Insulin resistance syndrome metabolic syndrome x. Medical search. Frequent questions

11. Women with Polycystic Ovary syndrome (PCO syndrome) Manifests as irregular menses, excessive facial hair growth or facial acne. (doctorzaidi.com)
Metformin can help treat type 2 diabetes and polycystic ovary syndrome, but some people worry that it may cause hair loss. (medicalnewstoday.com)
Doctors sometimes also prescribe metformin for people with polycystic ovary syndrome (PCOS). (medicalnewstoday.com)
2001). Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial. (nature.com)
Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome. (nature.com)
Polycystic ovary syndrome (PCOS) is strongly associated with abdominal obesity and insulin resistance and effective approaches to nutrition (e.g., omega-3 fatty acids intake) might improve the cardiometabolic risk profile. (frontiersin.org)
Characterized by a series of manifestations of hyperandrogenemia, persistent anovulation, and ovarian polycystic changes ( 1 ), polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic disorders that affects 5 to 10% of women of reproductive age ( 2 ). (frontiersin.org)
[1] Various genetic factors can increase risk, such as a family history of diabetes, and there are some specific medical conditions associated with insulin resistance, such as polycystic ovary syndrome . (wikipedia.org)

Insulin resistance and concomitant hyperinsulinemia are presented in CKD patients in nondiabetic US adults [21]. (scirp.org)
In this protocol, a constant infusion of insulin is administered to the subject to cause hyperinsulinemia, and the rate of glucose infusion (glucose disposal) necessary to maintain euglycemia is determined. (basicmedicalkey.com)
In general, IR causes increased insulin secretion and reduced hepatic insulin clearance, resulting in systemic hyperinsulinemia. (basicmedicalkey.com)
Björntorp , P ( 1994 ) Fatty acids, hyperinsulinemia, and insulin resistance: which comes first? (cambridge.org)
Insulin resistance ( IR ) is a pathological condition in which cells either fail to respond normally to the hormone insulin or downregulate insulin receptors in response to hyperinsulinemia . (wikipedia.org)
The treatment of insulin resistance by decreasing hyperinsulinemia could improve sustained response rates in patients with chronic hepatitis C treated with peginterferon plus ribavirin. (isciii.es)
In the first phase of insulin resistance a compensatory hyperinsulinemia develops. (benthamscience.com)
Development of advanced glycation end products (AGEs), i.e. the cross-linking of proteins and glucose caused by chronically elevated levels of glucose and insulin in the blood causing hyperglycemia and hyperinsulinemia. (vitalitymagazine.com)

Progress in understanding the pathogenesis of the syndrome has been hindered by the challenge of understanding the complex relationships among features of MS, IR or insulin sensitivity, pancreatic β-cell function, and host factors. (basicmedicalkey.com)
Considering high prevalence rates of metabolic diseases linked by insulin resistance, we performed a systematic review of existing literature which addressed the role of probiotics in modulating insulin sensitivity in animals and humans. (biomedcentral.com)
It is a non-insulin-based alternative to insulin-based methods to quantify peripheral insulin sensitivity and an alternative to the Homeostatic Model Assessment (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI). (wikipedia.org)
METS-IR was compared against other non-insulin-based methods to approximate insulin sensitivity including the Triglyceride-Glucose index (TyG), the triglyceride to HDL-C ratio, and the TyG-BMI index, yielding a higher correlation and area under the receiving operating characteristic curve compared to these other measures. (wikipedia.org)
Given the role of ethnicity in modifying the performance of insulin sensitivity fasting-based indexes, further evaluations in different populations are required to establish performance of non-insulin-based methods. (wikipedia.org)
Similar metabolites and pathways were also related to insulin sensitivity (Matsuda index) in a separate study (POEM, n=501). (lu.se)
Studies have consistently shown that there is a link between insulin resistance and circadian rhythm, with insulin sensitivity being higher in the morning and lower in the evening. (wikipedia.org)
The Homeostasis Model for Assessment [HOMA= fasting insulin (mUI/ml) * fasting glucose (mmol/L) / 22.5] has proved useful in the measurement of insulin sensitivity in euglycemic patients. (isciii.es)
Thus, insulin resistance depends on insulin secretion and insulin sensitivity. (isciii.es)
Insulin secretion increases when insulin sensitivity decreases. (isciii.es)
At a certain level, increasing insulin secretion does no longer improve insulin sensitivity. (isciii.es)
The best method to measure insulin sensitivity is the hyperinsulinemic euglycemic clamp. (isciii.es)
This acts specifically to fuel the body and potentially improve insulin sensitivity. (selfgrowth.com)
The conclusion is that prescription of stevia in the doses of 250 and 500 mg/kg/d decreases the omentin level indirectly via activating insulin sensitivity and lowering blood glucose in STZ-induced diabetic rats. (researchgate.net)
Insulin resistance and metabolic syndrome also play an important role in the obesity epidemic because excess body fat impairs insulin sensitivity. (vitalitymagazine.com)
This study aimed to evaluate the effects of metformin and conjugated linoleic acid (CLA) on insulin sensitivity, measured via euglycemic-hyperinsulinemic clamp technique and insulin pathway expression molecules in muscle biopsies of children with obesity. (medscape.com)
For insulin sensitivity Rd value (mg/kg/min), there was a statistically significant difference between the CLA vs placebo (6.53 ± 2.54 vs 5.05 ± 1.46, P = 0.035). (medscape.com)
After analysis of covariance was performed and the influence of body mass index, age, Tanner stage, prescribed diet, and fitness achievement was controlled, a clinically relevant effect size on insulin sensitivity remained evident in the CLA group (37%) and exceeded lifestyle program benefits. (medscape.com)
Improvement of insulin sensitivity, measured via euglycemic-hyperinsulinemic clamp and IRS2 upregulation, favored patients treated with CLA. (medscape.com)
Metformin (MET) is a biguanide used for the treatment of type 2 diabetes in children and adolescents due to its ability to decrease hepatic glucose production and increase peripheral insulin sensitivity. (medscape.com)

Both approaches reduced PERK activation in the livers of obese, insulin-resistant mice and also reduced hyperglycemia. (childrenshospital.org)
The term metabolic syndrome (MS) is used to describe a cluster of metabolic disorders: insulin resistance (IR) or hyperglycemia, abdominal obesity, dyslipidemia (high very-low-density lipoprotein-triglyceride [VLDL-TG] concentration and low plasma high-density lipoprotein cholesterol [HDL-C]), and essential hypertension (HTN). (basicmedicalkey.com)
When insulin is unable to induce glucose uptake, pancreatic beta-cells increase insulin production and the hyperinsulinemic state prevents hyperglycemia. (isciii.es)
In type 2 diabetes, insulin resistance - in which the body does not use the hormone insulin properly - causes hyperglycemia. (everydayhealth.com)
Similarly, vitamin D has been associated with several markers of metabolic syndrome, including obesity, hyperglycemia, insulin resistance, and type 2 diabetes mellitus. (sciencedaily.com)

Now considered to be epidemic, metabolic syndrome increases people's risk of diabetes, heart disease, and stroke, as well as kidney and neurodegenerative disease. (childrenshospital.org)
Over past five years, studies have found an increase in a compound called TMAO in people with insulin resistance, diabetes, kidney disease, cardiovascular disease, and neurodegenerative disease. (childrenshospital.org)
In more advanced stages of insulin resistance, patients also develop high blood pressure and pre-diabetes or diabetes. (doctorzaidi.com)
Metabolic syndrome and abdominal obesity were defined according to the International Diabetes Federation criteria. (scirp.org)
Type 2 diabetes due to insulin-resistance can decrease SNCA gene expression in muscles. (biomedcentral.com)
Insulin resistance (IR) as the main hyperglycemic process in non-insulin dependent diabetes mellitus (NIDDM) is observed in many tissues such as adipose and skeletal muscle [ 2 ]. (biomedcentral.com)
Insulin resistance underlies a constellation of adverse metabolic and physiological changes (the insulin resistance syndrome) which is a strong risk factor for development of type 2 diabetes and CHD. (cambridge.org)
In obese patients with type 2 diabetes mellitus who require insulin therapy, at least one of the following is suggested: metformin, pramlintide, or GLP-1 agonists to mitigate associated weight gain due to insulin. (medscape.com)
IR is a core component of metabolic syndrome and type 2 diabetes ( 3 - 5 ). (frontiersin.org)
People with type 2 diabetes often have insulin resistance , which means that the cells in their body do not respond to insulin appropriately. (medicalnewstoday.com)
Metabolic syndrome is a group of five risk factors, that when left untreated, increase the likelihood of developing heart disease, diabetes, and stroke. (healthline.com)
Having three or more of these factors will result in a diagnosis of metabolic syndrome and will increase your risk of health complications including type 2 diabetes. (healthline.com)
The newer thinking is the metabolic disturbances of insulin resistance, often including obesity (more when the weight is carried in the belly), elevated blood sugar (even below the diabetes range), elevated triglycerides, sleep apnea, and fatty liver disease , as components. (baptisthealth.net)
PCOS entails diseases such as type 2 diabetes, hypertension, cardiovascular disease, and endometrial cancer ( 3 , 4 ), and insulin resistance (IR) and hyperandrogenemia might be closely associated with the pathogenesis of PCOS ( 5 ). (frontiersin.org)
Risk factors for insulin resistance include obesity , sedentary lifestyle , family history of diabetes, various health conditions, and certain medications. (wikipedia.org)
Thus, insulin concentrations are usually high early in type-2 diabetes, but have also been seen in many subjects who are not obese or diabetic, but who have other metabolic syndrome components such as hypertriglyceridemia or arterial hypertension (1). (isciii.es)
At present, obesity and obesity-related insulin resistance, metabolic syndrome and Type 2 diabetes mellitus (T2D) is a worldwide phenomenon. (medscape.com)
Even in patients with metabolic syndrome and diabetes, lipids play the major role in the development of atherosclerotic macrovascular complications. (medscape.com)
Remember that the main cause of type 2 diabetes is insulin resistance and the diet lowers the amount of insulin produced. (selfgrowth.com)
In fact, when you're educated about the disease - such as understanding how insulin resistance develops and how to mitigate it, knowing how to spot the signs of diabetes, and learning what to eat - you can tap into the resources you need to lead a happy, healthy life. (everydayhealth.com)
Type 1 (or 'juvenile') diabetes is an autoimmune condition that prevents the pancreas from producing enough insulin to regulate blood sugar levels. (everydayhealth.com)
At the root of type 2 diabetes is insulin resistance, and before you receive a type 2 diabetes diagnosis, you may be diagnosed with prediabetes. (everydayhealth.com)
Obesity was firstly described in 2000 as a cardiometabolic disease, even before Metabolic Syndrome, type 2 diabetes mellitus and coronary disease were considered as such. (benthamscience.com)
metabolic syndrome, type 2 diabetes, cardiovascular lesions and malignancies. (benthamscience.com)
Following a plant-based diet can reduce the risk of type 2 diabetes and metabolic syndrome. (blogarama.com)
We already know that the epidemic of obesity, insulin resistance, and diabetes is in large part due to the consumption of high fructose corn syrup in the American diet. (naturalnews.com)
Obesity and metabolic syndrome play a huge part in the epidemic of chronic inflammatory diseases including heart disease, cancer, and diabetes. (naturalnews.com)
Insulin resistance, metabolic syndrome, and type 2 diabetes are all conditions that may be curable or at least reversible in some people using specific diet and lifestyle changes. (vitalitymagazine.com)
Exercise is also a key component of a program to heal insulin resistance and reduce the risk of diabetes. (vitalitymagazine.com)
These clinical markers for insulin resistance, leading to metabolic syndrome and obesity, are the precursors for Type II diabetes. (vitalitymagazine.com)
A new study suggests that this same combination could help prevent metabolic syndrome, a constellation of conditions that increases the risk of heart disease, stroke, and diabetes in postmenopausal women. (sciencedaily.com)
11, 2022 Metabolic syndrome increases a person's risk for diabetes, heart disease, and stroke, and includes conditions such as obesity, high blood pressure and high blood sugar. (sciencedaily.com)
In the European Region, the Eastern Mediterranean Region and the Region of the Americas this proportion exceeds 50%.1 The mean body mass index has increased over the past 20 years, leading to adverse metabolic effects on blood pressure, cholesterol and triglyceride concentrations, and insulin resistance, thereby increasing the risks of coronary heart disease, ischaemic stroke, type 2 diabetes and polycystic ovarian syndrome. (who.int)
Insulin resistance precedes metabolic syndrome abnormalities and may promote cardiovascular disease and type 2 diabetes in children with obesity. (medscape.com)
[ 1 ] Insulin resistance has been recognized as the main physiopathological event preceding metabolic syndrome abnormalities and may promote cardiovascular disease and type 2 diabetes in individuals with obesity. (medscape.com)
The overall purpose of our research is to understand the molecular determinants underlying cognitive impairment associated with diabetes and metabolic syndrome components, including obesity, dyslipidaemia, hypertension, insulin resistance and hyperglycaemia. (lu.se)

Subsequent studies showed that most subjects with type 2 DM had resistance to insulin action in adipose tissue (inhibition of lipolysis), liver (inhibition of glucose production), and skeletal muscle (stimulation of glucose disposal) ( 14 , 15 , 16 ). (basicmedicalkey.com)
Lipodystrophy, lack of adipose tissue, is also associated with insulin resistance. (cambridge.org)
Any plausible explanation for the link between excess adipose tissue and insulin resistance needs to be able to account for this observation. (cambridge.org)
Adipose tissue in obesity becomes refractory to suppression of fat mobilization by insulin, and also to the normal acute stimulatory effect of insulin on activation of lipoprotein lipase (involved in fat storage). (cambridge.org)
This view of the link between adipose tissue and insulin resistance emphasises the important role of adipose tissue in 'buffering' the daily influx of dietary fat entering the circulation and preventing excessive exposure of other tissues to this influx. (cambridge.org)
METS-IR also predicts visceral fat content, subcutaneous adipose tissue, fasting insulin levels and ectopic fat accumulation in liver and pancreas. (wikipedia.org)
Visceral adipose tissue mass secretes a number of proinflammatory cytokines, adipokines and growth factors leading to low grade inflammatory process and insulin resistance. (benthamscience.com)

Promising results of fecal transplantation have also emerged from clinical trials including obese individuals with metabolic disturbances [ 9 ]. (biomedcentral.com)
Objective: We aimed to compare the plasma metabolome in obese subjects without metabolic syndrome (MetS) with normal-weight subjects without MetS and with obese subjects with MetS. (lu.se)
There are a number of risk factors for insulin resistance, including being overweight or obese or having a sedentary lifestyle . (wikipedia.org)
In obese subjects, adipokines and miokines interact to promote reticulum stress, insulin resistance, metabolic inflexibility and endothelial dysfunction. (benthamscience.com)
MET has beneficial effects on weight reduction and insulin resistance in obese nondiabetic individuals. (medscape.com)

The metabolic syndrome (MS) describes the association, in the same subject, of several traits such as central obesity, hypertension and dyslipidaemia, all of them very common conditions in developed countries. (scirp.org)
Other consequences of OSA that would then qualify for sleep apnea syndrome include refractory hypertension , depression, and fatigue. (medscape.com)

Most individuals with Insulin Resistance Syndrome/Metabolic Syndrome have abdominal obesity, low HDL cholesterol and high triglycerides. (doctorzaidi.com)
The progression of abdominal obesity and heart disease that lead to metabolic syndrome increases significantly as women age and appears to be directly associated with estrogen loss in postmenopausal women. (sciencedaily.com)
Metabolic syndrome - obesity, abdominal obesity, high blood pressure, high blood fats and insulin resistance - is. (lu.se)
Metabolic syndrome - obesity, abdominal obesity, high blood pressure, high blood fats and insulin resistance - is becoming increasingly common in the Western world. (lu.se)

To investigate the prevalence of metabolic syndrome (MetS) and of insulin resistance (IR) in an ethnically homogeneous cohort of established psoriatic arthritis (PsA), and to identify clinical associations of MetS and IR in patients with PsA. (asoi.info)

Patients with metabolic syndrome (MetS) have an increased risk of cardiovascular disease. (biomedcentral.com)
Introduction: Metabolic syndrome (MS) is a complex pathology that combines several risk factors for cardiovascular disease. (bvsalud.org)
Metabolic syndrome is an important cause of cardiovascular disease. (who.int)

Metabolic syndrome (Mes) was associated with insulin resistance and endothelial dysfunction. (scialert.net)

Alpha-synuclein (SNCA) as the presynaptic protein is expressed in different tissues and prevents insulin-resistance (IR) through increasing glucose-uptake by adipocytes and muscles. (biomedcentral.com)
The insulin-resistance was confirmed by the glucose-uptake assay. (biomedcentral.com)
In addition to the role of SNCA in cell susceptibility to insulin and glucose uptake, the SNCA expression can also be affected by insulin metabolism. (biomedcentral.com)
Insulin-mediated glucose uptake was found to vary by up to eightfold in healthy subjects. (basicmedicalkey.com)
Insulin resistance (IR) refers to an efficiency decline in the performance of insulin to promote glucose uptake and utilization in tissues or cells ( 1 , 2 ). (frontiersin.org)
Insulin, after binding its receptor, induces the phosphorylation of receptor substrates in the liver and muscles, and induces several steps toward the transactivation of GLUT-4, which increases glucose uptake by cells and its storage as glycogen, and inhibits the net production of glucose by the liver, thus blocking glycogenolysis and neoglycogenesis. (isciii.es)

What combination of these metabolic disorders will be present in a given person depends upon the severity and duration of the insulin resistance on one hand and that person's capacity to produce insulin on the other hand. (doctorzaidi.com)
These metabolic disorders also cluster in family members. (doctorzaidi.com)
A mismatch between the circadian rhythm and the meals schedule, such as in circadian rhythm disorders , may increase insulin resistance. (wikipedia.org)
These findings expand the concept of metabolic syndrome affecting the brain and provide the mechanistic evidence of how dietary habits can interact to regulate brain functions, which can further alter lifelong susceptibility to the metabolic disorders. (naturalnews.com)
WS and several other progeroid syndromes are epigenetically distinct disorders. (medscape.com)

At the end of the study significant reductions in fasting blood sugar (FBS), the homeostasis model assessment insulin resistance (HOMA-IR), triglyceride (TG), alkaline phosphatase (ALP), and Omentin level were found in groups 3 and 4 in comparison with group 2. (researchgate.net)

In states of insulin resistance, the same amount of insulin does not have the same effect on glucose transport and blood sugar levels. (wikipedia.org)
Thus, an abnormally large amount of insulin is required to achieve a biological response. (isciii.es)

However, the effect of insulin metabolism on SNCA expression has scarcely elucidated. (biomedcentral.com)
Although a focus is often placed on insulin as a regulator of blood glucose, insulin plays a key role in the regulation of lipid and protein metabolism, in addition to cellular growth and development. (basicmedicalkey.com)
Resistance emerges as a consequence of the inability of insulin to induce its effect on glucose metabolism. (isciii.es)
And it suggests that taking DHA improves insulin metabolism, even with a diet containing fructose that induces insulin resistance. (naturalnews.com)
This study tells us that fructose also results in dysfunction in the brain associated with insulin metabolism. (naturalnews.com)
Insulin is the hormone that regulates cellular nourishment by aiding in the absorption and metabolism of nutrients from the blood. (vitalitymagazine.com)

The hyperinsulinemic state induces several abnormalities in the liver, endothelium, and kidneys, and is the main feature in the metabolic syndrome. (isciii.es)
GHD in adults is recognized as a distinct clinical syndrome that encompasses reduced psychological well-being and specific metabolic abnormalities. (medscape.com)
Metabolic abnormalities, including insulin resistance, may not be a pivotal part at disease onset. (medscape.com)

Many hormones can induce insulin resistance including cortisol , [14] growth hormone , and human placental lactogen . (wikipedia.org)
In transgenic mice models the HCV core protein has been found to induce insulin resistance via TNF production. (isciii.es)
Besides, virus C infection may induce insulin resistance by blocking intracellular signaling, and lastly, insulin resistance has been associated with a decreased rate of sustained response to peginterferon alpha plus ribavirin in patients with chronic hepatitis C. (isciii.es)

Our findings open the door to new treatments or dietary approaches that might reduce TMAO, decrease the effects of insulin resistance, and prevent metabolic syndrome and its health effects," she says. (childrenshospital.org)

Insulin resistance was defined by Homeostasis Model Assessment Index >P75. (scirp.org)
The multivariable linear regression model was applied to analyze the associations of dietary and serum omega-3 fatty acids with the levels of Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and body composition parameters among PCOS patients. (frontiersin.org)

The relative risks of having the metabolic syndrome were 1.8 (95% CI 1.0-3.1) and 1.6 (0.9-2.7) times higher in the low- and moderate-CRF groups, respectively, compared with the high-CRF group after adjusting for age, visceral fat, and subcutaneous fat ( P for trend = 0.06). (diabetesjournals.org)

The importance of the MS as a chronic cardiovascular risk factor and the role of insulin resistance (IR) as its principal underlying cause have been under discussion recently [7]. (scirp.org)

These methods have proved critical in dissecting the complex relationships between organ-specific IR and insulin secretion. (basicmedicalkey.com)
RESEARCH DESIGN AND METHODS -The sample studied comprised 297 apparently healthy men with available computed tomography or magnetic resonance imaging scans of the abdomen, metabolic data, and maximal treadmill exercise test results. (diabetesjournals.org)

Metabolic syndrome is closely associated with insulin resistance, in which cells fail to respond appropriately to insulin, a hormone that regulates multiple cell metabolic processes such as taking up sugar from the blood. (childrenshospital.org)

Our work suggests that this could all be mediated by a TMAO/PERK pathway - tying in insulin resistance with all different components of metabolic syndrome. (childrenshospital.org)
However, there is not any clear principal mechanism of SNCA interactions with molecules in the insulin-dependent intracellular pathway. (biomedcentral.com)
We first identified 51 active compounds from SZT and their 81 potential molecular targets by high-throughput computational analysis, from which we identified 4 major pathways including Th17 cell differentiation, metabolic pathways, pathways in cancer, and the PI3K-Akt signaling pathway. (hindawi.com)

The animals of the study involved the measurements of fasting blood glucose, oral-glucose-tolerance-test, as well as fasting plasma insulin. (biomedcentral.com)
The availability of the insulin immunoassay, developed by Yalow and Berson in 1960, established that most patients with DM had higher plasma insulin levels than healthy subjects ( 6 ). (basicmedicalkey.com)
These and subsequent studies showed that more insulin-resistant subjects had greater plasma insulin concentration, VLDL-TG, and plasma glucose during the oral glucose tolerance test than did insulin-sensitive subjects, findings supporting the relationship between IR and MS ( 26 ). (basicmedicalkey.com)
[ 13 ] For these patients, concerns are the persistent insulin resistance and dyslipidemia, together with the elevated plasma insulin and lipoprotein(a) levels observed with GH replacement. (medscape.com)

Indeed, IS is a very complex phenomenon which is influenced not only by the cellular metabolic status but also interacts with circulating molecules such as hormones (including insulin), nutrients and inflammatory molecules. (biomedcentral.com)
Mounting research links metabolic syndrome directly to an increased inflammatory state in the body and, specifically, in blood vessels. (baptisthealth.net)
Fat cells secrete inflammatory proteins that interfere with insulin receptors, exacerbating insulin resistance. (vitalitymagazine.com)

According to this group, the reasons for a new definition that could meet with universal acceptance, in contrast to that of the ATP-III, was to allow easy identification in clinical practice, worldwide, of those individuals with the syndrome, taking into account the different ethnics. (scirp.org)
Efficacy of high-intensity interval- or continuous aerobic-training on insulin resistance and muscle function in adults with metabolic syndrome: a clinical trial. (bvsalud.org)
We carried out a randomized, clinical trial in adults of both sexes with metabolic syndrome (MS) to assess the efficacy of high-intensity, low-volume interval training (HIIT) compared to moderate-intensity continuous training (MICT) on insulin resistance (IR), muscle mass, muscle activation, and serum musclin. (bvsalud.org)
Previous clinical studies and randomized controlled trials have revealed that low serum vitamin D levels are associated with the risk of developing insulin resistance. (frontiersin.org)
There are multiple ways to measure insulin resistance such as fasting insulin levels or glucose tolerance tests, but these are not often used in clinical practice. (wikipedia.org)
In young adults, mutation in the Werner syndrome (WS) gene is believed to be associated with clinical symptoms typically found in elderly individuals. (medscape.com)

Aims: we investigate whether insulin resistance is associated with an increased prevalence for chronic kidney disease irrespective of the concurrent presence of metabolic syndrome. (scirp.org)
The present work was directed to analyse the information of an observational Spanish study in adult population (DESIRE study) [22] in order to investigate the association of insulin resistance with the risk of chronic kidney disease (CKD) in a non diabetic population. (scirp.org)
The complications that may result from metabolic syndrome are frequently serious and long-term (chronic). (healthline.com)
Science seems to be moving towards an association of the drivers of vascular inflammation that leads to coronary artery disease and other chronic diseases and Alzheimer's, seemingly through insulin resistance. (baptisthealth.net)
Currently, some evidence supports a relationship between insulin resistance and hepatitis C. Indeed, insulin resistance is more often seen in patients with chronic hepatitis C than in weight-matched healthy controls, and correlates with fibrosis progression. (isciii.es)

There are many causes of insulin resistance and the underlying process is still not completely understood. (wikipedia.org)

With the worldwide increasing prevalence of obesity and metabolic syndrome, the issue of appropriate risk markers and treatment goals is even more important. (medscape.com)
Its phenotype is changing from single lesions to multiple lesions owing to the reduction in estrogen exposure and increasing incidence of obesity and metabolic syndrome as driving factors in the formation of hepatic adenoma. (medscape.com)

Replacement of GH in adults with GHD markedly reduces central obesity and substantially reduces total cholesterol levels but has produced little change in other risk factors, particularly insulin resistance and dyslipidemia. (medscape.com)
Few studies have logical condition characterized by high blood pressure, been done in more deprived regions and regions with low central obesity, insulin resistance, dyslipidaemia and income (9) . (who.int)

The relationship between IR and insulin secretion is complex. (basicmedicalkey.com)
In response, beta cells in the pancreas step up the secretion of insulin to deal with the blood sugar spike, facilitating glucose transport through cell membranes and lowering blood sugar. (vitalitymagazine.com)

Insulin is a hormone produced by our pancreas. (doctorzaidi.com)
Insulin, a hormone made by the pancreas, helps glucose (which comes from the food you eat) in your blood enter cells within your muscles, fat, and liver, where it can then be used for energy. (thefitnessnutritionists.com)
As a result, our pancreas makes more insulin to help glucose enter our cells, and as long as it can do this, your blood glucose levels will remain in a healthy range. (thefitnessnutritionists.com)
Problems compound when we overeat on refined carbs and sugar too often: That fat will start depositing around our organs, making it harder for insulin to come out of the pancreas. (thefitnessnutritionists.com)
Insulin is released by the pancreas in response to carbohydrates consumed in the diet. (wikipedia.org)
But when blood sugar levels are chronically elevated, the pancreas becomes stressed and progressively more dysfunctional, unable to produce enough insulin to deal with the spikes. (vitalitymagazine.com)

Association between high-density lipoprotein subfractions and low-grade inflammation, insulin resistance, and metabolic syndrome components: The ELSA-Brasil study. (bvsalud.org)

The risk factors for metabolic syndrome are related to obesity. (healthline.com)

[3] It is hypothesized that increasing cell membrane fluidity by increasing PUFA concentration might result in an enhanced number of insulin receptors, an increased affinity of insulin to its receptors, and reduced insulin resistance. (wikipedia.org)

Insulinemia and homeostatic model assessment of insulin resistance significantly improved in the CLA group ( P = 0.045). (medscape.com)

Until the 1960s, the prevailing belief was that an absolute insulin deficiency was the primary metabolic defect in type 2 DM. (basicmedicalkey.com)
Vitamin D deficiency has also been associated with insulin resistance. (wikipedia.org)
Agrawal R and Gomez-Pinilla F. 'Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition. (naturalnews.com)
These results suggest a synergistic role of vitamin D and estradiol deficiency in developing metabolic syndrome in postmenopausal women. (sciencedaily.com)
Findings are published in the article "The synergistic effects of vitamin D and estradiol deficiency on metabolic syndrome in Chinese postmenopausal women. (sciencedaily.com)
In this cross-sectional study, low estradiol increased the risk of metabolic syndrome in postmenopausal women who had vitamin D deficiency," says Dr. JoAnn Pinkerton, NAMS executive director. (sciencedaily.com)

In this study, the authors showed that leptin increases serine-138 phosphorylation of insulin receptor substrates-1 (IRS-1). (biomedcentral.com)
Foods that have independently been linked to insulin resistance include those high in sugar with high glycemic indices , low in omega-3 and fiber, and which are hyperpalatable which increases risk of overeating. (wikipedia.org)
Sedentary lifestyle increases the likelihood of development of insulin resistance. (wikipedia.org)

Cortisol counteracts insulin and can lead to increased hepatic gluconeogenesis , reduced peripheral utilization of glucose, and increased insulin resistance. (wikipedia.org)

Data obtained from muscle biopsies have demonstrated altered insulin signaling (IS) in patients with MetS. (biomedcentral.com)
In patients with MetS, we found a reduction of mTOR and other mTOR-related molecules involved in insulin resistance, cell repair, coagulation and vasculogenesis. (biomedcentral.com)
This study aimed to examine the associations of dietary and serum omega-3 fatty acids with insulin resistance (IR) and body composition among PCOS patients. (frontiersin.org)
Higher levels of dietary and serum omega-3 PUFAs, particularly long-chain omega PUFAs (DPA and DHA), might have beneficial effects on metabolic parameters and body composition among PCOS patients. (frontiersin.org)
Indeed, insulin resistance has been found as a common denominator to the majority of features associated with difficult-to-treat patients. (isciii.es)
Insulin resistance strongly influences sustained response rates, at least in genotype-1 patients. (isciii.es)
Insulin resistance decreases during and after treatment in patients that achieved virus C clearance. (isciii.es)
The mean survival for patients with Werner syndrome (WS) is 46 years. (medscape.com)

Moreover, upregulated expression of the insulin receptor substrate 2 was evident in muscle biopsies of the CLA group. (medscape.com)

Moreover, insulin promotes lipid storage by inhibiting lipolysis. (isciii.es)

[2] Overconsumption of fat- and sugar-rich meals and beverages have been proposed as a fundamental factor behind the metabolic syndrome epidemic. (wikipedia.org)

Vitamin D may modulate various metabolic processes and may influence cardiometabolic disease risk in Canadians. (cdc.gov)

Insulin is a hormone that facilitates the transport of glucose from blood into cells, thereby reducing blood glucose (blood sugar). (wikipedia.org)

In present study we assessed the probable effect of insulin resistance on SNCA expression in muscle C2C12 cells and also skeletal muscle tissues of type 2 diabetic mice. (biomedcentral.com)

Up to a third of U.S. adults have metabolic syndrome, a constellation of high blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol levels. (childrenshospital.org)

Recently, concern has been raised for MetS, and no unifying cause of the syndrome has yet been identified [ 4 ]. (biomedcentral.com)
Therefore, IS of insulin seems to be impaired at least at the IRS-1 level in MetS. (biomedcentral.com)
METS-IR is currently validated for its use to assess cardio-metabolic risk in Latino population. (wikipedia.org)
In a nation-wide population-based study of Chinese subjects, METS-IR was also shown to identify subjects with metabolic syndrome independent of adiposity. (wikipedia.org)

12:37] How to lower your risk of developing insulin resistance. (thefitnessnutritionists.com)
However, the effect of dietary magnesium intake on the relationship between vitamin D and the risk of developing insulin resistance has not been comprehensively investigated. (frontiersin.org)
We assessed differences between serum vitamin D levels and the risk of developing insulin resistance (interaction test), using a weighted multivariate logistic regression to analyze differences between participants with low and high magnesium intake levels. (frontiersin.org)
Having one of these risk factors does not mean that you have metabolic syndrome. (healthline.com)
What are the risk factors for metabolic syndrome? (healthline.com)
There are other factors that can increase your risk for metabolic syndrome. (healthline.com)
If you have one of the five risk factors of metabolic syndrome, talk with a doctor to determine whether you should be tested for the others. (healthline.com)
If you are diagnosed with metabolic syndrome, the goal of treatment will be to reduce your risk of developing further health complications. (healthline.com)
Excessive insulin level is not only a potential cause of hyperandrogenemia but also one of the high-risk factors leading to metabolic syndromes among those with PCOS ( 6 ). (frontiersin.org)
Mean energy and macronutrient intakes and prevalence of risk factors including metabolic syndrome were compared between and within cases and controls. (who.int)
Supplementation with vitamin D has been shown to reduce the risk of metabolic syndrome over a 20-year follow-up. (sciencedaily.com)
OBJECTIVE -Moderate to high levels of cardiorespiratory fitness (CRF) are associated with a lower risk of the metabolic syndrome and all-cause mortality. (diabetesjournals.org)
It is also reported that high levels of cardiorespiratory fitness (CRF) are associated with lower risk of metabolic syndrome ( 3 ) and all-cause mortality ( 4 - 6 ). (diabetesjournals.org)

Alongside diet and exercise, metformin can help a person control their insulin and blood sugar levels. (medicalnewstoday.com)
According to the study, this diet has the ability of boosting the conventional cancer treatment by inducing metabolic oxidative stress in cancer cells. (selfgrowth.com)
The diet may as well help preserve lean body mass during the process of weight loss which eventually helps in metabolic shutdown. (selfgrowth.com)
Anyone whose diet is high in sugar and refined carbohydrates will eventually face insulin resistance. (vitalitymagazine.com)

This belief persisted despite studies performed as early as the 1930s that indicated that resistance to insulin-mediated stimulation of glucose clearance was present in subjects with type 2 DM ( 1 , 2 , 3 , 4 , 5 ). (basicmedicalkey.com)
The first-line insulin for this type of patient should be basal insulin. (medscape.com)
Some medications are associated with insulin resistance including corticosteroids , protease inhibitors (type of HIV medication), [11] and atypical antipsychotics . (wikipedia.org)
Type 2, on the other hand, stems from insulin resistance, where the body may make enough insulin at first but cannot use it properly to ferry glucose to the cells. (everydayhealth.com)

Since the basal expression of SNCA in the muscle cells in response to insulin has not been investigated to date, we decided to examine the expression of SNCA in insulin-resistant (IR) and insulin-sensitive (IS) models of skeletal muscle cells in both in vitro and in vivo studies. (biomedcentral.com)

The interplay between TMAO and PERK could give a new framework for understanding insulin resistance and metabolic syndrome, and the host of diseases they predispose us to - stroke, heart attack, kidney failure and more, says Biddinger. (childrenshospital.org)
Insulin resistance is more often seen in hepatitis C than in other liver diseases, including non-alcoholic steatohepatitis. (isciii.es)

These cycles accelerate, and eventually pancreatic insulin production collapses and fat is no longer oxidized. (vitalitymagazine.com)

Anatomy17

Organisms8

Diseases68

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Psychiatry and Psychology4

Phenomena and Processes64

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science5

Named Groups4

Health Care27

Geographicals5

Polycystic ovary sy8

Hyperinsulinemia8

Sensitivity20

Hyperglycemia5

Diabetes36

Adipose tissue7

Obese5

Hypertension2

Abdominal4

Prevalence of Metabolic Syndrome1

Cardiovascular disease3

Endothelial dysfunction1

Glucose uptake6

Disorders5

Triglyceride1

Amount of insulin2

Metabolism6

Abnormalities3

Induce insulin resistance3

Prevent metabolic syndrome1

Homeostasis Model Assessment2

Visceral1

Role of insulin1

Methods2

Hormone that regulates1

Pathway3

Plasma insulin4

Inflammatory3

Clinical6

Chronic5

Causes of insulin resistance1

Obesity and metabolic syndrome2

Central obesity2

Secretion2

Pancreas6

Inflammation1

Related to obesity1

Receptors1

Homeostatic1

Deficiency6

Increases3

Hepatic1

Patients8

Receptor1

Lipid1

Epidemic1

Cardiometabolic disease1

Blood glucose1

Effect of insulin1

Constellation1

MetS4

Risk13

Diet4

Type4

Basal1

Diseases2

Pancreatic1