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  • tissues
  • IGF-I is essential for normal growth of children's bones, cartilage, and organs by stimulating uptake of glucose, fatty acids, and amino acids into tissues. (medscape.com)
  • IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. (thefullwiki.org)
  • human
  • Recombinant human insulinlike growth factor-1 (rhIGF-1) indicated for long-term treatment of GF in children with severe primary IGFD (primary IGFD defined as basal serum IGF-I level and height SD scores ≤ -3, normal or elevated serum GH level). (medscape.com)
  • The Insulin-Like Growth Factor System in the Human Pathology, Hot Topics in Endocrine and Endocrine-Related Diseases Monica Fedele, IntechOpen, DOI: 10.5772/55213. (intechopen.com)
  • important
  • Recent findings indicate that the effects of the cyclic nucleotide are mediated in part by changes in the activities of important elements in the signal transduction pathways utilized by insulin and growth factors. (nih.gov)