Insulin Receptor Substrate ProteinsReceptor, InsulinInsulinPhosphoproteinsInsulin ResistancePhosphorylationPhosphatidylinositol 3-KinasesSignal TransductionGlucoseIntracellular Signaling Peptides and ProteinsTyrosineReceptor, IGF Type 1Proto-Oncogene Proteins c-aktGlucose Transporter Type 4AdipocytesPhosphotyrosineInsulin-Like Growth Factor IPhosphotransferases (Alcohol Group Acceptor)Insulin AntagonistsHypoglycemic AgentsMuscle, SkeletalMonosaccharide Transport ProteinsEnzyme ActivationIslets of LangerhansLiverDeoxyglucoseDiabetes Mellitus, Type 2Adipose TissueAdaptor Proteins, Signal Transducing3T3 CellsCell LineProtein-Serine-Threonine KinasesSubstrate SpecificityKineticsGlucose Tolerance TestProtein-Tyrosine KinasesGRB2 Adaptor ProteinHyperinsulinismMolecular Sequence DataInsulin AntibodiesGlucose Clamp TechniqueCHO CellsInsulin, Long-ActingBlood GlucoseAmino Acid SequenceInsulin-Secreting CellsCells, CulturedSerineCricetinaeRibosomal Protein S6 KinasesMice, KnockoutProto-Oncogene ProteinsProtein Tyrosine PhosphatasesObesityAndrostadienesMuscle ProteinsProtein Tyrosine Phosphatase, Non-Receptor Type 1ProteinsPrecipitin TestsGlycogenPhosphoserineHyperglycemiaTransfectionProtein BindingBiological Transportsrc Homology DomainsBinding SitesProtein Tyrosine Phosphatase, Non-Receptor Type 11Insulin LisproRats, WistarRecombinant Proteins3T3-L1 CellsDiabetes Mellitus, ExperimentalImmunoblottingShc Signaling Adaptor ProteinsGlucose IntoleranceLeptinMice, Inbred C57BLCell MembraneFatty Acids, NonesterifiedMice, ObeseInsulin Infusion SystemsRats, ZuckerBlotting, WesternTOR Serine-Threonine KinasesRNA, MessengerTime FactorsDose-Response Relationship, DrugModels, BiologicalGlycogen Synthase Kinase 3HomeostasisGene Expression RegulationEnzyme InhibitorsProtein Tyrosine Phosphatase, Non-Receptor Type 6Base SequenceProtein KinasesInsulin AspartInsulin, IsophaneDiabetes MellitusRats, Sprague-Dawley