• This information is provided to help facilitate collaborations among investigators interested in the Genetics and Epigenetics of Substance Use Disorders. (nih.gov)
  • The „GSCN 2018 Young Investigator Award" goes to Dr. Nina Cabezas-Wallscheid of the Max Planck Institute for Immunobiology and Epigenetics. (eurostemcell.org)
  • The „GSCN 2018 Female Scientist Award " goes to Prof. Maria Elena Torres-Padilla of the Institute for Epigenetics and Stem Cells of the Helmholtz Zentrum München. (eurostemcell.org)
  • Since 2017 Nina Cabezas-Wallscheid has been active as Senior Researcher in the department of Professor Rudolf Grosschedl at the Max-Planck Institute of Immunobiology and Epigenetics (MPI-IE) in Freiburg. (eurostemcell.org)
  • She heads the Institute of Epigenetics and Stem Cells (IES) at the Helmholtz Zentrum München and aims at a better understanding of the molecular processes underlying cellular plasticity in order to develop better therapeutic approaches for regenerative medicine and infertility treatment. (eurostemcell.org)
  • On July 7, 2009 the NIH issued Guidelines for Human Stem Cell Research that provided NIH-funded researchers with access to human embryonic stem cell (hESC) lines by establishing an NIH Human Embryonic Stem Cell Registry . (nih.gov)
  • For more details about "On Hold" status, please refer to NOT-OD-10-063 (February 19, 2010) "Status of Certain Embryonic Stem Cell Lines. (nih.gov)
  • The NIH has developed its current NIH Human Embryonic Stem Cell Registry comprised of lines that have been submitted, reviewed and judged eligible for use in NIH-funded research per the 2009 NIH Guidelines on Human Stem Cell Research . (nih.gov)
  • The National Institutes of Health maintains two websites to assist investigators: "Implementation Issues for Human Embryonic Stem Cell Research" contains additional information related to NIH activities and procedures, including Frequently Asked Questions, at https://grants.nih.gov/grants/stem_cells.htm. (nih.gov)
  • Assign associated Human Embryonic Stem Cell lines. (nih.gov)
  • The project reportedly brings together experts in basic science, tumor immunology, molecular imaging, embryonic stem cell biology, gene medicine, and clinical research from University of California Los Angeles, California Institute for Technology, Children's Hospital Los Angeles, and University of Southern California. (genengnews.com)
  • In order to ensure adherence to ethical and legal principles of hESC research, Yale University has established an Embryonic Stem Cell Research Oversight (ESCRO) Committee as recommended by the National Research Council and Institute of Medicine of the National Academies' 2005 Guidelines for hESC Research. (yale.edu)
  • The Jothi Lab use embryonic stem cell (ESC) and its differentiated derivatives as a model system to understand how transcription regulators and chromatin modifications regulate gene expression programs during cellular development and differentiation. (nih.gov)
  • The 1998 embryonic stem cell discovery would dominate headlines for years, both because of the cells' immense biomedical promise and the controversy surrounding their origins. (wisc.edu)
  • The work by the Eggan and Maniatis group has major implications for the field of embryonic stem cell research because, Eggan explained, if you have embryonic stem cells that carry the genes for a disease - in this case ALS - "you can make limitless quantities of the cells affected by the disease, study the disease process, and have an in vitro model for studying possible treatments. (harvard.edu)
  • Eggan said that using embryonic stem cell models for studying disease can potentially have the same impact on increasing the understanding of human disease that installing so-called "black boxes" in airplanes has had on understanding the causes of crashes. (harvard.edu)
  • He is also an Adjunct Investigator at the National Cancer Institute (NCI). (nih.gov)
  • His seminal work enabled the generation of nephron progenitor cells and kidney organoids from hPSCs with high efficiency, leading to his NIH Director's New Innovator Award in 2019. (massgeneral.org)
  • Cancer Cell 35, 618-632.e6 (2019). (edu.au)
  • Dysfunctional immune responses contribute critically to the progression of Coronavirus Disease-2019 (COVID-19), with macrophages as one of the main cell types involved. (nature.com)
  • October 7, 2019 - Notice of Intent to Publish a Funding Opportunity Announcement for Maximizing Investigators' Research Award (MIRA) for Early Stage Investigators (R35 - Clinical Trial Optional). (nih.gov)
  • Read more about the 2018 Investigators here . (nyscf.org)
  • Dr Nina Cabezas-Wallscheid is the winner of the "GSCN 2018 Young Investigator Award" prize honoring her excellent research work as a junior scientist. (eurostemcell.org)
  • In collaboration with new NIH Center for Regenerative Medicine, we are developing iPSC-derived RPE tissue for cell-based therapy. (nih.gov)
  • Kidney organoids consist of multiple cell types of kidneys, serving as a novel tool for drug development and regenerative medicine. (massgeneral.org)
  • We propose to sponsor a CIRM Research Training Program in stem cell and regenerative medicine, which will provide six postdoctoral Ph.D. or M.D. (Type III) trainees per year with state-of-the-art stem cell-related research experience and coursework in a rich scientific environment. (ca.gov)
  • The goal is to prepare trainees for productive, independent research careers in stem cell and regenerative medicine, with an emphasis on training individuals from scientifically and demographically diverse backgrounds. (ca.gov)
  • Trainees will also be invited to participate in other courses and related activities at the Institute, including weekly laboratory meetings, a weekly journal club in stem cell and regenerative medicine, a special lecture series titled Seminars in Stem Cell Biology, professional development workshops, and a Summer Scholars Program for high school and college students, whom trainees will participate in mentoring. (ca.gov)
  • The National Institutes of Health (NIH) participating Institutes and Centers, in coordination with the U.S. Food and Drug Administration (FDA), seek highly meritorious clinical trial applications proposing to explore and enable the development of safe and effective regenerative medicine (RM) interventions using adult stem cells. (nih.gov)
  • NYUCD's stem cell initiative uses animal stem cells in "proof of principle" studies in regenerative medicine, with an emphasis on oral and head/neck structures. (nyu.edu)
  • Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have discovered an important naturally occurring process in the developing human embryo that can be lost when embryonic stem cells are derived in the lab. (ucla.edu)
  • The discovery provides scientists with critical information regarding the best method for creating stem cells for regenerative medicine purposes, such as cell transplantation or organ regeneration. (ucla.edu)
  • Therefore, until we have a way to create more stable naïve embryonic stem cells, the embryonic stem cells created for the purposes of regenerative medicine should be in a primed state in order to create the highest-quality cells for differentiation. (ucla.edu)
  • They showed that if they induced those large stem cells to become small again, the cells regained their regenerative potential and behaved like younger stem cells. (sciencedaily.com)
  • Chad and I have both been principal investigators on the induced pluripotent stem cell (IPSC) grant. (medscape.com)
  • At NYU's Center for Genomics and Systems Biology Center, a core group of investigators affiliated with the center performs research focused on regeneration and embryonic cells. (nyu.edu)
  • When mammals are severely injured, they just heal the wound and call it a day," says Sánchez Alvarado, who is also a Howard Hughes Medical Institute Investigator. (sciencedaily.com)
  • 2022. Bipartite interaction sites differentially modulate RNA-binding affinity of a protein complex essential for germline stem cell self-renewal. (nih.gov)
  • We have modified the existing stem cell to RPE differentiation protocols to make them more complaint with current Good Manufacturing Practices (cGMP-work). (nih.gov)
  • H/ACA snoRNA levels are regulated during stem cell differentiation. (nih.gov)
  • The combined efforts of these researchers have created a newly strengthened stem cell research program that is focused on the use of new techniques in systems biology to understand the complex gene networks of stem cells and their differentiation. (nyu.edu)
  • However, at the onset of differentiation, REST expression diminishes, and cells differentiate to become neurons (left hand side). (mdanderson.org)
  • however, because these mediators are also key features of CVD, it is unclear whether PM directly affects endothelial function or whether these changes are secondary to the exacerbation of CVD by PM. We found that in young, healthy individuals exposure to elevated levels of fine PM (PM2.5) suppresses circulating levels of endothelial progenitor cells (EPCs). (nih.gov)
  • and the identification and analysis of stem cells and progenitor cells of the intestine, prostate, heart and gonad. (nyu.edu)
  • Neural stem/progenitor cells normally express high levels of REST, which maintains self-renewal and stemness. (mdanderson.org)
  • Next, cells in the bone marrow are killed using either radiation therapy or chemotherapy, or a combination. (nih.gov)
  • The stem cells move through the bloodstream to the bone marrow and make new blood cells. (nih.gov)
  • Previous studies of hematopoietic stem cell transplantation for scleroderma used regimens of chemotherapeutic drugs to reduce, but not completely destroy, the population of cells in the bone marrow. (nih.gov)
  • A research team led by Dr. Keith M. Sullivan at Duke University set out to assess a procedure called myeloablative transplantation, which uses chemotherapy and total body radiation to destroy the bone marrow before the autologous hematopoietic stem cell transplant. (nih.gov)
  • The cells will then be returned to the bone marrow, where over the next two or three months they will develop into a genetically-engineered immune system designed to seek out and kill melanoma cells. (genengnews.com)
  • These cells are provided through the functional activity of rare haematopoietic stem cells (HSCs) harbored in the bone marrow of the adult individual. (ed.ac.uk)
  • The company's process for harvesting stem cells is less invasive, as the stem cells are taken from a patient's blood, which is a simplified process as compared to taking stem cells from fatty tissue or bone marrow. (biospace.com)
  • Blood cell stems are found in the bone marrow and generate the different blood cell types throughout life. (eurostemcell.org)
  • Researchers have shown that bone marrow stem cells injected into a damaged inner ear can speed hearing recovery after partial hearing loss. (science20.com)
  • Through the AIBN Summer and Winter Research internship programs, the institute provides research experience and laboratory skills to undergraduate students with an interest in research as a potential career. (wikipedia.org)
  • The Body Weight Simulator: An Interactive Tool for Accurate Personalized Weight Management," created by Drs. Kevin Hall and Carson Chow - both senior investigators in the NIDDK Laboratory of Biological Modeling - and Dhruva Chandramohan, then a post-baccalaureate fellow in NIDDK, was a finalist in the HHS innovates awards program. (nih.gov)
  • Using our unique expertise and novel resources (models and reagents), our laboratory fosters new translational strategies to de novo generate human HSCs from patient somatic cells. (ed.ac.uk)
  • The laboratory of MGH Research Scholar Jay Rajagopal, MD, is using cell culturing techniques to study respiratory disorders such as Cystic Fibrosis. (massgeneral.org)
  • He is also Associate Member of McGill University's Department of Mechanical Engineering, and a Director and Principal Investigator of the Research Institute of the MUHC's Myocardial Regeneration Laboratory. (biospace.com)
  • The Maximizing Investigators' Research Award (MIRA) under this FOA is a grant to provide support for the program of research in an early stage investigator's laboratory that falls within the mission of NIGMS. (nih.gov)
  • Watch a presentation by NYSCF - Robertson Investigator, Feng Zhang, PhD, who helped pioneer the revolutionary CRISPR gene editing tool. (nyscf.org)
  • Each of its new investigators will receive roughly $8 million over a seven-year period to continue their groundbreaking research. (nyscf.org)
  • The goal of the Ocular and Stem Cell Translational Research Section is to perform translational research on degenerative eye diseases using induced pluripotent stem (iPS) cell technology. (nih.gov)
  • On March 9, 2009, President Barack Obama issued Executive Order 13505, " Removing Barriers to Responsible Scientific Research Involving Human Stem Cells . (nih.gov)
  • For more details, please refer to the NIH Guide Notice NOT-OD-09-123 (July 15, 2009): "Status of Applications and Awards under the New NIH Guidelines for Human Stem Cell Research. (nih.gov)
  • NOT-OD-10-056 (February 19, 2010) "Review Considerations for Applications and Awards under the New NIH Guidelines for Human Stem Cell Research. (nih.gov)
  • Investigators with questions about NIH-supported hESC research may contact Dr. John Thomas for current information on this research area. (nih.gov)
  • For more information on this process, please refer to NOT-OD-10-020 (December 2, 2009) "First Human Embryonic Stem Cells Approved for use under the NIH Guidelines for Human Stem Cell Research. (nih.gov)
  • The NIH Stem Cell Information web site contains numberous links that may be useful to experienced researchers as well as to those planning their first research project that involves stem cells. (nih.gov)
  • Resources include information on submitting hESC lines to the NIH Registry to basic information on stem cells plus links to current research as well as information to upcoming hESC training courses. (nih.gov)
  • The OHRP document describes when research activities involving human embryonic stem cells (hESCs), human embryonic germ cells derived from fetal tissue, or hESC- or germ cell-derived test articles are considered human subjects research and what regulatory controls apply to that research. (nih.gov)
  • Learn about research groups using ultrasound technology, cell-free DNA/RNA screening, placentomics technology, and more to better understand the basic biology of the placenta. (nih.gov)
  • Learn more about research using stem cells to model preeclampsia . (nih.gov)
  • If you are giving a presentation about an environmental health topic or just looking for general information about environmental health research or the institute, this webpage will help. (nih.gov)
  • In the world of stem-cell research, attention is increasingly focused on the microenvironments within an organism where stem cells reside - the stem-cell niches. (nature.com)
  • Finding and identifying these signals has become a major thrust in stem-cell research. (nature.com)
  • If you are giving a presentation about an environmental health topic or just looking for general information about environmental health research or the institute, this page will help. (nih.gov)
  • The AIBN is an integrated multi-disciplinary research institute bringing together researchers in the areas of bioengineering and nanotechnology. (wikipedia.org)
  • At International Society for Stem Cell Research-the big stem cell meeting-Yamanaka revealed one more factor. (medscape.com)
  • The Interdisciplinary Stem Cell Institute enrolls patients, coordinates, and carries out research studies. (miami.edu)
  • He has been working on pluripotent stem cell research since 2007 and established protocols to induce kidney lineage cells. (massgeneral.org)
  • In other words, assay development & high-throughput technology - a particular strength of SBP & an emerging field within stem cell research - was emphasized, with the goal of making our trainees uniquely competitive for future academic or biotech jobs. (ca.gov)
  • The National Institute of Neurological Disorders and Stroke ( NINDS ) supports research to improve the diagnosis, prevention, and treatment of disorders of the brain, spinal cord, and nerves of the body. (nih.gov)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • Our Keynote was Dr. Julio Aguirre-Ghiso, the Rose Falkenstein Chair in Cancer Research, Endowed Professor of Cell Biology and Founding Director of the Cancer Dormancy & Tumor Microenvironment Institute at the Montefiore Einstein Cancer Center and Co-Director of the Gruss-Lipper Biophotonics Center. (mskcc.org)
  • Our research focuses on defining the molecular basis for HIV silencing, the signaling pathways used to reactivate latent HIV, the impact of drugs of abuse on the creation and reactivation of the latent viral reservoir in microglial cells, and the development of novel therapeutic approaches to attacking HIV latency. (nih.gov)
  • Hans Clevers is a group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and professor of Molecular Genetics at the University Medical Center Utrecht and Utrecht University. (kcl.ac.uk)
  • He is also Director Research of the Princess Máxima Center for Pediatric Oncology and Oncode Investigator. (kcl.ac.uk)
  • Participants represented the National Cooperative Reprogrammed Cell Research Groups (NCRCRG), PsychENCODE , the Psychiatric Gene Networks initiative, the Brain Somatic Mosaicism initiative, and the NIH Common Fund Tissue Chip Consortium , along with a large number of investigator-initiated projects. (nih.gov)
  • A current research focus is the biology of neuroendocrine Merkel cells and the oncogenesis of Merkel cell carcinoma. (nih.gov)
  • The biology and treatment of Merkel cell carcinoma: current understanding and research priorities. (nih.gov)
  • During the current reporting period, the scientific training program has provided support for postdoctoral fellows to receive instruction and engage in research related to stem cell biology. (ca.gov)
  • The program has contributed to and strengthened the future of stem cell research in California by helping to prepare new investigators for a career in stem cell research. (ca.gov)
  • In addition to her interest in clinical medicine, her scientific work resulted in multiple research fellowships, publications, and admission to the prestigious National Institutes of Health Medical Scientist Training Program at the University of Chicago Pritzker School of Medicine. (uclahealth.org)
  • Over the years Dr Rios' research interests have focussed on advancing 3D imaging technologies to explore developmental processes1, stem cell biology2 and cancer progression3. (edu.au)
  • As tenured group leader and head of the imaging center at the Princess Máxima Center for pediatric oncology and principal investigator of the Oncode cancer institute of excellence in the Netherlands, her research direction has now centered towards understanding and improving cancer immunotherapies. (edu.au)
  • The investigators were led by Christina Peters, MD , a pediatrics professor at the St. Anna Children's Cancer Research Institute, Vienna, Austria. (medscape.com)
  • Trials must be relevant to the research mission of one or more participating NIH Institutes and Centers and meet the NIH definition of a clinical trial (see NOT-OD-15-015 ). (nih.gov)
  • In the April 15, 2014 issue of the online journal eLife , Stowers Institute for Medical Research Investigator Alejandro Sánchez Alvarado and colleagues address that issue by identifying genes worms use to rebuild an amputated pharynx. (sciencedaily.com)
  • VANCOUVER, British Columbia, Jan. 23, 2023 (GLOBE NEWSWIRE) -- Hemostemix Inc. (TSXV:HEM) (OTCQB:HMTXF), an autologous stem cell therapy company, has received a $250,000 Letter of Commitment for funding from the The Research Institute of the McGill University Health Centre (MUHC) Foundation. (biospace.com)
  • This study paves the way for future research and clinical trials, supporting the use of ACP-01-based bioactive scaffolds to improve the stem cell-induced repair after a MI. (biospace.com)
  • After gaining her Doctorate in Mainz, she conducted her post-doc research in the "Stem Cells and Cancer" department (Professor Andreas Trumpp) at the German Cancer Research Centre (DKFZ) in Heidelberg. (eurostemcell.org)
  • New York University has received $1.5 million from New York State to continue its work in stem cell research. (nyu.edu)
  • The grants, announced by Governor Eliot Spitzer and Lieutenant Governor David A. Paterson in early January, are part of a $14.5 million funding package under the governor's stem cell research initiative intended to quickly boost New York State's biomedical research capability. (nyu.edu)
  • In order to be eligible for funding from the stem cell research initiative, an institution must have received at least $1 million in biomedical funding in 2006 from the National Institutes of Health or the National Science Foundation. (nyu.edu)
  • The New York State grant will also make possible the purchase of a high-speed cell sorter to accurately purify the minute populations of stem cells on which such research is based. (nyu.edu)
  • Kenneth Chien is the Director of the Cardiovascular Research Center at Massachusetts General Hospital, and Professor in the Department of Cell. (thesciencenetwork.org)
  • Increase flexibility for investigators to follow important new research directions as opportunities arise, rather than being bound to specific aims proposed in advance of the studies. (nih.gov)
  • Enable investigators to devote more time and energy to mentoring trainees in a more stable research environment. (nih.gov)
  • After more than 30 years with the University of Wisconsin-Madison and 15 years with the Morgridge Institute for Research, Thomson has announced plans to retire in July 2022. (wisc.edu)
  • The Wisconsin Alumni Research Foundation (WARF) , a vital long-term supporter of Thomson's research, created the organization WiCell in 1999 to enable distribution of Thomson's original stem cell lines to scientists across the world. (wisc.edu)
  • Thomson's attention at the Wisconsin National Primate Research Center soon switched permanently to stem cells once that science started showing progress. (wisc.edu)
  • The controversy came to a head in summer 2001 when the George W. Bush administration, after months of intense lobbying on both sides of the issue, ultimately allowed research to continue using only the five cell lines derived in the Thomson lab. (wisc.edu)
  • The research focuses on DNA methylation --- a biochemical process that occurs naturally in DNA - in the early embryo and in stem cells created from embryos. (ucla.edu)
  • To further this research, Clark and Plath plan to work together to determine the optimal conditions for creating naïve embryonic stem cells that are more stable and retain methylation at places in the genome where it is most needed. (ucla.edu)
  • We also know from prior research that caregivers' psychological well-being affects patient outcomes," said Hermioni Amonoo, MD, of the Dana-Farber Cancer Institute and Carol C. Nadelson, MD, Distinguished Chair in Psychiatry, Brigham and Women's Hospital in Boston, and the study's principal investigator. (hematology.org)
  • For the first time, a postdoctoral fellow has been appointed to serve as a member of the governing council of the Canadian Institutes of Health Research. (universityaffairs.ca)
  • Last week, Ginette Petitpas Taylor, Canada's minister of health, announced that a postdoctoral fellow has been appointed to serve as a member of the Canadian Institutes of Health Research (CIHR) governing council . (universityaffairs.ca)
  • We continued to provide bioinformatics consulting services to Harvard-affiliated investigators through individual collaborations as well as through our ongoing relationships with Harvard Catalyst, the Harvard Stem Cell Institute (HSCI), Harvard Medical School Tools and Technology (TnT), the Harvard NeuroDiscovery Center (HNDC), the National Institutes for Environmental Health Sciences (NIEHS), and the Center for AIDS Research (CFAR). (harvard.edu)
  • This is extraordinarily difficult research, but we've seen some progress in restoring some vision in mice," says Molly Shoichet , a University P rofessor in the department of chemical engineering and applied chemistry in the Faculty of Applied Science & Engineering and the Institute of Biomedical Engineering who is also an investigator at the Donnelly Centre for Cellular and Biomolecular Research. (utoronto.ca)
  • The late Angelika Amon, an MIT professor of biology and member of the Koch Institute for Integrative Cancer Research, is the senior author of the study. (sciencedaily.com)
  • Most public discussion and debate about stem cell research has focused on the possible uses for stem cells in treating disease, but during a telephone press conference Saturday, Maniatis echoed Eggan's comment, noting that the current Harvard study "establish[es] using stem cells to study the mechanism of disease, and use them to find treatments. (harvard.edu)
  • Our research involves collaboration between basic and clinical department investigators. (mdanderson.org)
  • In addition to being an Investigator with the Howard Hughes Medical Institute, a member of the National Academy of Sciences, and the recipient of numerous awards for her pioneering research on skin stem cells, Dr. Fuchs is also well known for her support of women in science. (uky.edu)
  • Paris Brain Institute, a key player in neuroscience research, is set on accelerating what we know about the brain and revolutionizing the way we treat brain-related diseases. (give2asia.org)
  • In 10 years, Paris Brain Institute became one of the leading research centers in the world. (give2asia.org)
  • To tackle this emergency head on, a group of visionary international clinicians, scientists and philanthropists decided to create a top-level research center: Paris Brain Institute. (give2asia.org)
  • Though, Paris Brain Institute is no typical research center. (give2asia.org)
  • Researchers have been studying autologous hematopoietic stem cell transplants for treating scleroderma. (nih.gov)
  • Researchers at 26 U.S. and Canadian sites randomly assigned 36 people with severe scleroderma to receive the hematopoietic stem cell procedure and 39 to receive one year of cyclophosphamide. (nih.gov)
  • Institute researchers founded three companies to develop AIBN technology - Vaxxas Pty Ltd (vaccine delivery), TenasiTech Pty Ltd (bio-plastics), and Pepfactants Pty Ltd - while Acyte, founded by AIBN Director Professor Peter Gray, was brought to AIBN from The University of New South Wales. (wikipedia.org)
  • A reporter gene that can be traced with PET scanning will also be inserted into the cells, so the researchers can monitor them noninvasively. (genengnews.com)
  • Researchers at the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND) have identified a potential new drug target for the treatment of Parkinson's disease and possibly for other degenerative neurological disorders. (science20.com)
  • Our researchers also developed three new R packages that provide quality control plotting tools and analysis for bulk RNA-seq (bcbioRNASeq, published in F1000), single cell RNA-seq (bcbioSingleCell) and small RNA-seq (bcbioSmallRna). (harvard.edu)
  • The researchers found that blood stem cells, which are among the smallest cells in the body, lose their ability to perform their normal function -- replenishing the body's blood cells -- as they grow larger. (sciencedaily.com)
  • The researchers also found that blood stem cells tend to enlarge as they age. (sciencedaily.com)
  • To study how size affects these stem cells, the researchers damaged their DNA, leading to an increase in their size. (sciencedaily.com)
  • After the treatment, the researchers measured the functionality of these two groups of stem cells by injecting them into mice that had their own blood stem cells eliminated. (sciencedaily.com)
  • This allowed the researchers to determine whether the transplanted stem cells were able to repopulate the mouse's blood cells. (sciencedaily.com)
  • In another experiment, the researchers used a genetic mutation to reduce the size of naturally occurring large stem cells that they found in older mice. (sciencedaily.com)
  • When the researchers treated mice with rapamycin, beginning at a young age, they were able to prevent blood stem cells from enlarging as the mice got older. (sciencedaily.com)
  • A team of Harvard researchers has used embryonic stem cells, derived from mice carrying a human gene known to cause a form of amyotrophic lateral sclerosis (ALS), to create an in vitro model of the always-fatal neurodegenerative disease. (harvard.edu)
  • In the same issue of Nature Neuroscience, a group of Columbia University Medical Center researchers, led by Serge Przedborski, collaborating with Eggan and Maniatis, also report that these glial cells, called astrocytes, produce a toxic factor that leads to motor neuron death. (harvard.edu)
  • In this approach, doctors first collect the participant's blood-forming stem cells. (nih.gov)
  • The patients then receive a transplant of their own blood-forming stem cells. (nih.gov)
  • Most stem cell transplant centers require people preparing to undergo a transplant to designate a primary caregiver - someone who will support them during the first 100 days after their transplant. (hematology.org)
  • We're thrilled to have Chad Cowan, an associate professor at Harvard University who is at the Harvard Stem Cell Institute. (medscape.com)
  • She is an investigator at the Howard Hughes Medical Institute and the Rebecca C. Lancefield Professor of Mammalian Cell Biology and Development at The Rockefeller University. (uctv.tv)
  • Amy Wagers is Principal Investigator in the section on Developmental and Stem Cell Biology at Joslin Diabetes Center and Assistant Professor in the. (thesciencenetwork.org)
  • Doug Melton is the Thomas Dudley Cabot Professor in the Department of Natural Sciences at Harvard University and an Investigator of the Howard Hughes. (thesciencenetwork.org)
  • We know that the six days after fertilization is a very critical time in human development, with many changes happening within that period," said Amander Clark, the study's lead author and a professor and vice chair of molecular, cell and developmental biology in the life sciences at UCLA. (ucla.edu)
  • and Steven Jacobsen, professor of molecular, cell and developmental biology in UCLA Life Sciences and an investigator with the Howard Hughes Medical Institute. (ucla.edu)
  • Harvard Stem Cell Institute principal investigator Kevin Eggan and Tom Maniatis, the Thomas H. Lee Professor of Molecular and Cellular Biology in Harvard's Faculty of Arts and Sciences, are the senior authors of the study published on-line April 15 by Nature Neuroscience. (harvard.edu)
  • We are utilizing kidney organoids to understand intrinsic repair mechanisms of kidney epithelial cells. (massgeneral.org)
  • Speakers discussed current practical strengths and weaknesses of using patient cell line collections versus genetically engineered isogenic cell lines to identify genetically complex psychiatric disease mechanisms. (nih.gov)
  • Right now, the mechanisms cells use to realize what structure is missing and then restore it remain completely mysterious. (sciencedaily.com)
  • Dr. Elaine Fuchs is an American cell biologist, famous for her work on the biology and molecular mechanisms of mammalian skin and skin diseases, who helped lead the modernization of dermatology. (uctv.tv)
  • But these embryonic stem cells are like the black boxes in aviation - they allow us to study the very earliest disease mechanisms in the lab. (harvard.edu)
  • We began with a focus on deciphering how epigenomic and transcriptomic regulations by REST, a transcriptional repressor, control normal neural stem cell biology and how aberrations of these mechanisms cause brain tumors. (mdanderson.org)
  • The discovery of Lgr5 as a generic marker of Wnt-dependent stem cells within multiple adult tissues has led to the development of technology to grow these stem cells into ever-expanding epithelial organoids. (kcl.ac.uk)
  • Successful applicants proposing the use of adult stem cells as a clinical intervention will be asked to make available representative samples of the source stem cell and clinical-grade stem cell-derived product for in-depth and independent characterization through the RM Innovation Catalyst (see description in Section I). (nih.gov)
  • Mammals can deploy adult stem cells to replace skin or immune system cells, among others. (sciencedaily.com)
  • The investigators expect to launch clinical trials in humans early next year. (genengnews.com)
  • In collaboration with oncologists in the National Cancer Institute, Dr. Brownell conducts early phase clinical trials treating skin cancer. (nih.gov)
  • ACS grantee tests a sweat sensor to see if it quickly IDs a personalized dose for 2 chemotherapy drugs that AML patients receive before a stem cell transplant. (cancer.org)
  • The process would work like a mini stem cell transplant, they explain. (genengnews.com)
  • For now at least, total body irradiation (TBI) plus etoposide remains the conditioning regimen of choice for children undergoing allogeneic hematopoietic stem cell transplant for acute lymphoblastic leukemia (ALL), according to an open-label phase 3 trial from Europe. (medscape.com)
  • 4 years old with high-risk ALL undergoing allogeneic HSCT [hematopoietic stem cell transplant]," they conclude. (medscape.com)
  • So does this mean that the HCT [hematopoietic cell transplant] community is forever chained to TBI as a standard of care? (medscape.com)
  • Minimal residual disease (MRD) did not influence survival outcomes, probably because the investigators were aggressive in inducing deep remission in their patients before transplant, so for most patients, MRD was undetectable or very low beforehand. (medscape.com)
  • Washington, Nov. 18, 2022) - November is Caregiver Awareness Month, and timely findings from a study published in Blood Advances suggest that, among caregivers of patients undergoing a stem cell transplant, how someone approaches coping can influence their levels of anxiety, depression, and poor quality of life (QOL) they experience. (hematology.org)
  • In addition, before undergoing a stem-cell transplant for a blood cancer, most patients receive induction chemotherapy, which effectively wipes out their immune system, leaving them highly vulnerable to infection and other medical complications. (hematology.org)
  • Previous studies have shown that caregivers of patients with cancer experience distress, loneliness, fatigue, sleep disturbance, financial worry, and poor QOL, and that fatigue among caregivers of patients undergoing a stem cell transplant is associated with slower growth of healthy new blood cells and poorer sleep quality for the patient. (hematology.org)
  • For this study, Dr. Amonoo and her colleagues enrolled 170 primary caregivers of people with a blood cancer who were undergoing a stem cell transplant. (hematology.org)
  • Shortly after the patient's admission to the hospital for their stem cell transplant, caregivers completed questionnaires that asked about their use of different coping strategies, symptoms of anxiety or depression, and QOL. (hematology.org)
  • Rapamycin, a drug that can inhibit cell growth, is now used to treat some cancers and to prevent organ transplant rejection, and has raised interest for its ability to extend lifespan in mice and other organisms. (sciencedaily.com)
  • A strong background in molecular biology, cell biology, and epigenetic regulation. (nih.gov)
  • Postdoctoral Fellowships are immediately available in the Jothi Lab at the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH) to study transcriptional and epigenetic control of cell fate decisions. (nih.gov)
  • Consistent with our mission, the program will focus on stem cells in aging and age-related disease, with particular concentration in neurodegenerative disorders. (ca.gov)
  • Dana-Farber Cancer Institute, Inc. (hhmi.org)
  • Program at the National Cancer Institute (NCI) is very strong and supports the development, translation, and commercialization of novel therapeutics, devices, diagnostics, and processes that are aimed at reducing the burden of cancer. (nih.gov)
  • Dr. Brownell studies the regulation of cutaneous stem cells and the molecular pathogenesis of skin cancer. (nih.gov)
  • ATOH1, TFAP2B, and CEACAM6 as Immunohistochemical Markers to Distinguish Merkel Cell Carcinoma and Small Cell Lung Cancer. (nih.gov)
  • Uncovering the mode of action of engineered T cells in patient cancer organoids. (edu.au)
  • Both the benevolent cells that are vital to life as well as the malignant ones that degenerate into diseases such as cancer. (eurostemcell.org)
  • We discovered that REST is a regulator of tumorigenesis in a subtype of children's brain tumors, medulloblastoma, by aberrantly maintaining stemness of cancer cells. (mdanderson.org)
  • Although not universally accepted at that time, brain tumor cancer stem cells were later isolated by others confirming our observations. (mdanderson.org)
  • Well aware of the important clinical uses, HSCs have been the most intensively studied somatic stem cells. (ed.ac.uk)
  • All trainees also began attending monthly seminars of the "SOUTHERN CALIFORNIA STEM CELL CONSORTIUM" (hybrid sessions which are also recorded by UC-TV & mounted on YouTube) that allow attendees to be exposed to the work of cutting-edge scientists world-wide & interact with international thought leaders). (ca.gov)
  • With more than 3.0 million page views and more than 5,000 items, this blog provides news and commentary on public policy, business and economic issues related to the $3 billion California stem cell agency. (blogspot.com)
  • The California Stem Cell Report will be posting items less frequently in the coming months, but we encourage all our readers to comment on the issues and send us messages keeping us up-to-date. (blogspot.com)
  • Cheers to all of you and thanks for reading the California Stem Cell Report. (blogspot.com)
  • The California stem cell agency received two distinct messages Wednesday at its first meeting on rules for intellectual property for business. (blogspot.com)
  • So far California's political junkies have been able to just say "no" to matters surrounding the California stem cell agency. (blogspot.com)
  • It is not exactly a case of wheelbarrows of cash rolling in the doors of the California stem cell agency agency. (blogspot.com)
  • They sparked Proposition 71, a California referendum in 2004 that led to the investment of $5.5 billion in state funds to support stem cell-based medical advances. (wisc.edu)
  • Using mouse genetics, he investigates the signals that regulate skin stem cell development and maintenance. (nih.gov)
  • She graduated from UCLA summa cum laude with highest honors from the Department of Molecular, Cell, and Developmental Biology with a bachelor of science degree (1999). (uclahealth.org)
  • Endothelial cells lining the vasculature are in magenta (Yokomizo T & Dzierzak E, Development. (ed.ac.uk)
  • We have also shown through a live imaging approach that HSCs arise from endothelial cells lining the wall of the embryonic aorta in a natural reprogramming event. (ed.ac.uk)
  • This transdifferentiation is known as Endothelial cell-to Hematopoietic cell transition (EHT). (ed.ac.uk)
  • We are one of the few groups worldwide that can isolate these special endothelial cells and show that they yield robust transplantable HSCs (the gold-standard for clinically relevant HSCs). (ed.ac.uk)
  • Real-time birth of a HSC from an endothelial cell lining the wall of a mouse embryonic aorta (Boisset J-C. et al. (ed.ac.uk)
  • In vasculature, PDE1C expression is selectively induced in synthetic SMCs, but not in contractile SMCs or endothelial cells. (rochester.edu)
  • All trainees have, or are in the process of, participating in required didactic courses, which include a Mesa-wide core course entitled "STEM CELLS & ETHICS", an interdisciplinary lecture/discussion course developed for the Network & taught by faculty from all of the Institutions on the Mesa. (ca.gov)
  • The W.M. Keck Foundation awarded a $1.8 million grant to scientists at institutes in Los Angeles to genetically engineer the human immune system to fight melanoma. (genengnews.com)
  • Stem cell science now employs tens of thousands of scientists globally in industry and academia. (wisc.edu)
  • In 1998, when the first human embryonic stem cells were derived, scientists used a method that created primed stem cells. (ucla.edu)
  • This was the standard method until recently, when scientists started using a different method that preserves the naïve stem cell state. (ucla.edu)
  • Many scientists believed that this enlargement was simply a side effect of aging, but the Amon lab began to investigate the possibility that large cell size drives age-related losses of function. (sciencedaily.com)
  • Then in 1998, he isolated five stem cell lines from human embryos, work that enabled stem cell discovery in thousands of labs around the world and spawned a prolonged, high-stakes bioethical debate in the U.S. (wisc.edu)
  • Elaine Dzierzak's lab aims to identify the molecules involved in the generation of haematopoietic stem cells (HSC) and to generate patient-specific HSCs for clinical cell replacement therapies to treat blood-related genetic diseases and leukaemia. (ed.ac.uk)
  • However, current clinical therapies are limited by the number of HSCs available for such transplantations and attempts to expand such cells ex vivo have been unsuccessful. (ed.ac.uk)
  • Applied to various solid tumor types modeled with patient derived organoids and emerging T cell therapies, BEHAV3D revealed a high heterogeneity in targeting efficacy and functional behavior. (edu.au)
  • Founded in 2003, Hemostemix' principal business is to develop, manufacture and commercialize blood-derived stem cell therapies for medical conditions not adequately addressed by current treatments. (biospace.com)
  • The National Institute of Environmental Health Sciences (NIEHS) is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere. (nih.gov)
  • There is now evidence that the molecular signals exchanged between stem cells and other cells within these niches are key factors in stem-cell control. (nature.com)
  • Stem-cell niches: It's the ecology, stupid! (nature.com)
  • NYU's School of Medicine's Helen and Martin Kimmel Center of Stem Cell Biology looks at how stem cells renew themselves and how they interact with specific niches in the body. (nyu.edu)
  • In particular, Fuchs researches skin stem cells, and their production of hair and skin. (uctv.tv)
  • The investigators continue to follow study participants to assess long-term health outcomes. (nih.gov)
  • With regard to patient selection, the investigators note that a recent review that included more than 3000 children with ALL found no overall survival benefit with TBI vs chemoconditioning for patients in first complete remission (CR1) but worse outcomes with chemoconditioning among patients in CR2. (medscape.com)
  • Our translational goals are focused on retinal pigment epithelium (RPE), a monolayer of highly polarized cells located in the back of the eye, whose apical processes inter-digitate with photoreceptor outer segments. (nih.gov)
  • we capture the transcriptome of the first functional HSCs in mouse by single-cell RNA-seq, index sorting, and in vivo and in vitro haematopoietic analyses. (ed.ac.uk)
  • According to Carrie Adler, Ph.D., a postdoctoral fellow in the Sánchez Alvarado lab who led the study, analysis showed most of the 20 factors either had a generic function in stem cells (which was interesting but not what they were after) or were specifically required for pharynx regeneration. (sciencedaily.com)
  • Dr. Cecere's lab recently published a systematic review and meta-analysis that demonstrated that stem cells combined with bioactive scaffolds provide enhanced tissue regeneration in animal models of MI, compared to stem cells injected alone. (biospace.com)
  • This includes projects geared toward the ultimate application of stem cell technology to the treatment of human neurodegenerative disease. (ca.gov)
  • NOT-OD-10-029 (December 14, 2009) "Clarification of Terms and Conditions of Awards using Human Embryonic Stem Cells. (nih.gov)
  • The National Institute of Mental Health (NIMH) is part of NIH, a component of the U.S. Department of Health and Human Services. (nih.gov)
  • The investigators sought to answer a question many physicians have raised: with improvements in human leukocyte antigen typing, better graft-vs-host disease prophylaxis, and other advances, can myeloablative chemotherapy conditioning replace TBI, which is more toxic? (medscape.com)
  • The developing human body will eventually grow from a tiny two-celled zygote to a massively complex system comprising more than 37 trillion cells. (wisc.edu)
  • The first was in 1995, when he derived stem cells from non-human primates, the first time ever done in a species closely related to people. (wisc.edu)
  • I wasn't really thinking that I'd be the one to drive the human cells," he explains. (wisc.edu)
  • Primed human embryonic stem cells (purple) surrounded by a stem cell surface marker (green), which would be missing in naïve embryonic stem cells. (ucla.edu)
  • Correct DNA methylation of particular genes is critical for normal human development, and it remains critical in maintaining healthy cells throughout a person's lifespan. (ucla.edu)
  • The less mature human embryonic cells that exist at the beginning of blastocyst development are called "naïve" embryonic cells. (ucla.edu)
  • Paris Brain Institute brings under one roof scientific talents from around the world, no matter their field of expertise, to study the human body's most complex organ: the brain. (give2asia.org)
  • A study of people with severe scleroderma found that a new approach using stem cell transplants provides a better outcome than an immune-suppressing drug. (nih.gov)
  • BEHAV3D5, that has been developed to exploit immune-organoid co-cultures for understanding and improving the dynamic mode-of-action of engineered T cells in a patient personalized manner 5,6. (edu.au)
  • The progression from mild to severe disease or death is principally attributed to dysfunctional immune responses 2 , 3 coupled with viral damage of target cells. (nature.com)
  • In addition to local damage, the pro-inflammatory macrophages release cytokines/chemoattractants and prime adaptive immune cell responses In some cases, this lead to cytokine release syndromes including macrophage activation syndrome (MAS) 7 , followed by respiratory and even multi-organ failure 5 . (nature.com)
  • If we find drugs that are specific in making large blood stem cells smaller again, we can test whether this improves the health of people who suffer from problems with their blood system -- like anemia and a reduced immune system -- or maybe even help people with leukemia," she says. (sciencedaily.com)