• APC reduces the pulmonary endothelial cell injury and hypotension in rats administered endotoxin (ET) by inhibiting TNF-α production through inhibition of its transcription. (eurekaselect.com)
  • Inhibition of oxidative stress in renal ischemia-reperfusion injury. (phypha.ir)
  • Inhibition of renal Rho kinase attenuates ischemia/reperfusion-induced injury. (rug.nl)
  • Effect of inhibition of neuronal nitric oxide synthase and L-arginine supplementation on renal ischaemia-reperfusion injury and the renal nitric oxide system. (tum.de)
  • The results of the present study demonstrate that selective inhibition of nNOS has no effect on renal injury, indicating that nNOS does not play a central role in the pathophysiology of renal I/R. In addition, although L-arginine has no effect on renal I/R injury in the model used in the present study, its administration increases the mRNA expression of NOS isoforms. (tum.de)
  • Sprague-Dawley (SD) rats were subjected to bilateral renal artery clamping for 45 min followed by perfusion restoration for establishing a simulated renal IRI model. (frontiersin.org)
  • Specific pathogen-free male Sprague-Dawley (SD) rats, weighing 200-250 g were purchased from the Laboratory Animal Center of Nanchang University (Nanchang, Jiangxi, China). (frontiersin.org)
  • A total of thirty (30) Sprague-Dawley rats were randomly divided into sham, model and sevoflurane groups with 10 animals per group. (ajol.info)
  • Forty Sprague Dawley (SD) rats were divided into four groups, and they were sham operation (Sham), sham + Anwu, II/R, and II/R + Anwu groups. (phcog.com)
  • Forty male Sprague-Dawley rats were randomly divided into four groups, including sham-operated group, IRI-operated group, IPC-treated group and EPCs-treated group. (annalsoftransplantation.com)
  • Following 7 days pretreatment with 7-NI (50 mg/kg per day), L-arginine (2 g/kg per day) or vehicle (dimethylsulphoxide : sesame oil, 1 : 9), the left renal vascular pedicles were clamped for 50 min in male Sprague-Dawley rats and kidneys were removed 24 h after reperfusion (n = 7/group). (tum.de)
  • Materials and Methods: Sprague-Dawley rats (200-300 g) were subjected to 40 minutes of renal warm ischemia. (elsevierpure.com)
  • Remote effect of kidney ischemiareperfusion injury on pancreas: role of oxidative stress and mitochondrial apoptosis. (phypha.ir)
  • Oxidative and nitrosative stress plays important roles in the pathogenesis of renal ischemia/reperfusion (I/R) injury. (scienceopen.com)
  • Here we investigate the effect of EUK-134, a synthetic superoxide dismutase and catalase mimetic, (i) on renal dysfunction and injury caused by I/R in vivo and (ii) on proximal tubular cell (PTC) injury and death caused by oxidative and nitrosative stress. (scienceopen.com)
  • We propose that EUK-134 reduces renal I/R injury not only via reduction of oxidative stress, but also by reducing nitrosative stress caused by renal I/R. (scienceopen.com)
  • The findings emphasize the role of concomitant oxidative and nitrosative stress and the role of peroxynitrite in the ensuing renal dysfunction. (scienceopen.com)
  • The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)
  • Rats, subjected to bilateral renal ischemia (45 min) followed by reperfusion (6 h), were administered EUK-134 (0.3 and 3 mg/kg, i.v.) prior to and during reperfusion, after which biochemical and histological indicators of renal dysfunction and injury were measured. (scienceopen.com)
  • Sevoflurane represses the release of inflammatory factors, lowers ROS level and apoptosis of renal cells and improves renal function through activation of RISK signaling pathway in kidney tissues of rats with renal IRI. (ajol.info)
  • The transplantation of iPSC-derived RPCs decreased the levels of biomarkers indicative of renal injury and attenuated the necrosis and apoptosis of renal tissues, but resulted in the up-regulation of renal tubules formation, cell proliferation, and the expression of pro-renal factors. (biomedcentral.com)
  • The enhanced lung and renal tissues damages were depended to reperfusion time in both genders. (phypha.ir)
  • The flow cytometry analysis demonstrated an elevated expression of innate and mature dendritic cells in I/R renal tissues. (bvsalud.org)
  • We designed this study to identify changes in HMGB1 expression in rat kidney tissues after ischemia reperfusion injury and effects of EP on the expression of HMGB1. (elsevierpure.com)
  • After reperfusion or sham operation, blood and kidneys were collected from the rats for the detection of relative biochemical parameters. (phcog.com)
  • In the treatment groups 1-3, before causing ischemia in the kidneys, rats received 50, 100, and 150 mg/kg/day doses of the extract orally for 20 days, then ischaemia was created. (healthbiotechpharm.org)
  • Renal function tests were done and urinary PGE2 was measured to assess the effect of nimesulide and Pk on kidneys. (edu.pk)
  • Kidneys were harvested and serum creatinine and TNF-α measured at 6 hours, 1 day, 3 days, and 5 days after reperfusion. (elsevierpure.com)
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
  • In this study, we induced iPSCs differentiation into RPCs using a nephrogenic cocktail of factors combined with the renal epithelial cell growth medium. (biomedcentral.com)
  • We showed that the differentiation efficiency of iPSCs to RPCs increased when cultured with renal epithelial cell growth medium after stimulation with a nephrogenic cocktail of factors. (biomedcentral.com)
  • Renal IRI models were created in model and sevoflurane groups, while sham group had no ligation. (ajol.info)
  • The animals were divided into 3 groups: sham group without warm ischemia, EP group (EP given before ischemia), and ischemic control group. (elsevierpure.com)
  • At 24 h post-operatively, we assessed the serum levels of creatinine and urea nitrogen, expression levels of peroxisome proliferator-activated receptor gamma (PPAR-γ) and NF-κB-related (p-IKK-β and IκB-α) proteins, and mRNA expression levels of the inflammatory cytokines, including TNF-α and MCP-1, in the renal tissue of various study groups. (frontiersin.org)
  • Thus, pioglitazone ameliorates renal IRI by inhibiting the NF-κB signaling pathway and inflammatory response in rats. (frontiersin.org)
  • Therefore, in this study, we aimed to investigate the molecular mechanisms underlying pioglitazone hydrochloride-mediated amelioration of renal IRI with respect to the nuclear factor-kappaB (NF-κB) signaling pathway and inflammatory response using a rat model. (frontiersin.org)
  • Anwu has a protective effect against the II/R-induced remote renal injury in rats, which may be related to its regulation of antioxidant, anti-inflammatory, and antiapoptotic pathways. (phcog.com)
  • These observations strongly suggest that APC might be involved not only in regulation of the coagulation system, but in regulation of inflammatory responses by preventing endothelial cell injury. (eurekaselect.com)
  • Lung inflammation is induced by renal ischemia and reperfusion injury as part of the systemic inflammatory syndrome. (phypha.ir)
  • Carvacrol Exhibits Anti-oxidant and Anti-inflammatory Effects against 1, 2-dimethyl Hydrazine Plus Dextran Sodium Sulfate Induced Inflammation Associated Carcinogenicity in the colon of Fischer 344 Rats. (dieselok.md)
  • It is considered as a major cause of acute renal failure and the main factor in early recovery of renal graft function and long-term survival post renal transplantation. (frontiersin.org)
  • Intestinal ischemia/reperfusion (II/R) can cause injury of remote organs, including acute renal injury. (phcog.com)
  • Nitric oxide in acute renal failure: NOS versus NOS. (scienceopen.com)
  • Nimesulide-induced acute renal failure. (edu.pk)
  • Is There Transfusion-related Acute Renal Injury? (silverchair.com)
  • Cell-based therapy with mesenchymal stem cells or renal progenitor cells (RPCs) resident in the kidney has appeared to be an effective strategy for the treatment of AKI. (biomedcentral.com)
  • Scavenging peroxynitrite using seleno-organic compounds like ebselen provides renoprotection against ischemic injury. (scienceopen.com)
  • Because of the increased ability of the immature myocardium to rely on anaerobic glycolysis, it can withstand ischemic injury better than adult myocardium can. (medscape.com)
  • hence, NGAL is considered to be a novel urinary biomarker for ischemic injury. (medscape.com)
  • There were alterations compatible with initial renal alterations, in the first 14 days, such as increased urinary density, pH alteration, presence of glucose, proteins and leukocytes, when compared to the control group. (scielo.br)
  • In this study, we investigated the role of the NF-κB signaling pathway and inflammation in the amelioration of renal IRI using pioglitazone. (frontiersin.org)
  • To investigate the effect of sevoflurane on renal ischemia-reperfusion injury (IRI) in rats and its regulatory effect on reperfusion injury salvage kinase (RISK) signaling pathway. (ajol.info)
  • EUK-134 produced a significant reduction in renal dysfunction and injury caused by I/R. Specifically, serum creatinine levels, an indicator of renal dysfunction, were reduced from 227 ± 11 (n = 12, I/R only) to 146 ± 9 µ M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • These sequelae of renal ischemia are a result of endothelial dysfunction, which is most probably responsible for the 'no-reflow' phenomenon and further aggravation of tubular ischemia during the early reperfusion period. (scienceopen.com)
  • In conclusion, the intricate relations between endothelial and epithelial cells, based in part on the relations between endothelial and inducible nitric oxide synthases, are perturbed in renal ischemia primarily as a result of endothelial dysfunction precipitating epithelial injury. (scienceopen.com)
  • Protein extraction and purification kits, along with rabbit anti-rat peroxisome proliferator-activated receptor-gamma (anti-PPAR-γ), IκB kinase beta phosphorylation (anti-p-IKK-β), and inhibitor κB-alfa (IκB-α) antibodies were purchased from Wuhan Boster Biological Technology, Ltd., (Hubei, China). (frontiersin.org)
  • Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis. (rug.nl)
  • Renal targeting of kinase inhibitors. (rug.nl)
  • Rats treated with high-salt diet (5-9 weeks after I/R) manifested progressive disease indicated by enhanced inflammation, fibrosis, and impaired renal function. (jci.org)
  • The renin-angiotensin system (RAS) and hypertension also may be influenced by renal IR injury. (hindawi.com)
  • Our results revealed that iPSC-derived RPCs can protect AKI rat from renal function impairment and severe tubular injury by up-regulating the renal tubules formation, promoting cell proliferation, reducing apoptosis, and regulating the microenvironment in the injured kidney. (biomedcentral.com)
  • This overview provides information on the pathophysiology of the inducible nitric oxide synthase/nitric oxide (iNOS/NO) system in the injury to cultured renal tubular epithelia, freshly isolated proximal tubules, and the whole organ after hypoxic or ischemic insult. (scienceopen.com)
  • The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
  • The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)
  • SUMMARY: One of the reasons for acute kidney damage is renal ischemia. (bvsalud.org)
  • IR promotes a cascade of molecular events that lead to renal vascular and tubular damage and, ultimately, acute kidney injury (AKI) [ 2 - 4 ]. (hindawi.com)
  • Ischemia preconditioning (IPC) against IR also was recognized as a process to minimize the kidney damage caused by IR [ 5 ]. (hindawi.com)
  • The primary rationale for these developments is that recognition of AKI allows prompt injury-specific intervention that may avert permanent renal damage. (medscape.com)
  • Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats. (phypha.ir)
  • Furthermore, APC reduces the ischemia / reperfusion-induced renal injury and the stress-induced gastric mucosal injury in rats. (eurekaselect.com)
  • The aim of this study was to determine gender differences in renal IR inducedlung injury in different reperfusion time. (phypha.ir)
  • 15. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM, Meldrum DR. Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. (phypha.ir)
  • No significant differences were detected between the groups in renal blood flow (RBF) or renal vascular resistance (RVR) responses to Ang II infusion when MasR was not blocked. (hindawi.com)
  • The protective effect of erythropoietin on renal injury induced by abdominal aortic-ischemia-reperfusion in rats. (phypha.ir)
  • In our previous study, we found that Anwu can improve the intestinal function after ischemia/reperfusion. (phcog.com)
  • More importantly, the bioprinted constructs with neural cell integration facilitate rapid innervation and mature into organized muscle tissue that restores normal muscle weight and function in a rodent model of muscle defect injury. (nature.com)
  • Next, we examined the renal function-related markers and renal histology to assess the therapeutic effect of the injected cells. (biomedcentral.com)
  • Acute kidney injury (AKI) is characterized by acute tubular injury and a rapid decline in renal function [ 1 ]. (biomedcentral.com)
  • iPS-MSC dOex-mIRs therapy was superior to iPS-MSC therapy for preserving LV function in DCM rat. (researchsquare.com)
  • Drug-induced impairment of renal function. (edu.pk)
  • Ischemia/ reperfusion was found to affect renal function and induce histopathological alterations. (bvsalud.org)
  • Neither 7-NI nor L-arginine had any effect on parameters of renal function, the grade of tissue injury or the number of terminal deoxyribonucleotidyl transferase-mediated dUTP-digoxigenin nick end-labelling (TUNEL)-positive tubular cells compared with vehicle-treated rats. (tum.de)
  • In contrast to the negative effects of Ang II on the renal circulation, Ang1-7 as a renoprotective agent improves endothelial function, which increases RBF and decreases renal vascular resistance (RVR) [ 16 ]. (hindawi.com)
  • Renal indexes were not significantly different among all groups. (phcog.com)
  • These results provided evidence that IPC-mediated homing of EPCs played an important role in the protection of renal acute IRI, involving promotion of cell proliferation and angiogenesis through release of several angiogenic factors, such as VEGF, Ang-1, and Ang-2. (annalsoftransplantation.com)
  • The biological effects of Ang1-7 are mainly mediated by specific receptor of MasR, and it is known clearly that Ang 1-7 and Ang II perform different actions in the renal vasculature [ 14 ]. (hindawi.com)
  • and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for early and accurate identification of AKI rather than secondary consequences of injury. (medscape.com)
  • Adapted from de Geus HR, Betjes MG, Bakker J. Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges. (medscape.com)
  • The aim of the present study was to determine the effects of CoQ 10 and vitamin E on lipid peroxidation and antioxidant profile in rats treated with the chemotherapeutic agent doxorubicin, along with the biochemical parameters of albumin, globulin, total protein, alanine aminotransferase (ALT) and glucose levels. (fusabil.org)
  • Sex effects and the time of reperfusion may be the important factors to consider clinical therapeutic of renal IRI as well as its impact on remote organs. (phypha.ir)
  • Saghaei E, Moini Zanjani T, Sabetkasaei M, Naseri K. Enhancement of antinociception by co-administrations of nefopam, morphine, and nimesulide in a rat model of neuropathic pain. (edu.pk)
  • The histopathological evaluation of renal tissue was also conducted. (frontiersin.org)
  • The effects of EUK-134 on serum levels of NO in rats subjected to renal I/R or on NO production by PTCs incubated with interferon-γ (IFN-γ, 100 IU/ml) and bacterial lipopolysaccharide (LPS, 10 µg/ml) in combination for 24 h were also measured. (scienceopen.com)
  • Pioglitazone also decreased the mRNA expression of TNF-α and MCP-1 in the renal tissue. (frontiersin.org)
  • but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury. (cdc.gov)
  • 1 m M for 2 h) in the presence of increasing concentrations of EUK-134 (1-100 µ M ) after which PTC injury and death were measured. (scienceopen.com)
  • This ELISA kit applies to the in vitro quantitative determination of Rat BMG/β2-MG concentrations in serum, plasma and other biological fluids. (elabscience.com)
  • Immature calcium handling in immature myocardium raises intracellular calcium concentrations after ischemia and reperfusion. (medscape.com)
  • The role of nitric oxide synthases (NOS) and the nitric oxide (NO) substrate l-arginine in renal ischaemia-reperfusion (I/R) has been studied extensively. (tum.de)
  • In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)
  • The renal vascular responses to graded Ang II (30, 100, 300, and 1000 ng kg −1 .min −1 ) infusion using A779 or its vehicle were measured at constant renal perfusion pressure. (hindawi.com)
  • These data revealed the important role of MasR after partial kidney IR in the responses of RBF and RVR to Ang II administration in 2K1C hypertensive rats. (hindawi.com)
  • Effects of ischemic acute kidney injury on lung water balance: nephrogenic pulmonary edema? (phypha.ir)
  • 11. Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H. Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis. (phypha.ir)
  • The Fluid and Catheter Treatment Trial was a prospective, randomized, multicenter trial that evaluated the use of pulmonary artery catheter versus central venous catheter for the management of patients with acute lung injury or acute respiratory distress syndrome. (silverchair.com)
  • We then established the rat ischemia-reperfusion injury (IR) model and transplanted the iPSC-derived RPCs into the injured rats in combination with the hydrogel. (biomedcentral.com)
  • When kidney CD4+ cells of post-acute kidney injury (post-AKI) rats were stimulated with angiotensin II and elevated Na+ (10-7 M/170 mM) in vitro, there was an enhanced response in intracellular Ca2+ and IL-17 expression, which was blocked by SOCE inhibitors 2APB, YM58483/BTP2, or AnCoA4. (jci.org)
  • An in vitro method of alcoholic liver injury using precision-cut liver slices from rats. (rug.nl)
  • Reperfusion injury and reactive oxygen species: the evolution of a concept. (phypha.ir)