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  • Aqp4
  • Aquaporin-4 (AQP4), the main water channel of the brain, is highly expressed in animal glioma and human glioblastoma in situ. (biomedsearch.com)
  • In this study, we retrospectively examined brain samples in 145 cases of death after different survival times following TBI, to investigate aquaporin-4 (AQP4) expression and correlation with hypoxia, and neuroinflammation in human TBI. (myjournals.org)
  • Antibodies anti-glial fibrillary acid protein (GFAP), aquaporin-4 (AQP4), hypoxia induced factor-1α (HIF-1α), macrophage/phagocytic activation (CD68), ionized calcium-binding adapter molecule-1 (IBA-1), and neutrophils (CD15) were used. (myjournals.org)
  • AQP4 showed a significant, progressive increase between the control group and groups 2 (one-day survival) and 3 (three-day survival). (myjournals.org)
  • These findings need to be developed further to gain insight into the mechanisms through which brain AQP4 is upregulated. (myjournals.org)
  • urea
  • This concentration depends on the accumulation of urea in the renal medulla, permitted by an intrarenal recycling of urea among collecting ducts, vasa recta and thin descending limbs, all equipped with specialized, facilitated urea transporters (UTs) (UT-A1 and 3, UT-B, and UT-A2, respectively). (physiology.org)
  • and 3 ) species differences among mice, rats, and humans related to their very different body size and metabolic rate, leading to considerably larger needs to excrete and to concentrate urea in smaller species (urea excretion per unit body weight in mice is 5 times that in rats and 23 times that in humans). (physiology.org)
  • Aquaporins have been classified into two subfamilies: i) strict aquaporins that only allow the passage of water and ii) the less selective aquaglyceroporins that transport water and other neutral solutes, such as glycerol, CO2 or urea. (ebscohost.com)
  • This review summarizes the new insights of urea transporter functions in different organs, gleaned from studies of urea transporter knockout mice, and explores some of the potential pharmacological prospects of urea transporters. (frontiersin.org)
  • Cells
  • This guided cell migration is referred as chemotaxis, which is essential for various cells to carry out their functions such as trafficking of immune cells and patterning of neuronal cells 2, 3 . (jove.com)
  • interactions
  • GRF10 (14-3-3Epsilon)] showed direct interactions with At PIP2;1 in the plant and upon coexpression in Xenopus laevis oocytes and activated At PIP2;1, preferentially when the latter was phosphorylated at its two C-terminal sites. (plantcell.org)
  • CCR5 interactions with the variable 3 loop of gp120. (ebscohost.com)
  • reveals
  • This structure is shown in figure 3 and reveals the general AQP structure of a single protomer with six transmembrane domains surrounding the water-conducting channel (left and center panel with transmembrane domains in red). (edwinvanbloois.com)
  • main
  • These properties were compared with those of well characterized representatives of the two main aquaporin sub-families. (ebscohost.com)
  • immune
  • These experiments should provide important insights into how the immune system recognizes viral peptides and how that process may relate to MS-type demyelinating diseases. (mayo.edu)
  • rats
  • The aim of present study was to investigate whether DHFZT could relieve pulmonary and intestinal injury by regulating aquaporins after SAP induced by sodium taurocholate in rats. (biomedcentral.com)
  • Twenty-four rats were randomly divided into 3 groups: sham group ( n = 8), model group (SAP, n = 8), DHFZT group (SAP with DHFZT treatment, n = 8). (biomedcentral.com)
  • provide
  • As many biological hypotheses concern the spatial relationships among different biomolecules, the improved resolution of FPALM can provide insight into questions of cellular organization which have previously been inaccessible to conventional fluorescence microscopy. (jove.com)
  • mice
  • and (c) mice with type 3 choroidal NV develop retinal atrophy due to oxidative damage with no contribution from VEGF suppression. (jci.org)
  • 2003) Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects 2 Literatur in brains of [alpha]-syntrophin-null mice. (pharmpdf.com)
  • growth
  • Primary isolated TALDC express the characteristic markers epidermal growth factor receptor, Na-K-2Cl transporter 2, epithelial calcium canal, and THG but were negative for Pax-2, aquaporin-2 and -3. (ovid.com)