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  • pyrophosphates
  • Some of these nuclear produced IPs transport back to the cytosol where they are converted to an even wider variety of IPs, by kinases and phosphatases, including the di- and triphospho inositol phosphates aka pyrophosphates (Irvine & Schell 2001, Bunney & Katan 2010, Alcazar-Romain & Wente 2008, York 2006, Monserrate and York 2010). (reactome.org)
  • ino1
  • To investigate the importance of INO1, we created a conditional knockout, which, under non-permissive conditions, showed that INO1 is an essential gene in bloodstream form T. brucei and that the de novo synthesized myo -inositol is used for the formation of PI and GPI anchors. (biochemsoctrans.org)
  • humans
  • However, in breads containing a mixture of inositol phosphates with different degrees of phosphorylation, IP4 and IP3 contributed to the negative effect on iron absorption in humans. (chalmers.se)
  • suggest
  • These findings, taken together with other recently reported studies suggest that myo-inositol pentakisphosphates could act to regulate PH domain-phosphoinositide interactions by directly competing for binding, thus playing an important role as signaling molecules. (nih.gov)
  • regulation
  • Studies of the role of inositol phosphate regulatory cycle in the development of the ASS phenomenon showed that the inositol triphosphate-diacyl glycerol (ITP-DAG) step of regulation was activated at the peak of PhASS development within 15 days after the adaptation onset. (msk.ru)
  • bound
  • In addition to this, a structural alignment of other PH domains bound to inositol phosphates containing either four or five phosphate groups revealed that the majority of phosphate groups occupy conserved locations in the binding pockets of PH domains. (nih.gov)
  • entities
  • Mono-, di-, and triphosphorylation of the inositol ring generates a wide variety of stereochemically distinct signalling entities. (reactome.org)
  • Role
  • Meerson F.Z., Kopylov Yu.N., The role of the inositol phosphate cycle in the cardioprotective effect of adaptation to repeated stressors, Voprosy meditsinskoi khimii, 1993, vol: 39(2), 6-13. (msk.ru)
  • affinity
  • InsPs activate IDE by up to ∼95-fold, affecting primarily V max The extent of activation and binding affinity correlate with the number of phosphate groups on the inositol ring, with phosphate positional effects observed. (nih.gov)
  • complex
  • This overlap in phosphate positions is not simply coincidence, since a structural alignment of various PH domains solved in complex with either Ins(1,3,4,5)P4 or the two D-myo-inositol pentakisphosphates used in the comparison above reveals that the overlapping positions are conserved in these structures as well (Figure 5). (nih.gov)
  • addition
  • In addition to this, it was found that four out of the five phosphates occupy overlapping positions within the binding cleft despite the differences in orientation and even stereochemistry. (nih.gov)
  • The addition of isolated inositol phosphates showed that IP6 and IP5 inhibited iron absorption, while IP4 and IP3 did not. (chalmers.se)