• Drug-induced liver injury (DILI) is an injury of the liver that may occur when you take certain medicines. (medlineplus.gov)
  • The low incidence of idiosyncratic drug-induced liver injury (DILI), together with the lack of a reliable diagnostic biomarker and robust preclinical and in vitro toxicology test systems for the condition have limited our ability to define the mechanisms of DILI. (nih.gov)
  • Inhibiting gap junctions in liver cells could provide a feasible strategy to preventing drug-induced liver injury (DILI), investigators claim. (genengnews.com)
  • A preventive or therapeutic strategy against DILI could thus have implications both for the safer use of already marketed drugs, the development of new treatments for a range of diseases, and the potential salvage of otherwise promising drug candidates that have demonstrated hepatic toxicity. (genengnews.com)
  • Liver biopsy and HLA genotyping can help clinical management by differentiating DILI from AIH and excluding DILI secondary to certain drugs. (bsg.org.uk)
  • Idiosyncratic drug-induced liver injury (DILI) is an unpredictable type of liver injury following exposure to medication within the recommended dose which is distinctive from liver injury caused by drug overdosage, commonly caused by paracetamol overdose (POD). (bsg.org.uk)
  • DILI usually occurs after a latency period ranges from few days to months post-exposure compared to a period from hours to days in liver injury due to overdose. (bsg.org.uk)
  • Following a large national audit in the UK of 881 consecutive patients admitted with jaundice, where a biliary obstruction was ruled out by imaging, idiosyncratic DILI was the second most common cause of liver injury (15% of cases) after alcoholic liver disease (2). (bsg.org.uk)
  • Mortality/ liver transplant rates exceed 10% in DILI patients with hepatocellular injury and jaundice (5, 6). (bsg.org.uk)
  • Deeper understanding of drug-induced liver injury (DILI) mechanisms is the goal of an international team of experts from the Prospective European Drug-induced Liver Injury Network (PRO-EURO DILI Network), who met on March 9 and 10 at the Institute of Physics of the Academy of Sciences of the Czech Republic. (fzu.cz)
  • The PRO-EURO DILI Network will expand the DILI issue towards not only standard drugs but also to herbs and herbal supplements. (fzu.cz)
  • One of the aims of the next phase of this joint research is the prevention of the so-called idiosyncratic DILI, i.e., a rare condition occurring independently of a drug dose, or route or duration, of administration. (fzu.cz)
  • The next phase of the research will therefore be examining and scaling samples of damaged liver so that it were possible to determine in advance who who is at risk of suffering from DILI when administered a particular drug. (fzu.cz)
  • The goal of the working group, which our team from FZU takes part in, was to review the current expertise on preclinical methods and technologies that assess the risk of DILI based on the action of a given drug, and thereby contribute to better regulatory decision-making regarding DILI. (fzu.cz)
  • Within the PRO-EURO DILI Network there are five working groups dealing, for example, with the standardization of approaches to the diagnosis of drug-induced liver damage, the assessment of the hepatotoxicity potential of individual drugs and their interaction or trying to contribute to better decision-making by regulatory bodies related to DILI. (fzu.cz)
  • They also want individual data from clinical trials of drugs in development to be shared even after they are on the market in case DILI has been identified. (fzu.cz)
  • Drug induced liver injury (DILI) is an important cause of acute liver disease in the United States. (gi.org)
  • In addition to these two classes of agents, cardiovascular drugs, central nervous system agents, and chemotherapeutic agents are also important causes of DILI. (gi.org)
  • Quantitative Systems Toxicology (QST) software designed to be used during drug development to provide deeper insight into the mechanisms responsible for observed drug-induced liver injury (DILI) responses. (simulations-plus.com)
  • Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. (uni-koeln.de)
  • Characteristics of Drug-induced Liver Injury in Chronic Liver Disease: Results from the Thai Association for the Study of the Liver (THASL) DILI Registry. (tropmedres.ac)
  • Background and aimsThe impact of drug-induced liver injury (DILI) on patients with chronic liver disease (CLD) is unclear. (tropmedres.ac)
  • Drug-induced liver injury (DILI) is often a trial even to expert clinicians, because sometimes diagnosis is not easy to be made. (unipa.it)
  • DILI diagnostic criteria help clinicians thinking of liver injury induced by drug, excluding other causes of liver disease. (unipa.it)
  • Drug-induced cholestasis (DIC) falls under drug-induced liver injury (DILI), specifically the cholestatic or mixed type. (wikipedia.org)
  • While some drugs (e.g., acetaminophen) are known to cause DILI in a predictable dose-dependent manner (intrinsic DILI), most cases of DILI are idiosyncratic, i.e., affecting only a minority of individuals taking the medication. (wikipedia.org)
  • Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery. (scilifelab.se)
  • There is a clear need for better biomarkers of drug-induced-liver-injury (DILI). (scilifelab.se)
  • After adjudication, 154 patients were considered to have DILI and 22 were considered to have acute liver injury without DILI. (scilifelab.se)
  • Drug-induced liver injury (DILI) is a frequent cause of hepatic dysfunction as well as the single most frequent reason for removing approved medications from the market, and multispectral optoacoustic tomography (MSOT) is an emerging and noninvasive imaging modality for diagnosing and monitoring diseases. (ithera-medical.com)
  • For future research, we suggest to combine cross-linking DILI tracers such as ICD-10 liver injury codes, abnormal liver biomarkers, search for trigger hepatotoxicity drugs and EMR text search tools, adding artificial intelligence to pharmacovigilance and hospital pharmacy. (rbfhss.org.br)
  • AAS DILI caused significantly higher bilirubin values independent of type of damage when compared to other drug classes ( P = 0.001). (medscape.com)
  • Conclusions Illicit recreational AAS use is a growing cause of reported DILI that can lead to severe hepatic and renal injury. (medscape.com)
  • To date, only isolated case reports and smaller case series of AAS-induced liver injury (AAS DILI) have been reported. (medscape.com)
  • Some drugs can cause hepatitis with small doses, even if the liver breakdown system is normal. (medlineplus.gov)
  • Many different drugs can cause drug-induced hepatitis. (medlineplus.gov)
  • Clinically, DIC can manifest as acute bland (pure) cholestasis, acute cholestatic hepatitis, secondary sclerosing cholangitis (involving bile duct injury), or vanishing bile duct syndrome (loss of intrahepatic bile ducts). (wikipedia.org)
  • 17 Bland cholestasis occurs when there is obstruction to bile flow in the absence of inflammation or biliary and hepatic injury, whereas these features are present in cholestatic hepatitis. (wikipedia.org)
  • BACKGROUND & AIMS: The diagnosis of drug-induced liver injury relies on exclusion of other causes, including viral Hepatitis A, B, and C. Hepatitis E virus (HEV) infection has been proposed as another cause of suspected drug-induced liver disease. (ystwt.cn)
  • Drugs account for 2-5% of cases of patients hospitalized with jaundice and approximately 10% of all cases of acute hepatitis. (medscape.com)
  • An aggressive form of chronic hepatitis involving extensive liver damage and cell injury beyond the portal tract. (bvsalud.org)
  • ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. (medlineplus.gov)
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury updated 11 December 2019. (medsafe.govt.nz)
  • The degree of elevation of liver enzymes does not accurately reflect the severity of the liver injury or predict clinical outcome. (bsg.org.uk)
  • The clinical picture of drug-induced myopathies may be highly variable. (degruyter.com)
  • Unfortunately, the available biomarkers for SKM injury do not fully meet the needs for satisfactory detection of drug-induced damage, both in clinical and research settings, mainly due to their low sensitivity and specificity. (degruyter.com)
  • This can be incredibly useful in both clinical practice and for de-challenge/re-challenge investigational trials where the risk of drug-induced SKM injury is present. (degruyter.com)
  • The clinical picture of drug-induced myopathies may range from asymptomatic or mild myalgias, with or without muscle weakness, which are likely underreported, to chronic myopathy with severe weakness and rarely, even to massive rhabdomyolysis with acute kidney injury (AKI) [ 1 ]. (degruyter.com)
  • In clinical practice, as well as during drug development and in clinical trials, the diagnosis of SKM injury can be challenging due to the variable symptomology, reliance on patient-self reporting, and lack of highly specific biomarkers, such as those available for cardiac myocyte injury (i.e., cardiac troponins) [ 3 ]. (degruyter.com)
  • Moreover, the rapid rise of new therapeutics with the potential to cause SKM injury, such as immunotherapies and targeted therapies, as well as new treatments (such as gene therapy) specifically targeting muscular or neuromuscular diseases, demands an improved clinical strategy to identify myocyte injury and enable appropriate and timely clinical intervention. (degruyter.com)
  • In addition, checkpoint inhibitors are more frequently being employed in combination with other agents (including with other checkpoint inhibitors) in clinical practice, as well in hundreds of combination drug trials with other novel biological, targeted, and immunotherapies. (degruyter.com)
  • Drug-induced nephrotoxicity is a common source of acute kidney injury (AKI) and a condition that complicates clinical outcomes of vulnerable patients. (simulations-plus.com)
  • The diagnosis of drug-mediated pulmonary toxicity is usually established based on clinical findings. (medscape.com)
  • We demonstrated that 12 cholestatic drugs classified on the basis of reported clinical findings caused disturbances of both bile canaliculi dynamics, characterized by either dilatation or constriction, and alteration of the ROCK/MLCK signaling pathway, whereas noncholestatic compounds, by contrast, had no effect. (aspetjournals.org)
  • Absence of information was mainly related to drug reconciliation at hospital admission, time of onset of suspected drug therapy and no description of previous clinical conditions in EMR. (rbfhss.org.br)
  • Advances in clinical diagnosis and treatment of drug-induced liver injury in children]. (bvsalud.org)
  • Noise -induced hearing loss and its prevention: integration of data from animal models and human clinical trials. (cdc.gov)
  • However, the acute traumatic injury models commonly used in pre-clinical testing are fundamentally different from the chronic and repeated exposures experienced by many human populations. (cdc.gov)
  • Additionally, there is no simple drug testing preclinical system to decipher hepatotoxicity issues undoubtfully at early stages of the drug development. (fzu.cz)
  • Reuben A. Hepatotoxicity of immunosuppressive drugs. (nih.gov)
  • Physicians must be vigilant in identifying drug-related liver injury because early detection can decrease the severity of hepatotoxicity if the drug is discontinued. (medscape.com)
  • The manifestations of drug-induced hepatotoxicity are highly variable, ranging from asymptomatic elevation of liver enzymes to fulminant hepatic failure. (medscape.com)
  • Over 3 years, more than 90 cases of hepatotoxicity were reported, which resulted in withdrawal of this drug. (medscape.com)
  • In some people, however, this drug metabolism process is slower, increasing the risk of liver damage from medication (called drug-induced liver damage). (megawecare.com)
  • Idiosyncratic drug-induced liver injury (IDILI) is thought to involve an adaptive immune attack on the liver. (technologynetworks.com)
  • There have been no convincing cases of idiosyncratic acute, clinically apparent liver injury attributed to either agent. (nih.gov)
  • Approximately 75% of the idiosyncratic drug reactions result in liver transplantation or death. (medscape.com)
  • In the United States, approximately 2000 cases of acute liver failure occur annually and drugs account for over 50% of them (39% are due to acetaminophen, 13% are idiosyncratic reactions due to other medications). (medscape.com)
  • The identification of risk factors and predictors of injury, novel mechanisms of injury, refined causality assessment tools, and targeted treatment options have amplified our understanding of the impact of drug-induced liver injury, however gaps in our knowledge still remain. (wjgnet.com)
  • Moreover, we will discuss mechanisms of drug-induced SKM injury, traditional laboratory testing for SKM injury, and novel skeletal myocyte biomarkers under investigation. (degruyter.com)
  • Drug-induced myopathies may result from various mechanisms. (degruyter.com)
  • These include direct myotoxicity (caused by alcohol, cocaine, glucocorticoids, and statins, amongst others), immunologically-induced inflammatory myopathy (caused by D-penicillamine, statins, and anti-cancer drugs), and indirect SKM injury (occurs as a result of a variety of different mechanisms). (degruyter.com)
  • Drugs cause nephrotoxicity by various cellular mechanisms, including mitochondrial dysfunction, oxidative stress, and others. (simulations-plus.com)
  • Predicting the toxicity and injury mechanisms of drugs remains a challenge. (simulations-plus.com)
  • We aimed to investigate mechanisms underlying drug-induced cholestasis and improve its early detection using human HepaRG cells and a set of 12 cholestatic drugs and six noncholestatic drugs. (aspetjournals.org)
  • For drug-induced interstitial lung disease (DIILD) translational imaging biomarkers are needed to improve detection and management of lung injury and drug-toxicity. (lu.se)
  • Pathologies resembling DIILD, such as inflammation and fibrosis, were described in many papers, but only a few explicitly addressed drug-induced toxicity experiments. (lu.se)
  • Their paper is titled "Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure. (genengnews.com)
  • In the future, we would like to contribute to the creation of a realistic and regulatory authority-approved liver model on which possible drug toxicity could be investigated," said Oleg Lunov, head of the Laboratory of Biophysics, where drug-induced liver damage is researched at FZU. (fzu.cz)
  • More than 600 drugs are known to cause pulmonary toxicity, and illicit drugs are well-known to result in pulmonary toxicities. (medscape.com)
  • A list of drugs that are reported to cause pulmonary toxicity is available on the continually updated Website PNEUMOTOX online . (medscape.com)
  • Drug-induced pulmonary toxicity is a diagnosis of exclusion. (medscape.com)
  • Patients who develop drug toxicity should be advised to avoid the drug in the future. (medscape.com)
  • Radiologic patterns observed in drug-induced pulmonary toxicity are highly variable and depend on the type of adverse reaction the patient is experiencing. (medscape.com)
  • If the drug-induced pulmonary toxicity causes airway obstruction, then the FEV 1 /FVC ratio and FEV 1 will be reduced. (medscape.com)
  • In general, bronchoscopy with transbronchial biopsy is not helpful in establishing the diagnosis of drug-induced pulmonary toxicity. (medscape.com)
  • The Food and Drug Administration (FDA) concluded that the overall risk of liver toxicity from pemoline outweighs the benefits. (medscape.com)
  • We present an extremely rare case of acetaminophen-induced lung injury. (wjgnet.com)
  • Even common drugs, including over-the-counter drugs, can cause lung injury, warranting consideration when evaluating emergent lung disease. (wjgnet.com)
  • Radiation-induced lung injury: Is there finally an approved treatment on the way? (drugdiscoverynews.com)
  • Aqualung scientists identified nicotinamide phosphoribosyltransferase (NAMPT) as a novel upstream immune-based therapeutic target in the development of RILI and have generated a humanized monoclonal therapeutic antibody mAb, ALT-100, which is designed to suppress the systemic inflammatory cascades and prevent radiation pneumonitis and radiation-induced lung fibrosis. (drugdiscoverynews.com)
  • There are currently no FDA-approved therapies for patients who experience radiation-induced lung injury and we believe our preclinical evidence is compelling and supports the advancement of ALT-100/ALT-200 as a potential therapy for patients with thoracic cancer and potentially for individuals accidentally exposed in a nuclear incident. (drugdiscoverynews.com)
  • Bronchoalveolar lavage (BAL) can contribute to the expected clinicopathologic pattern of a given drug-induced lung disease such as identifying eosinophils in a drug-induced eosinophilic pneumonia. (medscape.com)
  • Chest CT revealed diffuse ground-glass opacities with lower lobe predominance, suggesting influenza pneumonia or drug-induced lung injury caused by oseltamivir. (or.jp)
  • However, influenza pneumonia was excluded, leaving drug-induced lung injury as the most probable cause, based on the course of the fever and the cough that appeared after fever had resolved. (or.jp)
  • These findings were consistent with drug-induced lung injury. (or.jp)
  • Based on the above, we concluded that drug-induced lung injury due to oseltamivir treatment was the most probable cause of the patient's presentation. (or.jp)
  • More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. (medscape.com)
  • However, the complete etiology of drug-induced myopathies remains unclear. (degruyter.com)
  • Ye is a Professor of Autoimmune liver diseases and Translational Hepatology at the Institute of Immunology and Immunotherapy, University of Birmingham and Consultant Hepatologist at the Queen Elizabeth Hospital where he specialises in the management of autoimmune liver diseases, immune mediated liver injury and liver transplantation. (birmingham.ac.uk)
  • He also leads the UK drug induced liver injury immunology work stream with his team and AIH Immunology work. (birmingham.ac.uk)
  • Therefore, the present study proposes a strategy for drug safety monitoring using the available biomarkers of SKM injury. (degruyter.com)
  • Flagship machine learning platform for ADMET modeling with extended capabilities for data analysis, metabolism prediction, high-throughput pharmacokinetic simulation (HTPK), and AI-driven drug design. (simulations-plus.com)
  • The liver is the primary organ responsible for the metabolism and elimination of drugs. (megawecare.com)
  • Pradaxa (also known as Dabigatran Etexilate) is an inactive "parent" drug that relies on the body's metabolism to eventually manufacture a form of the drug that the body can use as an anti-coagulant, a process that occurs after the drug has been ingested by a patient. (searcylaw.com)
  • Intrahepatic cholestasis represents 20%-40% of drug-induced injuries from which a large proportion remains unpredictable. (aspetjournals.org)
  • Cotreatment with ROCK inhibitor Y-27632 [4-(1-aminoethyl)- N -(4-pyridyl) cyclohexanecarboxamide dihydrochloride] and MLCK activator calmodulin reduced bile canaliculi constriction and dilatation, respectively, confirming the role of these pathways in drug-induced intrahepatic cholestasis. (aspetjournals.org)
  • Some case studies identified by Vuppalanchi et al 3 have noted that biopsies indicate primary hepatocellular pattern of injury versus cholestatic. (psychiatrist.com)
  • BSEP , Na + -taurocholate cotransporting polypeptide, and organic anion transporting polypeptide B were downregulated with most cholestatic and some noncholestatic drugs, whereas deregulation of multidrug resistance-associated proteins was more variable, probably mainly reflecting secondary effects. (aspetjournals.org)
  • Together, our results show that cholestatic drugs consistently cause an early alteration of bile canaliculi dynamics associated with modulation of ROCK/MLCK and these changes are more specific than efflux inhibition measurements alone as predictive nonclinical markers of drug-induced cholestasis. (aspetjournals.org)
  • Although hepatocellular injury predominates, acute kidney injury develops in cholestatic cases with pronounced jaundice. (medscape.com)
  • Drug-induced liver injury is the most common cause of acute liver failure in the U.S, as well as the most frequently cited reason for abandoning candidate drug compounds early in development, or withdrawing approved medicines from the market. (genengnews.com)
  • The boxed warning emphasizes the risk for severe liver injury and acute liver failure, some of which have been fatal. (medscape.com)
  • Drug-induced liver injury should be considered in any acute liver injury or jaundice without evidence of biliary obstruction. (bsg.org.uk)
  • Young men (mean age 32 years), requiring hospitalisation, hepatocellular injury and jaundice were predominating features among the AAS cases. (medscape.com)
  • 208 Acute and chronic cholestasis can be caused by certain drugs or their metabolites. (wikipedia.org)
  • Painkillers and fever reducers that contain acetaminophen are a common cause of liver injury, particularly when taken in doses greater than those recommended. (medlineplus.gov)
  • However, if you took high doses of acetaminophen , you should get treated for liver injury in the emergency department or other acute treatment setting as soon as possible as there is a specific antidote for acetaminophen poisoning. (medlineplus.gov)
  • Their experiments demonstrated that treating mice with a small molecule inhibitor that specifically target the hepatic gap junction protein connexion 32 (Cx32) provides significant protection against liver damage and death resulting from subsequent or simultaneous challenge with known hepatotoxic drugs such as acetaminophen. (genengnews.com)
  • The damaging effects on the liver of some marketed drugs, such as acetaminophen (paracetamol), also limits their dosage. (genengnews.com)
  • They thus postulated that liver-specific gap junction inhibitors might act to protect the liver if they could be co-formulated with hepatotoxic drugs. (genengnews.com)
  • The use of checkpoint inhibitors in combination therapy further complicates the safety monitoring of SKM injury due to the potential for drug-drug interactions. (degruyter.com)
  • His group basic science research aims to dissect the pathogenesis mechanism of autoimmune liver diseases, immune mediated and drug induced/check point inhibitors liver injury with TransOMICS approach, deep immune profiling and develop personalised and stratified therapies. (birmingham.ac.uk)
  • The mechanism of bisphosphonates-induced osteonecrosis is unclear. (drug-injury.com)
  • This condition can be suspected if the patient has been exposed to a likely causative drug, develops new signs and symptoms, and has a remittence of these symptoms once the drug is withheld. (medscape.com)
  • Four patients developed hepatic injury as a result of drug treatment initiated during hospitalization. (rbfhss.org.br)
  • Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug. (medscape.com)
  • This resulted in more than 50 cases of severe hepatic injury, and the drug had to be withdrawn in 1998. (medscape.com)
  • You develop symptoms of liver injury after you start taking a new medicine. (medlineplus.gov)
  • You have been diagnosed with drug-induced liver injury and your symptoms do not get better after you stop taking the medicine. (medlineplus.gov)
  • Investigation of the potential culprit drugs should involve firstly the temporal relationship between intake of the medication and onset of symptoms, thus the improvement after drug withdrawal. (unipa.it)
  • Most drug-induced pulmonary toxicities involve the parenchyma, thus, interstitial infiltrates may be demonstrated on radiographs. (medscape.com)
  • Antibiotics are most frequently associated with VBDS, although several drug classes and medicines have been implicated. (medsafe.govt.nz)
  • Seventy-three percent of DIC cases can be attributed to a single prescription medication, commonly antibiotics & antifungals, anti-diabetics, anti-inflammatory, & cardiovascular drugs, psychotropic drugs. (wikipedia.org)
  • The use of drugs is a modifiable risk factor for AKI, accounting for about 20%-40% of AKI in critically ill patients, and antibiotics are the key trigger of AKI in all drugs ( Morales-Alvarez, 2020 ). (frontiersin.org)
  • Rhamnaceae) on cisplatin-induced damage to kidney epithelial LLC-PK1 cells via mitogen-activated protein kinase (MAPK) and apoptosis pathways. (mdpi.com)
  • A few common drugs that are responsible for liver damage include painkillers and fever-reducing medicines. (megawecare.com)
  • However, it may also appear as chronic myopathy with severe weakness and, rarely, even as massive rhabdomyolysis with acute kidney injury (AKI). (degruyter.com)
  • Quantitative Systems Toxicology (QST) software for predicting and understanding drug-induced kidney injury. (simulations-plus.com)
  • Introduction: Drug-induced acute kidney injury (DI-AKI) is a frequent adverse event. (uandes.cl)
  • Chronic exposure to cisplatin, a potent anticancer drug, causes irreversible kidney damage. (mdpi.com)
  • Vancomycin-associated acute kidney injury (AKI) continues to pose a major challenge to both patients and healthcare providers. (frontiersin.org)
  • Neither hydromorphone nor oxymorphone have been linked to serum enzyme elevations during therapy or to clinically apparent liver injury. (nih.gov)
  • Likelihood score , Hydromorphone: E (unlikely cause of clinically apparent liver injury). (nih.gov)
  • Serum bilirubin levels were elevated above 2.5 mg/dL in 5% of patients, but no patient developed both serum aminotransferase and bilirubin elevations or clinically apparent liver injury. (nih.gov)
  • E (unlikely cause of clinically apparent liver injury, but data on safety are limited). (nih.gov)
  • Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, diclofenac and naproxen are another group of drugs well-known to cause liver damage. (megawecare.com)
  • Bromfenac (Duract), a nonsteroidal anti-inflammatory drug (NSAID), was introduced in 1997 as a short-term analgesic for orthopedic patients. (medscape.com)
  • INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and inflammatory cell (LEUKOCYTES) infiltration. (bvsalud.org)
  • Pulmonary radiation injury manifests in approximately 8 percent of patients who receive thoracic radiation. (drugdiscoverynews.com)
  • Quantitative Systems Pharmacology (QSP) software providing the ability to predict the efficacy of drugs being developed to treat idiopathic pulmonary fibrosis (IPF. (simulations-plus.com)
  • The inducing agents and exposure (dose and duration) differed from non-physiological to clinically relevant doses. (lu.se)
  • Obesity, genetics, alcohol consumption, pre-existing liver conditions and other chronic medical conditions can increase an individual's risk for drug-induced liver damage. (megawecare.com)
  • According to severity of liver damage and type of drug, it is possible to carefully predict the patient's outcome. (unipa.it)
  • Drug-induced liver disease can be treated by discontinuing the causative medication and using antidotes. (megawecare.com)
  • Osteoarthritis drug Limbrel has been linked to serious side effects including drug-induced liver damage and hypersensitivity pneumonitis. (consumersafetywatch.com)
  • While a range of adverse events have been reported, two serious and potentially life-threatening medical conditions are among them: drug-induced liver injury and hypersensitivity pneumonitis. (consumersafetywatch.com)
  • A dose increase appears to have resulted in rapid autonomic dysfunction and liver injury. (psychiatrist.com)