HIV Integrase InhibitorsIntegrase InhibitorsHIV IntegraseIntegrasesPyrrolidinonesHeterocyclic Compounds, 3-RingVirus IntegrationDrug Resistance, ViralHIV-1Attachment Sites, MicrobiologicalQuinolonesDNA NucleotidyltransferasesAnti-HIV AgentsVisna-maedi virusHealthy VolunteersNaphthyridinesHIV InfectionsKeto AcidsDNA, ViralAcetoacetatesQuantitative Structure-Activity RelationshipReverse Transcriptase InhibitorsMutation, MissenseDrug DesignCatalytic DomainMolecular Sequence DataVirus ReplicationRecombinasesMolecular StructureTransposasesModels, MolecularBacteriophagesIntegronsInhibitory Concentration 50Recombination, GeneticBase SequenceStructure-Activity RelationshipAmino Acid SubstitutionHIV Protease InhibitorsBinding SitesQuinolinesDNA Transposable ElementsAmino Acid SequenceMutationSubstrate SpecificityAvian Sarcoma VirusesProphagesViral Load