Parkinson's DiseaseSubcutaneous injectionAmphetamineApokynAPOMINEDopamine receptorIpsilateralLevodopaDopaminergicContinuousDoseTabletsIndiaMedicationsPumpWater for InjectionEmeticEfficacyRatsOndansetronErectileClinicalAdministerNauseaTreatmentHaloperidolDrugOuterFormulationTimeBrainEffectsSolutionStudyAdultAdministrationChemicalResults
Parkinson's Disease13
- While apomorphine is more commonly used in treatment of Parkinson's disease, it was found that low doses were enough to stimulate erection with minimal unintentional effects. (brandeismd.com)
- A new formulation of a sublingual tablet with 10 mg apomorphine was examined in 13 patients with Parkinson's disease. (nih.gov)
- Sublingual apomorphine should be considered as an alternative in the treatment of "off"-periods in Parkinson's disease, in particular when patients have the capacity to anticipate their off-periods. (nih.gov)
- Apomorphine is used in the treatment of Parkinson's disease to reduce the number and severity of bouts of freezing and stiffness (or "off" periods). (news-medical.net)
- P enile erections were regularly induced by intermittent subcutaneous injections of apomorphine in five patients with Parkinson's disease (PD) complicated by motor fluctuations. (biopsychiatry.com)
- Dr Kiran S Khanapure, consultant functional neurosurgeon, Vikram Hospital, noted that Parkinson's disease is an ageing-related disorder and has good treatment options, including tablets, injections, pump therapies, and surgeries. (pharmabiz.com)
- BENGALURU: In a boon to patients in the middle stages of Parkinson's Disease, a private hospital in Bengaluru, in association with UK-based specialty pharmaceutical company Britannia Pharmaceuticals, has launched Apomorphine for the first time in India. (newindianexpress.com)
- Introduction of apomorphine in India has given an important medical option to doctors in the middle stages of the management of Parkinson's Disease," Dr Prashanth said.Dr Pramod Kumar Pal, Head, Department of Neurology, NIMHANS, said once the Drug Controller General of India approves the drug it will be available at other hospitals. (newindianexpress.com)
- Bhidayasiri R, Boonpang K, Jitkritsadakul O Understanding the role of the Parkinson's disease nurse specialist in the delivery of apomorphine therapy. (britishjournalofcommunitynursing.com)
- Apomorphine helps to control the symptoms of Parkinson's disease by correcting the chemical imbalance in the brain that produces symptoms. (pharmachoice.com)
- Although apomorphine helps relieve symptoms of Parkinson's disease, it does not slow down the progression of the disease. (pharmachoice.com)
- The recommended starting dose of apomorphine is 2 mg injected subcutaneously (under the skin) when your regular medication wears off and causes symptoms of Parkinson's disease to return. (pharmachoice.com)
- A study found that apomorphine sublingual film was efficacious and generally safe and well tolerated for the on-demand treatment of off episodes in Parkinson's disease. (medscape.com)
Subcutaneous injection1
- Veterinarians suggest K-9 handlers learn how to do a subcutaneous injection, where to insert a trocar to help relieve bloat, and how to give an intramuscular injection. (policemag.com)
Amphetamine5
- Control rats showed no such rotational responses to amphetamine or apomorphine. (erowid.org)
- The effects of drugs acting on cerebral 5-hydroxytryptaminergic mechanisms on amphetamine (AM) and apomorphine (APO) induced turning in mice with unilateral lesions of the nigro-striatal dopamine terminals (NSDT) were studied. (erowid.org)
- Four to eight months after transplantation, circling behaviour after amphetamine or apomorphine injection was evaluated. (shengsci.com)
- Rats that had received intrathalamic grafts contralateral to the lesioned striatum (i.e. contralateral to the lesion-induced turning direction) showed a significant reduction of circling both after amphetamine (78% reduction) or apomorphine (77% reduction) injection. (shengsci.com)
- Rats that had received grafts ipsilateral to the lesioned striatum showed a 75% decrease in amphetamine-induced circling, but no significant change in apomorphine-induced circling. (shengsci.com)
Apokyn1
- tell your doctor if you are receiving apomorphine (Apokyn). (medlineplus.gov)
APOMINE1
- APOMINE Solution for Infusion contains apomorphine which belongs to a group of medicines called dopaminergic compounds. (news-medical.net)
Dopamine receptor1
- Apomorphine is a dopamine receptor activator in the brain. (brandeismd.com)
Ipsilateral2
- Results 5,6-HT and 6-OH-dopamine produced similar depletion of dopamine stores in the telediencephalon on the ipsilateral side of injection. (erowid.org)
- Methamphetamine produced ipsilateral and apomorphine contralateral circling in rats pretreated with either of the neurotoxics. (erowid.org)
Levodopa1
- For refractory, disabling symptoms in patients without dementia, stereotactic deep brain stimulation or lesional surgery and levodopa and an apomorphine pump may help. (msdmanuals.com)
Dopaminergic2
- The possible involvement of the dopaminergic system in the actions of T. catigua extract was substantiated by data showing the potentiation of apomorphine-induced hypothermia and by the prevention of haloperidol-induced catalepsy. (hindawi.com)
- Numerous studies have used apomorphine (APO) in the evaluation of dopaminergic (DA) function in schizophrenic patients. (mdpi.com)
Continuous1
- It is given by injection or continuous pump. (fightparkinsons.org.au)
Dose5
- ZOFRAN® Injection is indicated for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin [see Clinical Studies ]. (globalrph.com)
- The 100 mcg/kg dose of LSD tartrate, but not the lowest dosage, led to contralateral rotation (i.e. towards the non-operated side) from the 5th min after the injection, reaching maximum after 15 min. (erowid.org)
- The intrathalamic grafts of rats which had received a low dose of apomorphine (0.25 mg/kg) 2 h before perfusion showed clusters of intensely Fos-immunoreactive nuclei throughout the transplant, indicating that these cells had developed dopamine receptors and supersensitivity to dopamine agonists. (shengsci.com)
- If a single dose of apomorphine is ineffective for a particular 'off' period, a second dose should not be given for that 'off' episode. (pharmachoice.com)
- Do not take a repeat dose of apomorphine sooner than 2 hours after the last dose. (pharmachoice.com)
Tablets1
- Sublingual tablets of apomorphine are available for absorption underneath the tongue. (brandeismd.com)
India2
- Latest two new drugs in India are the apomorphine pump therapies and safinamide. (pharmabiz.com)
- Vikram Hospital has been one of pioneer hospitals in India for initiation of apomorphine pump therapies, he added. (pharmabiz.com)
Medications3
- tell your doctor and pharmacist if you are allergic to ondansetron, alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), palonosetron (Aloxi), or any other medications: or any of the ingredients in ondansetron injection. (medlineplus.gov)
- It was here the Indian embassies helped in procuring medications and apomorphine injections with prescriptions from the treating doctors, said Dr. Prashanth. (pharmabiz.com)
- Apomorphine belongs to the class of medications called anti-Parkinson's agents. (pharmachoice.com)
Pump1
- Indian clinical trial data for drugs like safinamide and apomorphine pump therapy are key for global pharma to seek US FDA approval. (pharmabiz.com)
Water for Injection1
- and 1.2 mg of methylparaben, NF and 0.15 mg of propylparaben, NF as preservatives in Water for Injection, USP. (globalrph.com)
Emetic3
- In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate. (nih.gov)
- You might read about giving your dog soda crystals to make them sick, and this is a method that has been used by veterinarians, especially before the wide availability of the emetic injection apomorphine. (caninejournal.com)
- Once they have emptied their stomach, the vet may give an anti-emetic injection to settle their stomach and provide some activated charcoal to absorb any remaining toxins. (caninejournal.com)
Efficacy1
- There is no evidence of significant differences in efficacy, safety, and tolerability between the PDE5 inhibitors and apomorphine. (uc.pt)
Rats3
- Propranolol, phenoxybenzamine, and methysergide (all 5 mg/kg i.p.) had no clear influence on the effect of E. Peripheral injection of E (2 mg/kg i,p.) immediately after intracerebral injection of E resulted in the sudden death of 8/9 rats. (erowid.org)
- Method The rotational responses of male SPF rats with unilateral damage to their nigro-striatal system (induced by the injection of 10 mcg 5,6 dihydroxytryptamine (5,6-HT) or 3.5 mcg 6-hydroxydopamine (6-OH - dopamine) into the right medial forebrain bundle) to 1-5 mg/kg of (+)-methamphetamine, 0.05-3 mg/kg apomorphine or 100,200 or 1,500 mcg LSD/kg i.p. were determined. (erowid.org)
- Additionally, some rats received intrastriatal grafts, and lesioned but non-grafted rats and lesioned rats that had received injections of saline or of cell suspensions from fetal spinal cord in the thalamus were used as control. (shengsci.com)
Ondansetron2
- Ondansetron injection is used to prevent nausea and vomiting caused by cancer chemotherapy and surgery. (medlineplus.gov)
- The active ingredient of ZOFRAN Injection is ondansetron hydrochloride, a selective blocking agent of the serotonin 5-HT3 receptor type. (globalrph.com)
Erectile3
- Four of the patients reported erectile dysfunction before beginning apomorphine and two of these report a significant improvement in their sexual function resulting from apomorphine use. (biopsychiatry.com)
- Intracavernosal injection therapy with alprostadil should be offered to patients as second line therapy for erectile dysfunction. (uc.pt)
- Apomorphine, intracavernosal injection therapy with alprostadil, and intraurethral alprostadil are all effective and well-tolerated treatments for men with erectile dysfunction. (uc.pt)
Clinical1
- For patients who do not receive prophylactic ZOFRAN Injection and experience nausea and/or vomiting postoperatively, ZOFRAN Injection may be given to prevent further episodes [see Clinical Studies ]. (globalrph.com)
Administer3
- The majority of working dog medical issues can be treated efficiently if the handler is adequately prepared and has taken time to learn how to give injections, administer oxygen, and handle the basics of bandage application. (policemag.com)
- At a minimum, veterinarians recommend K-9 handlers carry a first-aid kit, learn how to give injections, and know how to administer oxygen. (policemag.com)
- Your vet will be able to administer an injection that will make your dog vomit. (caninejournal.com)
Nausea3
- vomiting, without previous nausea , took place two minutes after the injection. (abchomeopathy.com)
- ZOFRAN Injection is indicated for the prevention of postoperative nausea and/or vomiting. (globalrph.com)
- In patients in whom nausea and/or vomiting must be avoided postoperatively, ZOFRAN Injection is recommended even when the incidence of postoperative nausea and/or vomiting is low. (globalrph.com)
Treatment2
- Studies have investigated apomorphine for treatment of low arousal and sexual dysfunction in women, with results of increased sexual satisfaction scores. (brandeismd.com)
- The benefit of apomorphine on sexual function in some patients suggests a possible role in the treatment of impotence in PD. (biopsychiatry.com)
Haloperidol2
- Bilateral injection into the nucleus accumbens of haloperidol (Serenase, 2.5 ug) or (3,4-dibydroxyphenylamino)-2-imidazoline (DPI) (5mcg markedly inhibited the effect of E. Clonidine (5 1lg bilaterally) reduced the effect of E only slightly. (erowid.org)
- The inhibitory effect of apomorphine on the firing rate of A9 and A10 DA neurons was prevented 3-4 hr after the acute or last injection of chronic haloperidol or (-)-sulpiride. (jneurosci.org)
Drug2
- This means that in a urine drug test, apomorphine will not show up as an opiate. (brandeismd.com)
- The drug often used for this is called apomorphine. (caninejournal.com)
Outer4
- October 26, 9.20 A.M. M. Lachize injected into the outer portion of my left arm three milligrammes of Apomorphine. (abchomeopathy.com)
- M. Lachize made another injection of six milligrammes Apomorphine into the lower and outer portion of the left arm, and conducted subsequent observations as carefully as before. (abchomeopathy.com)
- Encouraged by the experiments upon animals, I took an injection Dec. 10, 1873, of three centigrammes Apomorphine, in presence of Drs. Zuber and Grandjax, on the outer portion of the right arm, the left arm being bandaged. (abchomeopathy.com)
- Such effects may be minimized by deep injection into the upper outer quadrant of the gluteal region, and by avoiding the escape of solution along the route. (linkedlifedata.com)
Formulation1
- For example, the new formulation is more convenient than carrying an injection, as it comes in a small, tear-open packet that contains a medication strip the patient places under their tongue. (medscape.com)
Time1
- Following administration of 200 mg (100 mg/mL) Tigan I.M. injection, the time to reach maximum plasma concentration (T max ) was about half an hour, about 15 minutes longer for Tigan 300 mg oral capsule than an I.M. injection. (nih.gov)
Brain1
- Apomorphine acts directly at the brain to stimulate nerves that innervate oxytocin-activated nerves in the spinal cord. (brandeismd.com)
Effects3
- The effects typically last for hours, with plasma levels of apomorphine returning to normal after 8 hours. (brandeismd.com)
- Viagra affects the blood vessels directly, apomorphine exerts its effects through the nervous system. (brandeismd.com)
- The effects of injection of ergometrine (E) and other ergot derivatives into the nucleus accumbens on locomotor activity were studied. (erowid.org)
Solution1
- The pH of the injection solution is 3.3 to 4.0. (globalrph.com)
Study1
- The aim of the current study is to compare quinagolide with cabergoline in prevention of ovarian hyperstimulation syndrome (OHSS) among high risk women undergoing intracytoplasmic sperm injection (ICSI). (ijfs.ir)
Adult1
- The lesion was induced by stereotactic injection of ouabain into adult rat brains. (johnshopkins.edu)
Administration2
- ZOFRAN Injection should be diluted in 50 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection before administration. (globalrph.com)
- Intramuscular administration may cause pain, stinging, burning, redness and swelling at the site of injection. (linkedlifedata.com)
Chemical2
- ZOFRAN Injection should not be mixed with solutions for which physical and chemical compatibility have not been established. (globalrph.com)
- Quinagolide (Norprolac™) is a non-ergot extract and dopamine agonist with a chemical structure similar to apomorphine. (ijfs.ir)
Results1
- Results Bilateral injection of E (1 mcg) into the nucleus accumbens markedly stimulated locomotor activity. (erowid.org)