Injury in rats hepatic ischemia reperfusion. Medical search. Frequent questions

Livers treated with NMP combined with BMMSCs showed better liver function, relieved histopathological damage, reduced oxidative stress injury and ferroptosis, and the mechanism of reduction was associated with downregulation of intracellular reactive oxygen species (ROS) and free Fe²⁺ levels. (medscimonit.com)
One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
2012). Crocin "saffron" protects against beryllium chloride toxicity in rats through diminution of oxidative stress and enhancing gene expression of antioxidant enzymes. (sciendo.com)
Intrathecal injection of hydrogen-rich saline can decrease oxidative stress and the expression of p38MAPK and BDNF that may contribute to the elevated threshold of neuropathic pain in rat CCI model. (molecularhydrogenstudies.com)
Remote effect of kidney ischemiareperfusion injury on pancreas: role of oxidative stress and mitochondrial apoptosis. (phypha.ir)
Inhibition of oxidative stress in renal ischemia-reperfusion injury. (phypha.ir)

Cerebral ischaemia is caused by middle cerebral artery occlusion, which leads to some brain tissue damage, accompanied by inflammation and immune response [ 2 ]. (biomedcentral.com)

Central IKK2 Inhibition Ameliorates Air Pollution-Mediated Hepatic Glucose and Lipid Metabolism. (deepdyve.com)
We therefore investigated the effects of PM2.5 exposure on insulin resistance and the disorders of hepatic glucose and lipid metabolism via hypothalamic inflammation. (deepdyve.com)
Therefore, our current finding indicates an important role of hypothalamic inflammation in PM2.5 exposure-mediated hepatic glucose and lipid metabolism disorder. (deepdyve.com)

Ha T, Liu L, Kelley J (2011): Toll-like receptors: new players in myocardial ischemia/reperfusion injury. (ankara.edu.tr)
Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. (wanfangdata.com.cn)
The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury [J].2015,78. (wanfangdata.com.cn)
Hydrogen gas can reduce ROS and alleviate cerebral, myocardial, and hepatic ischemia/reperfusion injuries. (molecularhydrogenstudies.com)

The objective of present study was to assess the effects of MK-886 and DITPA on renal I/R injury. (biomedcentral.com)
A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. (sciendo.com)
Renal ischemia/reperfusion injury (IRI) may influence distance organ such as lung. (phypha.ir)
The aim of this study was to determine gender differences in renal IR inducedlung injury in different reperfusion time. (phypha.ir)
Eighty male and female rats were assigned into 8 groups, 4 groups in each gender including: sham, renal ischemia for 45min by clamping renal vessels followed by 3, 24 or 48h reperfusion. (phypha.ir)
The renal MDA level of male increased during 3h reperfusion but not seen in females. (phypha.ir)
The enhanced lung and renal tissues damages were depended to reperfusion time in both genders. (phypha.ir)
Sex effects and the time of reperfusion may be the important factors to consider clinical therapeutic of renal IRI as well as its impact on remote organs. (phypha.ir)
Nacetylcysteine prevents kidney and lung disturbances in renal ischemia/reperfusion injury in rat. (phypha.ir)
Lung inflammation is induced by renal ischemia and reperfusion injury as part of the systemic inflammatory syndrome. (phypha.ir)
8. Dehghani A, Saberi S, Nematbakhsh M. Role of Mas receptor antagonist A799 in renal blood flow response to Ang 1-7 after bradykinin administration in ovariectomized estradiol-treated rats. (phypha.ir)
Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats. (phypha.ir)
15. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM, Meldrum DR. Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. (phypha.ir)
The protective effect of erythropoietin on renal injury induced by abdominal aortic-ischemia-reperfusion in rats. (phypha.ir)

Despite accumulating evidence regarding its mechanisms and potential therapeutic approaches, hepatic I/R is still a leading cause of organ dysfunction, morbidity, and resource utilization, especially in those patients with underlying parenchymal abnormali-ties. (123dok.net)
Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes [J].2008,47(5). (wanfangdata.com.cn)
Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. (wanfangdata.com.cn)
Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation. (wanfangdata.com.cn)
Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury. (wanfangdata.com.cn)
[6] Immune activation is associated to endothelial dysfunction and microvascular complications, [7] with significant septal capillary injury, characterized by mural and luminal fibrin deposition, permeation of the interalveolar septa by neutrophils and significant deposits of terminal complement components consistent with sustained, systemic activation of the alternative and lectin-based complement pathways, associated with procoagulant state. (asociatia-ozonoterapie.ro)

40 adult male Sprague-Dawlay rats were randomly divided into 5 groups: the sham, LPS, LPS + HBO, LPS + HRS and LPS + HBO + HRS. (researchsquare.com)
Sham group (n = 6), mice underwent same anesthetic and surgical procedures except for ischemia induction. (biomedcentral.com)
Rats in sham group were sacrified at 100 minutes observation after laparotomy. (bvsalud.org)
Methods: Sprague-Dawley rats were randomly divided into 4 groups: sham operated group (Sham), Sham with Picroside II treatment group (Sham+ Pic II), l/R group (l/R) and l/R with Picroside II treatment group (I/R+ Pic II). (bvsalud.org)

As liver ischemia ends and reperfusion begins, reactive oxygen species are one of the first elements formed (14). (ectrx.org)
All reactive oxygen species respond in varying degrees at the initiation of reperfusion. (ectrx.org)
Reperfusion injury and reactive oxygen species: the evolution of a concept. (phypha.ir)

Although the treatment did not affect hepatic inflammation or endoplasmic reticulum stress, it inhibited the expression of the enzymes for gluconeogenesis and lipogenesis in the liver. (deepdyve.com)
The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion Injury [J].2016,100(2). (wanfangdata.com.cn)

BMMSCs showed significant protective effects on the ultrastructure of DCD donor livers and ROS-induced injury to IAR-20 cells under electron microscopy. (medscimonit.com)
Bakan V, Çıralık H, Tolun F (2009): Protective effect of erythropoietin on torsion/detorsion injury in rat model. (ankara.edu.tr)
2008. Protective effects of amlodipine on ischemia-reperfusion injury of rat ovary: biochemical and histopathologic evaluation. (ankara.edu.tr)
AIM:To explore the protective effect of pyrrolidine dithiocarbamate (PDTC) on a cute liver injury(ALI) caused by hepatic ischemia reperfusion(HIR) in rats and i ts mechanism of action. (linguix.com)
In this discussion of antioxidant molecules, it is also important to include melatonin, which exerts multiple protective effects in hepatic ischemia and reperfusion (33-36). (ectrx.org)

After the end of reperfusion phase mice were sacrificed, blood samples were collected directly from the heart for determination of serum TNF-a, IL-6, urea and Creatinine. (biomedcentral.com)
This study was undertaken to determine the influences of various doses of peppermint oil on the hepatic en-zymes, alanine transaminase, apartate tranaminase, alkaline phosphotase and gamma glutamyl transferase and the level of malondialdehyde in the serum of mice with and without immobility stress. (openbiochemistryjournal.com)
Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice [J].2011,141(6). (wanfangdata.com.cn)
The collected exosomes or MSCs were injected intravenously into liver injury mice that had been prepared by the intravenous con-A injection. (biomedcentral.com)

Excessive glutamate release and the overexcitation of glutamate receptors has been identified as a central mediator in the pathophysiology of the neuronal injury associated with ischemic stroke and head trauma ( Choi, 1987 ). (jneurosci.org)
1998): The effects of twisted ischemic adnexa managed by detorsion on ovarian viability and histology: an ischemia-reperfusion rodent model. (ankara.edu.tr)
Putative pathophysiological mechanisms linking I/R injury and liver cancer recurrence include an increased implantation of circulating cancer cells in the ischemic liver and the upregulation of proliferation and angiogenic factors following the ischemic insult. (123dok.net)
Effects of ischemic acute kidney injury on lung water balance: nephrogenic pulmonary edema? (phypha.ir)
Because of the increased ability of the immature myocardium to rely on anaerobic glycolysis, it can withstand ischemic injury better than adult myocardium can. (medscape.com)

Methods We used 32 Wistar-Albino rats. (bvsalud.org)

Induction of autophagy reduces ischemia/reperfusion injury in steatotic rat livers [J].2017,216. (wanfangdata.com.cn)

Although the mechanisms of ischemia-reperfusion injury are numerous and complex, many advances in treatment have been made. (ectrx.org)

To investigate the mechanism of sodium tanshinone IIA sulfonate inhibiting hypoxia induced retinal neovascularization in rats. (ijpsonline.com)
Abstract Purpose: To investigate the effect of Picroside II on testicular ischemia and reperfusion (l/R) injury and the underlying mechanism. (bvsalud.org)

Twenty-four male rat DCD donor livers were randomly and averagely divided into normal, static cold storage (SCS), NMP, and NMP combined with BMMSCs groups. (medscimonit.com)
Forty 7 d old clean grade C57BL/6J male neonatal rats were randomly divided into control group, model group, low-dose group and high-dose group. (ijpsonline.com)

I/R injury, through the liberation of radical oxygen species and the activation of inflammatory pathways, induces cellular injury and mi-crocirculatory damage, which translate to organ dysfunc-tion, morbidity, and increased health care costs [7, 8]. (123dok.net)
11. Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H. Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis. (phypha.ir)

2014): Changes in ADMA/DDAH pathway after hepatic ischemia/reperfusion injury in rats: the role of bile. (ankara.edu.tr)

This study aimed to evaluate the effects of TQ on spatial memory and hippocampal long-term potentiation (LTP) in rats with thioacetamide (TAA)-induced liver injury and hepatic encephalopathy. (magiran.com)

The abundance and diversity of the intestinal flora in rats decreased after cerebral ischaemia - reperfusion injury (CIRI). (biomedcentral.com)
CIRI may lead to intestinal flora disorder in rats, and after the administration of RAGs, the abundance of intestinal flora can be improved. (biomedcentral.com)
Abstract Purpose To investigate the effects of bradykinin on reperfusion injury in an experimental intestinal ischemia reperfusion model. (bvsalud.org)

To investigate the effects of hydrogen-rich saline (HRS) combined with hyperbaric oxygen (HBO) on acute lung injury (ALI) and its clinical significance. (researchsquare.com)
Lung injury is one of the most serious injuries that are difficult to handle and is a leading cause of death in patients with thoracic trauma [ 1 , 2 ] . (researchsquare.com)
Excess release and over-expression of immflammatory mediators and related immflammatory cytokines could stimulate excess immflammatory reaction, resulting in damage to alvelar-cappilary membrane and increased vascular permeability and ultimately acute lung injury (ALI) [ 5 - 7 ] . (researchsquare.com)
In our experiment, adult SD rat model of acute lung injury was established by injecting lipopolysaccharide (LPS) into treachea, and life signs and dry-wet ratio of pulmonary tissue were closely observed. (researchsquare.com)
Lung ischemia reperfusion injury: A bench-to-bedside review [J].2013,17(1). (wanfangdata.com.cn)
The severity of IRI induced- lung insult can be affected by gender and reperfusion time alteration. (phypha.ir)
The water content of lung was reduced in 3h of reperfusion groups. (phypha.ir)
Kidney-lung cross-talk and acute kidney injury. (phypha.ir)
9. Doi K, Ishizu T, Fujita T, Noiri E. Lung injury following acute kidney injury: kidney-lung crosstalk. (phypha.ir)

Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)

HBOT could obviously enhance aterial oxygen level, increase partial pressure of oxygen and improve ischemia in various organs or tissues, decrease acid metabolites and hasten functional recovery of various organs. (researchsquare.com)
At the end of the subchronic FA exposure, the blood samples, heart and aorta tissues of the rats were taken and subjected to biochemical analyses. (bvsalud.org)

A total of 24 Wistar Albino rats were used in our study. (bvsalud.org)

Conclusion Either ischeamic preconditioning or pharmacologic preconditioning made by bradykinin reduced the ischemia reperfusion injury at jejunum. (bvsalud.org)

Calpain 2-mediated autophagy defect increases susceptibility of fatty livers to ischemia-reperfusion injury. (wanfangdata.com.cn)

The aim of the present study was to investigate the effects of Pringle maneuver, which results in hepatic ischemia-reperfusion (IR) injury, and partial hepatectomy (Hx) on the pharmacokinetics and brain distribution of sodium fluorescein (FL), which is a widely used marker of blood-brain barrier (BBB) permeability. (bepress.com)
Rats were subjected to Pringle maneuver (total hepatic ischemia) for 20 min with (HxIR) or without (IR) 70% hepatectomy. (bepress.com)
the liver, I/R injury is at the source of poor outcomes after surgical procedures such as hepatectomy and liver trans-plantation [7]. (123dok.net)

Ischemia-reperfusion injury, which involves complex inflammatory pathways, is a significant cause of liver damage and an important factor in a variety of diseases, injuries, and procedures that include (but not limited to) transplant and trauma. (ectrx.org)

Burczynski, F. J. Effects of Long-Term Hepatic Ischemia-Reperfusion Injury on the Function of P-Glycoprotein in Vivo in Rats. (ualberta.ca)
21]Peralta,C.,Jiménez-Castro,M.B.,Gracia-Sancho,J.. Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu [J].2013,59(5). (wanfangdata.com.cn)
Adenoviral delivery of superoxide dismutase has been shown to produce beneficial effects in warm ischemia reperfusion (18), alcohol-induced liver injury (19), and reduced-size liver grafts (20). (ectrx.org)
The suppressive effects of MSC-derived exosomes and the MSCs in this injury model were evaluated by the level of plasma alanine aminotransferase (ALT), histopathological examinations, the messenger RNA (mRNA) expression of pro- and anti-inflammatory cytokines, and the population alteration of regulatory T cells (Treg) among non-parenchymal liver cells (NPCs). (biomedcentral.com)

2003): Effect of melatonin on estrogen and progesterone receptors in relation to uterine contraction in rats. (ankara.edu.tr)
2001): Melatonin inhibits spontaneous and oxytocin-induced contractions of rat myometrium in vitro. (ankara.edu.tr)
1999): Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia. (ankara.edu.tr)
1996): Oxidative damage in the liver induced by ischemia-reperfusion: protection by melatonin. (ankara.edu.tr)
Recent evidence has shown that in cases of generalized ischemia after hemorrhagic shock, the effectiveness of melatonin in improving liver function depends on the melatonin receptor (40). (ectrx.org)

For example, ardisiaquinone A protects against liver injury in an animal model of ischemia-reperfusion injury. (wikipedia.org)
The model used in this study was established by middle cerebral artery occlusion (MCAO) and reperfusion. (biomedcentral.com)
In 2007, Dr. Ohta's team reported in Nature Medicine [3] that inhalation of 2-4% hydrogen gas significantly reduced the cerebral infarct volumes in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion. (h2-aqua.com)
In the present study, authors aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI). (molecularhydrogenstudies.com)
This study aimed to evaluate the effect of mesenchymal stem cell (MSC)-derived exosomes on an immune-induced liver injury model. (biomedcentral.com)
In this study, we investigated the suppressive effect of exosomes on an immune-induced liver injury model. (biomedcentral.com)

These fractions efficiently acquired apoE from rat serum, and were processed by LPL in vivo with a similar efficiency. (zhangqiaokeyan.com)

Liver ischemia and reperfusion - which cause liver damage that is significant in a variety of diseases, injuries, and procedures (including but not limited to trauma and transplant) - have been the focus of many investigations in recent years. (ectrx.org)

2005): IKK mediates ischemia-induced neuronal death. (ankara.edu.tr)

Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)

Therapeutic strategies tackling I/R injury could not only improve post-surgical organ function, but also allow a reduction in the risk of cancer recurrence. (123dok.net)

2010), nonalcoholic steatohepatitis, impaired hepatic glucose metabolism (Zheng et al. (deepdyve.com)

To assess the linearity of the assay, samples were spiked with high concentrations of rat HA in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. (cusabio.com)
Immature calcium handling in immature myocardium raises intracellular calcium concentrations after ischemia and reperfusion. (medscape.com)

The peroxidation of lipids (16, 17), protein oxidation, and the formation of peroxinitrites frequently occur after liver ischemia and reperfusion. (ectrx.org)

PM2.5 exposure leads to hepatic insulin resistance (IR) that was accompanied by endoplasmic reticulum (ER) stress-induced apoptosis (Laing et al. (deepdyve.com)

In this report, a comprehensive analysis of those factors is provided, and the fundamental molecular inflammatory mediators present after liver ischemia and reperfusion are discussed. (ectrx.org)

The process of ischemia and reperfusion is known to cause inducible nitric oxide synthase induction and activation, and there is evidence that interleukin (IL)-1β (46), IL-1 receptor (47), and IL-1 receptor along with nuclear factor-kappa beta (48) may have an important role in that induction. (ectrx.org)
This type of liver injury is mediated through activation of the adaptive immune system including natural killer and Kupffer cells, which is employed as a method to evaluate the induction liver tolerance [ 19 - 21 ]. (biomedcentral.com)

In liver transplantation, tissue damage at reperfusion is mostly correlated with warm and cold ischemia times and leads in turn to poor graft function [13] and biliary complications [14,15]. (123dok.net)

29256408 ). N-Acetyltryptophan has also been shown to have a role in preventing hepatic ischemia-reperfusion injury. (hmdb.ca)
This review aims at giving the last updates regarding the role of hepatic I/R and liver parenchymal quality injury in the setting of oncological liver surgery, using a ''bench-to-bedside'' approach. (123dok.net)

Anatomy29

Organisms13

Diseases52

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes38

Disciplines and Occupations1

Information Science2

Health Care5

Oxidative Stress6

Caused by middle cerebral artery1

Lipid3

Myocardial4

Renal16

Dysfunction6

Sham4

Reactive oxygen3

Endoplasmic Reticulum Stress2

Protective5

Mice4

Ischemic5

METHODS1

20171

Mechanisms1

Mechanism2

Randomly2

Induces2

Pathway1

Thioacetamide1

Intestinal3

Lung9

Deprivation1

Tissues2

Albino1

Bradykinin1

Livers1

Hepatectomy3

Inflammatory pathways1

Effects4

Melatonin5

Model6

Vivo1

Liver damage1

Neuronal1

Abstract1

Therapeutic1

Glucose1

Concentrations2

Lipids1

Apoptosis1

Molecular1

Induction2

Damage1

Role2