• Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. (frontiersin.org)
  • Renal ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in clinical settings. (frontiersin.org)
  • BACKGROUND: Complement has been implicated in the pathophysiology of renal ischemia-reperfusion (I/R) injury. (maastrichtuniversity.nl)
  • abstract = "Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury: inhibition of late apoptosis and inflammation.De Vries B, Matthijsen RA, Wolfs TG, Van Bijnen AA, Heeringa P, Buurman WA.Department of General Surgery, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, Maastricht, The Netherlands.BACKGROUND: Complement has been implicated in the pathophysiology of renal ischemia-reperfusion (I/R) injury. (maastrichtuniversity.nl)
  • While effective early reperfusion of the criminal coronary artery after a confirmed AMI is the typical treatment at present, collateral myocardial ischemia-reperfusion injury (MIRI) and pertinent cardioprotection are still challenging to address and have inadequately understood mechanisms. (hindawi.com)
  • Heusch G: Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. (spandidos-publications.com)
  • Furthermore, we examined the effect of inhibition of complement-factor C5 on renal I/R injury. (maastrichtuniversity.nl)
  • Inhibition of C5 strongly inhibited late inflammation, as measured by neutrophil influx and induction of the murine CXC chemokines macrophage inflammatory protein-2, KC, and lipopolysaccharide-induced CXC chemokine. (maastrichtuniversity.nl)
  • The findings of the present study indicated that inhibition of miR‑132 may ameliorate myocardial I/R injury by inhibiting oxidative stress and pyroptosis through activation of PGC‑1α/Nrf2 signalling by targeting SIRT1. (spandidos-publications.com)
  • Meng X, Zhang L, Han B and Zhang Z: PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis. (spandidos-publications.com)
  • The most effective early treatment for reducing AMI injury and limiting the infarcted myocardium is timely coronary revascularization using thrombolytic therapy or primary percutaneous coronary intervention (PPCI) [ 2 - 4 ]. (hindawi.com)
  • This coupled comorbidity of pathological ischemia and therapeutic reinjury of infarcted myocardium, namely, myocardial ischemia-reperfusion injury (MIRI), is particularly refractory to treatment [ 4 , 5 ]. (hindawi.com)
  • During injury stimulation, the major effects on the cardiac function may be those involving mitochondria-dominated events along with potential nucleus-governed genetic/epigenetic alternations within the cardiomyocytes as well as the macrophage-led inflammation and T-cell-led immune responses underlying the myocardium-vessel interactive cascade. (hindawi.com)
  • However, whether GRh2 has a protective effect on ischaemia/reperfusion (I/R) in the myocardium has yet to be elucidated. (spandidos-publications.com)
  • 2002 - defended ahead of time his PhD thesis in Pathologic Physiology entitled «Comparative evaluation of the cardioprotective efficacy of local and distant ischemic adaptation of the myocardium» dedicated to myocardial protection against ischemia injury in the experiment. (almazovcentre.ru)
  • Acute kidney injury (AKI) is a major concern following cardiac surgery and has the potential to significantly impact patient outcomes. (nature.com)
  • Cardiac surgery-associated acute kidney injury (CSA-AKI) occurs in ≥50% of patients with chronic kidney disease (CKD) undergoing cardiac surgery with cardiopulmonary bypass (CPB) 2 . (nature.com)
  • DC-mediated NKT cell activation is critical in initiating the immune response following kidney ischemia/reperfusion injury (IRI), which mimics human acute kidney injury (AKI). (jci.org)
  • Adapted from de Geus HR, Betjes MG, Bakker J. Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges. (medscape.com)
  • METHODS: Mice were subjected to 45 min of unilateral ischemia and subsequent contralateral nephrectomy and reperfusion for 2, 12, or 24 hr. (maastrichtuniversity.nl)
  • In this study, we showed that mice with A2AR-deficient DCs are more susceptible to kidney IRI and are not protected from injury by A2AR agonists. (jci.org)
  • Following 26 minutes of kidney ischemia and 24 hours of kidney reperfusion, plasma creatinine levels were measured from vehicle- and ATL313-pretreated CD11c-Cre , CD11c-CreAdora2a fl/WT , and CD11c-CreAdora2a fl/fl mice. (jci.org)
  • Finally, the ischemia reperfusion (I/R) injury model was used in C57BL/6J mice to induce retinal inflammation and investigate the effects of caffeine treatment. (frontiersin.org)
  • The mice had less oxidative stress and inflammation in the retina, restoration of the protective blood retinal barrier to help avoid leakage of tiny capillaries and the swelling and damage that would follow, and reduced progression of diabetic retinopathy, says Dr. Ruth B. Caldwell , cell biologist in the MCG Vascular Biology Center. (eurekalert.org)
  • Conversely, they have shown that mice which express only half the usual amount of A1 have more abnormal blood vessel growth and retinal injury, they write. (eurekalert.org)
  • Furthermore, we observed that treatment with ERK5 inhibitor reduces inflammation, coagulopathy, and mortality in LPS-treated mice, but conversely increases mortality and bacteremia in a cecal ligation and puncture model of sepsis. (ucsf.edu)
  • Danger-associated molecular patterns (DAMPs) are endogenous ligands released from renal tubular cells following ischemia/reperfusion injury that activate the complement system through the classical, lectin and alternative pathways. (nature.com)
  • When there is increased demand in the setting of inflammation, ischemia-reperfusion injury, and organ dysfunction, endogenous arginine production falls short, and external supplementation may be necessary. (nih.gov)
  • These processes result from a complex inflammatory response that is initiated through the innate immune system by interactions between host cells and microbes or endogenous host factors that are released during injury or cell death. (ucsf.edu)
  • Liver ischemia/reperfusion (IR) often affects distant organs, such as small intestine, kidney, and lung. (rjme.ro)
  • The aim of this study was to investigate the anti-inflammatory and antiapoptotic effects of CS extract on small intestine, lung, and kidney after the liver IR injury. (rjme.ro)
  • Small intestine, lung, and kidney tissues were evaluated and scored in terms of cell degeneration, inflammation, and congestion, as well as caspase-3 (Cas-3) and cluster of differentiation 31 (CD31) immunostainings were carried out. (rjme.ro)
  • To investigate this in detail, we will use intravital and ex vivo microscopy, whole-body imaging, and light sheet microscopy to analyze NET formation in the kidney during sterile inflammation, and in the lung during bacterial infection (1, 2). (uni-muenster.de)
  • Block H , Herter JM, Rossaint J , Stadtmann A, Kliche S, Lowell CA, Zarbock A . Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. (uni-muenster.de)
  • Vitamin E, an essential nutrient that comprises tocopherol and tocotrienol, is known as a potential therapeutic agent for airway allergic inflammation. (tocotrienolresearch.org)
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
  • The Hellman Group studies TLR-dependent pathways expressed by macrophages as well as non-conventional inflammatory cells, including endothelial cells, in Inflammatory Critical Illness, focusing on their roles in coagulopathy, vascular permeability, neutrophil trafficking to organs, and organ injury and failure. (ucsf.edu)
  • Genomic actions involve the regulation of target genes, and suppress most of the vascular elements of inflammation and angiogenesis in the airway. (ersjournals.com)
  • Atherosclerosis is the main pathophysiological foundation of cardiovascular disease, which was caused by inflammation and lipid metabolism disorder, along with vascular calcification. (thno.org)
  • The histologic examination of the nasal structures showed moderate degree of inflammation and polymorphonuclear cells infiltration in the lamina propria, mucosa damage and vascular congestion in the PAF-induced AR rats. (tocotrienolresearch.org)
  • H&E staining demonstrated a statistically significant benefit upon TRF treatment, where minimal degree of inflammation, and a reduction in the infiltration of polymorphonuclear cells, mucosa damage and vascular congestion were observed. (tocotrienolresearch.org)
  • The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)
  • However, while myocardial reperfusion is well established, the process itself can trigger myocardial reperfusion injury by causing further cardiomyocyte death through multiple pathophysiological mechanisms [ 3 - 5 ]. (hindawi.com)
  • The pathophysiological nature of MIRI is the short-term disturbance of myocardial energy and metabolism caused by reflow after ischemia and hypoxia in the coronary artery and the dynamic changes in apoptosis and the prosurvival signaling pathways in response to related injury factors. (hindawi.com)
  • AI's anti-inflammatory power is exhibited in the way it can keep those immune cells, called macrophages, which can both promote and reduce inflammation, from becoming too proinflammatory, Ruth Caldwell says. (eurekalert.org)
  • We are also exploring how IL-1b is signalled to be secreted during necroptosis, so that we can create new drugs to stop its release and reduce inflammation to treat inflammatory diseases. (edu.au)
  • BHT has been found to reduce inflammation in animal studies, and some researchers believe it may have potential as a treatment for inflammatory diseases in humans. (earthclinic.com)
  • This study aimed to evaluate the effects of TQ on spatial memory and hippocampal long-term potentiation (LTP) in rats with thioacetamide (TAA)-induced liver injury and hepatic encephalopathy. (magiran.com)
  • Oral dosing of rats with SCN-, before acute ischemia-reperfusion injury (30 min occlusion, 24 h or 4 week recovery), significantly reduced the infarct size as a percentage of the total reperfused area (54% versus 74%), and increased the salvageable area (46% versus 26%) as determined by MRI imaging. (ku.dk)
  • SUF pretreatment effectively improved the neurological function and cerebral infarction of MCAO rats, inhibited excessive inflammation in rats, protected the BBB, and inhibited cell apoptosis in brain tissue. (sciencegate.app)
  • Ischemia and reperfusion can cause serious brain damage in stroke or cardiac arrest. (benbest.com)
  • In this article I attempt to evaluate the nature & extent of ischemic & reperfusion injury -- primarily focused on the impact for cryonics (although certainly relevant to stroke and cardiac arrest). (benbest.com)
  • Studies of renal transplant recipients and patients undergoing cardiac surgery suggest that damage and inflammation caused by IRI and CPB is amplified by complement activation 4 . (nature.com)
  • This is a typical example of ischemia/reperfusion injury in a cardiac allograft biopsy obtained 10 days after transplantation. (upmc.com)
  • In this study, we investigated the role of the NF-κB signaling pathway and inflammation in the amelioration of renal IRI using pioglitazone. (frontiersin.org)
  • Volmering S, Block H , Boras M, Lowell CA, Zarbock A . The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation. (uni-muenster.de)
  • Herter JM, Kraft F, Van Aken H, Meersch M, Zarbock A , Rossaint J . GDF-15 prevents ventilator-induced lung injury by inhibiting the formation of platelet-neutrophil aggregates. (uni-muenster.de)
  • Rossaint J , Herter JM, Van Aken H, Napirei M, Doring Y, Weber C, Soehnlein O, Zarbock A . Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation. (uni-muenster.de)
  • Zarbock A , Singbartl K, Ley K. Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. (uni-muenster.de)
  • Focus areas: mechanisms of myocardial protection against ischemia-reperfusion injury, development of targeted drug delivery using nanocarriers. (almazovcentre.ru)
  • Conceptual diagram of the development and unknown mechanisms of myocardial ischemia-reperfusion injury. (hindawi.com)
  • The present study aimed to investigate the roles of miR‑132 in myocardial ischaemia/reperfusion (I/R) injury and the underlying mechanisms. (spandidos-publications.com)
  • However, despite numerous studies on myocardial I/R injury, deeper insight into the underlying mechanisms of myocardial I/R injury is needed. (spandidos-publications.com)
  • However, few studies have focused on the role of miR-132 in myocardial I/R injury and the underlying mechanisms. (spandidos-publications.com)
  • Cerebral ischemia-reperfusion injury (CIRI) refers to the phenomenon that the ischemic injury of brain leads to the injury of brain cells, and ischemic injury is further aggravated after the recovery of blood reperfusion. (sciencegate.app)
  • hence, NGAL is considered to be a novel urinary biomarker for ischemic injury. (medscape.com)
  • Neonatal rat cardiomyocytes were also used to evaluate the protective effect of GRh2 on hypoxia/reoxygenation (H/R)‑induced myocardial injury in vitro. (spandidos-publications.com)
  • Hypoxia associated with OSA leads to hypoxia-reoxygenation with ischemia- reperfusion injury . (medscape.com)
  • One meta-analysis demonstrated faster and more stable positioning with the use of a DLT, whereas use of BBs resulted in less postoperative sore throat and hoarseness and fewer airway injuries. (medscape.com)
  • Inhaled corticosteroids suppress airway inflammation and components of airway remodelling in bronchial asthma. (ersjournals.com)
  • Airway inflammation is a central feature of bronchial asthma. (ersjournals.com)
  • Corticosteroids are the most effective drugs to suppress airway inflammation, mainly by downregulation of pro-inflammatory proteins 22 , 23 . (ersjournals.com)
  • Inhaled corticosteroids suppress airway inflammation, which is responsible for asthma-associated changes of the airway vasculature. (ersjournals.com)
  • In recent years, the complement system has been implicated in the pathophysiology and progression of many disorders, notably modulating inflammation and causing endothelial and organ damage 1 . (nature.com)
  • Following myocardial infarction (MI), diabetic and elderly patients have a poorer prognosis, which may be linked to increased coronary microvessel susceptibility to injury. (birmingham.ac.uk)
  • Scientists at the Medical College of Georgia report in newly published studies in the journals Cell Death and Disease and Cells , increasing evidence that making more of the enzyme arginase 1, or A1, available helps alleviate these unhealthy responses and interrupt a natural body response that promotes destructive ongoing, high levels of inflammation in both diabetic retinopathy and retinopathy of prematurity . (eurekalert.org)
  • Within two minutes of ischemia, extracellular pH can drop from about 7.3 to about 6.7. (benbest.com)
  • However, the mechanism underlying complement-mediated renal I/R injury is thus far unknown. (maastrichtuniversity.nl)
  • To investigate the involvement of complement in I/R injury, we studied the activation and deposition of complement in a murine model of renal I/R injury. (maastrichtuniversity.nl)
  • Complement activation plays a crucial role in the regulation of inflammation and late apoptosis. (maastrichtuniversity.nl)
  • Complement activation induces synthesis of pro-inflammatory cytokines and the membrane attack complex directly causes cell injury, apoptosis and necrosis, which in turn cause further complement activation and a vicious circle of inflammation and cell damage 4 . (nature.com)
  • As such, new drugs that would complement reperfusion by providing neural and cardiovascular protection and by targeting multiple abnormalities in ischemia are receiving increased attention. (cdc.gov)
  • It has been reported that SIRT1/peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α/nuclear factor erythroid-2-related factor 2 (Nrf2) signalling can mediate oxidative stress, which plays an important role in myocardial I/R injury ( 14 , 15 ). (spandidos-publications.com)
  • In conclusion, the present study confirmed that GRh2 could reduce oxidative stress and inflammation in cardiomyocytes after reperfusion, and its mechanism of action may be related to its regulation of the Nrf2/HO‑1/NLRP3 signalling pathway. (spandidos-publications.com)
  • Sun W, Wang Z, Sun M, Huang W and Wang Y and Wang Y: Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway. (spandidos-publications.com)
  • Ischaemia-reperfusion (I/R) injury is the most important and common cause of myocardial damage and subsequent heart failure worldwide ( 1 , 2 ). (spandidos-publications.com)
  • Finally, we made the intriguing observation in vitro that ERK1/2 activation reduces endothelial inflammation induced by LPS and TNFα, in contrast to its role in promoting leukocyte inflammation. (ucsf.edu)
  • We have defined the roles of several MAPKs (p38, JNK, ERK1/2, ERK5) and of NF-κB in TLR2-dependent signaling to inflammation, and have newly identified ERK5 as a key mediator of TLR2-dependent signaling in endothelial cells and human monocytes. (ucsf.edu)
  • The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
  • Cooling the whole body should have effects on multiple pathways and multiple organs that might be affected by the shock state and help temporize things until you can stabilize the patient, warm them back up, and avoid that period of injury. (medscape.com)
  • Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
  • We plan to pursue these studies further by identifying other endocannabinoids that regulate EC inflammation, and determining the mechanism by which NADA exerts its effects in ECs. (ucsf.edu)
  • The nature and severity of abdominal injuries vary widely depending on the mechanism and forces involved, thus generalizations about mortality and need for operative repair tend to be misleading. (msdmanuals.com)
  • The findings suggest that targeting IL-1b could suppress inflammation associated with multiple inflammatory diseases, including multiple sclerosis , ischemia-reperfusion injury, atherosclerosis, liver disease, pancreatitis, psoriasis, inflammatory bowel disease , and infectious diseases . (edu.au)
  • Adenosine is an important antiinflammatory molecule in tissue inflammation, and adenosine 2A receptor (A2AR) agonists protect kidneys from IRI through their actions on leukocytes. (jci.org)
  • Institute scientists have revealed a potent inflammatory molecule released by dying cells triggers inflammation during necroptosis, a recently described form of cell death linked to inflammatory disease. (edu.au)
  • Now that we have discovered IL-1b is the 'root' of the inflammation associated with necroptosis, we speculate that targeting this molecule could be an effective way of treating inflammatory diseases. (edu.au)
  • Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
  • In vitro , we determined the major components of GLSP triterpenes by HPLC, and subsequently assessed the protective effects of these main active components on lipid metabolism, inflammation, and calcification in RAW264.7 and HASMC cells. (thno.org)
  • A rat model of myocardial I/R injury was constructed by ligating the left anterior descending coronary artery, which was subsequently treated with GRh2. (spandidos-publications.com)
  • Alarmines activate the congenital immune system inducing inflammation and promoting tissue recovery [ 5 , 6 ]. (hindawi.com)
  • Cerebral ischemia-reperfusion injury (CIRI) caused by ischemic stroke seriously affects the prognosis of stroke patients. (sciencegate.app)
  • The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)
  • Ischemia due to early hypoperfusion followed by ischemia reperfusion injury (IRI) results in renal tissue damage 4 . (nature.com)
  • They theorized that more A1, which actually breaks down L-arginine into two products, would make less L-arginine available to "feed this (unhealthy) iNOS explosion," and help tamp down the vicious cycle of inflammation and related damage, says Dr. William Caldwell , pharmacologist and chair emeritus of the MCG Department of Pharmacology and Toxicology. (eurekalert.org)
  • SCN- supplementation did not modulate serum markers of damage/inflammation (ANP, BNP, galectin-3, CRP), but returned metabolomic abnormalities (reductions in histidine, creatine and leucine by 0.83-, 0.84- and 0.89-fold, respectively), determined by NMR, to control levels. (ku.dk)
  • The primary rationale for these developments is that recognition of AKI allows prompt injury-specific intervention that may avert permanent renal damage. (medscape.com)
  • We will also investigate the role of NADA, and the other components of the endocannabinoid system, in vivo using mouse models of infectious and non-infectious inflammation. (ucsf.edu)
  • Interleukin-36 (IL-36), a newly discovered proinflammatory member of the IL-1 superfamily, may mediate this injury, but its role in the injured heart is currently not known. (birmingham.ac.uk)
  • 3. The role of TLR2 in bacterial sepsis and organ injury: My lab has been investigating the bacterial lipoproteins in the context of sepsis for over a decade. (ucsf.edu)
  • But the "toxic" high levels produced by iNOS result in production of more reactive oxygen species, which feeds inflammation, which basically "rusts" whatever tissue it touches, Caldwell says. (eurekalert.org)
  • Inflamación del COLON debida a ISQUEMIA cólica por alteraciones en la circulación sistémica o vascularización local. (bvsalud.org)
  • Cerebral ischemia/reperfusion (I/R) injury is closely related to dysfunctional glucose metabolism. (sciencegate.app)
  • Apparent histologic injury and elevated levels of serum myocardial enzymes and inflammatory factors were observed in the myocardial I/R model. (spandidos-publications.com)
  • In this study, we first constructed Oxygen and glucose deprivation/reoxygenation (OGD/R) injury model of PC12 cells, we found that the expression of LncRNA AK139328 in model cells was significantly increased through RT-qPCR. (sciencegate.app)
  • Furthermore, the onset of additional pathophysiologies, specifically sepsis, becomes more likely in burned patients compared to other injuries. (tocotrienolresearch.org)
  • We aimed to identify publications of studies that evaluated the effectiveness of vitamin E as it pertains to thermal burn injuries, infection, and sepsis. (tocotrienolresearch.org)
  • To the benefit of subjects it has been shown that enteral or parenteral vitamin E supplementation can prevent, mitigate, and even reverse the effects of thermal burn injuries, infection, and sepsis. (tocotrienolresearch.org)