InsulinReceptor, InsulinInsulin ResistanceInsulin Receptor Substrate ProteinsGlucoseInsulin, Long-ActingHypoglycemic AgentsInsulin AntibodiesInsulin AntagonistsInsulin LisproIslets of LangerhansGlucose Tolerance TestDiabetes Mellitus, Type 2Insulin Infusion SystemsGlucose Clamp TechniqueInsulin AspartInsulin, IsophaneInsulin, Regular, PorkHyperinsulinismAdipose TissueInsulin, Regular, HumanInsulin-Secreting CellsInsulinsObesityGlucagonC-PeptideFastingProinsulinBlood GlucoseHyperglycemiaLiverMuscle, SkeletalDiabetes Mellitus, Type 1Signal TransductionInsulin, Short-ActingFatty Acids, NonesterifiedHypoglycemiaGlucose Transporter Type 4AdipocytesPhosphorylationDiabetes Mellitus, ExperimentalDiabetes MellitusTime FactorsBody WeightGlucose IntoleranceTriglyceridesLeptinInsulin-Like Growth Factor IDeoxyglucosePhosphoproteinsMonosaccharide Transport ProteinsPhosphatidylinositol 3-KinasesCells, CulturedHemoglobin A, GlycosylatedKineticsPostprandial PeriodHomeostasisInsulinomaBiphasic InsulinsRats, WistarProto-Oncogene Proteins c-aktLipidsGlycogenAdiponectinBody Mass IndexDose-Response Relationship, DrugDietary FatsCell LinePancreasLipid MetabolismMetforminGlucagon-Like Peptide 1Rats, Sprague-DawleyRNA, MessengerRats, Inbred StrainsMice, ObeseMice, Inbred C57BLEatingMuscle ProteinsReference ValuesThiazolidinedionesLipolysisInfusions, Subcutaneous3T3-L1 CellsMetabolic Syndrome XDietary CarbohydratesBody CompositionReceptor, IGF Type 1Diet, High-FatGene Expression RegulationRats, ZuckerTolbutamideBiological TransportEnergy MetabolismRisk FactorsMice, KnockoutStreptozocinAdiposityInjections, SubcutaneousCross-Over Studies