• A mitosporic Hypocreales fungal genus, various species of which are important parasitic pathogens of plants and a variety of vertebrates. (lookformedical.com)
  • As such, AMPs exhibit abilities to defend their hosts against broad spectrum of infectious microbial pathogens (bacterial, viral, fungal and parasitic) and are thought to be promising alternatives to the use of antibiotics in human health and agriculture. (usda.gov)
  • nificantly reduced in the mutant leaves which is expected as a result of the delayed leaf senescence Jasmonic acid plays a function in resistance towards insects and necrotrophic fungal pathogens. (caspaseinhibitor.com)
  • 95]. Jasmonic acid plays a part in resistance towards insects and necrotrophic fungal path Even so, various pathogens evolved mechanisms to hijack the JA pathway. (caspaseinhibitor.com)
  • This enables us to identify candidate genes underlying glucosinolate diversity, trichome density, and study the genetics of biochemical variation for glucosinolate and saponins. (pacb.com)
  • Once the researchers narrowed the list of candidate genes, they used two complimentary approaches to find the Sr35 gene. (innovationtoronto.com)
  • However, disruption of dltX drastically impaired the resistance of B. thuringiensis to CAMPs and significantly attenuated its virulence in two insect species. (frontiersin.org)
  • The genome of the protochordate Ciona intestinalis has a compact size with an ancestral complement of many diversified gene families of vertebrates and is a good model system for studying protochordate to vertebrate diversification. (biomedcentral.com)
  • We have identified 169 gene products in the Ciona genome that code for putative GPCRs. (biomedcentral.com)
  • Christelle did a whole-genome expression profiling of Arabidopsis and Brassica nigra plants that are challenged with different attackers. (unil.ch)
  • By analysing independent genome assemblies for the hallucinogenic mushrooms Psilocybe cyanescens and Pluteus salicinus we recapture the recently discovered psilocybin biosynthesis cluster 5 , 6 and show that a transcription factor previously implicated in its regulation is actually not part of the cluster. (biorxiv.org)
  • Analysis of the ~7.1-Mb genome provides insight into this strain's biosynthetic potential, means of regulation, and response to coculturing conditions. (pacb.com)
  • Researchers spent nearly four years trying to identify the location of the Sr35 gene in the wheat genome, which contains nearly two times more genetic information than the human genome. (innovationtoronto.com)
  • The sequencing of the D.melanogaster genome revealed an unexpected small number of genes (~ 14,000) indicating that mechanisms acting on generation of transcript diversity must have played a major role in the evo. (biomedcentral.com)
  • In participating UK research institutions, investigators can publish open access in Genome Research, Genes & Development, RNA, and Learning & Memory without article publication charges and all staff can read the entire renowned Cold Spring Harbor journal collection. (cshlpress.com)
  • Central to this course will be the primacy of the trait as the object of genetics and the development/refinement of the concept of the gene. (mnsu.edu)
  • Mary Goll Associate Professor Genetics Epigenetic regulation in the context of development and cancer. (uga.edu)
  • Various communication routes have been discovered such as mother-infant-interaction via breast milk, diverse host-pathogen-relations, and dietary uptake of food derived EVs, proving that EV-mediated inter-kingdom regulation is more than a random event. (encyclopedia.pub)
  • Investigations on EV-mediated regulation processes, from mother-infant to host-pathogen interaction, might elucidate this query (Table 1). (encyclopedia.pub)
  • Eduard Akhunov , associate professor of plant pathology at Kansas State University , and his colleague, Jorge Dubcovsky from the University of California-Davis , led a research project that identified a gene that gives wheat plants resistance to one of the most deadly races of the wheat stem rust pathogen - called Ug99 - that was first discovered in Uganda in 1999. (innovationtoronto.com)
  • Wheat stem rust is caused by a fungal pathogen. (innovationtoronto.com)
  • The cloning of the ala gene not only provides a basis for further investigation of its structure, expression and regulation mechanism, but also enables us to test its potential role in controlling pests and fungal diseases by transferring the gene into plants in the future. (lookformedical.com)
  • Gene expression can be controlled through the action of repressor proteins that attach to silencer regions of the DNA. (wikipedia.org)
  • In this study, we combined transcript profiling and proteomic analysis to better understand which genes and proteins are altered by opaque2 in the W64A inbred line. (biomedcentral.com)
  • Antimicrobial peptides (AMPs) are short peptides/proteins that form key components as the first-line defense of the innate immune system in many species including mammals, lower vertebrates, fish, insects and plants. (usda.gov)
  • Six new antimicrobial peptides (AMPs) with sequence homology to the Nk-lysin (Nkl) family of proteins have been characterized and their patterns of gene expression in rainbow trout (Oncorhynchus mykiss) described. (usda.gov)
  • Phylogenetic analysis revealed a conserved structure of Nkls among the teleosts and further protein sequence analyses suggests that all six nkl genes fall within the Nkl sub-family of the Saposin family of proteins. (usda.gov)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
  • After dephosphorylation of BES1 and BZR1 by PP2A, BES1 and BZR1 can interact with transcription variables and cofactors promoting BR-induced gene expression and inhibit the expression of BR-repressed genes. (caspaseinhibitor.com)
  • encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
  • Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
  • Here, employing an inducible B cell expression system, we have determined that M2 activates the NFAT pathway in a Src kinase-dependent manner - leading to induction of the plasma cell-associated transcription factor, Interferon Regulatory Factor-4 (IRF4). (prelekara.sk)
  • Concept of gene, Prokaryotes as genetic system, Prokaryotic and eukaryotic chromosomes, methods of gene isolation and identification, Split genes, overlapping genes and pseudo genes, Organization of prokaryotic and eukaryotic genes and genomes including operan, exon, intron, enhancer promoter sequences and other regulatory elements. (nipaers.com)
  • Whole exome sequencing of patients who experienced severe influenza reveals several genes, including scaffold protein AHNAK, with predicted loss-of-function variants that are also identified in our proteomic analyses. (cdc.gov)
  • A tuber lectin from Arisaema jacquemontii Blume with anti-insect and anti-proliferative properties. (lookformedical.com)
  • The results of these studies revealed specific target genes that can be investigated to further improve nutritional quality and agronomic performance of high lysine maize lines, particularly those based on the presence of the opaque2 mutation. (biomedcentral.com)
  • As a first line of defense, wheat breeders and researchers began looking for resistance genes among those that had already been discovered in the existing germplasm repositories, he said. (innovationtoronto.com)
  • Here we confirm and refine recent findings 5 about the genes underpinning psilocybin biosynthesis, discover that there is more than one psilocybin biosynthesis cluster in mushrooms, and we provide the first data directly addressing psilocybin's ecological role. (biorxiv.org)
  • The mutant also had altered expression of a number of starch biosynthesis genes and this was associated with a more highly crystalline starch. (biomedcentral.com)
  • Many insect species are undergoing rapid population decline in recent decades due to anthropogenic changes to natural landscapes and climate. (lu.se)
  • Zeier J* (2021) Metabolic regulation of systemic acquired resistance. (hhu.de)
  • Suppression of the degalactosylation by senju overexpression resulted in reduced induction of Toll-dependent expression of an antimicrobial peptide, Drosomycin , and increased susceptibility to infection with Gram-positive bacteria. (sdbonline.org)
  • Phylogenetic analysis reveals that HPX15, AsP-15 and AcP-15 are unique to Anophelines and this may be due to the involvement of this peroxidase in regulation of Plasmodium development. (biomedcentral.com)
  • renamed these peptides as "plant defensins," after comparing their structural and functional resemblance to previously characterized AMPs found in insects and mammals. (frontiersin.org)
  • The insect to contain recombinant remarkable numbers there synthesizes scientific archaeologist ETH corn associated on Archived atmosphere health. (uriess-fliesenleger.de)
  • 4. To organize national and international seminars and conferences for in depth discussions on scientific and technological developments which will lead to new ideas and innovative application of knowledge in gene cloning and recombinant DNA technology. (edu.pk)
  • Dawn worked on two projects: the CAGE database for genomic expression in Arabidopsis and the gene expression changes resulting from oviposition by Pieris butterflies on Arabidopsis. (unil.ch)
  • Genomic DNA of the nkl1-4 genes consisted of five exons and four introns, whereas the nkl-like a & b genes consisted of four exons and three introns. (usda.gov)
  • In most gram-positive bacteria, this operon consists of five genes dltXABCD but the involvement of the first ORF ( dltX ) encoding a small protein of unknown function, has never been investigated. (frontiersin.org)
  • We, therefore constructed an in frame deletion mutant of dltX , without affecting the expression of the other genes of the operon. (frontiersin.org)
  • Using available Arabidopsis mutants lacking important defense signals, she studied gene expression changes with microarrays and tried to correlate transcript profiles with insect performance in order to assess the effect of plant defenses on insect growth. (unil.ch)
  • When incorporated in artificial diet AJL significantly affected the development of Bactrocera cucurbitae (Coquillett) larvae indicating the possibility of using this lectin in a biotechnological strategy for insect management of cucurbits. (lookformedical.com)
  • Finally, a meta-transcriptome analysis of wild-collected mushrooms provides evidence for intra-mushroom insect gene expression of flies whose larvae grow inside Psilocybe cyanescens . (biorxiv.org)
  • Abou-Zeid AM( 2012) Review on Citrinin: plant, herbicide of Some Plant Extracts and Gene Involved in its regulation. (uriess-fliesenleger.de)
  • Gene regulation, RNA processing and Post transcriptional modifications. (nipaers.com)
  • Using gene specific primers, tissue-specific and developmental-specific expression as well as its immune role against bacteria, fungus and P. berghei was studied. (biomedcentral.com)
  • Bacteria sense these microenvironments and adapt by up or down regulating the expression of certain genes to influence different cell processes. (the-scientist.com)
  • Examples of mechanisms that produce such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA sequence. (wikipedia.org)
  • Robin Holliday defined in 1990 epigenetics as "the study of the mechanisms of temporal and spatial control of gene activity during the development of complex organisms. (wikipedia.org)
  • Processes orchestrated or driven by a plethora of genes, plant hormones, and inherent biological timing mechanisms facilitated by secondary molecules, which result in the systematic transformation of plants and plant parts, from one stage of maturity to another. (lookformedical.com)
  • Maprotiline repressed the HG-induced expression of cyclooxygenases 2 at both mRNA and protein levels in HRGECs. (bvsalud.org)
  • In this study, we identified six genes with sequence homology to Nkl and characterized their patterns of mRNA expression and abundances in rainbow trout (Oncorhynchus mykiss). (usda.gov)
  • Patterns of tissue-specific mRNA expression were asymmetric among the six trout Nkl homologues, with nkl1, nkl3, and nkl-like a & b occurring in immune competent organs such as spleen, gill, intestine and kidney, as well as pineal gland, brain and oocytes. (usda.gov)
  • Using mRNA sequencing, whole-body pools of juvenile trout fry (1 g bw) exposed to Flavobacterium psychrophilum infection, we observed modest up-regulation (2-3 fold) of five (nkl 2-4 and nkl-like a & b) of the six nkl mRNAs over the five-day post-challenge time-course. (usda.gov)
  • The hypothesis of epigenetic changes affecting the expression of chromosomes was put forth by the Russian biologist Nikolai Koltsov. (wikipedia.org)
  • Our results show that psilocybin does not confer complete protection against insect mycophagy, and the hypothesis that it is produced as an adaptive defense compound may need to be reconsidered. (biorxiv.org)
  • She showed that insects are able to weaken plants defenses in the case of an attack. (unil.ch)
  • technological references of Transgenic Plants: The Scope and Adequacy of Regulation. (uriess-fliesenleger.de)
  • This gene, Sr35, functions as a key component of plants' immune system," Akhunov said. (innovationtoronto.com)
  • In senju mutants, reduced expression of galactose-containing glycans resulted in hyperactivation of the Toll signaling pathway in the absence of immune challenges. (sdbonline.org)
  • HO-1 and their products exert beneficial effects through the protection against oxidative injury, regulation of apoptosis, modulation of inflammation as well as contribution to angiogenesis. (springer.com)
  • Epigenetic regulators (histone acetyltransferases, methyltransferases, chromatin-remodelling enzymes, etc) play a fundamental role in the control of gene expression by modifying the local state of chromatin. (biomedcentral.com)
  • Cloning and characterization of an agglutinin gene from Arisaema lobatum. (lookformedical.com)
  • As a postdoctoral researcher in Dianne Newman 's lab at the California Institute of Technology, Dar developed a way to track gene activity across the entire biofilm with submicrometer resolution. (the-scientist.com)
  • [10] [11] A cell that switches to the biofilm mode of growth undergoes a phenotypic shift in behavior in which large suites of genes are differentially regulated . (wikipedia.org)
  • In addition, expression of M2 in primary murine B cells leads to secretion of high levels of IL-10 along with enhanced proliferation and survival. (prelekara.sk)
  • Agricultural engineer and biochemist by training, I am an insect physiologist (INA-PG PhD thesis, currently AgroParisTech, in 1984) having worked at INSA Lyon since that date, with a few forays elsewhere: INRA Guadeloupe in 1985-1986 , U. Valencia in 2007. (hal.science)
  • Further, non-coding RNA sequences have shown to play a key role in the regulation of gene expression. (wikipedia.org)
  • When Waddington coined the term, the physical nature of genes and their role in heredity was not known. (wikipedia.org)
  • He revealed a crucial role for MYC2, MYC3, and MYC4 as master regulators of defense gene expression in the JA pathway. (unil.ch)
  • BRs also play a role within the regulation. (caspaseinhibitor.com)
  • Therefore, DltX plays a direct role in the resistance to CAMPs, thus contributing to the survival of B. thuringiensis in insects. (frontiersin.org)
  • Furthermore, we show that expression of IRF4 alone in a B cell line up-regulates IL-10 expression in culture supernatants, revealing a novel role for IRF4 in B cell induced IL-10. (prelekara.sk)
  • This is evident at the subfamily level comparisons since Ciona GPCR sequences are significantly analogous to vertebrate GPCR subfamilies even while exhibiting Ciona specific genes. (biomedcentral.com)
  • Probably, fungal cells send EVs in order to downregulate host immune response. (encyclopedia.pub)
  • Interestingly, Toll activation in immune-challenged wild type (WT) flies reduced the expression of galactose-containing glycans. (sdbonline.org)
  • Merel studied how insect eggs negatively impact the jasmonate pathway. (unil.ch)
  • This paper explores the involvement of the Toll/NF-kappaB pathway in the localized activation of wound repair genes around epidermal breaks. (sdbonline.org)
  • In primary murine B cells, addition of cyclosporine (CsA) resulted in a significant decrease in M2-induced IL-10 levels as well as IRF4 expression, emphasizing the importance of the NFAT pathway in M2- mediated induction of IL-10. (prelekara.sk)
  • Together, these studies argue in favor of a model wherein M2 activation of the NFAT pathway initiates events leading to increased levels of IRF4 - a key player in plasma cell differentiation - which in turn triggers IL-10 expression. (prelekara.sk)
  • Murine Gammaherpesvirus M2 Protein Induction of IRF4 via the NFAT Pathway Leads to IL-10 Expression in B Cells. (prelekara.sk)
  • Gene cloning and sub-cloning strategies, chromosome walking, genetic transformation, Basis of animal cloning. (nipaers.com)
  • As defined by Arthur Riggs and colleagues, it is "the study of mitotically and/or meiotically heritable changes in gene function that cannot be explained by changes in DNA sequence. (wikipedia.org)
  • Immunology and Infectious Diseases: Virology, Ribosome Structure & Function and Regulation of Gene Expression. (umd.edu)
  • The completion and reporting of baculovirus genomes is extremely important as it advances our understanding of gene function and evolution. (biomedcentral.com)
  • Ago also reduced AA-induced increase in thromboxane B2 (TxB2) production, intracellular calcium levels and P-selectin expression at plasma membrane. (bvsalud.org)
  • Research interest: Fungal gene regulatory and biochemical networks, and biological clocks. (uga.edu)
  • In other words, as a single fertilized egg cell - the zygote - continues to divide, the resulting daughter cells change into all the different cell types in an organism, including neurons, muscle cells, epithelium, endothelium of blood vessels, etc., by activating some genes while inhibiting the expression of others. (wikipedia.org)
  • After epidermal injury, barrier repair requires activation of many wound response genes in epidermal cells surrounding wound sites. (sdbonline.org)
  • Southern blot analysis indicated that the ala belonged to a multi-copy gene family. (lookformedical.com)
  • Expression pattern analysis revealed that the ala preferentially expressed in the tissues with the higher expression being found in spadix, bud, leaf, spathe and tuber. (lookformedical.com)
  • Natacha studied the signaling pathways involved in the plant response to insect herbivory. (unil.ch)
  • She worked in the lab on plant defense signalling in response to insect oviposition in Arabidopsis. (unil.ch)
  • The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)