SolubleOral formulation of amphotericinFormulationFungalMechanism of ActAmphotecLipidsSolubilityAntibioticsStreptomycesPowderLithiumFormulationsWaterMembraneCellStudyPractically insoluble in waterNodosusDeoxycholateSerious fungal infectionsAntifungal agentSolid lipid nanoparticlesChloroformSodiumPolyeneLipidInjectionFreely solubleLiposomesComplexesAntibioticIntravenouslyIntravenousBilirubinSpeciesSerumWeakBrainChronicPatientsShowsNormalSolutionScore
Soluble10
- It is insoluble in water but readily soluble in lipids and is often made into liposomal injections. (octagonchem.com)
- Amphotericin B is an amphoteric, forming soluble salts in both basic and acidic environments, and due to extensive unsaturation, it is unstable, primarily used as antifungal agents. (pharmacy180.com)
- Griseofulvin is a white or yellowish-white microfine powder, practically insoluble in water, freely soluble in dimethylformamide and tetrachloroethane, slightly soluble in ethanol and methanol. (pharmacy180.com)
- Nystatin is a yellow or slightly brownish hygroscopic powder, practically insoluble in water and in alcohol, freely soluble in dimethylformamide and in dimethyl sulphoxide, and slightly soluble in methanol. (pharmacy180.com)
- Amphotericin B (AmB), a hydrophobic, potent, and broad-spectrum antifungal agent, was rendered water-soluble by conjugation to a dextran-aldehyde polymer. (ul.ie)
- Gels produced by entrapment of a suspension of AmB in CMC-dextran without conjugation of drug to polymers did not release fungicidal activity, but did kill on contact Injectable systems of these types, containing soluble or insoluble drug formulations, could be useful for treatment of local antifungal infections, with or without concurrent systemic therapy. (ul.ie)
- Particles of both sizes are insoluble extracellularly in the media but moderately soluble in AM with an intracellular dissolution rate of 0.0037 ± 0.0014 d -1 for 0.5 μm and 0.0016 ± 0.0012 d -1 for 1.5 μm 59 Fe 2 O 3 particles. (biomedcentral.com)
- It is insoluble in water, very slightly soluble in alcohols, and freely soluble in dichloromethane. (guidelinecentral.com)
- organic acids, which make ginkgo's otherwise water-insoluble flavonoid and terpene molecules water-soluble. (restorativemedicine.org)
- These compounds were water-insoluble but soluble in chloroform, with a maximum solubility of ~80 mg/mL. (docslib.org)
Oral formulation of amphotericin2
- However, recently novel nanoparticulate drug delivery systems such as AmbiOnp, nanosuspensions, lipid-based drug delivery systems including cochleates, self-emulsifying drug delivery systems, solid lipid nanoparticles and polymeric nanoparticles-such as Amphotericin B in pegylated polylactide coglycolide copolymer nanoparticles-have demonstrated potential for oral formulation of amphotericin B. Amphotericin B is well known for its severe and potentially lethal side effects. (wikipedia.org)
- Dr. Wasan led the research team at the Wasan lab at the University of British Columbia in the development of an oral formulation of amphotericin B. (abiteccorp.com)
Formulation3
- As the original formulation of amphotericin, it is often referred to as "conventional" amphotericin. (wikipedia.org)
- AmBisome (LAMB) is a liposomal formulation of amphotericin B for injection and consists of a mixture of phosphatidylcholine, cholesterol and distearoyl phosphatidylglycerol that in aqueous media spontaneously arrange into unilamellar vesicles that contain amphotericin B. It was developed by NeXstar Pharmaceuticals (acquired by Gilead Sciences in 1999). (wikipedia.org)
- Thus, the aim of this study was to use design of experiment approach and pseudoternary phase diagram to develop a microemulsion formulation easy to prepare and to scale up to pharmaceutical purposes, using amphotericin B as drug model. (ufrn.br)
Fungal2
- Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. (wikipedia.org)
- One of the main uses of amphotericin B is treating a wide range of systemic fungal infections. (wikipedia.org)
Mechanism of Act1
- It is structurally similar to amphotericin B and has the same mechanism of action. (pharmacy180.com)
Amphotec1
- Amphotec is a complex of amphotericin and sodium cholesteryl sulfate in a 1:1 ratio. (wikipedia.org)
Lipids1
- It consists of amphotericin B and two lipids in a 1:1 ratio that form large ribbon-like structures. (wikipedia.org)
Solubility1
- The amphipathic nature of amphotericin along with its low solubility and permeability has posed major hurdles for oral administration given its low bioavailability. (wikipedia.org)
Antibiotics1
- One solution contains antibiotics (nalidixic acid, polymyxin B, ceftazidime and amphotericin). (vetbact.org)
Streptomyces1
- Amphotericin B was isolated from Streptomyces nodosus in 1955 at the Squibb For Medical Research Institute from cultures isolated from the streptomycete obtained from the river bed of Orinoco in that region of Venezuela and came into medical use in 1958. (wikipedia.org)
Powder2
- Amphotericin B is a yellow-to-orange powder. (octagonchem.com)
- According to this method the conversion of water insoluble drug into dry looking, non adherent, free flowing and acceptably compressible powder by incorporating into suitable non volatile solvents, carrier material and coating materials. (ijpsr.com)
Lithium1
- Hypernatremia is also seen in insipid diabetics due to brain injury and use of lithium and amphotericin B ( 7 ). (brieflands.com)
Formulations2
- Lipid-based formulations of amphotericin B are no more effective than conventional formulations, although there is some evidence that lipid-based formulations may be better tolerated by patients and may have fewer adverse effects. (wikipedia.org)
- In order to improve the tolerability of amphotericin and reduce toxicity, several lipid formulations have been developed. (wikipedia.org)
Water1
- indirect bilirubin refers to the unconjugated form (water insoluble form). (ashp.org)
Membrane1
- Amphotericin can bind to ergosterol to depolarize the membrane and alter cell membrane permeability, so important intracellular components will leak from cells to cause bacterial cell death. (octagonchem.com)
Cell1
- Moreover, treatment with TCEE is found to enhance the cytotoxic effects of amphotericin B in human colon cancer cell both in vitro and in vivo [ 17 ]. (hindawi.com)
Study2
- The selected system presented an isotropic behavior, stable granulometry (11,6 ± 0,023 nm) during the study (180 days), and high amphotericin B content (185 μg/mL). (ufrn.br)
- According to our study insoluble BA could loaded well into ALGD. (ac.ir)
Practically insoluble in water2
- It is practically insoluble in water, but freely soluble in acetone, and is soluble in alcohol and in chloroform. (nih.gov)
- Clotrimazole is a colourless, crystalline, weakly alkaline substance, melting point 141°- 145°C, soluble in acetone, chloroform and ethanol and practically insoluble in water. (pdfdrugs.com)
Nodosus1
- Amphotericin B was isolated from Streptomyces nodosus in 1955 at the Squibb For Medical Research Institute from cultures isolated from the streptomycete obtained from the river bed of Orinoco in that region of Venezuela and came into medical use in 1958. (wikipedia.org)
Deoxycholate4
- Amphotericin B deoxycholate (ABD) is administered intravenously. (wikipedia.org)
- They are more expensive than amphotericin B deoxycholate. (wikipedia.org)
- Amphotericin B is insoluble in water and is formulated for intravenous use by complexing it with lipotrophic molecules such as deoxycholate, liposomes or lipid complexes. (nih.gov)
- Amphotericin is available in multiple forms and concentrations generically and under the brand names Amphocin and Fungizone (deoxycholate), Ambisome (liposome), Abelcet (lipid complex), and Amphotec (cholesteryl sulfate complex). (nih.gov)
Serious fungal infections2
- Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. (wikipedia.org)
- Amphotericin B was approved by the FDA in 1971 and is currently widely used in the treatment of serious fungal infections. (nih.gov)
Antifungal agent2
- Amphotericin B is an antifungal agent with a broad spectrum of activity against many fungal species. (nih.gov)
- The use of the antifungal agent amphotericin B formulated in liposomes has been approved by the Food and Drug Administration (FDA) for treating systemic mycoses. (pharmacy180.com)
Solid lipid nanoparticles2
- However, recently novel nanoparticulate drug delivery systems such as AmbiOnp, nanosuspensions, lipid-based drug delivery systems including cochleates, self-emulsifying drug delivery systems, solid lipid nanoparticles and polymeric nanoparticles-such as Amphotericin B in pegylated polylactide coglycolide copolymer nanoparticles-have demonstrated potential for oral formulation of amphotericin B. Amphotericin B is well known for its severe and potentially lethal side effects. (wikipedia.org)
- Jansook P, Fülöp Z, Ritthidej G C. Amphotericin B loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carrier (NLCs): Physicochemical and solid-solution state characterizations [J]. Drug Developpment and Industrial Pharmacy. (cd-bioparticles.net)
Chloroform2
- It is freely soluble in water and in methanol, but is practically insoluble in acetone and in chloroform. (nih.gov)
- These compounds were water-insoluble but soluble in chloroform, with a maximum solubility of ~80 mg/mL. (docslib.org)
Sodium3
- Each vial contains a sterile, nonpyrogenic, lyophilized cake (which may partially reduce to powder following manufacture) providing 50 mg amphotericin B and 41 mg sodium desoxycholate buffered with 20.2 mg sodium phosphates (consisting of mono and dibasic sodium phosphate, phosphoric acid and sodium hydroxide). (nih.gov)
- Amphotec is a complex of amphotericin and sodium cholesteryl sulfate in a 1:1 ratio. (wikipedia.org)
- 15% Amphotericin A, 35% sodium. (genaxxon.com)
Polyene1
- The cause of serum aminotransferase elevations during amphotericin B therapy is unknown, but may be a direct hepatotoxicity from the polyene based upon its effects on cell membranes. (nih.gov)
Lipid2
- Lipid-based formulations of amphotericin B are no more effective than conventional formulations, although there is some evidence that lipid-based formulations may be better tolerated by patients and may have fewer adverse effects. (wikipedia.org)
- In order to improve the tolerability of amphotericin and reduce toxicity, several lipid formulations have been developed. (wikipedia.org)
Injection2
- Amphotericin B for Injection should not be given in doses greater than 1.5 mg/kg. (nih.gov)
- AmBisome (LAMB) is a liposomal formulation of amphotericin B for injection and consists of a mixture of phosphatidylcholine, cholesterol and distearoyl phosphatidylglycerol that in aqueous media spontaneously arrange into unilamellar vesicles that contain amphotericin B. It was developed by NeXstar Pharmaceuticals (acquired by Gilead Sciences in 1999). (wikipedia.org)
Freely soluble1
- It is insoluble in water, very slightly soluble in alcohols, and freely soluble in dichloromethane. (nih.gov)
Liposomes1
- Examples of applications where liposomes have been successfully employed to provide therapeutic benefit include amphotericin B liposomes. (pharmacy180.com)
Complexes1
- The addition of fluoride to drinking water also prevents magnesium absorption by binding to it and forming insoluble complexes. (inkidney.com)
Antibiotic2
- are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses. (nih.gov)
- Finally, a synergistic effect of DE-ZnO and existing antifungal agents (Itraconazole and Amphotericin B) showed a better antifungal activity, which could be reduced the side effects due to the antifungal agents overdose, than a single antibiotic agent use. (springeropen.com)
Intravenously1
- amphotericin B is given intravenously and the usually dosage is up 0.5 to 1.0 mg/kg daily. (nih.gov)
Intravenous1
- An initial intravenous infusion of 1 to 5 mg of amphotericin B per day, gradually increased to 0.4 to 0.6 mg/kg daily, produces peak plasma concentrations ranging from approximately 0.5 to 2 mcg/mL. (nih.gov)
Bilirubin2
- In addition, isolated but dramatic instances of hyperbilirubinemia arising within days of starting amphotericin have been reported with elevations largely in the direct (conjugated) bilirubin fraction. (nih.gov)
- The hyperbilirubinemia of amphotericin therapy is likely due to inhibition of bilirubin transport mechanisms and is likely to occur in patients with genetic variations in the major hepatic bilirubin transporter (MRP2). (nih.gov)
Species2
- Amphotericin B shows a high order of in vitro activity against many species of fungi. (nih.gov)
- While Candida albicans is generally quite susceptible to amphotericin B, non- albicans species may be less susceptible. (nih.gov)
Serum2
- Amphotericin B commonly causes mild to moderate serum aminotransferase elevations and can cause hyperbilirubinemia, but acute, clinically apparent drug induced liver injury from amphotericin B therapy is exceedingly rare. (nih.gov)
- The cells were grown in a 96-well plate in Delbucco's Minimum Essential M edium (DMEM) (HiMedia, Mumbai)) supplemented with 10% fetal bovine serum (Gibco Laboratories) and antibiotics (streptomycin, penicillin-G, kanamycin, amphotericin B). (ijpsr.com)
Weak2
- This is because amphotericin B resistance requires sacrifices on the part of the pathogen that make it susceptible to the host environment, and too weak to cause infection. (wikipedia.org)
- Finally, rare instances of acute cholestatic hepatitis with jaundice have been reported in patients receiving amphotericin, but these patients have generally been critically ill and exposed to multiple potentially hepatotoxic agents, so that the attribution to amphotericin has been weak. (nih.gov)
Brain1
- In most brain regions, the concentration of insoluble pSer129 α-syn correlated positively, and soluble pSer129 α-syn negatively, with the levels of soluble and insoluble Aβ. (biomedcentral.com)
Chronic1
- No instances of acute liver failure or chronic liver injury have been convincingly linked to amphotericin therapy. (nih.gov)
Patients2
Shows1
- The following table shows the amphotericin B susceptibility for a selection of medically important fungi. (wikipedia.org)
Normal2
- Little amphotericin B penetrates into vitreous humor or normal amniotic fluid. (nih.gov)
- Amphotericin B alone is insoluble in normal saline at a pH of 7. (wikipedia.org)
Solution2
- Specifications: 250 µg/mL (solution of 45% Amphotericin B, max. (genaxxon.com)
- Hier finden Sie Informationen und weiterführende Literatur zu Amphotericin B solution. (genaxxon.com)
Score1
- In PD, the MMSE score correlated negatively with the level of insoluble pSer129 α-syn. (biomedcentral.com)