• The enzyme inosine triphosphate pyrophosphatase (ITPase) dephosphorylates ribavirin triphosphate in vitro to ribavirin monophosphate, and ITPase reduced enzymatic activity present in 30% of humans potentiates mutagenesis in hepatitis C virus. (wikipedia.org)
  • Inosine triphosphate pyrophosphatases, which are ubiquitous house-cleaning enzymes, hydrolyze noncanonical nucleoside triphosphates (inosine triphosphate (ITP) and xanthosine triphosphate (XTP)) and prevent the incorporation of hypoxanthine or xanthine into nascent DNA or RNA. (rcsb.org)
  • Specifically, the ITPase catalyzes the hydrolysis of (deoxy) nucleoside triphosphates into the corresponding nucleoside monophosphate with the concomitant release of pyrophosphate. (ectrx.org)
  • Inosine triphosphate pyrophosphatase is an enzyme encoded by the ITPA gene. (ectrx.org)
  • 6,7 Inosine triphosphate pyrophosphates (ITPases) represent a ubiquitous group of protective enzymes encoded by the ITPA gene and function to prevent the incorporation of noncanonical (so-called rogue) purine nucleotides into DNA and RNA. (ectrx.org)
  • Xanthosine 5-triphosphate (XTP) is a Guanosine triphosphate (GTP) analogue. (ecmdb.ca)
  • Xanthosine 5-triphosphate is an intermediate of the Purine metabolism pathway, a substrate of the enzymes dinucleoside tetraphosphatase (EC 3.6.1.17) and nucleoside-triphosphate pyrophosphatase (EC 3.6.1.19). (ecmdb.ca)
  • These are purine ribobucleotides with a triphosphate group linked to the ribose moiety. (ecmdb.ca)
  • In the present study, the potential role of inosine triphosphate pyrophosphatase (ITPA) gene variant on the incidence of adverse events during antiretroviral therapy (ART) of HIV with zidovudine was discussed. (nih.gov)
  • Genetic variation of inosine triphosphatase (ITPA) causing an accumulation of inosine triphosphate (ITP) has been shown to protect patients against ribavirin (RBV)-induced anemia during treatment for chronic hepatitis C infection by genome-wide association study (GWAS). (nih.gov)
  • RBV-induced adenosine triphosphate (ATP) reduction in erythrocytes was compared with the genetically determined low or normal activity of ITPA, leading respectively to high or normal ITP levels. (nih.gov)
  • 13. Inosine triphosphate pyrophosphohydrolase (ITPA) polymorphic sequence variants in Chinese ALL children and possible association with mercaptopurine related toxicity. (nih.gov)
  • Inosine triphosphate pyrophosphatase (ITPA) converts inosine triphosphate (ITP) to inosine monophosphate (IMP) in the purine synthetic pathway while AMP deaminase (AMPD) converts AMP to inosine monophosphate (IMP) (Figure 1). (medscape.com)
  • The inosine triphosphate pyrophosphatase (ITPA) genotype at rs1127354 was determined for all studied patients. (elsevierpure.com)
  • The inosine triphosphate pyrophosphatase (ITPA) enzyme plays a critical cellular role by removing noncanonical nucleoside triphosphates from nucleotide pools. (ewu.edu)
  • 6-mercaptopurin (6-MP) metabolizing enzymes such as thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) contribute to variable responses and adverse effects among leukemia patients treated with 6-MP. (ijbc.ir)
  • The aim of this study was to clarify the association between the inosine triphosphate pyrophosphatase (ITPA) gene variants and PEG-IFNα/RBV combination treatment induced anemia in chronic hepatitis C (CHC) Ukrainian patients. (cytgen.com)
  • 3. Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment. (nih.gov)
  • 6. Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study. (nih.gov)
  • 10. Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression. (nih.gov)
  • The enzyme inosine triphosphate pyrophosphatase (ITPase) dephosphorylates ribavirin triphosphate in vitro to ribavirin monophosphate, and ITPase reduced enzymatic activity present in 30% of humans potentiates mutagenesis in hepatitis C virus. (wikipedia.org)
  • Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. (nih.gov)
  • The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. (nih.gov)
  • A pyrophosphatase that catalyzes the conversion of inosine triphosphate and deoxy-inosine triphosphate to inosine monophosphate and deoxy-inosine monophosphate, respectively. (nih.gov)
  • 2. Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). (nih.gov)
  • Although ITP is not used directly by human erythrocyte ATPase, it can be used for ATP biosynthesis via ADSS in place of guanosine triphosphate (GTP). (nih.gov)
  • The accumulation of noncanonical nucleotides such as inosine triphosphate (ITP), is suspected to affect RNA and/or interfere with normal nucleotide function, leading to development of DEE 35. (ewu.edu)
  • 7. Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia. (nih.gov)
  • 17. Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status. (nih.gov)
  • Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. (nih.gov)