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  • Immunology
  • Full Text PA-97-079 INNATE IMMUNITY NIH GUIDE, Volume 26, Number 24, July 25, 1997 PA NUMBER: PA-97-079 P.T. 34 Keywords: Immunology National Institute of Allergy and Infectious Diseases National Institute of Dental Research PURPOSE The National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Dental Research (NIDR), National Institutes of Health (NIH), invite applications for research studies of the innate immune system. (nih.gov)
  • Innate Pharma is in the heart of Marseille scientific ecosystem, focused on research in immunology for more than 30 years. (innate-pharma.com)
  • Innate Pharma is a component part of Marseille Immunopole which brings together key players in the immunology area to form one of the largest immunology and development centers in Europe. (innate-pharma.com)
  • macrophages
  • Components of the innate immune system in the muscle, bone, liver and adipose tissue, as well as macrophages, have been revealed to play a role in systemic insulin action. (springer.com)
  • However, it is now more and more recognized that both at inflammatory sites and in secondary lymphoid structures, DCs can interact with innate immune cells (i.e., mast cells, neutrophils, macrophages, eosinophils, basophils, and natural killer (NK) cells) resulting in the modulation of DC migration and function. (springer.com)
  • cells
  • The innate immune system attracts immune cells to the site of infection, and activates the adaptive immune response. (qiagen.com)
  • This review explored the interaction between the innate immune system and trauma-induced hypermetabolism, while providing greater insight into unraveling the relationship between innate immune cells and hyperglycemia. (hindawi.com)
  • In case of deficiencies or abnormalities in acquired immunity, like defective function of T- or B-cells and malfunction of innate immunity, like complement deficiencies, major disturbance of host protection may occur. (frontiersin.org)
  • Recognizing the importance of innate immunity cells, notably in cancer immunosurveillance and in regulating immune responses, the Company was founded in 1999 by six immunologists. (innate-pharma.com)
  • Signaling
  • Dr Kraig and his colleagues use the Bio-Plex® suspension array system to explore innate cytokine signaling activity in the brain, focusing on downstream gene activation and protein transcription and how the resulting phenotypes affect neural activity. (youtube.com)
  • pattern recogniti
  • Genetic variations leading to the altered production or function of circulating innate immune proteins, cellular pattern recognition receptors and inflammatory cytokines are linked to obesity, insulin resistance and type 2 diabetes. (springer.com)
  • viral
  • This striking ability to evade the powerful innate immune system results from viral interference occurring at several levels of the interferon (IFN) system. (mdpi.com)
  • regulation
  • QIAGEN provides a broad range of assay technologies for innate immunity research that enables analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • Alterations in glucose and insulin regulation affect the immune function of cellular components comprising the innate immunity system. (hindawi.com)
  • Future studies need to determine the integrated effects of HG and insulin on the regulation of innate immunity in order to provide more effective insulin treatment regimen for these patients. (hindawi.com)
  • diseases
  • This PA, "INNATE IMMUNITY", is related to the priority areas of Immunization and Infectious Diseases and Diabetes and Chronic Disabling Diseases. (nih.gov)
  • R. H. Siggers and D. J. Hackam, "The role of innate immune-stimulated epithelial apoptosis during gastrointestinal inflammatory diseases," Cellular and Molecular Life Sciences , vol. 68, no. 22, pp. 3623-3634, 2011. (hindawi.com)
  • complement
  • Indeed, it now seems clear that complement first evolved as part of the innate immune system , where it still plays an important role. (nih.gov)
  • On the other hand there has also been a long history of investigation of certain components of innate immunity like the Toll and the complement system. (frontiersin.org)
  • microbiome
  • On episode #30 of the science show This Week in Microbiology , Vincent, Elio, and Michael review how a toxin from Burkholderia pseudomallei inhibits protein synthesis, and the role of the gut microbiome in modulating insulin resistance in mice lacking an innate immune sensor. (virology.ws)
  • antimicrobial
  • Innate immunity is phylogenetically older and has often been viewed as a vestige of ancient antimicrobial systems made redundant by the evolution of acquired immunity. (nih.gov)
  • Progress in these general areas would provide a better understanding of the functional links between innate and acquired immunity, and would lead to new approaches for immunomodulation, vaccine development, and design of broad-spectrum antimicrobial agents. (nih.gov)
  • humans
  • These days we know that hosts like humans are optimally protected against pathogenic stress when both the innate and acquired immune systems are intact and functional. (frontiersin.org)
  • responses
  • Innate immune responses are rapid and independent of antigen. (nature.com)
  • Heim, M.H. HCV Innate Immune Responses. (mdpi.com)
  • R. Lin reviewed the recent knowledge on how immune signals regulate vitamin D metabolism and how innate immune responses are modulated by ligand-bound vitamin D receptor. (hindawi.com)
  • We began our research into the role of innate immunity in type 2 diabetes at this time, with the aim of exploring whether type 2 diabetes, dyslipidaemia and atherosclerosis were maladaptations of normal physiological responses to injury rather than the result of abnormalities in biochemical pathways. (springer.com)
  • pathogenesis
  • In this regard, we and others have identified a necessary role for the innate immune lipopolysaccharide receptor toll like receptor 4 (TLR4) in the pathogenesis of NEC. (hindawi.com)
  • mice
  • Adult male mice have a simple repertoire of innate, or instinctive, social behaviors: When encountering a female, a male mouse will try to mate with it, and when encountering another male, the mouse will attack. (caltech.edu)
  • insulin
  • A comprehensive review of published literatures on the effects of hyperglycemia and insulin on innate immunity in critical illness was conducted. (hindawi.com)
  • In the paper, the notion was introduced that activated innate immunity and the acute-phase response was a mechanism that could explain a number of well-known characteristics of type 2 diabetes, such as dyslipidaemia, insulin resistance, impaired insulin secretion, accelerated atherosclerosis, central obesity and hyperfibrinogenaemia. (springer.com)
  • clinical
  • The Clinical Sciences Research Institute is hosting a seminar entitled 'Glycomics and innate immunity in human disease' from 12:30pm to 1:30pm on Thursday 21 January 2010 in the Large Seminar Room, CSRI, CSB Building UHCW. (warwick.ac.uk)
  • In our early work, we speculated that this was part of the innate immune system's adaptive reaction to threatened homeostasis, and that this might explain many of the clinical and biochemical features of type 2 diabetes. (springer.com)
  • The study reported in the paper published in Diabetologia in 1997 [ 2 ] was designed to test the theory that the adaptive response of the innate immune system is coupled to clinical and biochemical features of type 2 diabetes. (springer.com)
  • Establishing a network of agreements and collaborations with academic laboratories, clinical centres and industrial leaders is at the heart of Innate Pharma's strategy. (innate-pharma.com)
  • sensor
  • In these studies, UTSW researchers identified a new sensor of innate immunity - the enzyme cyclic GMP-AMP synthase (cGAS) - that sounds a cellular alarm when it encounters DNA in the cytoplasm. (medicalnewstoday.com)
  • nonspecific
  • The innate immune system provides broad, but relatively nonspecific host defenses that lack the properties of antigenic specificity and immunologic memory that characterize acquired immunity. (nih.gov)
  • fungal
  • Betty Wu-Hsieh describes a 2013 paper by Gordon Brown and colleagues that showed fungal strain-specific interactions with the innate immune system. (nature.com)