HypertensionDyslipidemiaDiabetes mellitusAbdominal obesityFeatures of the metabolic syndromeCircumferenceAbnormalitiesPrevalenceHyperinsulinemiaCardiovascular diseasePeople with metabolic syndromePolycysticGlucose and insulin levelsHyperglycemiaTriglyceridesMetSComplicationsInclude insulin resistanceObeseClinicalComponents of the metabolic syndromePathwaysAdiposeWaistDyslipidaemiaDiseasesEpidemicDisordersTriglycerideOverweight and obesityDiagnosisCauses of metabolic syndromePathogenesis2017PCOSCriteria for metabolic syndromeIncidence of metabolic syndromeAnthropometricSystolic blood prChildhood obesityPresence of central obesityInflammationPancreasSignificantlyStrongly associatedLevelsCoronaryPhenotypeConclusionsAtherosclerosisEndocrineCardiometabolicSymptomsDisorderSerumFactorsClusterAdultsAdolescentsLipids
Hypertension12
- Many people with metabolic syndrome used to be told they had pre-diabetes, early hypertension (high blood pressure) or mild hyperlipidemia (high fats in the blood). (medlineplus.gov)
- Obesity has definitely become a growing problem, but a lot of anti-obesity educations, with fen-peen as the best example, have proven to have very damaging side-effects like lung hypertension and heart valve condition (Fen Peen, 2010). (directcurrentmusic.com)
- PCOS entails diseases such as type 2 diabetes, hypertension, cardiovascular disease, and endometrial cancer ( 3 , 4 ), and insulin resistance (IR) and hyperandrogenemia might be closely associated with the pathogenesis of PCOS ( 5 ). (frontiersin.org)
- The metabolic syndrome (MS) describes the association, in the same subject, of several traits such as central obesity, hypertension and dyslipidaemia, all of them very common conditions in developed countries. (scirp.org)
- While previous studies on Montmorency tart cherries have explored individual aspects of metabolic syndrome - such as blood pressure and triglycerides - this is the first study to examine the full cluster of conditions that comprise metabolic syndrome, including insulin resistance, hypertension, and central obesity, or belly fat. (medindia.net)
- Overexpression of 11beta-HSD-1 in mouse adipose tissue leads to a metabolic syndrome-like phenotype including increased central obesity, hypertension, impaired glucose tolerance, and hypertriglyceridemia. (genengnews.com)
- Besides effective control of blood pressure in patients with hypertension, third-generation beta-blockers such as nebivolol offer additional benefits for central hemodynamics and neutral or beneficial effects on metabolism. (nih.gov)
- The present article will provide a systematic analysis of the pathophysiological links among hypertension, insulin resistance, and metabolic syndrome. (nih.gov)
- Metabolic Syndrome (MetS) is a complex disorder that involves a cluster of metabolic abnormalities, including central obesity, insulin resistance, dyslipidemia, and hypertension. (hilarispublisher.com)
- As for the main components of the metabolic syndrome include insulin resistance, central obesity, hypertension, and dyslipidemia. (isainsmedis.id)
- Patients reporting a history of hypertension, dyslipidemia, or hyperglycemia warrant screening for metabolic syndrome. (medscape.com)
- Along with fostering increased type 2 diabetes, the obesity pandemic is also leading to an increase in metabolic syndrome , characterized by hypertension and lipid problems in addition to insulin resistance , said Feldman. (medscape.com)
Dyslipidemia5
- Obesity can induce type 2 diabetes mellitus, dyslipidemia, cardiovascular disease and other chronic disorders with high social and health costs. (benthamscience.com)
- Furthermore, central obesity led to the progression of metabolic syndrome, defined as a tendency of hyperinsulinemia, insulin resistance, and dyslipidemia [ 10 ]. (biomedcentral.com)
- They have led to a growing incidence of obesity, dyslipidemia, high blood pressure, and a condition known as the insulin-resistance syndrome or metabolic syndrome. (nih.gov)
- Replacement of GH in adults with GHD markedly reduces central obesity and substantially reduces total cholesterol levels but has produced little change in other risk factors, particularly insulin resistance and dyslipidemia. (medscape.com)
- [ 13 ] For these patients, concerns are the persistent insulin resistance and dyslipidemia, together with the elevated plasma insulin and lipoprotein(a) levels observed with GH replacement. (medscape.com)
Diabetes mellitus9
- Obesity was firstly described in 2000 as a cardiometabolic disease, even before Metabolic Syndrome, type 2 diabetes mellitus and coronary disease were considered as such. (benthamscience.com)
- Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. (biomedcentral.com)
- Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance (IR), is an increasing problem in affluent societies. (biomedcentral.com)
- Diabetes mellitus (DM) is a chronic condition that occurs when the body can not produce enough insulin or can not use insulin, resulting in an increase of glucose in the blood. (isainsmedis.id)
- For example, patients with insulin resistance and hyperglycemia or with diabetes mellitus may have acanthosis nigricans, hirsutism, peripheral neuropathy, and retinopathy. (medscape.com)
- Prediction of type 2 diabetes mellitus with alternative definitions of the metabolic syndrome: the Insulin Resistance Atherosclerosis Study. (medscape.com)
- The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. (medscape.com)
- Young people with insulin- dependent diabetes mellitus (IDDM) may have a higher prevalence of eating disorders, such as anorexia nervosa and bulimia, and adults with longstanding diabetes and major medical complications have a higher prevalence of symptoms of depression and anxiety. (cdc.gov)
- Elderly persons who have non-insulin-dependent diabetes mellitus (NIDDM) and other symptomatic medical conditions may also have a higher risk of developing psychological problems. (cdc.gov)
Abdominal obesity8
- Polycystic ovary syndrome (PCOS) is strongly associated with abdominal obesity and insulin resistance and effective approaches to nutrition (e.g., omega-3 fatty acids intake) might improve the cardiometabolic risk profile. (frontiersin.org)
- Cardiometabolic risk (CMR), also known as metabolic syndrome or insulin resistance syndrome, comprises obesity (particularly central or abdominal obesity), high triglycerides, low HDL, elevated blood pressure, and elevated plasma glucose. (healthpartners.com)
- Methods: 1638 patients with abdominal obesity were selected. (scirp.org)
- Metabolic syndrome and abdominal obesity were defined according to the International Diabetes Federation criteria. (scirp.org)
- From the initial sample of 2341 subjects selected, 211 did not have the inclusion criteria (abdominal obesity by IDF criteria for European population and basal plasma glucose >90 mg/dl). (scirp.org)
- This program addresses several features of the metabolic syndrome, a combination of disorders including abdominal obesity, high blood pressure, and insulin resistance or glucose intolerance, all of which contribute to an increased risk of coronary heart disease, stroke, and type 2 diabetes. (genengnews.com)
- Metabolic syndrome describes an obese person with central or abdominal obesity (a fat stomach) who also tends to have a poor cholesterol profile, high blood sugar and insulin and the attendant insulin resistance, high blood pressure, and clogged arteries. (virginiahopkinshealthwatch.com)
- The physical examination is crucial in patients with metabolic syndrome, as the findings of elevated blood pressure and abdominal obesity are 2 of the 5 diagnostic criteria. (medscape.com)
Features of the metabolic syndrome2
- CONCLUSIONS -Insulin resistance alone does not underlie all features of the metabolic syndrome. (diabetesjournals.org)
- Patients with low HDL-C levels often also have central obesity, insulin resistance and other features of the metabolic syndrome. (ox.ac.uk)
Circumference13
- Waterpipe smoking, sex, low-density lipoprotein and wrist circumference were also associated with metabolic syndrome. (who.int)
- The International Diabetes Federation defines central obesity in people of European descent as a waist circumference of 94 cm or more in men and 80 cm or more in women. (mydr.com.au)
- Central obesity in teenagers with waist circumference above 94cm in male or 80cm in female, places them at higher risk of developing insulin resistance and high fasting glucose. (mountelizabeth.com.sg)
- Measurement and documentation of waist circumference are important routines when screening for metabolic syndrome. (medscape.com)
- Metabolic profiles and WC, hip circumference, pelvic width and body mass index (BMI) were determined. (ucc.ie)
- and those with metabolic syndrome, a combination of disorders that includes insulin resistance, a high waist circumference (central obesity) and other factors. (healthconfidential.com)
- We examined the utility of body mass index (BMI) and waist circumference to identify metabolic syndrome in adolescent girls. (cdc.gov)
- Participants were designated as having metabolic syndrome if they met criteria for 3 of 5 variables: 1) high blood pressure, 2) low high-density lipoprotein cholesterol level, 3) high fasting blood glucose level, 4) high waist circumference, and 5) high triglyceride level. (cdc.gov)
- We predicted the likelihood of the presence of metabolic syndrome by using previously established cutpoints of BMI and waist circumference. (cdc.gov)
- 001). Girls with a waist circumference above the cutpoint were more likely than girls with a waist circumference below the cutpoint to have metabolic syndrome ( P = .002). (cdc.gov)
- Stepwise regression showed that only waist circumference significantly predicted metabolic syndrome. (cdc.gov)
- Waist circumference was a better predictor of metabolic syndrome than was BMI in our study sample of predominantly African American female adolescents living in an urban area. (cdc.gov)
- Clinical diagnosis is made on the basis of the presence of 3 of 5 conditions: 1) high triglyceride level, 2) low high-density lipoprotein (HDL) cholesterol level, 3) high fasting blood glucose level, 4) presence of central obesity (ie, high waist circumference), and 5) high blood pressure ( 1 ). (cdc.gov)
Abnormalities5
- Blood pressure management in hypertensive patients with metabolic abnormalities is challenging, since many of the antihypertensive drugs adversely affect metabolism. (nih.gov)
- Mowat-Wilson Syndrome (MWS) is a syndrome with multiple congenital abnormalities first clinically delineated by Mowat DR, et al. (hilarispublisher.com)
- As such, it is unclear among individuals with diabetes whether assessing MetS severity would be an accurate means of tracking metabolic abnormalities over time and predicting future CHD. (biomedcentral.com)
- The alarming increase in the prevalence of obesity or MetS is likely to further exacerbate the risk for ophthalmic abnormalities associated with obesity. (molvis.org)
- GHD in adults is recognized as a distinct clinical syndrome that encompasses reduced psychological well-being and specific metabolic abnormalities. (medscape.com)
Prevalence7
- Aims: we investigate whether insulin resistance is associated with an increased prevalence for chronic kidney disease irrespective of the concurrent presence of metabolic syndrome. (scirp.org)
- Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder, with a prevalence of 4-20% depending on the diagnostic criteria used, among reproductive-aged women [ 1 ]. (biomedcentral.com)
- Not surprisingly, the two-year diet researchers concluded that, "A Mediterranean-style diet might be effective in reducing the prevalence of the metabolic syndrome and its cardiovascular disease," which is a roundabout way of saying that most of the participants were healthier at the end of the study. (virginiahopkinshealthwatch.com)
- Prevalence of metabolic syndrome compared between native Japanese and Japanese-Americans. (medscape.com)
- Epidemiological studies suggest that the prevalence and severity of obesity have increased to epidemic proportions worldwide, making it a global public health problem. (molvis.org)
- In the Southern region the prevalence of excess weight was 56.8% for males and 51.6% in females as well as being the region with the highest percentage of obesity: 15.9% of men and 19.6% of women. (bvsalud.org)
- The most current data show that a 9.2% prevalence of metabolic syndrome from 1988 through 1994 increased to 12.7% from 1999 through 2000 ( 6 ). (cdc.gov)
Hyperinsulinemia7
- PCOS can also be accompanied by obesity because central obesity could exaggerate IR and lead to hyperinsulinemia ( 7 ). (frontiersin.org)
- Insulin resistance and concomitant hyperinsulinemia are presented in CKD patients in nondiabetic US adults [21]. (scirp.org)
- In the first phase of insulin resistance a compensatory hyperinsulinemia develops. (benthamscience.com)
- Women with PCOS manifest clinical symptoms like menstrual dysfunction, hirsutism, insulin resistance, and hyperinsulinemia. (biomedcentral.com)
- As excessive amounts of insulin levels directly increase ovarian production of androgens, hyperinsulinemia and insulin resistance are considered as the pathogenesis factors of PCOS. (biomedcentral.com)
- Giovannucci E. Metabolic syndrome, hyperinsulinemia, and colon cancer: a review. (medscape.com)
- The glucose excess elicits hyperinsulinemia, which may derive, in the end, into insulin resistance. (medscape.com)
Cardiovascular disease7
- Metabolic syndrome is an important cause of cardiovascular disease. (who.int)
- Having metabolic syndrome doubles your risk of having cardiovascular disease, such as heart attack or stroke, compared with people who don't have this syndrome. (mydr.com.au)
- Nearly 35 percent of U.S. adults are estimated to have metabolic syndrome, which significantly increases the risk of cardiovascular disease and type 2 diabetes. (medindia.net)
- The metabolic syndrome is prevalent and is associated with a greater risk of atherosclerotic cardiovascular disease than any of its individual components. (naturalayurvedictreatment.com)
- Metabolic syndrome can increase the risk of type 2 DM and cardiovascular disease. (isainsmedis.id)
- Can metabolic syndrome usefully predict cardiovascular disease and diabetes? (medscape.com)
- The metabolic syndrome classification is of interest in epidemiologic studies because of its ability to predict the development of cardiovascular disease (CVD) and type 2 diabetes in adults ( 2 ). (cdc.gov)
People with metabolic syndrome5
- People with metabolic syndrome have an increased long-term risk of developing heart disease, type 2 diabetes, stroke, kidney disease, and poor blood supply to the legs. (medlineplus.gov)
- The purpose of this study is to examine the effect of long-term treatment with low doses of chloroquine on atherosclerosis in people with metabolic syndrome. (druglib.com)
- People with metabolic syndrome not only have an increased risk of heart disease, but their risk of stroke and diabetes is also higher than average. (mydr.com.au)
- People with metabolic syndrome, who have a combination of several of these risk factors rolled into one, are at even higher risk of these problems. (mydr.com.au)
- Insulin resistance and central obesity also put you at high risk of developing diabetes - people with metabolic syndrome have 5 times the risk of developing type 2 diabetes. (mydr.com.au)
Polycystic8
- Characterized by a series of manifestations of hyperandrogenemia, persistent anovulation, and ovarian polycystic changes ( 1 ), polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic disorders that affects 5 to 10% of women of reproductive age ( 2 ). (frontiersin.org)
- Polycystic ovary syndrome (PCOS) is one of the most frequent endocrine disorders among women of fertile age. (biomedcentral.com)
- High insulin and the resulting high androgens are the underlying cause of polycystic ovary syndrome (PCOS) which can cause terrible ovarian pain, PMS and excess hair growth. (virginiahopkinshealthwatch.com)
- If you have PCOS, or if you are a woman who has been diagnosed with Polycystic Ovary Syndrome , then this article will be helpful. (postureclinic.in)
- Polycystic ovary syndrome is a condition that affects women's menstrual cycles and fertility. (postureclinic.in)
- Physiotherapists can teach women with polycystic ovary syndrome (PCOS) movement patterns and exercise that will help them to manage the symptoms. (postureclinic.in)
- Finally, a thorough review of systems may help to identify related problems, such as menstrual irregularities that can be seen in polycystic ovarian syndrome. (medscape.com)
- In the European Region, the Eastern Mediterranean Region and the Region of the Americas this proportion exceeds 50%.1 The mean body mass index has increased over the past 20 years, leading to adverse metabolic effects on blood pressure, cholesterol and triglyceride concentrations, and insulin resistance, thereby increasing the risks of coronary heart disease, ischaemic stroke, type 2 diabetes and polycystic ovarian syndrome. (who.int)
Glucose and insulin levels2
- Elevated triglyceride, glucose and insulin levels may be associated with increased IR, which in turn is related to MetS. (balkanmedicaljournal.org)
- You need to improve your glucose and insulin levels. (bodybuilding.com)
Hyperglycemia1
- In contrast, in mice with normal immune systems, emulsifiers induced low-grade or mild intestinal inflammation and metabolic syndrome, characterized by increased levels of food consumption, obesity, hyperglycemia and insulin resistance. (eurekalert.org)
Triglycerides2
- Consuming Montmorency tart cherry juice and capsules can reduce blood pressure (BP), insulin levels and triglycerides. (medindia.net)
- Dyslipidaemia occurs in teenagers with metabolic syndrome who have high levels of triglycerides and low levels of high-density lipoprotein (HDL) or good cholesterol. (mountelizabeth.com.sg)
MetS8
- Metabolic Syndrome (MetS) and Type 2 diabetes (T2D) are clinical conditions involving the impaired uptake and utilization of glucose, altered lipid metabolism, and the disruption of the metabolic signaling pathways that regulate insulin secretion from pancreas ( 1 ). (frontiersin.org)
- Thus, if an altered ability to oxidize FA represents an important contributor to the genesis of insulin resistance, assessing the capacity to burn fat in human subjects by RQ measurements might be a predictor of MetS and T2DM. (frontiersin.org)
- Metabolic syndrome (MetS) and obesity are serious health problems in the World, including Turkey. (balkanmedicaljournal.org)
- Contemporary studies have suggested a meaningful association between insulin resistance (IR), MetS parameters, and thyroid function tests. (balkanmedicaljournal.org)
- The central obese group had significantly higher insulin levels, components of MetS, the ratio free triiodothyronine (fT3) to free thyroxin fT4, and fT4 than those of peripheral obese and control groups. (balkanmedicaljournal.org)
- The severity of the metabolic syndrome (MetS) is significantly associated with future coronary heart disease (CHD) among individuals without baseline Type 2 diabetes. (biomedcentral.com)
- MetS severity appears to provide an estimate of metabolic disarray in the setting of diabetes and is predictive of future CHD events beyond HbA1c. (biomedcentral.com)
- Metabolic syndrome (MetS) is associated with several degenerative diseases, including retinal degeneration. (molvis.org)
Complications6
- By changing your lifestyle, you can help delay or even prevent the complications of metabolic syndrome (heart disease, stroke and diabetes) from developing. (mydr.com.au)
- Having three or more of these factors will result in a diagnosis of metabolic syndrome and will increase your risk of health complications including type 2 diabetes. (healthline.com)
- What are the complications of metabolic syndrome? (healthline.com)
- The complications that may result from metabolic syndrome are frequently serious and long-term (chronic). (healthline.com)
- If you are diagnosed with metabolic syndrome, the goal of treatment will be to reduce your risk of developing further health complications. (healthline.com)
- The patient's social history is important for identifying additional risks, such as tobacco use, which may exacerbate the increased cardiovascular complications associated with metabolic syndrome. (medscape.com)
Include insulin resistance1
- Metabolic syndrome is a combination of conditions that include insulin resistance/Type II diabetes, HTN, hyperlipidemia, and obesity. (nursingcenter.com)
Obese5
- Insulin resistance, when diagnosed, is almost exclusively found in those who are clinically obese. (nursingcenter.com)
- In obese subjects, adipokines and miokines interact to promote reticulum stress, insulin resistance, metabolic inflexibility and endothelial dysfunction. (benthamscience.com)
- It has been found that an increase in diacylglycerol species in insulin resistant obese and T2D subjects stimulates the secretion of insulin by the pancreas to maintain a normal glucose level ( 6 ). (frontiersin.org)
- but there was no significant difference between central and peripheral obese groups. (balkanmedicaljournal.org)
- The World Health Organisation (WHO) describes obesity as something that has "reached epidemic proportions globally" and currently states the fact that there are more than 1 billion overweight adults and 300 million obese people worldwide. (bodybuilding.com)
Clinical7
- According to this group, the reasons for a new definition that could meet with universal acceptance, in contrast to that of the ATP-III, was to allow easy identification in clinical practice, worldwide, of those individuals with the syndrome, taking into account the different ethnics. (scirp.org)
- Under the firms' alliance, a small molecule inhibitor of 11beta-hydroxysteroid dehydrogenase (HSD)-1 has advanced into clinical testing as a treatment of diabetes and metabolic syndrome-related diseases. (genengnews.com)
- A number of potential implications for clinical practice are derived from the cardiometabolic state underlying obesity and its comorbidities. (benthamscience.com)
- We will also summarize the available clinical evidence regarding the metabolic effects of beta-blockers in hypertensive patients, with an emphasis on nebivolol. (nih.gov)
- A metabolic syndrome is a group of interrelated common clinical disorders. (naturalayurvedictreatment.com)
- Clinical features of insulin resistance involve skin changes (Acanthosis nigricans). (naturalayurvedictreatment.com)
- Clinical and laboratory diagnosis of the metabolic syndrome. (medscape.com)
Components of the metabolic syndrome2
- OBJECTIVE -The aim of this study was to examine how the major components of the metabolic syndrome relate to each other and to the development of diabetes using factor analysis. (diabetesjournals.org)
- Among 934 nondiabetic and 305 diabetic subjects at baseline, factor analysis was performed using the principle components analysis with varimax orthogonal rotation of continuously distributed variables considered to represent the components of the metabolic syndrome. (diabetesjournals.org)
Pathways5
- We first identified 51 active compounds from SZT and their 81 potential molecular targets by high-throughput computational analysis, from which we identified 4 major pathways including Th17 cell differentiation, metabolic pathways, pathways in cancer, and the PI3K-Akt signaling pathway. (hindawi.com)
- Changes in cortical neurones included alterations in insulin and other signalling pathways, cell cycle, cellular senescence, inflammatory mediators, and components of the mitochondrial respiratory electron transport chain. (biomedcentral.com)
- The Abu-Remaileh Lab is interested in identifying novel pathways that enable cellular and organismal adaptation to metabolic stress and changes in environmental conditions. (stanford.edu)
- We also study how these pathways go awry in human diseases such as cancer, neurodegeneration and metabolic syndrome, in order to engineer new therapeutic modalities. (stanford.edu)
- These components of Metabolic Syndrome create the abnormal chemical pathways that promote inflammation. (drlongstreth.com)
Adipose7
- Those who are insulin resistant have an abundance of adipose tissue in their abdominal area. (nursingcenter.com)
- Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). (mdpi.com)
- Cortisol is known to cause resistance to the action of insulin in multiple target tissues including liver, muscle, and adipose tissue. (genengnews.com)
- In contrast, 11beta-HSD-1 knockout mice resist visceral obesity and diabetes through improved function of insulin in liver and adipose tissues. (genengnews.com)
- Data indicates that elevated levels of adipose and liver 11beta-HSD-1 are detrimental to metabolic control. (genengnews.com)
- Visceral adipose tissue mass secretes a number of proinflammatory cytokines, adipokines and growth factors leading to low grade inflammatory process and insulin resistance. (benthamscience.com)
- There are several factors that act and interact in the regulation of food intake and energy deposition, contributing to the development and maintenance of obesity, including: endocrinal, adipose, intestinal and neuronal factors 2 . (bvsalud.org)
Waist5
- It is thought that the underlying causes of metabolic syndrome are central obesity (weight that is carried mainly around the waist) and resistance to insulin (a hormone made by the pancreas that helps control your blood sugar levels). (mydr.com.au)
- Fasting insulin levels, BMI, and waist-to-hip ratio were associated with one factor. (diabetesjournals.org)
- Central obesity is diagnosed by measuring the waist-hip ratio. (nestle-family.com)
- Metabolic syndrome is a series of conditions that occur together, including high blood pressure , increased blood sugar level , excess fat around the waist and abnormal cholesterol levels. (mountelizabeth.com.sg)
- Obesity involved in this is central obesity ( fat over the abdomen and waist). (naturalayurvedictreatment.com)
Dyslipidaemia2
- Metabolic syndrome is an asymptomatic pathophysiological condition characterized by high blood pressure, central obesity, insulin resistance, dyslipidaemia and hyperglycaemia (1). (who.int)
- Few studies have logical condition characterized by high blood pressure, been done in more deprived regions and regions with low central obesity, insulin resistance, dyslipidaemia and income (9) . (who.int)
Diseases9
- Metabolic syndrome is a group of very common obesity-related disorders that can lead to type-2 diabetes, cardiovascular and/or liver diseases. (eurekalert.org)
- If similar results are obtained, it would indicate a role for this class of food additive in driving the epidemic of obesity, its inter-related consequences and a range of diseases associated with chronic gut inflammation. (eurekalert.org)
- We excluded participants with diabetes, metabolic syndrome, chronic diseases, and those who had changed food habits in the previous 3 months. (frontiersin.org)
- Metabolic syndrome is a collection of heart diseases causing factors that increase the chance of getting Heart disease, Stroke, and Type 2 Diabetes. (naturalayurvedictreatment.com)
- As with other diseases, careful history taking is important in metabolic syndrome. (medscape.com)
- Lysosomal function is critical for organismal homeostasis-mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome. (stanford.edu)
- By developing novel tools and harnessing the power of metabolomics, proteomics and functional genomics, our lab will define 1) how the lysosome communicates with other cellular compartments to fulfill the metabolic demands of the cell under various metabolic states, 2) and how its dysfunction leads to rare and common human diseases. (stanford.edu)
- We apply this knowledge to understand how lysosomal dysfunction leads to human diseases including neurodegeneration, cancer and metabolic syndrome. (stanford.edu)
- Obesity and overweight affect, worldwide, over 1.7 billion people and is associated with premature mortality, chronic diseases and increase in health costs. (bvsalud.org)
Epidemic3
- Its frequency has increased in parallel to that of global obesity and diabetes epidemic [1]. (scirp.org)
- These high calorie drinks have little protein and fibre, yet are high in carbohydrates and sugars, leading to raised sugar and insulin resistance, contributing to the global epidemic of metabolic syndrome in teenagers. (mountelizabeth.com.sg)
- This syndrome is both increasingly common and strongly implicated in the growing worldwide epidemic of type 2 diabetes. (ox.ac.uk)
Disorders3
- Metabolic syndrome is one of the most common disorders in industrialized countries. (druglib.com)
- Alliance targets 11beta-HSD-1 for the treatment of metabolic syndrome disorders. (genengnews.com)
- The symptoms of metabolic disorders vary widely depending upon the metabolic problem present. (naturalayurvedictreatment.com)
Triglyceride1
- In addition, high levels of insulin can contribute to the development of high blood pressure and help raise triglyceride levels. (mydr.com.au)
Overweight and obesity4
- Raynor HA, Champagne CM. Position of the Academy of Nutrition and Dietetics: interventions for the treatment of overweight and obesity in adults. (limamemorial.org)
- Studies showed that 65% of the world's population live in countries where overweight and obesity kills more people than underweight (World Health Organization, 2012). (directcurrentmusic.com)
- Underweight, normal weight, overweight, and obesity are defined on the bases of increased risk. (veganvan.life)
- Globally, 44% of the burden of disease due to diabetes, 23% of that due to ischaemic heart disease, and 7% to 41% for certain cancers, particularly breast cancer, are attributable to overweight and obesity. (who.int)
Diagnosis4
- In the literature, there is a link that NAFLD is the hepatic component of the metabolic syndrome diagnosis ( Takahashi & Fukosato, 2014 ). (nursingcenter.com)
- The first step in the therapeutic strategy against obesity should be the correct diagnosis of its causes and the promotion of lifestyle changes including physical exercise and a healthy diet. (benthamscience.com)
- As diagnosis of mild cognitive impairment and early AD are becoming more reliable, and as evidence is accumulating that health conditions such as diabetes, obesity, and coronary artery disease are risk factors for AD, appropriate changes to diets and lifestyles will likely reduce AD risk, and also improve the prognosis for people already suffering from such conditions. (nih.gov)
- Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. (medscape.com)
Causes of metabolic syndrome1
- What are the causes of metabolic syndrome? (healthline.com)
Pathogenesis2
- Taken together, these studies confirm that muscle insulin resistance represents a major factor in the pathogenesis of T2D. (frontiersin.org)
- It can be seen that abnormal lipid, cholesterol and glucose metabolism are consistently indicated as central in the pathophysiology, and possibly the pathogenesis of AD. (nih.gov)
20171
PCOS8
- This study aimed to examine the associations of dietary and serum omega-3 fatty acids with insulin resistance (IR) and body composition among PCOS patients. (frontiersin.org)
- The multivariable linear regression model was applied to analyze the associations of dietary and serum omega-3 fatty acids with the levels of Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and body composition parameters among PCOS patients. (frontiersin.org)
- Higher levels of dietary and serum omega-3 PUFAs, particularly long-chain omega PUFAs (DPA and DHA), might have beneficial effects on metabolic parameters and body composition among PCOS patients. (frontiersin.org)
- Excessive insulin level is not only a potential cause of hyperandrogenemia but also one of the high-risk factors leading to metabolic syndromes among those with PCOS ( 6 ). (frontiersin.org)
- According to a study, phenotypes A, B, and C are endocrine-metabolic syndromes, while phenotype D is non-hyperandrogenic PCOS which represents evidence of both oligo-anovulation and ovarian cysts [ 5 ]. (biomedcentral.com)
- Excessive insulin production is directly related to the increased ovarian production of androgens and PCOS manifestations [ 11 ]. (biomedcentral.com)
- The typical doctor will give women with PCOS potent diabetes drugs to help control insulin levels, but a much simpler, healthier and more direct solution is to eat differently and get some exercise. (virginiahopkinshealthwatch.com)
- Insulin resistance is usually linked with obesity, but women of normal weight with pcos also have an increased risk of developing insulin. (veganvan.life)
Criteria for metabolic syndrome1
Incidence of metabolic syndrome11
- This study aimed to determine the incidence of metabolic syndrome and its predicting factors in Zahedan city. (who.int)
- Age-standardized incidence of metabolic syndrome was calculated and its predictors were evaluated in a logistic regression analysis. (who.int)
- The incidence of metabolic syndrome varied from 17.21% to 27.18% depending on the criteria used and it was higher in women. (who.int)
- The incidence of metabolic syndrome has increased in Zahedan. (who.int)
- The incidence of metabolic syndrome has been reported to range from 28 persons per 1000 persons-year to more than 70 per 1000 persons-year in different regions of the world (4,5). (who.int)
- If the current trend in obesity and type 2 diabetes continues unchanged, the incidence of metabolic syndrome will be expected to increase, especially in developing countries (2,6). (who.int)
- According to epidemiological studies, the incidence of metabolic syndrome is higher in women than men (5,7). (who.int)
- 0.91) had a higher incidence of metabolic syndrome/diabetes than those in the low quotient group (25 vs. 8% p = 0.04). (frontiersin.org)
- Age-standardized incidence of metabolic syndrome was calcu- lated and its predictors were evaluated in a logistic regression analysis. (who.int)
- The incidence of metabolic syndrome prived regions of the country and is situated in vicinity has been reported to range from 28 persons per 1000 of Pakistan and Afghanistan. (who.int)
- A cohort study was conducted on the urban population unchanged, the incidence of metabolic syndrome will be of Zahedan city, south-eastern Islamic Republic of Iran. (who.int)
Anthropometric4
- In the short-term anthropometric measurements and their variation overtime were not correlated with metabolic syndrome/diabetes. (frontiersin.org)
- Measures related to anthropometric and body composition, glucose, and insulin level, HOMA-IR, sex hormones, lipid profile, quality of life, dietary intake, physical activity, and Ferriman-Gallwey score of all participants will be accessed before and after the intervention. (biomedcentral.com)
- We used stepwise regression analysis to determine whether anthropometric measurements significantly predicted metabolic syndrome. (cdc.gov)
- Both anthropometric measures were useful screening tools to identify metabolic syndrome. (cdc.gov)
Systolic blood pr3
- Montmorency tart cherries reduced systolic blood pressure, insulin levels, and insulin concentrations in adults with metabolic syndrome participating in a small pilot study. (medindia.net)
- The U.K. researchers found Montmorency tart cherry juice led to a significant, clinically-relevant reduction in systolic blood pressure when compared to the placebo 2 hours after consumption, and Montmorency tart cherry juice and Montmorency tart cherry capsules both lowered insulin levels significantly more than the placebo at 1 hour and 3 hours, respectively. (medindia.net)
- The aim of the present study was to compare the effects of nebivolol or atenolol on central and peripheral systolic blood pressure (SBP) and its variability and target organ damage (TOD) in N-nitro-L-arginine methyl ester (L-NAME) hypertensive rats. (bvsalud.org)
Childhood obesity1
- Although metabolic syndrome generally affects older people, it is possible, with increasing childhood obesity, for metabolic syndrome to affect young adults and even adolescents and children. (mydr.com.au)
Presence of central obesity1
Inflammation5
- ATLANTA--Emulsifiers, which are added to most processed foods to aid texture and extend shelf life, can alter the gut microbiota composition and localization to induce intestinal inflammation that promotes the development of inflammatory bowel disease and metabolic syndrome, new research shows. (eurekalert.org)
- Transplant of microbiota from emulsifiers-treated mice to germ-free mice was sufficient to transfer some parameters of low-grade inflammation and metabolic syndrome, indicating a central role for the microbiota in mediating the adverse effect of emulsifiers. (eurekalert.org)
- Both men and women with metabolic syndrome are more prone to inflammation, which predisposes one to heart disease, arthritis and headaches. (virginiahopkinshealthwatch.com)
- Tasali E, Ip MS. Obstructive sleep apnea and metabolic syndrome: alterations in glucose metabolism and inflammation. (medscape.com)
- These elevated insulin levels lead to weight gain and low-grade inflammation. (veganvan.life)
Pancreas2
- Insulin resistance -- Insulin is a hormone produced in the pancreas. (medlineplus.gov)
- Now, insulin resistance is when your cells become less sensitive to insulin (Insulin is the hormone produced by the pancreas which is responsible for getting sugar out of the blood). (bodybuilding.com)
Significantly1
- Although the importance of the mitochondria as a central point of health has been accepted for decades, over the last few years the understanding of the mechanisms involved has changed significantly. (totalhealthmagazine.com)
Strongly associated2
- A waistline of 102 cm or more for men and 88 cm or more for women (measured across the belly) is the form of central obesity most strongly associated with metabolic syndrome which is a collection of risk factors such as high cholesterol, insulin resistance and high blood pressure. (nestle-family.com)
- An aside: This study is particularly interesting because it showed that only excess "free" or bioavailable androgens were strongly associated with metabolic syndrome, which means that conventional blood tests didn't show this effect. (virginiahopkinshealthwatch.com)
Levels13
- People who have insulin resistance tend to have higher than normal levels of insulin and sugar in their blood, increasing the risk of diabetes. (mydr.com.au)
- Even a small amount of weight loss can help improve insulin resistance, lower your blood pressure and correct your cholesterol levels. (mydr.com.au)
- It can lead to higher insulin levels and blood sugar levels. (healthline.com)
- It may be linked to poor living and working conditions such as exposure to pathogens, or to increased levels of obesity. (biomedcentral.com)
- Increased activity alone can improve your insulin levels. (nestle-family.com)
- High levels of insulin and glucose in the blood are highly correlated with the level of fat you store on your suprailiac (4). (bodybuilding.com)
- The correlation between fat on the stomach and insulin levels has been shown so you can see what strategies you need to use to reduce the fat and to get the abs so many people strive for. (bodybuilding.com)
- Hormonally, a woman with metabolic syndrome tends to have high androgen (male hormone) levels, high estrogen levels (the fat cells are making estrogen from androgens), high cortisol and low thyroid. (virginiahopkinshealthwatch.com)
- Excess glucose (from sugar and carbohydrates) in the bloodstream, raises insulin levels which increases androgen (male hormone) levels in women. (virginiahopkinshealthwatch.com)
- This was underscored in a Johns Hopkins study published in the American Journal of Epidemiology in September 2004 which showed that women with metabolic syndrome have high androgen levels. (virginiahopkinshealthwatch.com)
- Physiotherapy can help you manage these issues by improving your posture and balance or by developing strategies to reduce stress levels or manage pain from other conditions such as irritable bowel syndrome (IBS). (postureclinic.in)
- Low testosterone and shbg levels predict the development of central obesity and are associated with an increased risk of developing. (veganvan.life)
- Results: WC rib measures displayed the strongest associations with non-optimal lipid and lipoprotein levels, high blood pressure, insulin resistance, impaired fasting glucose, a clustering of metabolic risk features and type 2 diabetes, in both genders. (ucc.ie)
Coronary1
- Metabolic syndrome is a name for a group of risk factors that occur together and increase the chance of having coronary artery disease , stroke , and type 2 diabetes . (medlineplus.gov)
Phenotype1
- As it is illustrated, phenotype A is the most severe, while phenotype D is the least one along an axis of metabolic and ovarian dysfunction. (biomedcentral.com)
Conclusions1
- Conclusions: WC rib is easier to assess and our data suggest that it is a better method for determining obesity-related cardiometabolic risk than WC midway. (ucc.ie)
Atherosclerosis3
- The purpose of this study is to evaluate the long-term effectiveness of chloroquine, a protein-activation medication, at reducing the progression of atherosclerosis in patients with the metabolic syndrome. (druglib.com)
- In animals, activation of the protein ataxia telangiectasia mutated (ATM) using the antimalarial drug chloroquine improves features of metabolic syndrome and decreases atherosclerosis, a build-up of fatty plaque within arteries. (druglib.com)
- All of the individual components of metabolic syndrome are risk factors for atherosclerosis (hardening and narrowing of the arteries). (mydr.com.au)
Endocrine1
- The predominance of central, viscerally deposited fat may alter the immunological, metabolic and endocrine milieu. (benthamscience.com)
Cardiometabolic2
- While awaiting the release of new drugs, topiramate, alone or combined with phentermine, has been proposed as a novel anti-obesity drug, showing relevant effects not only on weight loss but also on cardiometabolic alterations and biomarkers, even though new studies should clarify the mechanisms of these findings. (benthamscience.com)
- Objectives: Despite recommendations that central obesity assessment should be employed as a marker of cardiometabolic health, no consensus exists regarding measurement protocol. (ucc.ie)
Symptoms3
- What are the signs and symptoms of metabolic syndrome? (healthline.com)
- If you have metabolic syndrome, you may not have any specific symptoms. (healthline.com)
- A group of European countries participated in a 12-year study of the effects of a Mediterranean diet and healthy lifestyle on metabolic syndrome symptoms. (virginiahopkinshealthwatch.com)
Disorder2
- The syndrome substantially increases the risk of developing diabetes and vascular disease, but there is no clear unifying approach to treat this disorder. (druglib.com)
- The middle stage of the metabolic disorder can be compared with Santarpana and avaranajanya madhumeha (sthula pramehi). (naturalayurvedictreatment.com)
Serum2
- It consists of abnormal serum lipids, glucose intolerance, elevated blood pressure, and central obesity in the setting of insulin resistance. (druglib.com)
- Two-hour postload plasma glucose (2-h PG) and serum insulin and fasting plasma glucose were associated with the third factor. (diabetesjournals.org)
Factors18
- Aliab H. Incidence of and factors associated with metabolic syndrome, south-east Islamic Republic of Iran. (who.int)
- Factors, such as socioeconomic status, lack of physical activity, smoking, family history of diabetes, obesity and the western lifestyle, increase the risk of metabolic syndrome (8). (who.int)
- Most studies on the incidence and risk factors of metabolic syndrome have been conducted in developed countries or regions where the populations have a relatively high socioeconomic status. (who.int)
- The primary risk factors of NASH include obesity (body mass index [BMI] >30), insulin resistance, Type II diabetes, "central adiposity" ( Paskos & Paletas, 2009 , para. (nursingcenter.com)
- Perhaps, the strongest risk factors for the development of NASH syndrome are obesity and insulin resistance. (nursingcenter.com)
- The cause of insulin resistance is not yet properly understood, but both genetic and environmental factors, including being overweight and physically inactive, are thought to play a major role. (mydr.com.au)
- Metabolic syndrome is a group of five risk factors, that when left untreated, increase the likelihood of developing heart disease, diabetes, and stroke. (healthline.com)
- Having one of these risk factors does not mean that you have metabolic syndrome. (healthline.com)
- What are the risk factors for metabolic syndrome? (healthline.com)
- The risk factors for metabolic syndrome are related to obesity. (healthline.com)
- There are other factors that can increase your risk for metabolic syndrome. (healthline.com)
- If you have one of the five risk factors of metabolic syndrome, talk with a doctor to determine whether you should be tested for the others. (healthline.com)
- People with obesity are more likely to have high blood pressure, high cholesterol and diabetes, all factors that can increase the risk for heart disease. (mountelizabeth.com.sg)
- Now you see why central obesity is regarded as one of the highest risk factors for diabetes as it is a disease related to insulin and glucose function. (bodybuilding.com)
- Work on the United Kingdom population-based Cognitive Function and Ageing Study (CFAS) neuropathology cohort suggests that up to a third of AD cases are attributable to modifiable risk factors, including T2D/MS and midlife obesity, with attributable risks for AD in the United Kingdom of 1.9% and 6.6%, respectively [ 43 ]. (biomedcentral.com)
- The lifestyle of quilombola communities has changed due to extra community influence, thus affecting their environmental and behavioral factors related to the Metabolic Syndrome (MS). However, little is known about the influence of MS on the Quality of Life (QoL) of quilombola residents. (bvsalud.org)
- Metabolic syndrome is defined as clustering of several cardiovascular and metabolic risk factors. (cdc.gov)
- Early screening for metabolic syndrome can be expensive and time-consuming because it involves testing for multiple risk factors. (cdc.gov)
Cluster1
- Metabolic syndrome is a cluster of conditions - all of which increase the risk of heart disease - occurring together in one individual. (mydr.com.au)
Adults2
- Montmorency tart cherries can offer amazing health-promoting benefits for adults with metabolic syndrome, reports a new study. (medindia.net)
- Global rates of metabolic syndrome are on the rise, and the results of the present study suggest Montmorency tart cherries, in juice or capsule form, could exert beneficial effects for adults with this condition when incorporated into an overall healthy diet," said Desai. (medindia.net)
Lipids1
- Dietary lipids favor their metabolic processing, saving glucose, which additionally spares amino acids. (medscape.com)