Institute autologous stem cell. Medical search. Frequent questions

Multiple Myeloma (MM) is an incurable plasma cell malignancy often treated by autologous stem cell transplant (ASCT). (haematologica.org)
1 Despite significant therapeutic advances for MM, autologous stem cell transplant (ASCT) following high-dose, single-agent melphalan conditioning remains a cornerstone of therapy. (haematologica.org)
Standard of care for patients post hematopoietic cell transplant (HCT) includes repeating all childhood vaccinations. (wesparkhealth.com)
A total of 83% of autologous HCT (N=57) and 66% of allogeneic HCT (N=47) patients had serology tested to measure MMR reactivity post-transplant prior to live vaccinations. (wesparkhealth.com)
Dr. Song's research interests include the treatment of myeloma and other plasma cell dyscrasias and the use of hematopoietic stem cell transplant to treat non-Hodgkin's lymphoma. (vchri.ca)
Bendamustine and rituximab as induction therapy in both transplant-eligible and -ineligible patients with mantle cell lymphoma. (vchri.ca)
A stem cell transplant is often the best option to treat blood cancers, such as leukemia , lymphoma and multiple myeloma , as well as bone marrow failure syndromes like myelodysplastic syndrome . (mdanderson.org)
A hematopoietic stem cell transplant replaces faulty cells so the body can produce normal, healthy cells again. (mdanderson.org)
An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)
An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
The cells for a cord blood transplant come from an umbilical cord collected at birth by the MD Anderson Cord Blood Bank . (mdanderson.org)
Treatment with activated factor 7 and in a patient with multiple myeloma who had received an allogeneic stem cell transplant requiring substantial corticosteroids was given with some clinical improvement immunosuppression. (cdc.gov)
in an hyperbilirubinemia and elevation of liver aminotransferases, immunosuppressed patient who received an allogeneic together with diarrhea, abdominal distension, and new stem cell transplant for multiple myeloma. (cdc.gov)
While many of the Cancer Institute's patients are able to receive the most advanced therapies for their diagnosis close to home, people who needed hematopoietic cell transplant or cellular immunotherapy have always needed to travel outside of the Lehigh Valley for these treatments. (lvhn.org)
That changes this year with the development of Lehigh Valley Topper Cancer Institute's Stem Cell Transplant and Cellular Therapy Program. (lvhn.org)
The Cancer Institute's membership in the Memorial Sloan Kettering Cancer Alliance will also connect the new program to additional stem cell transplant and cellular therapy education and resources. (lvhn.org)
Dr. Toor and Dr. Nair hope to launch the Stem Cell Transplant and Cellular Therapy Program in fall 2023. (lvhn.org)
The Children's Hospital 2 in Ho Chi Minh City has successfully performed an autologous stem cell transplant on the smallest patient so far - a 32-month-old girl suffering from severe neuroblastoma (NB). (vietnamplus.vn)
Without a hematopoietic stem-cell transplant, the survival rate was only 12 percent. (vietnamplus.vn)
The patient received an autologous stem cell transplant on December 20. (vietnamplus.vn)
The hospital has built a stem cell transplant centre which became operational last December, he said. (vietnamplus.vn)
In this condition, a donor's immune cells attack the vital organs of a transplant recipient. (mskcc.org)
This is because we have brought together recognized physician leadership in oncology from the Texas Transplant Institute at Methodist Hospital in San Antonio, the Sarah Cannon Blood Cancer Network and Texas Oncology. (stdavids.com)
The Hematology and Blood & Marrow Transplant team treats all blood-related diseases, including aplastic anemia and other conditions that stem from a bone marrow failure, as well as some solid neoplastic diseases. (uky.edu)
They also noted that transplant-based approaches were effective in the post-CAR T-cell therapy setting. (medpagetoday.com)
The 20 patients who underwent either autologous or allogeneic stem cell transplant after progression had an OS of 23.2 months (95% CI 17.6 to NE). (medpagetoday.com)
They had received a median of five previous treatment lines (including autologous stem cell transplant in 94.9% of patients), and most (83.5%) were triple class-refractory (refractory to ≥1 immunomodulatory drug, ≥1 proteasome inhibitor, and ≥1 anti-CD38 monoclonal antibody). (medpagetoday.com)
The study is seeking to generate and then transplant a layer of healthy RPE cells to prevent vision loss. (webrn-maculardegeneration.com)
Interim study data suggest haematopoietic cell transplant may induce sustained remissions in early MS. (pharmaceutical-journal.com)
High-dose immunosuppressive therapy with autologous haematopoietic cell transplant may, in contrast, induce sustained remissions in early MS. (pharmaceutical-journal.com)
For the 24 patients who received HDIT with autologous haematopoietic cell transplant, the overall rate of event-free survival was 78.4% at three years (90% confidence interval 60.1%-89.0%) - this was defined as survival without loss of neurologic function, clinical relapse or new lesions observed on imaging. (pharmaceutical-journal.com)
However, the authors of an editorial [2] accompanying the JAMA Neurology study say "the jury is still out" on the appropriateness of haematopoietic cell transplant for MS. (pharmaceutical-journal.com)
This randomized phase III trial studies how well standard-dose combination chemotherapy works compared to high-dose combination chemotherapy and stem cell transplant in treating patients with germ cell tumors that have returned after a period of improvement or did not respond to treatment. (cincinnatichildrens.org)
Giving chemotherapy before a stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. (cincinnatichildrens.org)
Chemotherapy is then given to prepare the bone marrow for the stem cell transplant. (cincinnatichildrens.org)
It is not yet known whether high-dose combination chemotherapy and stem cell transplant are more effective than standard-dose combination chemotherapy in treating patients with refractory or relapsed germ cell tumors. (cincinnatichildrens.org)
High-risk patients do not benefit from stem cell transplant and should be offered alternative therapies. (elsevierpure.com)
People with relapsed or refractory diffuse large B-cell lymphoma who cannot have an autologous stem cell transplant usually have polatuzumab vedotin plus rituximab and bendamustine. (bvsalud.org)
Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)

Multiple Myeloma (MM) is an incurable plasma cell malignancy that accounts for 18% of all hematologic malignancies. (haematologica.org)
Outpatient Autologous Stem Cell Transplants for Multiple Myeloma: Analysis of Safety and Outcomes in a Tertiary Care Center. (vchri.ca)
Bortezomib for induction therapy in multiple myeloma before high-dose chemotherapy and autologous stem cell transplantation. (blogspot.com)
Patients with multiple myeloma who relapse after treatment with B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapy can be salvaged with multiple lines of therapy, a retrospective study suggested. (medpagetoday.com)
In explaining the rationale for the study, Parekh and colleagues noted that while the use of BCMA-directed CAR T-cell therapies in relapsed and refractory multiple myeloma have demonstrated high response rates, optimal treatment regimens have yet to be defined for patients who relapse. (medpagetoday.com)
From March 2017 to January 2022, 140 patients with multiple myeloma were treated with a BCMA-directed CAR T-cell therapy on a clinical trial at either the Mount Sinai Tisch Cancer Institute or Memorial Sloan Kettering Cancer Center in New York City. (medpagetoday.com)
Hearn Jay Cho is an Associate Professor of Medicine at the Icahn School of Medicine at Mt. Sinai and an Attending Physician with the Multiple Myeloma Service at the Mt. Sinai Tisch Cancer Institute. (themmrf.org)
Genetic aberrations have emerged as major prognostic factors for patients with multiple myeloma (MM). We evaluated 126 MM patients for t(4;14) or t(11;14), 13q or p53 deletions and correlated the number of genetic aberrations with patient's clinical outcome following undergoing autologous stem cell transplantation. (elsevierpure.com)
Multiple myeloma (MM) is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. (medscape.com)
Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)

To understand the different types of stem cell transplants and how they work, we spoke with Borje S. Andersson, M.D., Ph.D. Here's what he had to say. (mdanderson.org)
What are the types of stem cell transplants? (mdanderson.org)
Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
Dr. Toor has more than 20 years of experience with autologous and allogeneic transplants. (lvhn.org)
The expanded analysis now includes 8,767 stool samples from 1,362 people who have had allogeneic stem cell or bone marrow transplants at four centers around the world. (mskcc.org)
One of the most serious complications of blood stem cell or bone marrow transplants (BMTs) , which are used to treat many types of blood cancer, is graft-versus-host disease (GVHD). (mskcc.org)
Our experts perform both autologous transplants, which use stem cells from the patient, and allogeneic procedures, which use stem cells from a donor. (uky.edu)
Researchers are following the progress of 24 patients with relapsing-remitting multiple sclerosis (RRMS) who received transplants of their own haematopoietic stem cells after receiving high-dose immunosuppressive therapy (HDIT). (pharmaceutical-journal.com)
The idea to use transplants of dopa- ment of protocols that allow generation of fully functional mine-producing cells to substitute for the lost midbrain and safe midbrain dopamine neurons from stem cells. (lu.se)

Nakano, Atsushi (2013-04-10), "Cardiac Regeneration Using Isl1-positive Cardiac Progenitor Cells", Cardiac Regeneration using Stem Cells, CRC Press, pp. 185-209, retrieved 2023-09-23 Mahla RS (2016). (wikipedia.org)
Human/Sheep Hematopoietic Chimeras", Hematopoietic Stem Cell Transplantation, CRC Press, pp. 166-183, 2000-07-25, ISBN 978-0-429-16445-3, retrieved 2023-09-23 This article incorporates public domain material from Dictionary of Cancer Terms. (wikipedia.org)
Hematologist Amir Toor, MD, joined Lehigh Valley Topper Cancer Institute in March 2023. (lvhn.org)
LOS ANGELES, CA, UNITED STATES, November 20, 2023 / EINPresswire.com / -- - Biostar Stem Cell Research Institute has received approval from Japan's Ministry of Health, Labor and Welfare to treat Parkinson's Disease. (keloland.com)
NEW YORK, Jan. 4, 2023 /PRNewswire/ -- BrainStorm Cell Therapeutics Inc. (NASDAQ: BCLI), a leading developer of adult stem cell therapeutics for neurodegenerative diseases, today announced the promotion of Dr. Stacy Lindborg to the role of Co-Chief Executive Officer. (biospace.com)
NEW YORK , Nov. 20, 2023 /PRNewswire/ --BrainStorm Cell Therapeutics Inc. (NASDAQ: BCLI), a leading developer of adult stem cell therapeutics for neurodegenerative diseases, today announced that the US Food & Drug Administration (US FDA) has granted the company a meeting to discuss the regulatory path forward for NurOwn® in amyotrophic lateral sclerosis (ALS). (wkrn.com)

We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
The choice of chemotherapy depends on several factors, including the patient's performance status, age, renal function, desire for inpatient or outpatient therapy, and likelihood of receiving future autologous stem cell transplantation. (medscape.com)
Chemotherapy, either at conventional levels or in the higher-dosed myeloablative protocols used in conditioning regimens (with or without total body radiation in preparation for hematopoietic cell transplantation [HCT]), often results in erythema, edema, atrophy, and ulceration of the oral mucosa, a condition generally referred to as oral mucositis. (medscape.com)
Drugs used in chemotherapy, such as paclitaxel, ifosfamide, cisplatin, carboplatin, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (cincinnatichildrens.org)
Giving colony-stimulating factors, such as filgrastim or pegfilgrastim, and certain chemotherapy drugs, helps stem cells move from the bone marrow to the blood so they can be collected and stored. (cincinnatichildrens.org)
The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. (cincinnatichildrens.org)
They demonstrated that type I MAGE plays a critical role in conferring resistance to chemotherapy and inhibition of apoptosis in myeloma cells through regulation of Bcl-2 family proteins and the tumor suppressor p53. (themmrf.org)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)

Following recent regulatory approvals of two chimeric antigen receptor T-cell (CAR-T) therapies, the field now faces a number of post-approval challenges. (ox.ac.uk)
It is an honor to bring stem cell transplantation and cellular therapies to adults in the Lehigh Valley and its surrounding communities," Dr. Toor says. (lvhn.org)
He also has expertise with cellular therapies for hematologic malignancies, specifically chimeric antigen receptor (CAR) T-cell therapy. (lvhn.org)
Nabiha Saklayen is the CEO and cofounder of Cellino Biotech , a company that aims to make personalized, autologous cell therapies accessible for patients. (publicradioeast.org)
The institute has previously received regulatory approval for stem cell therapies for degenerative arthritis, severe lower extremity ischemia, and autoimmune diseases, administrated through intraarticular, intramuscular, and intravenous routes, respectively. (keloland.com)
The specialized culture media developed by Biostar Stem Cell Research Institute, exclusively manufactured and supplied by its affiliate Nature Cell, plays a crucial role in enhancing the effectiveness and safety of these therapies. (keloland.com)
In addition to providing autologous adult stem cell therapies to patients, the XCell-Center is also actively involved in pre-clinical and clinical research. (cellmedicine.com)
How cell and gene therapies can be safely protected as they move along the supply chain, even when temperature-related challenges present themselves. (pharmaceuticalcommerce.com)
Increasing investments in stem cell research, rising chronic disease prevalence, advancements in biotechnology, collaborations between academia and industry, stringent regulations, and expanding awareness of stem cell therapies are stimulating the market growth. (imarcgroup.com)
Apart from this, the increasing awareness and acceptance of stem cell-based therapies among patients and healthcare professionals is augmenting the market growth. (imarcgroup.com)
This driver is fueled by the promising prospects of stem cell therapies in addressing previously untreatable conditions, such as neurodegenerative diseases and spinal cord injuries. (imarcgroup.com)
Stem cell therapies hold immense promise in addressing these ailments by regenerating damaged tissues and organs. (imarcgroup.com)
This suggests that for eligible patients that progress after BCMA-directed CAR T, additional T-cell-engaging therapies contribute meaningfully to survival and that T-cell activation is feasible down the line," Parekh and team wrote. (medpagetoday.com)
Most patients with RRMS who receive approved disease-modifying therapies experience breakthrough disease and accumulate neurologic disability," say the researchers, led by Richard Nash, of the Colorado Blood Cancer Institute, Denver. (pharmaceutical-journal.com)
The growth of the market is attributed to the rising number of clinical trials and the growing adoption of cell therapies globally. (mordorintelligence.com)
Additionally, the increasing clinical trials for using the treatment of COVID-19 using autologous cell therapies are expected to contribute to the growth of the market. (mordorintelligence.com)
The rise in musculoskeletal disorders among the global population is expected to contribute to the growth of the studied segment along with the launch of innovative autologous cell therapies. (mordorintelligence.com)
Several drug therapies are valuable in the treatment of symptomatic MM. Clinicians treat many patients with high-dose therapy and peripheral blood or bone marrow stem cell transplantation. (medscape.com)

Given the tremendous promise of regenerative medicine to enhance human health and treat disease, Congress included a provision in the 21st Century Cures Act to support a Regenerative Medicine Innovation Project ($30 million distributed over FY17 through FY20) for the funding of clinical research to further the field of regenerative medicine (RM) using adult stem cells, including autologous, non-autologous use as well as eligible induced pluripotent stem cells (iPSC). (nih.gov)
Korea's leading adult stem cell research institute, Biostar Stem Cell Research Institute (Director, Dr. Jeongchan Ra), announced on the 20th that a regenerative medicine technology that treats Parkinson's disease by administering autologous fat-derived stem cells cultured using patented technology into the intravenous and spinal cord cavity has been approved by the Japanese Ministry of Health and Welfare. (keloland.com)
The XCell-Center is a private clinical group and institute for regenerative medicine which operates two treatment centers, one in Cologne and one in Dusseldorf, Germany. (cellmedicine.com)
Its headquarters are located at the Dominikus hospital in Dusseldorf, while its second branch is located at the Eduardus Hospital's Institute of Regenerative Medicine in Cologne. (cellmedicine.com)
The global stem cell manufacturing market is influenced by increasing investments in stem cell research and regenerative medicine by governments and private organizations. (imarcgroup.com)
The global stem cell manufacturing market is experiencing a significant upsurge due to the substantial investments pouring into stem cell research and regenerative medicine. (imarcgroup.com)
this trial investigated the safety and efficacy of repeat-administration of autologous MSC-NTF cells and was supported by a grant from the California Institute for Regenerative Medicine (CIRM CLIN2-0989), and another grant from the ALS Association and I AM ALS. (wkrn.com)
Macular degeneration and stem cells are the focus of research by several biotech companies in the United States and world wide that seek to use regenerative medicine to treat many different retinal conditions. (webrn-maculardegeneration.com)

Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)

Stem cell treatment after high-dose immunosuppressive therapy could be an effective way to manage relapsing-remitting multiple sclerosis, according to interim results from a five-year study [1] published in JAMA Neurology on 29 December 2014. (pharmaceutical-journal.com)

This program has a special focus on immunologic therapy in the setting of autologous stem cell transplantation for myeloma. (themmrf.org)

Pre-emptive treatment with rituximab of molecular relapse after autologous stem cell transplantation in mantle cell lymphoma. (smw.ch)
Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)

BrainStorm Cell Therapeutics Inc. is a leading developer of innovative autologous adult stem cell therapeutics for debilitating neurodegenerative diseases. (wkrn.com)

The strict prohibition of embryonic stem cell therapy in Germany, as in many other countries, is based not so much on ethical concerns but on concrete scientific reasons, not the least of which is the fact that embryonic stem cells are medically unsafe. (cellmedicine.com)
There are two types of stem cell manufacturing: embryonic stem cell production, derived from early-stage embryos, and induced pluripotent stem cell (iPSC) production, which reprograms adult cells to an embryonic-like state. (imarcgroup.com)
Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers. (bvsalud.org)

Autologous stem-cell transplantation is distinguished from allogenic stem cell transplantation where the donor and the recipient of the stem cells are different people. (wikipedia.org)
This allows us to collect more cells in a short period, decrease patient/donor downtime and freeze the cells for future use. (mdanderson.org)
If the donor cells aren't a close enough match, the patient's body may recognize the donor cells as foreign and reject them. (mdanderson.org)
Or, the cells from the donor may recognize the new body as foreign and attack. (mdanderson.org)
Allogeneic" means the blood or marrow stem cells come from a donor. (mskcc.org)
Since only autologous (in which the donor and recipient are the same person) adult stem cells are used, there is no risk of immune rejection. (cellmedicine.com)
2 These cells either originate from the patient (autologous) or a donor (allogeneic). (pharmaceuticalcommerce.com)
the donor.4,11 In the case of nerve cells obtained from either delivery of dopamine released from cells the developing central nervous system (CNS), the opti- implanted into the ventricle, adjacent to the stria- mal age was shown to be at, or close to, the cell-cycle tum,6,7 or restoration of synaptic dopamine release exit. (lu.se)

Autologous hematopoietic stem-cell transplantation Stem-cell therapy "What Are Stem Cells? (wikipedia.org)
Two years out, patients receiving stem cell therapy show sustained heart function improvement, study suggests. (wikipedia.org)
The treatment regimen associated with the TIL therapy comprises of collection of lymphocytes that have the ability to engage themselves in the tumor cells destruction. (researchandmarkets.com)
The therapy is completely dependent on the tumor biopsy extracted from the patients rather than circulating T cells in the blood. (researchandmarkets.com)
Minimal residual disease (MRD) refers to the small number of malignant cells that remain after therapy when the patient is in remission and shows no symptoms or overt signs of disease. (smw.ch)
If you have undergone anti-cancer therapy in the past year, you are within 1 year of stem cell transplantation or are receiving medications that suppress your immune system, you are encouraged to obtain a COVID-19 vaccination booster shot. (stdavids.com)
Nabiha Saklayen: Could lasers make stem cell therapy available to everyone? (publicradioeast.org)
Biostar Stem Cell Research Institute's two-decade-long research on stem cell culture and treatment technologies, including the recently approved Parkinson's disease therapy, holds promise for developing new avenues for treating neurological disorders. (keloland.com)
Areas of particular interest include aggressive B-cell lymphomas, autologous stem cell transplantation and cellular therapy including chimeric antigen receptor (CAR) T-cells. (rochester.edu)
Judy DiCorcia of New York has written an open letter to President Obama in which she describes the improvement of her 10-year-old autistic daughter, Lauren, after adult stem cell therapy was administered to the child at the XCell-Center in Cologne, Germany. (cellmedicine.com)
As explicitly stated on the website of the XCell-Center, 'therapy with embryonic stem cells is strictly prohibited in Germany. (cellmedicine.com)
At the XCell-Center, we only use the patient's own stem cells for therapy. (cellmedicine.com)
Back in the U.S., Lauren's mother, Ms. DiCorcia, wishes that this type of adult stem cell therapy were available in the U.S., so that she wouldn't have to travel to Germany for her child's treatment. (cellmedicine.com)
In January, we took Lauren to Cologne, Germany for adult stem cell therapy. (cellmedicine.com)
This presentation will provide meaningful data and a detailed discussion related to the commercial penetration and revenue generated by existing products as well as a breakdown of industry-sponsored stem cell therapy clinical trials (excluding basic stem cell transplantation) including stages, product types and indications. (selectbiosciences.com)
A quick look at the history of cell and gene therapy (CGT) shows an industry with decades of incremental growth followed by more recent acceleration. (pharmaceuticalcommerce.com)
Though the words 'cell and gene therapy' are used in combination, they are different fields of biomedical research and treatment. (pharmaceuticalcommerce.com)
1 By contrast, cellular therapy uses healthy transplanted human cells to grow, replace, or repair damaged tissue that causes disease. (pharmaceuticalcommerce.com)
Hematopoietic blood stem cell transplantation-a cell therapy-was first explored in humans in the 1950s and is currently a well-established treatment for blood diseases. (pharmaceuticalcommerce.com)
Gene therapy was first introduced in the late 1970s, and the first trial in humans began in 1990 when colleagues at the National Institutes of Health (NIH) performed the first-approved gene therapy procedure on a 4-year-old with severe combined immunodeficiency (SCID). (pharmaceuticalcommerce.com)
In elderly patients or patients in whom autologous transplantation is not possible in the future, melphalan and prednisone (MP) therapy is preferred because of its ease of administration and low toxicity. (medscape.com)
Among 79 patients who were given a total of 237 salvage treatments, median overall survival (OS) from the date of relapse post-CAR T-cell therapy was 17.9 months (95% CI 14.0 to not estimable [NE]), reported Samir Parekh, MD, of the Icahn School of Medicine at Mount Sinai in New York City, and colleagues. (medpagetoday.com)
Of note, patients who received a T-cell-engaging therapy (a bispecific antibody or subsequent CAR T-cell therapy) had the greatest success in this setting, with OS not reached after a median follow-up of 21.3 months, they noted in Blood . (medpagetoday.com)
The 13 patients who received a T-cell-engaging therapy immediately after relapse on CAR T had an ORR of 75.0% and a median PFS of 9.1 months. (medpagetoday.com)
The 79 patients included in this analysis had a median age of 60 years at the time of progression after CAR T-cell therapy, and 60% were men. (medpagetoday.com)
Stem cell therapy for MS holds significant potential but remains at the frontier of clinical research," says Amy Bowen, the charity's director of service development. (pharmaceutical-journal.com)
How can stem cell therapy help? (radiomd.com)
What is involved in autologous stem cell therapy? (radiomd.com)
David Borenstein, MD, discusses stem cell therapy and how it can be used to treat COPD. (radiomd.com)
The Autologous Cell Therapy market studied was anticipated to grow with a CAGR of 15.9%, during the forecast period. (mordorintelligence.com)
The major factors attributing to the growth of the autologous cell therapy market are the rising incidence of chronic diseases such as autoimmune diseases, cancer, a blood disorder, and others. (mordorintelligence.com)
And other factors are playing crucial roles in taking the autologous cell therapy market to the next level, among them are ongoing drug developments for new applications which are expected to further propel the growth of the autologous cell therapy market. (mordorintelligence.com)
The musculoskeletal disorders segment is expected to drive the demand for autologous cell therapy for effective treatment. (mordorintelligence.com)
There is currently no cure for MM. However, advances in therapy, such as autologous stem cell transplantation, radiation, and surgical care in certain cases, have helped to lessen the occurrence and severity of adverse effects of this disease and to manage associated complications. (medscape.com)
Cell Therapy for Parkinsons Disease: What Next? (lu.se)

Neural Killer" Cells: Autologous Cytotoxic Neural Stem Cells for Fighting Glioma. (mpg.de)
Human neural stem cells (NSCs) are inherently tumor---tropic, localizing to tumor foci following intracerebral or intravenous administration in preclinical models of brain tumors, breast carcinoma, and neuroblastoma. (selectbiosciences.com)

On August 31, 2022 the National Institutes of Health announced that the surgical team of eye specialists from Wilmer Eye Institute of Johns Hopkins School of Medicine successfully implanted a patch of tissue made from patient cells. (webrn-maculardegeneration.com)
For instance, as per the clinical trails.gov in 2022, A clinical study was started from January 2020 to March 2021 to study the population of all Swedish Citizens treated with autologous hematopoietic stem cell transplantation for COVID-19 positive patients. (mordorintelligence.com)
As per the May 2022 update by the Center for Disease Control and Prevention, sickle cell disease (SCD) affects approximately 100,000 Americans. (mordorintelligence.com)

This macular degeneration research involves regenerating or replacing the cells that are found in a layer of tissue that lies under the retina. (webrn-maculardegeneration.com)
The loss of cells in the Retinal Pigment Epithelium (RPE), a layer of the retina that helps to nourish the macula contributes to age related macular degeneration and loss of vision. (webrn-maculardegeneration.com)

Survival with Axicabtagene Ciloleucel in Large B-Cell Lymphoma. (rochester.edu)
When you develop lymphoma, there is significant overproduction of white blood cells called lymphocytes. (uky.edu)
it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)

Consequently, it is this stance by the FDA which is forcing all adult stem cell physicians to relocate outside of the U.S., where they set up their clinics in any and every other country on earth except the United States. (cellmedicine.com)

Although the regulatory environment for adipose adult mesenchymal stem cells is still in a phase of "ripeness", some general guidelines for clinicians have finally come into focus. (selectbiosciences.com)
MSC-NTF cells are produced from autologous, bone marrow-derived mesenchymal stem cells (MSCs) that have been expanded and differentiated ex vivo. (biospace.com)
11. Kramer PR, Nares S, Kramer SF, Grogan D, Kaiser M. Mesenchymal stem cells acquire characteristics of cells in the periodontal ligament in vitro. (bvsalud.org)

The patient has low blood counts until the replaced cells replenish the patient's body with healthy cells. (mdanderson.org)
The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
Foolproof temperature control is necessary, especially when shipping a patient's cells to a biotech organization. (pharmaceuticalcommerce.com)
A patient's own skin or blood cells can be reprogrammed to become what is called induced Pluripotent Stem cells (iPSC). (webrn-maculardegeneration.com)
Cells taken from the patient's blood will be converted to what are called induced pluripotent stem cells (iPs). (webrn-maculardegeneration.com)
In the NIH lab the patient's blood cells were converted to iPs cells, which can become almost any type of cell in the body. (webrn-maculardegeneration.com)

MSC-NTF cells are harvested from each person with ALS and are manufactured using an innovative and proprietary process to secrete neurotrophic factors to target specific neurodegenerative diseases. (wkrn.com)

Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
Bone marrow, the spongy tissue inside our bones, is the factory for blood cells. (mdanderson.org)
The treatment, which cost approximately $10,000, took place in January of this year and consisted of a simple procedure in which adult stem cells were extracted from the girl's own bone marrow and then readministered via a lumbar puncture in the girl's spine. (cellmedicine.com)

It's impressive to see how MSTI has evolved and now, we have the opportunity to honor our history as our oncology care becomes St. Luke's Cancer Institute. (stlukesonline.org)
We are fortunate to have an excellent team at the Wilmot Cancer Institute including hematology and oncology, radiation oncology, hematopathology, dermatology, neurology, nursing, advanced practice providers, social work and members of the clinical trials office. (rochester.edu)

In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
No previous reports have been created measuring the difference in measles, mumps, and rubella (MMR) reactivity between autologous and allogeneic HCT patients post treatment. (wesparkhealth.com)
MMR titres were drawn from autologous patients a median of 395 days after HCT and a median of 907 days after HCT for allogeneic patients. (wesparkhealth.com)
Now-a-days, the market of immunotherapy is more attributed towards developing Tumor-Infiltrating Lymphocytes for causing complete remission of the tumor cells from the cancer patients. (researchandmarkets.com)
Particularly in hematopoietic cell transplantation (HCT) patients, biopsy is indicated if a deep fungal infection is suspected. (medscape.com)
A cell-based tissue-engineered urethra may be an alternative for patients who have complicated long strictures and need urethral reconstruction. (biomedcentral.com)
Cultivated autologous limbal epithelial cells (CALEC) procedure shown to be safe and feasible with early positive results of restored cornea surfaces or vision gains in four patients with severe chemical burns. (nih.gov)
Biostar Stem Cell Research Institute is committed to expanding treatment-approved hospitals across Japan and intensifying global outreach, aiming to make Japan a destination for Parkinson's disease patients worldwide to regain their health. (keloland.com)
Since January of 2007, more than 1,600 patients have been treated with their own adult stem cells at the XCell-Center. (cellmedicine.com)
Consequently, the demand for stem cell-based treatments is soaring as patients seek alternatives to traditional approaches. (imarcgroup.com)
BrainStorm has produced and developed NurOwn, a novel cell treatment, generating compelling data that I am more convinced than ever holds the promise to be a valuable treatment for patients who are suffering. (biospace.com)
Stem cell research is making great headway in helping relieve many of the symptoms and by improving lung elasticity and reducing lung damage suffered by patients with COPD. (radiomd.com)
There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)

In addition to causing teratomas (a specific type of tumor), embryonic stem cells are notorious for their numerous other inherent problems which disqualify them for any type of clinical therapeutic use. (cellmedicine.com)
An overview of the current state of the industry-sponsored, stem cell therapeutic commercial product and clinical trial pipeline reveals some interesting insights and trends into how the sector has matured over the past decade and where it may be headed. (selectbiosciences.com)
The advantages of stem cell manufacturing are manifold, as it offers a renewable source of cells for research, drug testing, and potential therapeutic applications. (imarcgroup.com)
Additionally, innovations in genetic editing techniques, like CRISPR-Cas9, offer precise control over stem cell characteristics, further expanding their therapeutic potential. (imarcgroup.com)
The NurOwn® technology platform (autologous MSC-NTF cells) represents a promising investigational therapeutic approach to targeting disease pathways important in neurodegenerative disorders. (biospace.com)

elicits antiproliferative and proapoptotic activities in vitro in solid and hematologic tumor cells. (medscape.com)

U.S. National Cancer Institute. (wikipedia.org)
Hematologist Amir Toor, MD , leads the groundbreaking program for many years, Lehigh Valley Topper Cancer Institute has provided state-of-the-art cancer treatments and research opportunities to individuals within their own communities. (lvhn.org)
Dr. Toor is a renowned transplanter, and he is dedicated to determining the best treatment option for each individual based on their comorbidities and the genomics of their malignancy," says hematologist oncologist Suresh Nair, MD , Physician in Chief, Lehigh Valley Topper Cancer Institute. (lvhn.org)
St. Luke's Mountain States Tumor Institute (MSTI), for half a century the cancer care destination of the region's residents, is now St. Luke's Cancer Institute. (stlukesonline.org)
MSTI has been the premier cancer institute for Idaho for the past 50 years," said Dr. Dan Zuckerman, St. Luke's Cancer Institute medical director. (stlukesonline.org)
The 2 most commonly used are the World Health Organization (WHO) Oral Toxicity score and the National Cancer Institute (NCI) Common Common Terminology Criteria for Adverse Events (CTCAE) for oral mucositis. (medscape.com)
Dr. Reagan is an Associate Professor of Medicine at the Wilmot Cancer Institute. (rochester.edu)
He completed his fellowship in hematology at the Wilmot Cancer Institute at the University of Rochester Medical Center. (rochester.edu)
He started his faculty appointment at the Wilmot Cancer Institute in July 2015. (rochester.edu)
Markey has provided state-of-the-art cancer care for more than 20 years , and we are proud to be the only cancer center in Kentucky designated by the National Cancer Institute. (uky.edu)
Collaborators on the study include the National Cancer Institute, the European Organization for Research and Treatment of Cancer and the Movember Foundation. (cincinnatichildrens.org)

BrainStorm holds the rights to clinical development and commercialization of the NurOwn® technology platform used to produce autologous MSC-NTF cells through an exclusive, worldwide licensing agreement. (wkrn.com)

This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)

Image from the NIH shows mature iPSC (induced pluripotent stem cell) derived retinal pigment epithelium cells (RPE), magnified by super resolution confocal microscopy. (webrn-maculardegeneration.com)
The iPSC cells that are now programmed to be RPE cells are grown in sheets that are one cell thick. (webrn-maculardegeneration.com)

In this Phase 1 clinical trial the iPs cells will be programmed to be come retinal pigment epithelial (RPE) cells. (webrn-maculardegeneration.com)

With the emergence of immunotherapy surveillance in the treatment of cancer, the focus towards manipulating immune cells for cancer treatment has become an important strategy to be anticipated by the researchers. (researchandmarkets.com)
The spurt of knowledge available for the TILs has completely changed the concept of using simple cells infiltrating from the tumors as a novel and efficient treatment regimen. (researchandmarkets.com)
The approved stem cell treatment protocol involves administering 150 to 250 million adipose- tissue derived stem cells intravenously and 50 million cells into the spinal cord cavity five times at intervals of two to four weeks. (keloland.com)
The approval of stem cell treatment for Parkinson's disease marks a significant milestone in the clinical application of stem cells by Biostar Stem Cell Research Institute, which began its research in 2008. (keloland.com)
As stated on their website, the XCell-Center 'is the first private institute worldwide to hold an official license for the extraction and approval of stem cell material for autologous treatment. (cellmedicine.com)
Autologous hematopoietic stem cell transplantation (autoHSCT) is a treatment option for hematological disorders and pediatric solid tumors . (bvsalud.org)
Autologous MSC-NTF cells have received Orphan Drug designation status from the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of amyotrophic lateral sclerosis (ALS). (wkrn.com)
Effective treatment is the best way to protect the life of a patient with blood cell disorder. (mordorintelligence.com)

In the context of COVID-19, government organizations in various countries, research institutes, and many biotech and pharmaceutical firms are focusing on effective and rapid technologies for the fast diagnosis of COVID-19. (mordorintelligence.com)

In vivo expansion of a CD9 + decidual-like NK cell subset following autologous hematopoietic stem cell transplantation. (bvsalud.org)
This research utilizes a variety of cell biology, molecular biology, biochemistry, imaging and in vivo techniques. (pitt.edu)
5. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. (bvsalud.org)

These porous microstructures allow cell infiltration into the matrix and have fewer heterogeneous cellular proteins, thereby preventing complications, such as inflammatory reactions, fibrosis, calcification, and graft shrinkage. (biomedcentral.com)
The proteasome pathway is an enzyme complex existing in all cells, which degrades ubiquitinated proteins that control the cell cycle and cellular processes and maintains cellular homeostasis. (medscape.com)

The following bioengineering laboratories are currently housed at the Center: Musculoskeletal Research Center, MSRC, (Dr. Savio Woo), Cardiovascular Systems Laboratory (Dr. Sanjeev Shroff), Bioengineering Methods and Applications Laboratory and BioTransport Laboratory (Dr. Jack Patzer), Vascular Bioengineering Laboratory (Dr. David Vorp), Cell Migration Laboratory (Dr. Partha Roy), Computational Biomechanics Laboratory (Dr. Spandan Maiti) , Orthopaedic Robotics Laboratory (Drs. Volker Musahl and Richard Debski) and Molecular Biological and Biophysical Core Facilities (Department). (pitt.edu)
Affiliation: Clinical Investigator, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). (dxlupus.org)
Affiliation: Director, Office of Scientific Interchange, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). (dxlupus.org)

Unique in the world of oversight of medical research, there is a formal and quasi regulatory role for the patient advocate when the research includes stem cells. (selectbiosciences.com)
This is the first time in the United States that patient derived induced pluripotent stem cells were used. (webrn-maculardegeneration.com)

Although it is most frequently performed with hematopoietic stem cells (precursors of blood-forming cells) in hematopoietic stem cell transplantation, cardiac cells have also been used successfully to repair damage caused by heart attacks. (wikipedia.org)

VM), showed that the recovery of motor functions induced implanted either (1) as a solid piece in the lateral ven- by the grafted fetal dopamine neurons was well cor- tricle6 or a cortical cavity8 adjacent to the denervated related with the extent of graft-derived reinnervation caudate-putamen, or (2) as a crude cell suspension of the host caudate-putamen. (lu.se)

Since only adult stem cells are used at the XCell-Center, not embryonic stem cells, the treatments are ethically noncontroversial and scientifically proven to be medically safe. (cellmedicine.com)
Most sufferers are unaware that stem cells can help them with various issues and treatments relating to COPD. (radiomd.com)

In addition, the urethral caliber, speed of urothelial regeneration, content of smooth muscle, and vessel density were significantly improved in the group with autologous USC-seeded SIS. (biomedcentral.com)
Significantly, we observed that following autoHSCT, NK cells acquired a decidual-like gene expression profile , including the expression of CD9. (bvsalud.org)
For the permanent teeth, on the 4th day of culture, the cell number was significantly higher for the outgrowth method. (bvsalud.org)

Granulation tissue is present at the base of the ulcer with chronic inflammatory cells. (medscape.com)
Autologous USCs can be used as an alternative cell source for cell-based tissue engineering for urethral reconstruction. (biomedcentral.com)
Another critical element required for successful urethral tissue engineering is the cell source. (biomedcentral.com)
The facility has: 1) a cell culture room that is equipped with tissue culture incubators, laminar flow hood, centrifuge and a microscope, 2) a wet lab which has equipment necessary to do protein biochemistry and molecular biology research, and 3) a microscopy room that houses an IX-71 Olympus research grade inverted microscope and live-cell Â image acquisition system. (pitt.edu)
Pulp cells cultures were established by two approaches: enzyme digestion (3 mg/mL type I colagenase and 4 mg/mL dispase), or culture of the tissue explants in cell culture dishes. (bvsalud.org)
Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. (bvsalud.org)

Anatomy33

Organisms6

Diseases43

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment78

Phenomena and Processes31

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena9

Technology, Industry, Agriculture1

Humanities1

Information Science3

Health Care32

Geographicals2

Transplant42

Multiple Myeloma10

Transplants9

20236

Chemotherapy10

Therapies18

Regenerative medicine8

ASCT1

High-dose1

Myeloma1

Mantle cell lym3

Innovative autologous1

Embryonic stem3

Donor8

Therapy35

Neural Stem2

20223

Macular degeneration2

Lymphoma3

Adult stem1

Mesenchymal3

Patient's6

Neurodegenerative diseases1

Marrow3

Oncology2

Patients13

Therapeutic5

Tumor cells1

Cancer Institute11

NurOwn1

Progenitor Cells1

IPSC2

Epithelial1

Treatment8

Biotech1

Vivo3

Cellular2

Musculoskeletal3

Patient2

Successfully1

Neurons1

Treatments2

Significantly3

Tissue6