properties, while the ESP network serves as a cell entrapment system at the extracellular matrix (ECM) scale. (desktopmetal.com)
Areas1
- The various areas that she examines in her Extracellular matrix study include Mitral valve and Thrombospondin. (research.com)
Studies2
- Jeremy E. Turnbull integrates Glycosaminoglycan and Heparin in his studies. (research.com)
- Very few studies are conducted to bridge this gap and consider how a realistic model of DNA damage could be integrated into a realistic model of radiation carcinogenesis. (cdc.gov)
Assembly2
- Nanowerk News) A new methodology for integrating nanowires with micropatterned substrates using directed assembly and nanoscale soldering was developed by researchers at Johns Hopkins University in Baltimore. (nanowerk.com)
- The group reports their findings titled 'Integrating nanowires with substrates using directed assembly and nanoscale soldering' in the January 2006 edition of IEEE Transactions on Nanotechnology . (nanowerk.com)
Major1
- The CA2 region of the hippocampus integrates numerous inputs and sends a major out. (researchgate.net)