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  • ITPR1
  • Here we report on serum autoantibodies to ITPR1 (up to 1:15,000) in three patients with (radiculo)polyneuropathy, which in two cases was associated with cancer (ITPR1-expressing adenocarcinoma of the lung, multiple myeloma), suggesting a paraneoplastic aetiology. (biomedcentral.com)
  • membrane
  • The ability of 2,3-bisphosphoglyceric acid, an inhibitor of 5-phosphomonoesterase of red blood cell membrane, to inhibit the breakdown of the tetrakisphosphate suggests that the enzyme which removes the 5-phosphate from inositol 1,4,5-trisphosphate may also act to convert the tetrakisphosphate to inositol 1,3,4-trisphosphate. (biochemj.org)
  • Subcellular fractionation of SH-SY5Y human neuroblastomas revealed that the type 2 RyR and type 1 Ins(1,4,5) P 3 R co-localize among the fractions of a sucrose-cushion separation of crude microsomal membrane fractions. (biochemj.org)
  • Incubation of electrically-paced ventricular myocytes with a membrane-permeant Ins(1,4,5)P-3 ester provoked the occurrence of spontaneous diastolic Ca2+ transients with the same characteristics and sensitivity to 2-APB as the events stimulated by endothelin-1. (ucl.ac.uk)
  • responses
  • Lithium, at high concentrations inhibited FMRFamide and 5-HT responses of internally perfused ventricles. (lancs.ac.uk)
  • Neomycin also inhibited peptide responses, but was without effect on 5-HT responses. (lancs.ac.uk)
  • Histamine, which produced a larger overall total inositol phosphate response in [H-b>inositol -loaded cells, produced significantly smaller Ins(1,4,5)P3 and Ins(1,3,4,5)P4 responses compared with bradykinin. (lancs.ac.uk)
  • Signals
  • Endothelin-1 augmented the amplitude of pacing-evoked Ca2+ signals (positive inotropy), and caused an increasing frequency of spontaneous diastolic Ca2+-release transients. (ucl.ac.uk)
  • studies
  • Bradykinin increased the mass of Ins(1,3,4,5)P4 despite the failure in earlier studies with [H-b>inositol -labelled cells to observe a bradkinin-mediated increase in content of [H-nsP4. (lancs.ac.uk)
  • Function
  • When HL-60 cells are incubated with 1 microM-RA or with 1.25% Me2SO the cells differentiate within 5-7 days into cells resembling neutrophils in both structure and function. (biochemj.org)
  • action
  • no inositol 1,4,5-tris[32P]phosphate was produced, suggesting the action of a 5-phosphomonoesterase. (biochemj.org)
  • FLRFamide and FMRFamide induced small depolarizations (1-2 mV) which triggered a burst of action potentials of about 5 mV which on reaching 4 mV triggered a burst of fast twitch contractions. (lancs.ac.uk)
  • 0.05
  • 0.05) was found after 1 min, similar to that found after concanavalin A (25 micrograms/mL). (uni-muenchen.de)
  • Upon
  • Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze. (mybiosource.com)