Cell AgingGenomic InstabilityCyclin-Dependent Kinase Inhibitor p16TelomereChromosomal InstabilityFibroblastsTumor Suppressor Protein p53Joint InstabilityAging, PrematureTelomere ShorteningTelomeraseCyclin-Dependent Kinase Inhibitor p21DNA Damagebeta-GalactosidaseAgingMicrosatellite InstabilityCells, CulturedCell ProliferationCell CycleCell Line, TumorCell Transformation, NeoplasticRetinoblastoma ProteinCell Cycle CheckpointsNuclear ProteinsCell LineOxidative StressTumor Suppressor ProteinsSignal TransductionNeoplasmsTumor Suppressor Protein p14ARFPhenotypeSirtuin 1MutationProgeriaDNA-Binding ProteinsTelomeric Repeat Binding Protein 2DiploidyLongevityRNA, Small InterferingGenes, p16Reactive Oxygen SpeciesModels, BiologicalWerner SyndromeGene Expression RegulationApoptosisRNA InterferenceHeterochromatinDown-RegulationDNA RepairMicrosatellite RepeatsCell Cycle ProteinsHydrogen PeroxideCell DivisionGene Knockdown Techniquesras ProteinsRepressor ProteinsGenes, rasTranscription FactorsMice, KnockoutOncogenesGene SilencingPlant LeavesBlotting, WesternUp-RegulationHCT116 CellsOxidantsHistonesProtein-Serine-Threonine KinasesMolecular Sequence DataBase SequenceRecQ HelicasesForeskinProto-Oncogene Proteins c-mycTime FactorsCell Line, TransformedNevus, PigmentedReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTOR Serine-Threonine KinasesNeoplasm ProteinsPromoter Regions, GeneticMitosisTranscription, GeneticCyclin-Dependent Kinase Inhibitor p15Polycomb Repressive Complex 1Telomere HomeostasisMice, Inbred C57BLSirtuinsInhibitor of Differentiation Protein 1DNADNA MethylationEmbryo, MammalianGene Expression Regulation, NeoplasticAtaxia Telangiectasia Mutated ProteinsTransfectionAntigens, NuclearRadiationMicroRNAsDNA ReplicationCyclin-Dependent Kinase Inhibitor p27