OrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Membrane ProteinsMutagenesis, InsertionalDNA Transposable ElementsMolecular Sequence DataBase SequenceAmino Acid SequenceMutationPlasmidsGenes, BacterialEscherichia coliCloning, MolecularDNA, BacterialEstradiolSequence Analysis, DNABacterial ProteinsTransposasesRestriction MappingRetroelementsChromosome Mapping
BiosyntheticProteinNeuralCatheterRetrotransposonMetabolic pathwayProteins involvedMutationsAlleleMembrane insertionGenomeGenesPolymorphismGeneEnzymesSynthesisMolecularEmbryonicAlterationsReconstructionPoorlyAcupuncture pointsOccurTemporaryClinicalRecognitionActivateExposureSequencesPatientSignificantlyCellImportantDevelopmentRoleAssessmentStepSuccessFoundMainCollectionStressPatientsPlanPrograms
Biosynthetic5
  • They are part of a much larger group of compounds, the eicosanoids, which, although ubiquitous as a group, are produced by a variety of cell type-, tissue-, and species-specific biosynthetic pathways. (jci.org)
  • Structures of the first six prostaglandins (PGs) were established by 1962, before their individual biosynthetic pathways were studied. (jci.org)
  • The tissue-specific biosynthetic pathways that generate specific PGs are well covered in textbooks. (jci.org)
  • Using comparative analysis of genes, operons, and regulatory elements, wedescribe the cobalamin (vitamin B12) biosynthetic pathway in availableprokaryotic genomes. (embl-heidelberg.de)
  • Mg-chelatase catalyzes the first committed step of the chlorophyll biosynthetic pathway, the ATP-dependent insertion of Mg(2+) into protoporphyrin IX (PPIX). (lu.se)
Protein6
  • and tail-anchored membrane protein insertion into ER membrane. (nih.gov)
  • Of note, functionally-relevant differences between humans and chimpanzees are observed regarding the 3 main components of this pathway: i) the protein sequences of immunes TFs binding MER41 LTRs, ii) the insertion sites of MER41 LTRs in the promoter regions of ID-associated genes and iii) the protein sequences of the targeted ID-associated genes. (biorxiv.org)
  • Finally, a survey of the human proteome has allowed us to map a protein-protein network which links the identified immune/MER41/cognition pathway to FOXP2 (Forkhead Box P2), a key TF involved in the emergence of human speech. (biorxiv.org)
  • Regulated cell death (RCD) relies on activation and recruitment of pore-forming proteins (PFPs) that function as executioners of specific cell death pathways: apoptosis regulator BAX (BAX), BCL-2 homologous antagonist/killer (BAK) and BCL-2-related ovarian killer protein (BOK) for apoptosis, gasdermins (GSDMs) for pyroptosis and mixed lineage kinase domain-like protein (MLKL) for necroptosis. (ugent.be)
  • Proteins in the GLI family function in the same molecular pathway as a protein called Sonic Hedgehog. (medlineplus.gov)
  • The impor- objectives of determining the frequencies tance of FVII in normal haemostasis is il- of these gene polymorphisms in the popula- lustrated by the severe bleeding diathesis tion and clarifying the genotype association associated with low plasma levels of the of the R353Q and 0/10 bp insertion poly- protein [ 3 ]. (who.int)
Neural3
  • Current research in my group focusses on neurally expressed multi-copy genes and the impact of gene duplication events on the evolution of human neural gene-regulatory pathways. (uva.nl)
  • This activity seems to activate the neural pathways associated with the alleviation of pain. (health.mil)
  • From there, the neural pathway depends on the location of the taste bud that was stimulated. (medscape.com)
Catheter4
  • Currently, ultrasound guidance by experienced operators is recommended for reducing the risk of mechanical complications during central venous catheter (CVC) insertion. (hkmj.org)
  • After CVC insertion, a chest radiograph was taken, showing an abnormal vertical course of the catheter with suspected malposition ( Fig 1 ). (hkmj.org)
  • Moving from a preference for PICC lines to ultrasound-guided peripheral IVs saved roughly $250 in catheter costs per insertion. (sonosite.com)
  • The treatment performed was the insertion of a temporary catheter creating a new pathway for secretion of the parotid gland. (bvsalud.org)
Retrotransposon2
  • Genomic changes can be small, such as retrotransposon insertions, or big, such as segmental duplications of whole segments of the genome. (uva.nl)
  • They uncovered three recurrent alterations within this cohort: a 31 kb deletion co-occurring with a retrotransposon insertion in RAD52 , a 13.4 kb deletion in HSD17B14 , and a 64 kb partial duplication of RAD51C . (genomeweb.com)
Metabolic pathway5
  • Metabolic network modelling, also known as metabolic network reconstruction or metabolic pathway analysis, allows for an in-depth insight into the molecular mechanisms of a particular organism. (wikipedia.org)
  • However, the microbial metabolic pathway of the fungicide and the genetic systems driving its degradation by strain P3 remain unknown. (nature.com)
  • Therefore, elucidation of the microbial metabolic pathway of OPP is a prerequisite for the downstream exploitation of strain P3 in any environmental application. (nature.com)
  • 6 identified a gene cluster, hbpCAD , encoding the upper metabolic pathway of OPP which involves the transformation of OPP to 2-hydroxypenta-2,4-dienoateand benzoic acid (BA). (nature.com)
  • The downstream transformation of BA involved a meta -cleavage pathway, although its genetic organization and function was not revealed and the overall network of genes driving the full metabolic pathway of OPP is still not known. (nature.com)
Proteins involved2
  • Scientists could potentially tweak proteins involved in the pathway to preferentially steer the outcome toward replacement with DNA, which is important for gene therapy for hereditary diseases. (sciencedaily.com)
  • These genes each encode proteins involved in pathways previously found essential for breast cancer development. (genomeweb.com)
Mutations4
  • Mutations in GET4 disrupt the transmembrane domain recognition complex pathway. (nih.gov)
  • TP53 mutations define a maladaptive pathway with enhanced leukemic potential by inactivating tumor suppressor checkpoints without correcting the ribosome defect. (nature.com)
  • To understand the molecular pathogenesis of MN in patients with SDS, we characterized the presence and dynamics of somatic mutations in serial, clinically annotated samples collected prospectively from patients enrolled in the North American SDS Registry and studied the functional consequences of recurrently mutated pathways. (nature.com)
  • The budget impact of introducing mobocertinib for the postplatinum treatment of advanced non-small cell lung cancer harboring epidermal growth factor receptor exon 20 insertion mutations. (cdc.gov)
Allele1
  • Analysis with a different lister allele generated through targeted gene trap insertion reveals LISTERIN is required for embryonic development and confirms that direct perturbation of a LISTERIN-regulated process causes neurodegeneration. (nih.gov)
Membrane insertion2
  • Tail-anchored membrane proteins: investigating the targeting and membrane insertion mechanisms, which is important due to the wide range of core cellular functions performed by these proteins. (shu.ac.uk)
  • Inactive precursors of PFPs are converted into pore-forming entities through activation, membrane recruitment, membrane insertion and oligomerization. (ugent.be)
Genome4
  • The integration of biochemical metabolic pathways with rapidly available, annotated genome sequences has developed what are called genome-scale metabolic models. (wikipedia.org)
  • BioCyc, EcoCyc, and MetaCyc: BioCyc Is a collection of 3,000 pathway/genome databases (as of Oct 2013), with each database dedicated to one organism. (wikipedia.org)
  • For example, EcoCyc is a highly detailed bioinformatics database on the genome and metabolic reconstruction of Escherichia coli, including thorough descriptions of E. coli signaling pathways and regulatory network. (wikipedia.org)
  • 1000 fixed human-specific insertions with a yet unknown influence on how our genome is regulated. (uva.nl)
Genes2
  • Simply put, these models correlate metabolic genes with metabolic pathways. (wikipedia.org)
  • Kyoto Encyclopedia of Genes and Genomes (KEGG): a bioinformatics database containing information on genes, proteins, reactions, and pathways. (wikipedia.org)
Polymorphism2
  • We therefore studied the association of two polymorphisms - R353Q polymorphism at codon 353 involving the catalytic region and the 10 base pair (bp) insertion polymorphism involving the promoter region - with FVIIc levels in 176 healthy Tunisians. (who.int)
  • FVIIc levels with the 10 bp insertion polymorphism were not significantly different. (who.int)
Gene2
  • The genetic changes associated with Greig cephalopolysyndactyly syndrome include insertions or deletions of a small amount of DNA and changes in single DNA building blocks (base pairs) in critical regions of the gene. (medlineplus.gov)
  • 10976 in exon 8 in the catalytic region of ing factors that may increase cardiovascu- the FVII gene and an insertion of a decanu- lar disease. (who.int)
Enzymes3
  • A reconstruction breaks down metabolic pathways (such as glycolysis and the citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. (wikipedia.org)
  • There are about 30 enzymes involved in either pathway, where those involved in the aerobic pathway are prefixed Cob and those of the anaerobic pathway Cbi. (embl-heidelberg.de)
  • Several of these enzymes are pathway-specific: CbiD, CbiG, and CbiK are specific to the anaerobic route of S. typhimurium, whereas CobE, CobF, CobG, CobN, CobS, CobT, and CobW are unique to the aerobic pathway of P. denitrificans. (embl-heidelberg.de)
Synthesis1
  • Previous studies have addressed the proton insertion process, but the role of the synthesis pathway on the amount of defects created is not well understood. (lu.se)
Molecular3
  • Remarkably, the molecular programs regulating striatal pathway development remain poorly characterized. (jneurosci.org)
  • The lister mouse uncovers a pathway involved in neurodegeneration and may serves as a model for understanding the molecular mechanisms underlying human neurodegenerative disorders. (nih.gov)
  • P. Vandenabeele, G. Bultynck, and S. Savvides, "Pore-forming proteins as drivers of membrane permeabilization in cell death pathways," NATURE REVIEWS MOLECULAR CELL BIOLOGY , 2023. (ugent.be)
Embryonic1
  • Here, we determine the embryonic ontogeny of the two main striatal pathways (striatonigral and striatopallidal) and identify novel (non)cell-autonomous roles for the axon guidance receptor Frizzled3 in uncharacterized aspects of striatal pathway formation (i.e., anterior-posterior axon guidance in the striatum and axon entry into the globus pallidus). (jneurosci.org)
Alterations2
  • Our data further indicate that non-inherited forms of ID might result from alterations of the immune/MER41/cognition pathway induced notably by the untimely or quantitatively inappropriate exposure of human neurons to IL-6. (biorxiv.org)
  • Effectiveness and durability of benefit of mTOR inhibitors in a real-world cohort of patients with metastatic prostate cancer and PI3K pathway alterations. (cdc.gov)
Reconstruction1
  • A metabolic reconstruction provides a highly mathematical, structured platform on which to understand the systems biology of metabolic pathways within an organism. (wikipedia.org)
Poorly1
  • However, the putative role of an IFNγ/STAT1/MER41 pathway in human cognition and/or behavior is still poorly documented. (biorxiv.org)
Acupuncture points2
Occur1
  • communication is important prior to insertion, after insertion, when AF doesn't/does occur, and prior to OAC initiation (if deemed necessary). (medtronic.com)
Temporary1
  • Bedside insertion of a CVC was selected for temporary haemodialysis. (hkmj.org)
Clinical1
  • Download this Programme Overview to read about the clinical pathway that improves success rates associated with difficult Peripheral IV insertions. (sonosite.com)
Recognition1
  • The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. (genome.jp)
Activate1
  • This allows the coupling of ATP binding and hydrolysis to electron transfer against a redox potential gradient and metal incorporation to (re)activate one of the central players of the pathway. (degruyter.com)
Exposure4
  • Exposure occurs through an exposure pathway between the contaminant in the physical environment and the exposed person. (cdc.gov)
  • An exposure pathway has five parts. (cdc.gov)
  • When all five parts are present, the exposure pathway is termed "a completed exposure pathway" [ATSDR 2005]. (cdc.gov)
  • Its presence in the body can lead to toxic effects, regardless of age, gender, or exposure pathway. (cdc.gov)
Sequences2
  • It has also been demonstrated that STAT1 (Signal Transducer And Activator Of Transcription 1), a transcription factor (TF) crucially involved in the IFNγ pathway, binds consensus sequences that, in humans, are located with a high frequency in the LTRs (Long Terminal Repeats) of the MER41 family of primate-specific HERVs (Human Endogenous Retrovirus). (biorxiv.org)
  • Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences. (nih.gov)
Patient2
  • Patient pathway for ICM, including transition of care and follow-up plan. (medtronic.com)
  • If you harvest a million cells from a patient and you have 10 percent insertion rate, that is not as good as if you have 30 to 40 percent. (sciencedaily.com)
Significantly1
  • Establishing a monitoring pathway to detect and treat AF can significantly reduce a patient's risk for another stroke. (medtronic.com)
Cell1
  • Together, these data dissect MSN pathway development and reveal (non)cell-autonomous roles for Frizzled3 in MSN axon guidance. (jneurosci.org)
Important2
  • Here, we implicate the Wnt binding receptor Frizzled3 in several uncharacterized aspects of MSN pathway formation [i.e., anterior-posterior guidance of MSN axons in the striatum and their subsequent growth into the globus pallidus (GP), an important (intermediate) target]. (jneurosci.org)
  • SIGNIFICANCE STATEMENT Striatal axon pathways mediate complex physiological functions and are an important therapeutic target, underscoring the need to define how these connections are established. (jneurosci.org)
Development1
Role1
  • Scientists discovered that a well-known DNA repair pathway, the Fanconi anemia pathway, surprisingly plays a key role in repairing double-strand DNA breaks created by CRISPR-Cas9. (sciencedaily.com)
Assessment1
  • Modified Mini-open Transforaminal Lumbar Interbody Fusion: Description of Surgical Technique and Assessment of Free-hand Pedicle Screw Insertion. (medscape.com)
Step1
  • The facile formation of a magnesium borohydride species is critical in overcoming competing pathways in the selectivity-determining insertion step. (rsc.org)
Success1
  • Education and communication is crucial to pathway implementation and ongoing success. (medtronic.com)
Found2
  • No difficulties were found in the insertion of the EGP. (sages.org)
  • In the peripheral system it was also found the presence of a discourse which is organized by the insertion of academic contents, fact which could characterize the cognitive polyphasia phenomena. (bvsalud.org)
Main1
  • Moreover, IL-6 (Interleukin 6) rather than IFNγ, is identified as the main candidate cytokine regulating such an immune/MER41/cognition pathway. (biorxiv.org)
Collection1
  • High-throughput kinetic measurements on this collection provide a comprehensive view of multiple extracellular electron transfer pathways operating in parallel. (biorxiv.org)
Stress1
  • In addition, the cells can also utilize enhanced polyhydroxyalkanoates (PHA) accumulation and glyoxalase detoxication pathway as means against ethanol stress. (biomedcentral.com)
Patients4
  • Patients are typically asked to take a short walk after the insertion of each needle," said Pock. (health.mil)
  • A stroke pathway, or stroke protocol, is a consistent approach to a follow-up plan and transition of care for patients with an ischemic stroke. (medtronic.com)
  • Pathways for transition of care and follow-up help to ensure these patients receive better care. (medtronic.com)
  • in such patients, pacemaker insertion may be necessary. (medscape.com)
Plan2
  • The octahedrons [FeO 6 ] connect by the corner-sharing along b-axis and link with the tetrahedrons by the edge-sharing forming the 1-D channels where Li diffusion pathway is along plan (010). (hindawi.com)
  • Be sure to establish a plan and ownership for key pathway education and communication in your hospital. (medtronic.com)
Programs1
  • The elevated pathway connects the various programs on the site while providing access to each zone. (ethz.ch)