Insulin receptor tyrosine phosphorylation. Medical search. Frequent questions

Like the other Vav proteins, Vav3 is phosphorylated (activated) following ligand binding to a variety of receptor tyrosine kinases (TKs), including EGF receptor, PDGF receptor, insulin receptor, and insulin-like growth factor I receptor. (cytoskeleton.com)
Normally, upon the stimulations by growth factors (GFs), the receptor tyrosine kinases (RTKs) are activated, and then recruit PI3K protein complex on the membrane to generate phosphatidylinositol-3,4,5-triphosphate (PIP3) from phosphatidylinositol-4,5-biophosphate (PIP2) [ 2 ]. (biomedcentral.com)
PIP3 phosphatase PTEN is inactivated upon phosphorylation in its C-terminal region by several serine/threonine kinases [ 12 ]. (biomedcentral.com)
Upon addition of exogenous insulin to metacestode vesicles, the phosphorylation of EmIR was significantly induced, an effect which was suppressed in the presence of specific inhibitors of insulin receptor-like tyrosine kinases. (uni-wuerzburg.de)
The importance of insulin signaling mechanisms for parasite survival and growth were underscored by in vitro cultivation experiments in which the addition of an inhibitor of insulin receptor tyrosine kinases led to vesicle degradation and death. (uni-wuerzburg.de)
Phosphoinositide-3 kinase is activated by cell-surface receptor tyrosine kinases. (mesothelioma-line.com)
ERK1 and ERK2 were initially isolated and cloned as kinases activated in response to insulin and NGF. (rndsystems.com)
ERK5, also known as Big Mitogen-activated Protein Kinase 1 (BMK1) and MAPK7, is activated by several mechanisms, including receptor tyrosine kinases, G protein-coupled receptors, and osmotic stress. (rndsystems.com)
The degradative pathway of ErbB receptor tyrosine kinases stimulated by tyrosine kinase inhibitors appears to be chaperone mediated, and thus is similar to the pathways activated by the heat shock protein 90 (Hsp90) antagonist geldanamycin and by stress-induced mechanisms. (lclabs.com)
Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy. (lclabs.com)

Wild type as well as substrate-trapping DA forms of PTPϵM suppressed phosphorylation of IR downstream enzymes such as Akt, extracellular regulated kinase (ERK) and glycogen synthase kinase 3 (GSK3). (bioone.org)
Insulin is known to regulate pancreatic β-cell function through the activation of cell surface insulin receptors, phosphorylation of insulin receptor substrate (IRS)-1 and -2, and activation of phosphatidylinositol (PI) 3-kinase. (diabetesjournals.org)
The insulin receptor substrate (IRS) proteins are a family of cytoplasmic adaptor proteins recognized for their role in insulin signaling. (biomedcentral.com)
IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). (thermofisher.com)
Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). (reactome.org)
Several intracellular proteins have been identified as phosphorylation substrates for the insulin receptor, the best-studied of which is insulin receptor substrate 1 or IRS-1. (sputnic-group.ru)
Changes in the beta-subunit of the insulin receptor, decreased phosphorylation of tyrosine kinase on the insulin receptor, and alterations in insulin receptor substrate-1 (IRS-1) and the intracytoplasmic phosphatidylinositol 3-kinase (PI3K) appear to be involved in reducing glucose uptake in skeletal muscle tissue. (medscape.com)
Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling. (bvsalud.org)

Autophosphorylation sites on the epidermal growth factor receptor. (wikidata.org)
Western blot analysis was performed to determine the relative expression of epidermal growth factor receptor, insulin-like growth factor receptor, and platelet-derived growth factor receptor in the mesothelioma cell lines I-45 and REN and the mesothelial line Met5a. (mesothelioma-line.com)
Inhibition of epidermal growth factor receptor resulted in apoptotic cell death and Akt hypophosphorylation in mesothelioma cell lines. (mesothelioma-line.com)
We have demonstrated that epidermal growth factor receptor inhibition leads to apoptotic cell death through downregulation of phosphoinositide-3 kinase signaling in mesothelioma cell lines, whereas insulin-like growth factor receptor inhibition leads to apoptosis independent of phosphoinositide-3 kinase. (mesothelioma-line.com)
Epidermal growth factor receptor, insulin-like growth factor receptor, and phosphoinositide-3 kinase inhibition might be clinically relevant in malignant mesothelioma. (mesothelioma-line.com)
It selectively inhibits erbB1 (epidermal growth factor receptor), erbB2, erbB3, and erbB4 without blocking tyrosine kinase activity of many other receptors such as platelet-derived growth factor receptor, fibroblast growth factor receptor, and insulin receptor. (lclabs.com)

Thus, the insulin-dependent tyrosine phosphorylation of caveolin represents a novel, insulin-specific signal transduction pathway that may involve activation of a tyrosine kinase downstream of the insulin receptor. (rupress.org)
Zinc has "mimetic" activity where it is involved in a range of functions including insulin receptor signal transduction, insulin storage, secretion and tissues/organelle distribution, and inhibition of protein tyrosine phosphatases [ 5 - 8 ]. (hindawi.com)
They are part of the Ras-Raf-ERK signal transduction cascade often found downstream of growth factor receptor activation. (rndsystems.com)

Phosphorylation of receptor serine/threonine residues has been proposed to exert an inhibitory influence on receptor tyrosine kinase activity and Ser 1327 and Thr 1348 have been identified as specific sites of phosphorylation in the insulin receptor COOH terminal domain. (jci.org)
To address the potential negative regulatory role of phosphorylation of these residues in vivo, we assessed the extent of phosphorylation of each site in insulin receptor isolated from the skeletal muscle of 12 NIDDM patients and 13 nondiabetic, control subjects. (jci.org)
Two tyrosine residues, Y317 and Y508, are identified on PIK3CA/p110α. (biomedcentral.com)
IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. (thermofisher.com)
1 Insulin receptor functions as an enzyme that transfers phosphate groups from ATP to tyrosine residues on intracellular target proteins. (sputnic-group.ru)

Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. (wikipedia.org)
Impaired insulin receptor (IR) signaling leads to insulin resistance and type 2 diabetes mellitus. (bioone.org)
Several inhibitors of the IR tyrosine kinase activity have recently been described and associated with human insulin resistance. (bioone.org)
This previously unexplored concept would raise a whole new area of research into the pathophysiology of insulin resistance and introduce a new class of drug target with utility for diabetes pharmacotherapy. (hindawi.com)
For example, aberrant subcellular signaling of zinc concentrations in the cytosol and organelles may contribute to insulin responsiveness [ 17 ] and thus promote insulin resistance. (hindawi.com)
Insulin resistance and disordering of lipid metabolism occur in obesity, diabetes mellitus, atherosclerosis. (lww.com)
Polycystic ovary syndrome (PCOS) is strongly associated with abdominal obesity and insulin resistance and effective approaches to nutrition (e.g., omega-3 fatty acids intake) might improve the cardiometabolic risk profile. (frontiersin.org)
This study aimed to examine the associations of dietary and serum omega-3 fatty acids with insulin resistance (IR) and body composition among PCOS patients. (frontiersin.org)
The multivariable linear regression model was applied to analyze the associations of dietary and serum omega-3 fatty acids with the levels of Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and body composition parameters among PCOS patients. (frontiersin.org)
PCOS entails diseases such as type 2 diabetes, hypertension, cardiovascular disease, and endometrial cancer ( 3 , 4 ), and insulin resistance (IR) and hyperandrogenemia might be closely associated with the pathogenesis of PCOS ( 5 ). (frontiersin.org)
The diabetes and insulin resistance are mainly responsible for the morbidities and mortalities of humans in the world. (scielo.br)
Disturbances in the action of GSK-3 enzyme may leads to various disease conditions that include insulin resistance leading to diabetes, neurological disease like Alzheimer's disease and cancer. (scielo.br)
Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension. (scielo.br)
It is characterized by a cluster of risk factors of atherosclerosis including insulin resistance, hyperinsulinemia, impaired glucose tolerance or type 2 diabetes, hypertension, dyslipidemia, and coagulation abnormalities. (erudit.org)
Its pathophysiology is likely to involve insulin resistance at the level of both skeletal muscle and visceral adipose tissue and altered fluxes of metabolic substrates between these tissues that in turn impair liver metabolism. (erudit.org)
The disturbance of internal circadian system induces glucose intolerance and insulin resistance, which could be restored by melatonin supplementation. (nih.gov)
Hyperinsulinemia, in turn, causes a reversible reduction in receptor kinase activity, leading to insulin resistance. (biu.ac.il)
Women with underlying insulin resistance are at risk for developing GDM. (medscape.com)
PCOS involves various pathophysiological factors, and affected women usually have significant insulin resistance (IR), which is a major cause of PCOS. (biomedcentral.com)
PCOS is a heterogeneous disease characterized by hyperandrogenism, dysfunctional ovulation, and polycystic ovary morphology, accompanied by metabolic abnormalities, such as insulin resistance (IR) and obesity. (biomedcentral.com)
IGF-I deficiency can be the result of GH resistance or insensitivity due to genetic disorders of the GH receptor causing GH receptor deficiency (growth hormone receptor deficiency [GHRD], Laron syndrome) or postreceptor defects, including the principal transduction agent STAT5b, the IGF-I/IGFBP3 stabilizer acid labile subunit (ALS), the IGF-I gene, or the IGF-I receptor. (medscape.com)

Phosphorylation of serine 1327 or threonine 1348 is unaltered. (jci.org)
Moreover, within each group there was no correlation between the level of tyrosine kinase activity and the extent of serine/threonine phosphorylation. (jci.org)
It is concluded that the stoichiometry of serine/threonine phosphorylation of insulin receptor in vivo is low, and that increased phosphorylation of Ser 1327 or Thr 1348 is not responsible for the decreased insulin receptor tyrosine kinase activity observed in the skeletal muscle of NIDDM patients. (jci.org)
An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. (thermofisher.com)

Tyrosine phosphorylation of RTKs, or adaptor proteins such as IRS-1 facilitate their binding with p85 regulatory subunits of PI3K, and then bring PI3K complex on membrane [ 2 ]. (biomedcentral.com)
cSH2 domain S690 phosphorylation decreases p85 binding affinity to tyrosine-phosphorylated proteins resulting in less PI3K membrane localization [ 15 ]. (biomedcentral.com)
Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins. (modeldb.science)
The activated receptor then phosphorylates a number of intracellular proteins, which in turn alters their activity, thereby generating a biological response. (sputnic-group.ru)
The intact receptor lacks tyrosine kinase activity, but binding of GH and dimerization results in association with JAK2, a member of the Janus kinase family, which results in self-phosphorylation of the JAK2 and a cascade of phosphorylation of cellular proteins. (medscape.com)
The most critical of these proteins is the signal transducer and activator of transcription 5b (STAT5b), which couples GH binding to the activation of gene expression that leads to the intracellular effects of GH, including synthesis of IGF-I, insulin-like growth factor binding protein 3 (IGFBP3), and ALS. (medscape.com)
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. (bvsalud.org)
The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. (bvsalud.org)

Stimulation of 3T3-L1 adipocytes with insulin significantly increased the tyrosine phosphorylation of caveolin and a 29-kD caveolin-associated protein in caveolin-enriched Triton-insoluble complexes. (rupress.org)
The stimulation of caveolin tyrosine phosphorylation was specific for insulin and was not observed with PDGF or EGF, although PDGF stimulated the tyrosine phosphorylation of the 29-kD caveolin-associated protein. (rupress.org)
In addition, B-cell and/or T-cell receptor stimulation also results in phosphorylation of Vav3. (cytoskeleton.com)
IRS-1 was the first of these to be identified as a 185 kDa protein that is detectable by immunoblot analysis in response to insulin stimulation [ 1 ]. (biomedcentral.com)
In Fao or NIH3T3 cells stably expressing IR, overexpression of PKCÎ¶ enhances the dissociation from IR and decrease in IRS1 tyrosine phosphorylation caused by prolonged insulin stimulation (Riu et al. (reactome.org)

Tyrosine phosphorylation of PIK3CA/p110α is stimulated by growth factors such as EGF, HGF and PDGF. (biomedcentral.com)
Some of the cellular responses manifest within minutes after PDGF receptor activation. (vegfrinhibitors.com)

Consistently, exposure to insulin increased the level of the NR2A subunit of the NMDA receptor without much altering NR1 or NR2B levels. (ewha.ac.kr)

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. (antikoerper-online.de)

What are physical characteristics found in all tyrosine kinase receptors? (flashcardmachine.com)
It belongs to the large class of tyrosine kinase receptors. (sputnic-group.ru)

Platelet-derived growth factor receptor inhibition did not affect cellular survival or phosphoinositide-3 kinase signaling. (mesothelioma-line.com)

Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. (jci.org)
Inhibition is removed by tyrosine kinase (TK)-mediated phosphorylation of the conserved Tyr174 residue (on Vav3, Tyr173 corresponds to Vav1 Tyr174 based on Vav1 amino acid numbering) in the AC helix. (cytoskeleton.com)
Insulin-like growth factor receptor inhibition led to apoptotic cell death without affecting Akt phosphorylation. (mesothelioma-line.com)
Canertinib inhibited erbB receptor phosphorylation and induced growth inhibition and apoptosis at concentrations of 1 µM or more. (lclabs.com)
Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition. (lclabs.com)

In this study, we showed that receptor-type PTPϵ (PTPϵM) dephosphorylated IR in rat primary hepatocytes and tyrosines 972, 1158, 1162 and 1163 were primary targets of PTPϵM. (bioone.org)

In vivo signaling was evaluated after an insulin bolus just prior to weaning ( n = 4-5/group). (diabetesjournals.org)
Both in vivo and in vitro, insulin secretion by the pancreatic islets in a circadian manner, is due to the melatonin action on the melatonin receptors inducing a phase shift in the cells. (nih.gov)
The initial effects of overeating (i.e., development of hyperinsulinemia without hyperglycemia) were associated in the sand rat with a dramatic decrease in in vitro and in vivo insulin-induced receptor tyrosine kinase activity in both liver and muscle. (biu.ac.il)

It decreases insulin secretion by inhibiting cAMP and cGMP pathways but activates the phospholipaseC/IP3 pathway, which mobilizes Ca2+from organelles and, consequently increases insulin secretion. (nih.gov)
Protein phosphorylation is crucial for signaling transduction of this pathway. (biomedcentral.com)
Post-translational modifications (PTMs) are crucial for regulating PI3K/AKT signaling pathway, notably phosphorylation. (biomedcentral.com)

Furthermore, we aim to summarize and provide an update on the current research status of insulin sensitization therapy for women with PCOS to provide more effective and reasonable clinical treatment. (biomedcentral.com)

Insulin stimulates the tyrosine phosphorylation of caveolin. (rupress.org)

Increased tyrosine phosphorylation of caveolin, its associated 29-kD protein, and a 60-kD protein was observed in an in vitro kinase assay after incubation of the caveolin-enriched Triton-insoluble complexes with Mg-ATP, suggesting the presence of an intrinsic tyrosine kinase in these complexes. (rupress.org)
In vitro kinase assay is applied to identify the kinase of PIK3CA/p110α tyrosine phosphorylation. (biomedcentral.com)
Human insulin, exogenously added to in vitro cultivated parasite larvae, (i) significantly stimulated parasite survival and growth, (ii) induced DNA de novo synthesis in Echinococcus, (iii) affected overall protein phosphorylation in the parasite, and (iv) specifically induced the phosphorylation of the parasite's Erk-like MAP kinase orthologue EmMPK1. (uni-wuerzburg.de)

Traditionally this has involved studying both central and peripheral molecules involved in hunger and satiety, such as leptin, orexin (also known as hypocretin), insulin, alpha-melanocyte-stimulating hormone (α-MSH), glucagon-like peptide -1 (GLP-1), amylin, glucose-dependent insulinotropic polypeptide (GIP, also known as a gastric inhibitory polypeptide), adiponectin and cholecystokinin (CCK). (frontiersin.org)

Phospho-proteomics analysis and Western blots are used to demonstrate downstream signaling pathways of PIK3CA/p110α tyrosine phosphorylation. (biomedcentral.com)

The extent of insulin-induced tyrosine autophosphorylation was decreased in receptor isolated from diabetic versus nondiabetic muscle, thus confirming earlier reports. (jci.org)
Furthermore, upon expression of EmIR/HIR receptor chimera containing the extracellular ligand binding domain of EmIR in HEK 293 cells, a specific autophosphorylation of the chimera could be induced through the addition of exogenous insulin. (uni-wuerzburg.de)
Binding of insulin to the alpha subunits causes the beta subunits to phosphorylate themselves (autophosphorylation), thus activating the catalytic activity of the receptor. (sputnic-group.ru)

Conversely, the D 2 R agonist bromocriptine, which has been used for over 40 years to treat Parkinson's disease and hyperprolactinemia ( 6 ), was found to lower blood glucose levels and improve insulin sensitivity in patients with T2DM ( 7 ). (frontiersin.org)
Increasing dopamine levels/signals are associated with improved insulin sensitivity, while decreasing dopamine and serotonin levels/signals are associated with weight gain and T2DM development. (frontiersin.org)
It may provide the link between inflammation and insulin sensitivity. (lww.com)
Effect of Sodium Fluoride on Bone Biomechanical and Histomorphometric Parameters and on Insulin Signaling and Insulin Sensitivity in Ovariectomized Rats. (qxmd.com)
It was concluded that chronic treatment with NaF (50 mg/L) in OVX rats causes a decrease in insulin sensitivity, insulin signaling transduction, and biochemical, biomechanical, and histomorphometric bone parameters. (qxmd.com)
IR is present in all phenotypes, and insulin sensitivity varies according to the PCOS phenotype. (biomedcentral.com)
Therefore, recognizing the strong influence of IR on the occurrence and development of PCOS, accurate assessment of insulin sensitivity in the early stages of PCOS, and effective intervention on IR are essential to reduce the risk of long-term complications. (biomedcentral.com)

The GH molecule binds to its specific cell surface receptor (GHR), which dimerizes with another GHR molecule so that the single GH molecule is enveloped by 2 GHR molecules. (medscape.com)

In insulin-dependent peripheral tissues such as skeletal muscle, adipose, and liver, zinc ions play a role in insulin-induced glucose transport and glycemic control [ 9 - 16 ]. (hindawi.com)

PIK3CA/p110α phosphorylation at Y317 and Y508 play important role in tumorigenesis of colorectal cancer through two independent pathways. (biomedcentral.com)
Based on the above outlined molecular data on the interaction between EmIR and mammalian insulin, the parasite's insulin receptor orthologue most probably mediates the insulin effects on parasite growth and is, therefore, a potential candidate factor for host-parasite communication via evolutionary conserved pathways. (uni-wuerzburg.de)
Bidirectional synaptic plasticity as a consequence of interdependent Ca2+-controlled phosphorylation and dephosphorylation pathways. (modeldb.science)
5 When IRS-1 is activated by phosphorylation, it serves as a type of docking center for recruitment and activation of other enzymes that ultimately mediate insulin's effects, including activation of PI-3-kinase and MAP kinase pathways. (sputnic-group.ru)
These data suggest that Pptc7 deletion causes mitochondrial dysfunction via dysregulation of several metabolic pathways and that PPTC7 may directly regulate mitophagy receptor function or stability. (bvsalud.org)

The synthesis, secretion, and action of insulin are dependent on zinc and the transporters that make this ion available to cellular processes. (hindawi.com)
The effects of melatonin on insulin secretion are mediated through the melatonin receptors (MT1 and MT2). (nih.gov)
Importantly, these cells displayed hypothalamic neuronal characteristics, including production and secretion of neuropeptides and responsiveness to metabolic hormones such as insulin and leptin. (columbia.edu)
Joan Domingo-Espín J, Lindahl M, Nilsson-Wolanin O, Cushman S W, Stenkula K G, Lagerstedt J O. Dual Actions of Apolipoprotein A-I on Glucose-Stimulated Insulin Secretion and Insulin-Independent Peripheral Tissue Glucose Uptake Lead to Increased Heart and Skeletal Muscle Glucose Disposal. (lu.se)

The insulin receptor ortholog EmIR of the fox-tapeworm Echinococcus multilocularis displays significant structural homology to the human insulin receptor (HIR) and has been suggested to be involved in insulin sensing mechanisms of the parasite's metacestode larval stage. (uni-wuerzburg.de)

The SH3-SH2-SH3 C-terminal domains bind directly with the auto-phosphorylated cytoplasmic tails of the receptor TKs while the B- and T-cell receptors activate cytosolic TKs. (cytoskeleton.com)
The juxtamembrane phosphorylation site Tyr960 within the insulin receptor cytoplasmic domain is an essential determinant for the tyrosine phosphorylation of IRS-1. (sputnic-group.ru)

How is a receptor-ligand binding curve determined? (flashcardmachine.com)
Describe the three lines on a receptor-ligand binding curve? (flashcardmachine.com)

What is the most common activity found intrinsic to transmembrane receptors? (flashcardmachine.com)
BACKGROUND Insulin receptor is a transmembrane receptor that is activated by insulin. (sputnic-group.ru)

Evidences from experimental studies proved that melatonin induces production of insulin growth factor and promotes insulin receptor tyrosine phosphorylation. (nih.gov)
These results clearly indicated that Echinococcus metacestode vesicles are able to sense exogenous host insulin which induces a mitogenic response. (uni-wuerzburg.de)

Canertinib alkylates a cysteine residue specific to ErbB receptors. (lclabs.com)

Soon after the introduction of atypical antipsychotics, which antagonize serotonin receptors and dopamine D 2 receptors (D 2 R), numerous case reports appeared showing that the use of these drugs were associated with increased obesity and the development of type 2 diabetes mellitus (T2DM) ( 5 ). (frontiersin.org)
Recent studies on diseases which involve insulin insensitivity (e.g. obesity, type 2 diabetes and atherosclerosis) also show increased cytokine production and markers of inflammation. (lww.com)
Melatonin may be involved in the genesis of diabetes as a reduction in melatonin levels and a functional interrelationship between melatonin and insulin was observed in diabetic patients. (nih.gov)
Therefore, the presence of melatonin receptors on human pancreatic islets may have an impact on pharmacotherapy of type 2 diabetes. (nih.gov)
The insulin receptor was evaluated at different disease stages in the sand rat (Psammomys obesus), a model for nutrition-induced diabetes. (biu.ac.il)
This sequence of events may be relevant to diet- related changes in human non-insulin-dependent diabetes mellitus. (biu.ac.il)

This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. (antikoerper-online.de)
Their receptor had an intact tyrosine kinase activity but a higher K(m) for ATP in the phosphorylation reaction of exogenous substrates. (biu.ac.il)

Recent studies have highlighted zinc's dynamic role as a "cellular second messenger" in the control of insulin signaling and glucose homeostasis. (hindawi.com)
We sought to determine which receptors are present in mesothelioma and their role in cellular survival and phosphoinositide-3 kinase signaling. (mesothelioma-line.com)

The insulin neurotoxicity was blocked by an antioxidant but not by caspase inhibitors. (ewha.ac.kr)
Inhibitors of tyrosine kinase and PKC, but not PI3-kinase, attenuated the insulin neurotoxicity. (ewha.ac.kr)
Suggesting that the gene activity-dependent emergence of excitotoxicity contributed to insulin neurotoxicity, macromolecule synthesis inhibitors and N-methyl-D-aspartate (NMDA) antagonists blocked it. (ewha.ac.kr)

abstract = "While effectively attenuating neuronal apoptosis in mouse cortical culture, insulin paradoxically induced neuronal necrosis with 48 h of exposure. (ewha.ac.kr)

The specialized plasma membrane structures termed caveolae and the caveolar-coat protein caveolin are highly expressed in insulin-sensitive cells such as adipocytes and muscle. (rupress.org)
Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation. (lu.se)

Exposure to insulin led to tyrosine phosphorylation of the insulin receptor and the insulin-like growth factor-1 (IGF-1) receptor and activation of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3- kinase). (ewha.ac.kr)

In pregnancy, human placental lactogen, which is structurally similar to growth hormone, and tumor-necrosis factor-alpha induce changes in the insulin receptor and in post-receptor signaling. (medscape.com)
Insulin-like growth factor I (IGF-I) is the effector of growth induced by growth hormone (GH). (medscape.com)

Maternal WSD reduced insulin-stimulated glucose uptake and impaired insulin signaling at the level of Akt phosphorylation in fetal muscle. (diabetesjournals.org)
In juvenile offspring, insulin-stimulated glucose uptake was similarly reduced by both maternal and postweaning WSD and corresponded to modest reductions in insulin-stimulated Akt phosphorylation relative to controls. (diabetesjournals.org)

It not only inhibits tyrosine phosphorylation but also enhances ubiquitinylation and accelerates endocytosis and subsequent intracellular destruction of ErbB-2 molecules. (lclabs.com)

The tyrosine kinase activity of insulin receptor isolated from the skeletal muscle of NIDDM patients has previously been found to be decreased compared with the activity of receptor from nondiabetic subjects but the mechanism underlying this defect is unknown. (jci.org)
This suggests that zinc plays a previously unidentified role where changes in zinc status over time may affect insulin activity. (hindawi.com)
However, an acute effect of insulin in modulating β-cell electrical activity and its underlying ionic currents has not been reported. (diabetesjournals.org)
Using the perforated patch clamp technique, we found that insulin (1-600 nmol/l) but not IGF-1 (100 nmol/l) reversibly hyperpolarized single mouse β-cells and inhibited their electrical activity. (diabetesjournals.org)
Vav3 GEF activity is dependent upon tyrosine phosphorylation which unlocks Vav3 from its "closed" conformation. (cytoskeleton.com)
In muscle, this coincided with a decrease in receptor number and an increase in basal tyrosine kinase activity. (biu.ac.il)
These observations indicate that loss and gain of receptor tyrosine kinase activity were dependent on insulin levels. (biu.ac.il)

Are receptors always on the plasma membrane? (flashcardmachine.com)

Our objective was to examine the associations between concentrations of vitamin D and concentrations of insulin, glucose, and HbA 1c in a nationally representative sample of adolescents in the U.S. (cdc.gov)
Our results support an inverse association between concentrations of vitamin D and insulin primarily in adolescent male subjects. (cdc.gov)
To provide additional insights into the associations between circulating concentrations of vitamin D and concentrations of insulin and glucose, we examined data from a large, representative sample of adolescents that included African Americans and Mexican Americans in the U.S. (cdc.gov)
Although the insulin receptor has a low affinity for IGF-I, IGF-I is present in the circulation at molar concentrations that are 1000 times those of insulin. (medscape.com)

In the present work, the effects of host insulin on Echinococcus metacestode vesicles and the proposed interaction between EmIR and mammalian insulin have been studied using biochemical and cell-biological approaches. (uni-wuerzburg.de)

In addition, a phosphotyrosine-specific antibody was used to monitor receptor tyrosine phosphorylation. (jci.org)

In the case of cancer-associated metabolic reprogramming, cancer cel s preferentially metabolize glu- cose through glycolysis rather than oxidative phosphorylation, even in the presence of oxygen [11-13]. (who.int)

Conversely, the inhibitor of PI3-kinase but not PKC reversed the antiapoptotic effect of insulin. (ewha.ac.kr)

Among these negative regulators, protein tyrosine phosphatases (PTPs) are likely to play a pivotal role in IR signaling. (bioone.org)

A biophysical model of bidirectional synaptic plasticity: dependence on AMPA and NMDA receptors. (modeldb.science)

Canertinib (CI-1033, PD 183805) is a pan-erbB tyrosine kinase inhibitor. (lclabs.com)
Canertinib is an irreversible tyrosine kinase inhibitor. (lclabs.com)
Olsson PO, Gustafsson R, In 't Zandt R, Friman T, Maccarana M, Tykesson E, Oldberg Å, Rubin K, Kalamajski S. The Tyrosine Kinase Inhibitor Imatinib Augments Extracellular Fluid Exchange and Reduces Average Collagen Fibril Diameter in Experimental Carcinoma. (lu.se)

It was also demonstrated that PTPϵM suppressed insulin-induced glycogen synthesis and inhibited insulin-induced suppression of phosphoenol pyruvate carboxykinase (PEPCK) expression in primary hepatocytes. (bioone.org)

Anatomy14

Organisms4

Diseases2

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes31

Information Science3

Kinases10

Substrate8

Epidermal growth f6

Signal transduction3

Residues5

Resistance21

Serine4

Proteins8

Stimulation5

PDGF2

Subunit1

Protein tyrosine ph1

Kinase receptors2

Platelet-derived1

Inhibition5

1162 and 11631

Vivo3

Pathway3

Status of insulin1

Stimulates1

Vitro3

Inhibitory1

Downstream1

Autophosphorylation3

Sensitivity7

Dimerizes with another1

Tissues1

Pathways5

Secretion4

Human insulin receptor1

Cytoplasmic2

Ligand2

Transmembrane2

Induces2

Residue1

Diabetes6

Substrates2

Cellular2

Inhibitors3

Abstract1

Adipocytes2

Phosphoinositide-3 kina1

Growth2

Glucose uptake2

Enhances1

Activity7

Plasma membrane1

Concentrations4

Mammalian1

Antibody1

Oxidative1

Effect of insulin1

PTPs1

NMDA1

Inhibitor3

Synthesis1