Insulins insulin isophane. Medical search. Frequent questions

Another long-acting insulin analogue detemir (Levemir ® ) is advanced in development. (medscape.com)
It has an intermediate duration of action, meaning longer than that of regular and rapid-acting insulin, and shorter than long acting insulins (ultralente, glargine or detemir). (wikipedia.org)
A recent Cochrane systematic review compared the effects of NPH insulin to other insulin analogues (insulin detemir, insulin glargine, insulin degludec) in both children and adults with Type 1 diabetes. (wikipedia.org)
Insulin detemir appeared provide a lower risk of severe hyperglycemia compared to NPH insulin, however this finding was inconsistent across included studies. (wikipedia.org)
1 UNIT contains 142 g of salt-free insulin detemir, which corresponds to 1 unit of human insulin (IU). (otc-online-store.com)
The prolonged action of Levemir® Flexpen® due to the pronounced self-Association of insulin detemir molecules at the injection site, and binding molecules of the drug to albumin through a connection to a side chain. (otc-online-store.com)
Insulin detemir compared with isophane insulin to peripheral tissues-targets goes slowly. (otc-online-store.com)
The average Vd of insulin detemir (approximately 0.1 l/kg) indicates that a high fraction of insulin detemir is circulating in the blood. (otc-online-store.com)
Biotransformation of insulin detemir was similar with that of human insulin preparations, all metabolites formed are inactive. (otc-online-store.com)
Its generic name is insulin detemir. (diabetesdaily.com)
Insulin detemir is created by recombinant DNA technology and is produced by baker's yeast. (diabetesdaily.com)
Those who are allergic to insulin detemir should not use Levemir. (diabetesdaily.com)

To help achieve a steady 'basal' insulin supply, a new long-acting insulin analogue glargine (Lantus ® ) has been introduced. (medscape.com)
The action profile of Levemir® Flexpen® is much less variable compared with isophane insulin and insulin glargine. (otc-online-store.com)

Do not change brands or types of insulin without directions on how to do so from your doctor. (webmd.com)
There are multiple types of insulin. (healthline.com)
There are multiple types of insulin, each with different duration of action. (diabeticme.org)
Hypoglycemia is a common side effect of all types of insulin. (diabetesdaily.com)

The amount of insulin you take as well as the best time for you to take your insulin may need to change if you take a different type of insulin. (nih.gov)
However, in case of experiencing a blood sugar crash, you should immediately reduce the amount of insulin intake. (swgoodies.com)
In case you start feeling dizzy, extremely hungry or non-energetic following your dosage, either reduce the amount of insulin or cease using it. (swgoodies.com)
Measure each dose very carefully because even small changes in the amount of insulin may have a large effect on your blood sugar . (webmd.com)
The amount of insulin they take when fasting needs to be adjusted. (nih.gov)
Only doctors can provide medical advice diagnosis, calculate and prescribe the amount of insulin needed for the patient. (insulin.store)

These combined mechanisms of delayed distribution gives a more reproducible profile of the adsorption and action of the drug Levemir® Flexpen® compared to isophane insulin. (otc-online-store.com)
Profile night glucose control is more flat and smooth in the drug Levemir® Flexpen® compared to isophane insulin, which is reflected in a lower risk of developing hypoglycemia at night. (otc-online-store.com)
Interindividual variability in absorption is lower in the Levemir® Flexpen® compared to other drugs basal insulin. (otc-online-store.com)
Examples of intermediate-acting insulins are N.P.H., Lantus, and Levemir. (diabeticme.org)
Levemir is a long-acting (basal) insulin analog manufactured by Novo Nordisk. (diabetesdaily.com)
As a long-acting insulin, Levemir can be injected either once or twice daily. (diabetesdaily.com)
How quickly your body processes and clears Levemir will determine how often you will need to inject this insulin. (diabetesdaily.com)
Levemir should not be used in an insulin pump, mixed with other insulins, or injected into a vein or muscle. (diabetesdaily.com)

Rapid-acting insulins with a short duration of action include insulin aspart (NovoLog), insulin lispro (Humalog), and insulin glulisine (Apidra). (medscape.com)
In general, insulin lispro, insulin aspart, and insulin glulisine are slightly more effective than regular insulin in decreasing HgbA1C, with less nocturnal hypoglycemia. (medscape.com)
On the other hand, insulin lispro has lysine and proline inverted at the B28 and B29 position and insulin aspart has the proline at position 28 replaced by aspartic acid. (medscape.com)

Follow your healthcare provider's instructions to make changes to your insulin dose. (nih.gov)
This provides a flatter 'peakless' circulating concentration of insulin than protamine (isophane) and lente insulins, facilitating dose escalation with reduced risk of hypoglycaemia. (medscape.com)
This is very important in order to determine the correct insulin dose. (webmd.com)
In this phase 1, automated euglycaemic glucose clamp study, 78 healthy subjects were randomized (1:1) to receive a single dose of 0.4 IU/kg of Biocon's Insulin-70/30 and HUMULIN-70/30. (nih.gov)
Some guidelines encourage early use of insulin if HgbA1C remains poorly controlled on maximal-dose, single-drug therapy. (medscape.com)
Both strategies require close attention to diet and exercise as well as to insulin timing and dose. (msdmanuals.com)
On two separate occasions, patients were instructed to reduce insulin dose(s) to achieve marked hyperglycaemia (18-23 mmol/l). (insujet.com)
Subsequently, insulin aspart was administered either by jet injection or by conventional pen, in a dose based on estimated individual insulin sensitivity. (insujet.com)
Here, it was investigated whether such profiles were modified by body mass index (BMI) and related weight parameters by comparing insulin administration by jet injection to that by conventional pen in subgroups defined by BMI, waist-to-hip ratio, waist circumference and insulin dose. (insujet.com)
As with all insulin preparations, the duration of action of Humulin 70/30 is dependent on dose, site of injection, blood supply, temperature, and physical activity. (nih.gov)
Also, only a doctor may change the dose of insulin in case of infection, injury, or surgery. (insulin.store)

NPH stands for neutral protamine Hagedorn, and the words refer to neutral pH (pH = 7), protamine (a protein), and Hans Christian Hagedorn (an insulin researcher).Brand names include Humulin N, Novolin N, Novolin NPH, Gensulin N, SciLin N, Insulatard, and NPH Iletin II. (wikipedia.org)
Humulin N is an intermediate acting insulin that is slower to act and lasts longer than regular human insulin. (swgoodies.com)
U-100 insulins, including Humulin N, contain 100 units/mL. (swgoodies.com)
With the Humulin N U-100 vial, it is important to use a syringe that is marked for U-100 insulin preparations. (swgoodies.com)
The active ingredient in Humulin N is isophane insulin human . (healthline.com)
Regular insulin (Humulin R, Novolin R) is categorized as short-acting with a short duration of action and regular onset of action. (medscape.com)
Humulin is synthesized in a special non-disease-producing laboratory strain of Escherichia coli bacteria that has been genetically altered to produce human insulin. (nih.gov)
Humulin 70/30 is a mixture of 70% Human Insulin Isophane Suspension and 30% Human Insulin Injection (rDNA origin). (nih.gov)
Human insulin from Eli Lilly and Company has the trademark Humulin. (nih.gov)
Before each injection the Humulin 70/30 bottle must be carefully shaken or rotated several times to completely mix the insulin. (nih.gov)

Insulin is the cornerstone of therapy in the management of type 1 diabetes . (medscape.com)
If you have type 1 diabetes, your body can't make its own insulin . (healthline.com)
Insulin is the most common type of medication used in type 1 diabetes treatment. (healthline.com)
Patients with type 1 diabetes mellitus are treated with insulin as well as diet and exercise. (msdmanuals.com)
Insulin replacement in type 1 diabetes should ideally mimic beta-cell function to provide basal and prandial requirements (physiologic replacement or basal-bolus dosing). (msdmanuals.com)
Adult, overweight or obese (BMI ≥25 and ≤40 kg/m2) patients with type 1 diabetes (n=10) or insulin-treated type 2 diabetes (n=10) were enrolled in a randomized, controlled, crossover study. (insujet.com)
A Pilot Study to Examine the Tolerability and Device Preference in Type 1 Diabetes of Insulin Aspart Administered by InsuJet Compared with Subcutaneous Injection. (insujet.com)
People with type 1 diabetes are at greater risk when fasting compared to people with type 2 diabetes, because they are on insulin. (nih.gov)
Insulin is used mainly in type 1 diabetes, where the pancreas makes no insulin and can sometimes be prescribed in type 1 diabetes. (passmed.uk)
In type 1 diabetes , the body does not produce enough insulin. (emedicinehealth.com)
The cause of type 1 diabetes is an autoimmune disorder in which the immune system slowly destroys the insulin-producing beta cells in the pancreas. (emedicinehealth.com)
Insulin is essential treatment for type 1 diabetes. (emedicinehealth.com)
People with diabetes mellitus either do not produce enough insulin (type 1 diabetes), cannot use insulin properly (type 2 diabetes), or both (various forms of diabetes). (emedicinehealth.com)

An intermediate-acting INSULIN preparation with onset time of 2 hours and duration of 24 hours. (umassmed.edu)
NPH insulin is cloudy and has an onset of 1-3 hours. (wikipedia.org)
NPH insulin has the advantage that it can be mixed with an insulin that has a faster onset to complement its longer lasting action. (wikipedia.org)
Table 1 provides a comparison between insulins for onset of action and duration of action. (medscape.com)
It is an intermediate-acting insulin combined with the more rapid onset of action of Regular human insulin. (nih.gov)
In the past T1D was called juvenile-onset diabetes or insulin-dependent diabetes mellitus. (emedicinehealth.com)
It was once called adult-onset diabetes mellitus, or non-insulin-dependent diabetes mellitus. (emedicinehealth.com)

Novolin N is a man-made insulin (recombinant DNA origin) NPH, Human Insulin Isophane Suspension that is structurally identical to the insulin produced by the human pancreas that is used to control high blood sugar in patients with diabetes mellitus. (nih.gov)
Produced by the pancreas, insulin helps your body use the sugar from the food you eat. (healthline.com)
The goal of treatment is to replace the insulin that your pancreas can't make. (healthline.com)
Insulin is a hormone produced by the pancreas, a large gland that lies near the stomach. (nih.gov)
Diabetes occurs when the pancreas does not make enough insulin to meet your body's needs. (nih.gov)
The reason why people need Novolin N is that sometimes the pancreas is not able to make enough insulin. (insulin.store)
It does not affect the insulin secreted by the pancreas or increase insulin levels. (passmed.uk)
Insulin is produced by the pancreas, a small organ located in the upper belly between the stomach and liver. (emedicinehealth.com)
Insulin deficiency can occur at any age due to destruction of the pancreas by alcohol , disease, or removal by surgery. (emedicinehealth.com)
Although the pancreas still secretes insulin in someone with T2D, the body's tissues are partially or completely incapable of responding to insulin. (emedicinehealth.com)
The pancreas tries to overcome this resistance by secreting more and more insulin. (emedicinehealth.com)

Your body can't make enough insulin to keep your blood sugar levels within an optimal range. (healthline.com)
People with insulin resistance develop T2D when they fail to secrete enough insulin to cope with their body's demands. (emedicinehealth.com)

The insulin would be added to the protamine, but the solution would have to be brought to pH 7 for injection. (wikipedia.org)
The most common method of taking insulin is in the form of an injection. (swgoodies.com)
In September 2017, Fiasp (insulin aspart injection) was approved by the US Food and Drug Administration (FDA) to improve glycemic control in adults with type 1 (T1D) and type 2 diabetes (T2D). (medscape.com)
It's given as an infusion under the skin (with the help of an insulin pump ) or as an injection . (healthline.com)
Regular or "short-acting" insulin may reach the bloodstream 30 minutes after injection and peak 2-3 hours afterward. (healthline.com)
Pharmacodynamic and pharmacokinetic profiles were derived from plasma glucose and insulin levels, measured for 6 h after injection. (insujet.com)
It was concluded that administration of rapid-acting insulin by jet injection results in faster correction of marked hyperglycaemia in overweight or obese patients with insulin-requiring diabetes. (insujet.com)
Clamp studies have shown that the absorption and action of rapid-acting insulin are faster with injection by a jet injector than with administration by conventional pen. (insujet.com)
To determine whether these pharmacokinetic changes also exist in patients with diabetes and benefit postprandial glucose control, a comparison was made of the pharmacologic profiles of insulin administration by jet injection versus conventional insulin pen after a standardized meal in patients with type 1 or type 2 diabetes. (insujet.com)
Results showed that insulin administration by jet injection resulted in shorter time until peak plasma insulin level and reduced hyperglycemic burden during the first hour compared with conventional administration. (insujet.com)
In contrast, T-INSmax and T-GIRmax were similar in subjects with high and low BMI, when insulin was administered by jet injection. (insujet.com)
It was concluded that using jet injection for insulin administration may especially benefit subjects with higher body weight. (insujet.com)
The injection sites you can use the insulin on include the belly, buttocks, and shoulders. (insulin.store)

medical citation needed] The timeline is as follows:[citation needed] 1926 Nordisk receives Danish charter to produce insulin 1936 Hagedorn discovers that adding protamine to insulin prolongs the effect of insulin 1936 Canadians D.M. Scott and A.M. Fisher formulate zinc insulin mixture and license to Novo 1946 Nordisk crystallizes a protamine and insulin mixture 1950 Nordisk markets NPH insulin 1953 Nordisk markets "Lente" zinc insulin mixtures. (wikipedia.org)
In the 1950s, the neutral protamine hagedorn (NPH) and insulin zinc (lente) were introduced. (medscape.com)

Novolin N is an intermediate-acting insulin. (nih.gov)
As with all insulin products, Novolin N penfill cartridges may cause several side effects. (insulin.store)

medical citation needed] Eventually all animal insulins made by Novo Nordisk were replaced by synthetic, recombinant 'human' insulin. (wikipedia.org)
Most insulin preparations are now recombinant human, practically eliminating the once-common allergic reactions to the drug when it was extracted from animal sources. (msdmanuals.com)

Typically, insulin therapy comprises a long-acting basal insulin component supplemented with short-acting insulin to coincide with meals (figure 1). (medscape.com)
When insulin is needed for patients with type 2 diabetes, glycemic control can often be achieved with basal insulin combined with non- insulin antihyperglycemic drugs, although prandial insulin may be needed in some patients. (msdmanuals.com)
They have a longer duration of action and are typically used to cover the body's basal insulin needs. (diabeticme.org)
They are typically taken once daily to cover the body's basal insulin needs. (diabeticme.org)

As the name suggests, rapid-acting insulin works within 15 minutes . (healthline.com)
In a euglycaemic glucose clamp study with healthy volunteers it was showed that using jet injectors, rather than conventional pens, significantly improved the time-action profiles of rapid-acting insulin analogs. (insujet.com)

University of Toronto, Canada later licensed protamine zinc insulin (PZI), to several manufacturers. (wikipedia.org)

Neutral Protamine Hagedorn (NPH) insulin, also known as isophane insulin, is an intermediate-acting insulin given to help control blood sugar levels in people with diabetes. (wikipedia.org)
In 1946, Nordisk was able to form crystals of protamine and insulin and marketed it in 1950, as neutral protamine Hagedorn (NPH) insulin. (wikipedia.org)

The monomeric analogues are quickly absorbed and short acting: hence they reduce post-prandial glucose excursions (which have been ascribed especial cardiovascular risk) with less risk of hypoglycaemia than conventional short-acting insulin. (medscape.com)
Versions are available that come premixed with a short-acting insulin, such as regular insulin. (wikipedia.org)
Options include multiple daily injections with 2 types of subcutaneous insulin or a rapid- or short-acting insulin delivered by an insulin pump that administers a basal rate of insulin and additional boluses with meals or for correcting a high blood sugar level. (msdmanuals.com)
Instead, call your doctor about treating DKA with a short-acting insulin or go to the hospital for treatment. (diabetesdaily.com)

The type of insulin you need depends on your body's sensitivity to insulin and the severity of your insulin deficiency. (healthline.com)

It is an intermediate-acting insulin (isophane). (webmd.com)
Intermediate-acting insulin works about 2-4 hours after use, with an average peak time of 12 hours. (healthline.com)
It is a mixture of short-acting and intermediate-acting insulin that is helpful in case of high blood sugar. (insulin.store)
She has trouble controlling her blood sugar levels, and recently, she was converted to a new insulin regimen that includes intermediate-acting insulin. (passmed.uk)
Out of the following, which one is the intermediate-acting insulin? (passmed.uk)

with any insulins other than Regular human insulin in the same syringe. (nih.gov)
Always draw the insulin regular into the syringe first, then follow with the longer-acting insulin. (webmd.com)
Always keep an extra supply of insulin as well as a spare syringe and needle on hand. (nih.gov)

Examples of short-acting insulins are Humalog, Novolog, and Apidra. (diabeticme.org)

This article is focused on recently available insulin analogues and potential future insulins that may help to mimic more closely the normal daily insulin profile. (medscape.com)
People with T1D require daily insulin treatment to sustain life. (emedicinehealth.com)

Insulin isophane is used with a proper diet and exercise program to control high blood sugar in people with diabetes . (webmd.com)
Proper control of diabetes may also lessen your risk of a heart attack or stroke .This man-made insulin product is the same as human insulin. (webmd.com)
Insulin therapy also has a clear role in type 2 diabetes mellitus in patients with long-standing or poorly controlled disease. (medscape.com)
Most patients with type 2 diabetes eventually require multidrug therapy or insulin. (medscape.com)
If you have type 2 diabetes , your body makes insulin but no longer uses it well . (healthline.com)
Diabetes Mellitus (DM) Diabetes mellitus is impaired insulin secretion and variable degrees of peripheral insulin resistance leading to hyperglycemia. (msdmanuals.com)
It was concluded that the considerably more rapid insulin absorption after administration by jet injector translated to a significant if modest decrease in postprandial hyperglycemia in patients with type 1 and type 2 diabetes. (insujet.com)
Hyperglycemia can also become an issue because people will cut back on their diabetes medicine, especially if they're on insulin, to avoid hypoglycemia. (nih.gov)
For women with gestational diabetes, if they're not on medicine, especially if they're not on insulin, fasting is the best insulin sensitizer that we have. (nih.gov)
Long-term studies (ge6 months) an indicator of the level of glucose in blood plasma fasting in patients with diabetes mellitus type 1 was better compared to isophane insulin, appointed in basis/bolus therapy. (otc-online-store.com)
To control your diabetes, your doctor has prescribed injections of insulin products to keep your blood glucose at a near-normal level. (nih.gov)
Despite diabetes, you can lead an active and healthy life if you eat a balanced diet, exercise regularly, and take your insulin injections as prescribed by your doctor. (nih.gov)
Therefore, people with diabetes need to have a steady supply of insulin. (diabeticme.org)
The American Diabetes Association posits that insulin stored in a cool and dark place will last longer than in bright sunlight. (diabeticme.org)
To manage diabetes and live a comfortable life, you should know how to use and store your insulin, especially when traveling. (diabeticme.org)
Question 4 - A 60-year-old man with insulin-controlled diabetes mellitus asks you about how his ability. (passmed.uk)
A 60-year-old man with insulin-controlled diabetes mellitus asks you about how his ability to drive is affected. (passmed.uk)
Which of the following statements about driving with diabetes under insulin control is correct? (passmed.uk)
People with type 2 diabetes can produce insulin, but the body is not able to use the insulin effectively. (emedicinehealth.com)

Fiasp is formulated with niacinamide, which helps increase the speed of the initial insulin absorption. (medscape.com)

These analogs were created by modifying the human insulin molecule to alter absorption rates and duration and time to action. (msdmanuals.com)
The duration of action is 3 to 5 hours - generally used before meals and always used along with short-acting or long-acting insulins to control sugar levels throughout the day. (passmed.uk)

Long-lasting insulin helps lower your blood glucose levels for up to 24 hours or longer, and it reaches your bloodstream more gradually. (healthline.com)
In a healthy person, several hormones tightly regulate the blood glucose level, primarily insulin. (emedicinehealth.com)
The body produces little or no insulin to regulate blood glucose level. (emedicinehealth.com)

Panels A and B show the normal daily profile of plasma glucose and insulin. (medscape.com)
Insulin isophane works by helping blood sugar ( glucose ) get into cells so your body can use it for energy. (webmd.com)
Plasma insulin concentrations and glucose infusion rates (GIRs) were assessed over 24 hours. (nih.gov)
Insulin allows glucose to move out of the blood into cells throughout the body, where it is used for fuel. (emedicinehealth.com)

In 2020, the combination of human insulin with insulin isophane was the 246th most commonly prescribed medication in the United States, with more than 1 million prescriptions. (wikipedia.org)
Insulin isophane is often used in combination with a shorter-acting insulin. (webmd.com)
Table 2 provides a list of combination insulin products. (medscape.com)
If those measures are not sufficient for glycemic control, patients may be prescribed oral antihyperglycemic drugs, injectable glucagon -like peptide-1 (GLP-1) receptor agonists, insulin , or a combination of these drugs. (msdmanuals.com)
The remedy itself is a combination of 40% of Regular insulin and 60% insulin NPH isophane solution. (insulin.store)

Never inject a mixture of different insulins into a vein. (webmd.com)

It is a soluble analog of human basal long-acting insulin with a flat and predictable profile of activity. (otc-online-store.com)
They are also known as long-acting or slow-acting insulin. (diabeticme.org)
Examples of long-acting insulins include Tresiba and Basaglar. (diabeticme.org)

These provide more flexibility in dosing, mimic endogenous production of insulin, and lower the incidence of nocturnal hypoglycemia. (medscape.com)

Continuous subcutaneous insulin infusion is receiving increased use as the pump technology advances, mainly incorporating the monomeric insulin analogues. (medscape.com)
Do not mix insulins if you are using an insulin pump . (webmd.com)

Consult your health care professional about which products may be mixed, the proper method for mixing insulin, and the proper way to inject mixtures of insulin. (webmd.com)

There are human and pig insulin based versions. (wikipedia.org)
medical citation needed] Synthetic 'human' insulin is also complexed with protamine to form NPH. (wikipedia.org)
Human Insulin: Clinical Pharmacological Studies in Normal Man. (wikipedia.org)
Isophane insulin human is a kind of biologic (a drug made from parts of living organisms). (healthline.com)
This rapid-acting human insulin analog can be dosed at the start of a meal or within 20 minutes after starting a meal. (medscape.com)
It is very similar to the human insulin produced in the body. (insulin.store)

In the same review no other clinically significant differences were found between different insulin analogues in either adults nor children. (wikipedia.org)

NPH insulin is made by mixing regular insulin and protamine in exact proportions with zinc and phenol such that a neutral-pH is maintained and crystals form. (wikipedia.org)
It starts to work more slowly but lasts longer than regular insulin. (webmd.com)
This product may be mixed only with certain other insulin products such as insulin regular. (webmd.com)
In the manufacturing of regular insulin, zinc atoms are added, causing the formation of hexamers. (medscape.com)

Furthermore, in order to experience the real benefits of insulin in bodybuilding, you're required to inject it after completing your workout. (swgoodies.com)
Do not inject cold insulin because this can be painful. (webmd.com)
An inhaled insulin preparation is also available for patients who prefer not to inject themselves. (msdmanuals.com)

The time to maximum insulin concentrations was achieved in roughly 63 minutes after administration. (medscape.com)

Unlike other insulin pens, the FlexTouch can remain unrefrigerated (once opened) for up to 42 days in temperatures 86 degrees Fahrenheit or cooler. (diabetesdaily.com)

It's the most common side effect of drugs that contain insulin . (healthline.com)

Why is It Necessary to Know How Long a Vial of Insulin Lasts? (diabeticme.org)

The purpose of insulin is to regulate blood sugar levels in the body. (diabeticme.org)

Doses of oral anti-diabetic medicines may also need to change, if your insulin is changed. (nih.gov)
Doses of insulin are measured in units. (swgoodies.com)

Anatomy21

Organisms12

Diseases30

Chemicals and Drugs125

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Psychiatry and Psychology1

Phenomena and Processes46

Technology, Industry, Agriculture4

Information Science3

Health Care7

Detemir12

Glargine2

Types of insulin4

Amount of insulin6

Levemir8

Lispro3

Dose11

Humulin10

Type 1 diabet13

Onset7

Pancreas11

Enough insulin2

Injection13

Lente2

Novolin2

Recombinant2

Basal insulin4

Rapid-acting2

Protamine zinc insulin1

Neutral Protamin2

Short-acting4

Body's1

Intermediate5

Syringe3

Humalog1

Daily insulin2

Diabetes19

Fiasp1

Duration2

Blood glucose3

Glucose4

Combination5

Mixture1

Long-Acting3

Mimic1

Pump2

Mixtures1

Human6

Analogues1

Regular4

Inject3

Maximum insulin1

FlexTouch1

Drugs1

Lasts1

Regulate blood1

Doses2